Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework

The Image Biomarker Standardization Initiative: Standardized Quantitative Radiomics for High-Throughput Image-based Phenotyping

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What are biomarkers?

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Preclinical Alzheimer’s Disease: Definition, Natural History, and Diagnostic Criteria

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Chronic kidney disease

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Protein Analysis by Shotgun/Bottom-up Proteomics

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Wearable and flexible electronics for continuous molecular monitoring

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Biomarkers of Cardiovascular Disease: Molecular Basis and Practical Considerations

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Imaging biomarker roadmap for cancer studies

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HMGB1 in health and disease

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Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers

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Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer

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The role of vascular biomarkers for primary and secondary prevention. A position paper from the European Society of Cardiology Working Group on peripheral circulation

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The NIMH research domain criteria initiative: Background, issues, and pragmatics

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GFR decline as an end point for clinical trials in CKD: a scientific workshop sponsored by the National Kidney Foundation and the US Food and Drug Administration

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Change in albuminuria and GFR as end points for clinical trials in early stages of CKD: a scientific workshop sponsored by the National Kidney Foundation in collaboration with the US Food and Drug Administration and European Medicines Agency

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Applications of multi‐omics analysis in human diseases

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Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises

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Metabolomics and systems biology: making sense of the soup

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Amyloid biomarkers in Alzheimer's disease

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Interpreting prevotella and bacteroides as biomarkers of diet and lifestyle

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A Consideration of Biomarkers to be Used for Evaluation of Inflammation in Human Nutritional Studies

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The statistical interpretation of pilot trials: should significance thresholds be reconsidered?

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Peripheral biomarkers of endometriosis: a systematic review

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Biomarkers for monitoring clinical efficacy of allergen immunotherapy for allergic rhinoconjunctivitis and allergic asthma: an EAACI Position Paper

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HIFs, angiogenesis, and metabolism: Elusive enemies in breast cancer

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A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

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A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup

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Biomarkers of Parkinson’s disease: Present and future

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Therapies for rare diseases: therapeutic modalities, progress and challenges ahead

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Combined Dexamethasone/Corticotropin Releasing Hormone Test Predicts Treatment Response in Major Depression–A Potential Biomarker?

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Biomarkers in Psychiatry: Concept, Definition, Types and Relevance to the Clinical Reality

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Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis

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Value of biomarkers in osteoarthritis: current status and perspectives

Lotz, M., Martel-Pelletier, J., Christiansen, C., Brandi, M.-L., Bruyère, O., Chapurlat, R., Collette, J., Cooper, C., Giacovelli, G., Kanis, J. A., et al. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-203726 · Cited by 328

Solving neurodegeneration: common mechanisms and strategies for new treatments

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New concepts for an old problem: the diagnosis of endometrial hyperplasia

Sanderson, P. A., Critchley, H. O. D., Williams, A. R. W., Arends, M. J., & Saunders, P. T. K. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmw042 · Cited by 323

Untitled work

Akdis (2020) · doi:10.1111/pai.13189 · Cited by 320

Clinical applications of the functional connectome

Castellanos, F. X., Di Martino, A., Craddock, R. C., Mehta, A. D., & Milham, M. P. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.083 · Cited by 312

Attentional bias toward suicide-related stimuli predicts suicidal behavior

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Toward a Biosignature for Suicide

Oquendo, M. A., Sullivan, G. M., Sudol, K., Baca-Garcia, E., Stanley, B. H., Sublette, M. E., & Mann, J. J. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14020194 · Cited by 299

Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in the pathogenesis of neurodegenerative disorders

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Personalized medicine in psychiatry: problems and promises

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Immunological and biological changes during ipilimumab treatment and their potential correlation with clinical response and survival in patients with advanced melanoma

Simeone, E., Gentilcore, G., Giannarelli, D., Grimaldi, A. M., Caracò, C., Curvietto, M., Esposito, A., Paone, M., Palla, M., Cavalcanti, E., et al. (2014) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-014-1545-8 · Cited by 253

Idiopathic Pulmonary Fibrosis: Clinically Meaningful Primary Endpoints in Phase 3 Clinical Trials

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Next Generation Sequencing (NGS): A Revolutionary Technology in Pharmacogenomics and Personalized Medicine in Cancer

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Challenges and perspectives in obstructive sleep apnoea: Report by an ad hoc working group of the Sleep Disordered Breathing Group of the European Respiratory Society and the European Sleep Research Society

Randerath, W., Bassetti, C. L., Bonsignore, M. R., Farre, R., Ferini-Strambi, L., Grote, L., Hedner, J., Kohler, M., Martinez-Garcia, M.-A., Mihaicuta, S., et al. (2018) · European Respiratory Journal · doi:10.1183/13993003.02616-2017 · Cited by 245

