Evolutionarily conserved gene family important for fat storage

Global analysis of protein localization in budding yeast

Huh, W.-K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., & O'Shea, E. K. (2003) · Nature · doi:10.1038/nature02026 · Cited by 4,248

Obesity and the regulation of energy balance

Spiegelman, B. M., & Flier, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00240-9 · Cited by 2,398

Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism

Staels, B., Dallongeville, J., Auwerx, J., Schoonjans, K., Leitersdorf, E., & Fruchart, J.-C. (1998) · Circulation · doi:10.1161/01.cir.98.19.2088 · Cited by 1,786

Molecular evidence for an ancient duplication of the entire yeast genome

Wolfe, K. H., & Shields, D. C. (1997) · Nature · doi:10.1038/42711 · Cited by 1,785

Lipid droplets: a unified view of a dynamic organelle

Martin, S., & Parton, R. G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1912 · Cited by 1,179

Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis

Cases, S., Smith, S. J., Zheng, Y.-W., Myers, H. M., Lear, S. R., Sande, E., Novak, S., Collins, C. C., Welch, C. L., Lusis, A. J., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13018 · Cited by 1,138

Regulation of Lipolysis in Adipocytes

Duncan, R. E., Ahmadian, M., Jaworski, K., Sarkadi-Nagy, E., & Sul, H. S. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093734 · Cited by 1,021

Lipotoxicity: when tissues overeat

Schaffer, J. E. (2003) · Current Opinion in Lipidology · doi:10.1097/00041433-200306000-00008 · Cited by 933

Biochemistry and molecular biology of fishes

(1994) · Biochemistry and molecular biology of fishes · doi:10.1016/b978-0-444-82033-4.50001-5 · Cited by 857

Cloning of DGAT2, a Second Mammalian Diacylglycerol Acyltransferase, and Related Family Members

Cases, S., Stone, S. J., Zhou, P., Yen, E., Tow, B., Lardizabal, K. D., Voelker, T., & Farese, R. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106219200 · Cited by 818

Dynamics and functions of lipid droplets

Olzmann, J. A., & Carvalho, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0085-z · Cited by 2,740

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.

Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2391 · Cited by 2,292

Lipid Droplets and Cellular Lipid Metabolism

Walther, T. C., & Farese, R. V. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061009-102430 · Cited by 1,701

Triglyceride Metabolism in the Liver

Alves‐Bezerra, M., & Cohen, D. E. (2017) · Comprehensive physiology · doi:10.1002/cphy.c170012 · Cited by 1,324

Lipid Droplet Biogenesis

Walther, T. C., Chung, J., & Farese, R. V. (2017) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100616-060608 · Cited by 789

Lipid droplets and liver disease: from basic biology to clinical implications

Gluchowski, N. L., Becuwe, M., Walther, T. C., & Farese, R. V. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.32 · Cited by 690

Integrated physiology and systems biology of PPARα

Kersten, S. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.02.002 · Cited by 701

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

Cho, Y. S., Chen, C.-H., Hu, C., Ong, R. T., Ong, R. T. H., Sim, X., Takeuchi, F., Wu, Y., Go, M. J., Yamauchi, T., et al. (2011) · Nature Genetics · doi:10.1038/ng.1019 · Cited by 607

UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators

Rutkowski, D. T., Wu, J., Back, S.-H., Callaghan, M. U., Ferris, S. P., Iqbal, J., Clark, R. L., Miao, H. Z., Hassler, J. R., Fornek, J. L., et al. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.10.015 · Cited by 580

Not Just Fat: The Structure and Function of the Lipid DropletPreprint

Fujimoto, T., & Parton, R. G. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004838 · Cited by 506

Biogenesis of the multifunctional lipid droplet: Lipids, proteins, and sites

Pol, A., Gross, S. P., & Parton, R. G. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201311051 · Cited by 466

Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance

Choi, S. H., & Ginsberg, H. N. (2011) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.04.007 · Cited by 418

The dynamic roles of intracellular lipid droplets: from archaea to mammals

Murphy, D. J. (2011) · PROTOPLASMA · doi:10.1007/s00709-011-0329-7 · Cited by 410

Microplastics induce transcriptional changes, immune response and behavioral alterations in adult zebrafish

Limonta, G., Mancia, A., Benkhalqui, A., Bertolucci, C., Abelli, L., Fossi, M. C., & Panti, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-52292-5 · Cited by 406

