Cited by 986Memory and Neural MechanismsMemory Processes and InfluencesSpatial Cognition and Navigation

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Spatial memory, recognition memory, and the hippocampus

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Broadbent, Nicola J., Squire, Larry R., Clark, Robert E.·2004·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0406344101PMC PMC521976

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Abstract

There is wide agreement that spatial memory is dependent on the integrity of the hippocampus, but the importance of the hippocampus for nonspatial tasks, including tasks of object recognition memory is not as clear. We examined the relationship between hippocampal lesion size and both spatial memory and object recognition memory in rats. Spatial memory was impaired after bilateral dorsal hippocampal lesions that encompassed 30-50% total volume, and as lesion size increased from 50% to approximately 100% of total hippocampal volume, performance was similarly impaired. In contrast, object recognition was intact after dorsal hippocampal lesions that damaged 50-75% of total hippocampal volume and was impaired only after larger lesions that encompassed 75-100% of hippocampal volume. Last, ventral hippocampal lesions that encompassed approximately 50% of total hippocampal volume impaired spatial memory but did not affect object recognition memory. These findings show that the hippocampus is important for both spatial memory and recognition memory. However, spatial memory performance requires more hippocampal tissue than does recognition memory.

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Untitled work
(1978) · UA Campus Repository (The University of Arizona) · Cited by 8,010
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
Self-citation
The medial temporal lobe
Squire, L. R., Stark, C. E. L., & Clark, R. E. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144130 · Cited by 2,680
Self-citation
Recognition memory: What are the roles of the perirhinal cortex and hippocampus?
Brown, M. W., & Aggleton, J. P. (2001) · Nature reviews. Neuroscience · doi:10.1038/35049064 · Cited by 1,624
From Conditioning to Conscious Recollection
Eichenbaum, H., & Cohen, N. J. (2004) · doi:10.1093/acprof:oso/9780195178043.001.0001 · Cited by 1,026
Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions
Moser, E., Moser, M. ‐., & Andersen, P. N. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03916.1993 · Cited by 953
Spatial learning with a minislab in the dorsal hippocampus.
Moser, M., Moser, E. I., Forrest, E., Andersen, P. N., & Morris, R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9697 · Cited by 944
Impaired Recognition Memory in Rats after Damage to the Hippocampus
Clark, R. E., Zola, S. M., & Squire, L. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08853.2000 · Cited by 740
Self-citation
Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts
Mumby, D. G., Gaskin, S., Glenn, M. J., Schramek, T. E., & Lehmann, H. (2002) · Learning & Memory · doi:10.1101/lm.41302 · Cited by 714
Place cells and place recognition maintained by direct entorhinal-hippocampal circuitry
Brun, V. H., Otnæss, M. K., Molden, S., Steffenach, H.-A., Witter, M. P., Moser, M.-B., & Moser, E. I. (2002) · Science · doi:10.1126/science.1071089 · Cited by 606

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Fujimichi R. Naya Y. & Miyashita Y. in Cognitive Neurosciences III ed. Gazzaniga M. S. (MIT Press Cambridge MA) in press.
10.1037/0735-7044.111.6.1184 · DOI
Bannerman, D. M., Yee, B. K., Good, M. A., Heupel, M. J., Iversen, S. D. & Rawlins, J. N. (1999) Behav. Neurosci. 11, 1170-1188.
10.1073/pnas.0308528101 · DOI

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Authors: Broadbent, N. J., Squire, L. R., & Clark, R. E.
Affiliations: University of California San Diego (US)
Corresponding author: Clark, Robert E.
ORCID: Squire, Larry R.
Clark, Robert E.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2004-09-27
Volume: 101
Issue: 40
Pages: 14515-14520
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0406344101
PMC: PMC521976
OpenAlex: W2038813826
Cited by: 985
References: 37
Citations by year: 2026: 25 · 2025: 26 · 2024: 35 · 2023: 40 · 2022: 59 · 2021: 51 · 2020: 55 · 2019: 53 · 2018: 56 · 2017: 57 · 2016: 51 · 2015: 51 · 2014: 52 · 2013: 48 · 2012: 63
FWCI: 14.60
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
U.S. Department of Veterans Affairs
James S. McDonnell Foundation
National Alliance for Research on Schizophrenia and Depression
National Institute on Aging (P50AG005131, P50-AG05131)
National Institute of Mental Health (P50 AG05131, AG05131)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Social Sciences › Psychology › Experimental and Cognitive Psychology › Spatial Cognition and Navigation
Keywords: spatial memory, recognition memory, hippocampus, hippocampal lesions, lesion size, dorsal hippocampus, ventral hippocampus, object recognition, rats
MeSH terms: Animals, Hippocampus, Male, Memory, Spatial Behavior, Rats, Long-Evans, Recognition, Psychology, Rats

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Spatial memory, recognition memory, and the hippocampus

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