On the outside, looking in: A review and evaluation of the comparability of blood and brain “‐omes”

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Allostatic processes in the family

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Biomarkers for immunotherapy of hepatocellular carcinoma

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The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer’s Disease

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Endophenotypes in schizophrenia: A selective review

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Peripheral biomarkers of major depression and antidepressant treatment response: Current knowledge and future outlooks

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From biomarkers to medical tests: the changing landscape of test evaluation

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Diverse functional roles of lipocalin-2 in the central nervous system

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Peripheral Markers of Depression

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Markers and Biomarkers of Endothelium: When Something Is Rotten in the State

Goncharov, N. V., Nadeev, A. D., Jenkins, R. O., & Avdonin, P. V. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9759735 · Cited by 190

Mitochondrial Dysfunction, Protein Misfolding and Neuroinflammation in Parkinson’s Disease: Roads to Biomarker Discovery

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Stratified medicine for mental disorders

Schumann, G., Binder, E. B., Holte, A., de Kloet, E. R., Oedegaard, K. J., Robbins, T. W., Walker-Tilley, T. R., Bitter, I., Brown, V. J., Buitelaar, J., et al. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.09.010 · Cited by 186

Increased peripheral blood inflammatory cytokine levels in amyotrophic lateral sclerosis: a meta-analysis study

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Diagnostic potential and future directions of biomarkers in gingival crevicular fluid and saliva of periodontal diseases: Review of the current evidence

Ghallab, N. A. (2018) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2017.12.022 · Cited by 174

Premotor Parkinson’s disease: Concepts and definitions

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Circulating irisin levels as a predictive biomarker for sarcopenia: a cross-sectional community-based study

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Omics and Drug Response

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A Critical Evaluation of microRNA Biomarkers in Non-Neoplastic Disease

Haider, B. A., Baras, A. S., McCall, M. N., Hertel, J. A., Cornish, T. C., & Halushka, M. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089565 · Cited by 157

Precision radiology: predicting longevity using feature engineering and deep learning methods in a radiomics framework

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Upper Limb Recovery After Stroke Is Associated With Ipsilesional Primary Motor Cortical Activity: A Meta-Analysis

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Ageing with HIV: Challenges and biomarkers

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Diabetes mellitus correlates with increased biological age as indicated by clinical biomarkers

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Atopic dermatitis: a candidate for disease‐modifying strategy

Bieber, T., Cork, M., & Reitamo, S. (2012) · Allergy · doi:10.1111/j.1398-9995.2012.02845.x · Cited by 131

Biomarkers for attention-deficit/hyperactivity disorder (ADHD). A consensus report of the WFSBP task force on biological markers and the World Federation of ADHD

Thome, J., Ehlis, A.-C., Fallgatter, A. J., Krauel, K., Lange, K. W., Riederer, P., Romanos, M., Taurines, R., Tucha, O., Uzbekov, M., et al. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2012.690535 · Cited by 130

Exercise reduces circulating biomarkers of cellular senescence in humans

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Extracellular vesicles remodel tumor environment for cancer immunotherapy

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C-Reactive Protein: Clinical and Epidemiological Perspectives

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Biomarkers intersect with the exposome

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Mechanistic biomarkers for clinical decision making in rheumatic diseases

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Blood biomarkers and treatment response in major depression

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Identification of Gingival Crevicular Fluid Sampling, Analytical Methods, and Oral Biomarkers for the Diagnosis and Monitoring of Periodontal Diseases: A Systematic Review

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Biomarkers in Sporadic and Familial Alzheimer’s Disease

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Self-blame–Selective Hyperconnectivity Between Anterior Temporal and Subgenual Cortices and Prediction of Recurrent Depressive Episodes

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Molecular imaging with SPECT as a tool for drug development

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Synovial Fluid Biomarkers in Knee Osteoarthritis: A Systematic Review and Quantitative Evaluation Using BIPEDs Criteria

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Curcumin and major depression: A randomised, double-blind, placebo-controlled trial investigating the potential of peripheral biomarkers to predict treatment response and antidepressant mechanisms of change

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A Review of Biomarkers in Mood and Psychotic Disorders: A Dissection of Clinical vs. Preclinical Correlates

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Biomarkers in Neurodegenerative Diseases

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Diagnostic Accuracy of Oral Fluids Biomarker Profile to Determine the Current and Future Status of Periodontal and Peri-Implant Diseases

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Endothelial Dysfunction as the Common Pathway Linking Obesity, Hypertension and Atherosclerosis

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A systematic review of duloxetine and venlafaxine in major depression, including unpublished data

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ENDOPHENOTYPE, INTERMEDIATE PHENOTYPE, BIOMARKER: DEFINITIONS, CONCEPT COMPARISONS, CLARIFICATIONS: The Cutting Edge: Endophenotype, Intermediate Phenotype, and Biomarker

Lenzenweger, M. F. (2013) · Depression and Anxiety · doi:10.1002/da.22042 · Cited by 84

Is There a Role for IGF1R and c-MET Pathways in Resistance to Cetuximab in Metastatic Colorectal Cancer?