The unfolded protein response transducer IRE1α prevents ER stress‐induced hepatic steatosis

Zhang, K., Wang, S., Malhotra, J. D., Hassler, J. R., Back, S. H., Wang, G., Chang, L., Xu, W., Miao, H. Z., Leonardi, R., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.52 · Cited by 368

Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites

Gong, J., Sun, Z., Wu, L., Xu, W., Schieber, N. L., Xu, D., Shui, G., Yang, H., Parton, R. G., & Li, P. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201104142 · Cited by 362

A conserved family of proteins facilitates nascent lipid droplet budding from the ER

Choudhary, V., Ojha, N., Golden, A., & Prinz, W. A. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201505067 · Cited by 329

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

Sun, Z., Miller, R. A., Patel, R. T., Chen, J., Dhir, R., Wang, H., Zhang, D., Graham, M. J., Unterman, T. G., Shulman, G. I., et al. (2012) · Nature Medicine · doi:10.1038/nm.2744 · Cited by 335

Cell biology of lipid droplets

Thiele, C., & Spandl, J. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.05.009 · Cited by 307

Regulation of glucose and lipid metabolism in health and disease

Chen, L., Chen, X., Huang, X., Song, B., Wang, Y., & Wang, Y. (2019) · Science China Life Sciences · doi:10.1007/s11427-019-1563-3 · Cited by 313

ER Membrane Phospholipids and Surface Tension Control Cellular Lipid Droplet Formation

M’Barek, K. B., Ajjaji, D., Chorlay, A., Vanni, S., Foret, L., & Thiam, A. R. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.05.012 · Cited by 278

Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways

Promlek, T., Ishiwata‐Kimata, Y., Shido, M., Sakuramoto, M., Kohno, K., & Kimata, Y. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-04-0295 · Cited by 268

Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes

Sun, Z., Gong, J., Wu, H. J., Xu, W., Wu, L., Xu, D., Gao, J., Wu, J., Yang, H., Yang, M., et al. (2013) · Nature Communications · doi:10.1038/ncomms2581 · Cited by 258

Coatomer-dependent protein delivery to lipid droplets

Soni, K. G., Mardones, G. A., Sougrat, R., Smirnova, E., Jackson, C. L., & Bonifacino, J. S. (2009) · Journal of Cell Science · doi:10.1242/jcs.045849 · Cited by 258

Lactobacillus rhamnosus lowers zebrafish lipid content by changing gut microbiota and host transcription of genes involved in lipid metabolism

Falcinelli, S., Picchietti, S., Rodiles, A., Cossignani, L., Merrifield, D. L., Taddei, A. R., Maradonna, F., Olivotto, I., Gioacchini, G., & Carnevali, O. (2015) · Scientific Reports · doi:10.1038/srep09336 · Cited by 231

Packaging of Fat: An Evolving Model of Lipid Droplet Assembly and Expansion

Brasaemle, D., & Wolins, N. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.309088 · Cited by 229

LDAF1 and Seipin Form a Lipid Droplet Assembly Complex

Chung, J., Wu, X., Lambert, T. J., Lai, Z. W., Walther, T. C., & Farese, R. V. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.10.006 · Cited by 229

A journey into the world of insect lipid metabolism

Toprak, U., Hegedus, D. D., Doğan, C., & Güney, G. (2020) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.21682 · Cited by 222

Lipid Droplets and Peroxisomes: Key Players in Cellular Lipid Homeostasis or A Matter of Fat—Store ’em Up or Burn ’em Down

Kohlwein, S. D., Marten Veenhuis, A., & van der Klei, I. J. (2012) · Genetics · doi:10.1534/genetics.112.143362 · Cited by 213

Architecture of Lipid Droplets in Endoplasmic Reticulum Is Determined by Phospholipid Intrinsic Curvature

Choudhary, V., Golani, G., Joshi, A. S., Cottier, S., Schneiter, R., Prinz, W. A., & Kozlov, M. M. (2018) · Current Biology · doi:10.1016/j.cub.2018.02.020 · Cited by 201

Controlling the size of lipid droplets: lipid and protein factors

Yang, H., Galea, A. M., Sytnyk, V., & Crossley, M. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.05.012 · Cited by 200

Lipid droplets: size matters

Suzuki, M., Shinohara, Y., Ohsaki, Y., & Fujimoto, T. (2011) · Microscopy · doi:10.1093/jmicro/dfr016 · Cited by 197

Oil Accumulation by the Oleaginous Diatom Fistulifera solaris as Revealed by the Genome and Transcriptome

Tanaka, T., Maeda, Y., Veluchamy, A., Tanaka, M., Abida, H., Maréchal, É., Bowler, C., Muto, M., Sunaga, Y., Tanaka, M., et al. (2015) · The Plant Cell · doi:10.1105/tpc.114.135194 · Cited by 186

Lipid droplets, lipophagy, and beyond

Wang, C.-W. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.12.010 · Cited by 189

Zebrafish: gaining popularity in lipid research

Hölttä‐Vuori, M., Salo, V. T., Nyberg, L. K., Brackmann, C., Enejder, A. M. K., Panula, P., & Ikonen, E. (2010) · Biochemical Journal · doi:10.1042/bj20100293 · Cited by 180

Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation

Gross, D. A., Zhan, C., & Silver, D. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110817108 · Cited by 180

Turning Over a New Leaf in Lipid Droplet Biology

Pyc, M., Cai, Y., Greer, M. S., Yurchenko, O. P., Chapman, K. D., Dyer, J. M., & Mullen, R. T. (2017) · Trends in Plant Science · doi:10.1016/j.tplants.2017.03.012 · Cited by 162

Developmental toxicity screening in zebrafish

McCollum, C. W., Ducharme, N. A., Bondesson, M., & Gustafsson, J.-Α. (2011) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20210 · Cited by 161

Open Questions in Lipid Droplet Biology

Ohsaki, Y., Suzuki, M., & Fujimoto, T. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.08.009 · Cited by 156

Metabolic engineering for enhanced oil in biomass

Vanhercke, T., Dyer, J. M., Mullen, R. T., Kilaru, A., Rahman, M. M., Petrie, J. R., Green, A. G., Yurchenko, O., & Singh, S. P. (2019) · Progress in Lipid Research · doi:10.1016/j.plipres.2019.02.002 · Cited by 151

The obesity paradox in chronic disease: facts and numbers

Lainščak, M., von Haehling, S., Doehner, W., & Anker, S. D. (2012) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-012-0059-5 · Cited by 136

White adipose tissue development in zebrafish is regulated by both developmental time and fish size

Imrie, D., & Sadler, K. C. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22443 · Cited by 137

Re-evaluating lipotoxic triggers in skeletal muscle: Relating intramyocellular lipid metabolism to insulin sensitivity

Bosma, M., Kersten, S., Hesselink, M. K. C., & Schrauwen, P. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.11.003 · Cited by 135

Recent discoveries on absorption of dietary fat: Presence, synthesis, and metabolism of cytoplasmic lipid droplets within enterocytes

D’Aquila, T., Hung, Y.-H., Carreiro, A. L., & Buhman, K. K. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.04.012 · Cited by 142

Organelle biogenesis in the endoplasmic reticulum

Joshi, A., Zhang, H., & Prinz, W. A. (2017) · Nature Cell Biology · doi:10.1038/ncb3579 · Cited by 126

Rab8a-AS160-MSS4 Regulatory Circuit Controls Lipid Droplet Fusion and Growth

Wu, L., Xu, D., Zhou, L., Xie, B., Yu, L., Yang, H., Huang, L., Ye, J., Deng, H., Yuan, Y. A., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.07.005 · Cited by 125

Identification of the major functional proteins of prokaryotic lipid droplets

Ding, Y., Li, Y., Zhang, S., Wang, Y., Du, Y., Pu, J., Gong, P., Chen, Y., Zhang, H., Yu, J., et al. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m021899 · Cited by 119

Pet10p is a yeast perilipin that stabilizes lipid droplets and promotes their assembly

Gao, Q., Binns, D. D., Kinch, L. N., Grishin, N. V., Speer, N. O., Chen, X., & Goodman, J. M. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201610013 · Cited by 117

Lipid Metabolism in Macrophages: Focus on Atherosclerosis

Sukhorukov, V. N., Khotina, V. A., Chegodaev, Y. S., Ivanova, E. A., Sobenin, I. A., & Orekhov, A. N. (2020) · Biomedicines · doi:10.3390/biomedicines8080262 · Cited by 122

Recent insights into the molecular pathophysiology of lipid droplet formation in hepatocytes