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Phenotyping, Etiological Factors, and Biomarkers: Toward Precision Medicine in Autism Spectrum Disorders

Beversdorf, D. Q., & MISSOURI AUTISM SUMMIT CONSORTIUM* (2016) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0000000000000351 · Cited by 74

Variance of SUVs for FDG-PET/CT is Greater in Clinical Practice Than Under Ideal Study Settings

Kumar, V., Nath, K., Berman, C. G., Kim, J., Tanvetyanon, T., Chiappori, A. A., Gatenby, R. A., Gillies, R. J., & Eikman, E. A. (2013) · Clinical Nuclear Medicine · doi:10.1097/rlu.0b013e318279ffdf · Cited by 76

Systematic review: fluid biomarkers and machine learning methods to improve the diagnosis from mild cognitive impairment to Alzheimer’s disease

Blanco, K., Salcidua, S., Orellana, P., Sauma-Pérez, T., León, T., Steinmetz, L. C. L., Ibañez, A., Duran-Aniotz, C., & de la Cruz, R. (2023) · Alzheimer's Research & Therapy · doi:10.1186/s13195-023-01304-8 · Cited by 73

Longitudinal multi-level biomarker analysis of BDNF in major depression and bipolar disorder

Schröter, K., Brum, M., Brunkhorst-Kanaan, N., Tole, F., Ziegler, C., Domschke, K., Reif, A., & Kittel-Schneider, S. (2020) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-019-01007-y · Cited by 68

A systematic review on olfaction in child and adolescent psychiatric disorders

Schecklmann, M., Schwenck, C., Taurines, R., Freitag, C., Warnke, A., Gerlach, M., & Romanos, M. (2013) · Journal of Neural Transmission · doi:10.1007/s00702-012-0855-2 · Cited by 68

Neurotrophins, inflammation and oxidative stress as illness activity biomarkers in bipolar disorder

Pfaffenseller, B., Fries, G. R., Wollenhaupt-Aguiar, B., Colpo, G. D., Stertz, L., Panizzutti, B., Magalhães, P. V., & Kapczinski, F. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2013.811981 · Cited by 68

The road ahead to cure Alzheimer’s disease: development of biological markers and neuroimaging methods for prevention trials across all stages and target populations

Cavedo, E., Lista, S., Khachaturian, Z., Aisen, P., Amouyel, P., Herholz, K., Jack Jr, C. R., Sperling, R., Cummings, J., Blennow, K., et al. (2014) · The Journal of Prevention of Alzheimer's Disease · doi:10.14283/jpad.2014.32 · Cited by 67

Biomarkers for Aging Identified in Cross-sectional Studies Tend to Be Non-causative

Nelson, P. G., Promislow, D. E. L., & Masel, J. (2020) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glz174 · Cited by 65

Tissue-specific, non-invasive toxicity biomarkers: translation from preclinical safety assessment to clinical safety monitoring

Muller, P. Y., & Dieterle, F. (2009) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425250903114174 · Cited by 62

Fit‐for‐Purpose Biometric Monitoring Technologies: Leveraging the Laboratory Biomarker Experience

Godfrey, A., Vandendriessche, B., Bakker, J. P., Fitzer‐Attas, C., Gujar, N., Hobbs, M., Liu, Q., Northcott, C. A., Parks, V., Wood, W. A., et al. (2021) · Clinical and Translational Science · doi:10.1111/cts.12865 · Cited by 60

Mass spectrometry: A platform for biomarker discovery and validation for Alzheimer's and Parkinson's diseases

Cilento, E. M., Jin, L., Stewart, T., Shi, M., Sheng, L., & Zhang, J. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14635 · Cited by 60

Transcranial Magnetic Stimulation as a Potential Biomarker in Multiple Sclerosis: A Systematic Review with Recommendations for Future Research

Snow, N. J., Wadden, K. P., Chaves, A. R., & Ploughman, M. (2019) · Neural Plasticity · doi:10.1155/2019/6430596 · Cited by 56