Sahini, N., & Borlak, J. T. (2014) · Progress in Lipid Research · doi:10.1016/j.plipres.2014.02.002 · Cited by 117

Cytosolic lipid droplets: From mechanisms of fat storage to disease

Gross, D. A., & Silver, D. L. (2014) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2014.931337 · Cited by 117

Mechanisms of lipid droplet biogenesis

Chapman, K. D., Aziz, M., Dyer, J. M., & Mullen, R. T. (2019) · Biochemical Journal · doi:10.1042/bcj20180021 · Cited by 107

Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis

Choudhary, V., Atab, O. E., Mizzon, G., Prinz, W. A., & Schneiter, R. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.201910177 · Cited by 106

Major Facilitator Superfamily Domain-Containing Protein 2a (MFSD2A) Has Roles in Body Growth, Motor Function, and Lipid Metabolism

Berger, J. H., Charron, M. J., & Silver, D. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050629 · Cited by 105

The evolution of the adipose tissue: A neglected enigma

Ottaviani, E., Malagoli, D., & Franceschi, C. (2011) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2011.06.018 · Cited by 100

Lipid Droplets as Organelles

Cohen, S. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2017.12.007 · Cited by 102

PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans

Koves, T. R., Sparks, L. M., Kovalik, J., Mosedale, M., Arumugam, R., DeBalsi, K. L., Everingham, K., Thorne, L. B., Phielix, E., Meex, R. C. R., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.p028910 · Cited by 97

Lipid droplet formation on opposing sides of the endoplasmic reticulum

Sturley, S. L., & Hussain, M. M. (2012) · Journal of Lipid Research · doi:10.1194/jlr.r028290 · Cited by 96

Whole Exome Sequencing in Females with Autism Implicates Novel and Candidate Genes

Butler, M. G., Rafi, S. K., Hossain, W. A., Stephan, D. A., & Manzardo, A. M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16011312 · Cited by 93

Regulation of lipid droplet-associated proteins by peroxisome proliferator-activated receptors

Rodriguez, M. A. D. L. R., & Kersten, S. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.07.007 · Cited by 97

Lumenal Lipid Metabolism

Lehner, R. S., Lian, J., & Quiroga, A. D. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.241497 · Cited by 95

Lipid droplet dynamics in budding yeast

Wang, C.-W. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1903-5 · Cited by 90

Identification of Novel Inhibitors of Dietary Lipid Absorption Using Zebrafish

Clifton, J. D., Lucumi, E., Myers, M. C., Napper, A. D., Hama, K., Farber, S. A., Smith, A. B., Huryn, D. M., Diamond, S. L., & Pack, M. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012386 · Cited by 88

Dynamics of the Lipid Droplet Proteome of the Oleaginous Yeast Rhodosporidium toruloides

Zhu, Z., Ding, Y., Gong, Z., Li, Y., Zhang, S., Zhang, C., Lin, X., Shen, H., Zou, H., Xie, Z., et al. (2015) · Eukaryotic Cell · doi:10.1128/ec.00141-14 · Cited by 87

Effects of diethylene glycol dibenzoate and Bisphenol A on the lipid metabolism of Danio rerio

Santangeli, S., Notarstefano, V., Maradonna, F., Giorgini, E., Gioacchini, G., Forner-Piquer, I., Habibi, H. R., & Carnevali, O. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.04.291 · Cited by 82

Chemical Genetic Profiling and Characterization of Small-molecule Compounds That Affect the Biosynthesis of Unsaturated Fatty Acids in Candida albicans

Xu, D., Sillaots, S., Davison, J., Hu, W., Jiang, B., Kauffman, S., Martel, N., Ocampo, P., Oh, C., Trosok, S., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.019877 · Cited by 79

The evolution of plasma cholesterol: Direct utility or a “spandrel” of hepatic lipid metabolism?

Babin, P. J., & Gibbons, G. F. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.11.002 · Cited by 81

Bisphenol S induces obesogenic effects through deregulating lipid metabolism in zebrafish (Danio rerio) larvae

Wang, W., Zhang, X., Wang, Z., Qin, J., Wang, W., Tian, H., & Ru, S. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.01.163 · Cited by 78

FIT2 organizes lipid droplet biogenesis with ER tubule-forming proteins and septins

Chen, F., Yan, B., Ren, J., Lyu, R., Wu, Y., Guo, Y., Li, D., Zhang, H., & Hu, J. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.201907183 · Cited by 73

Fat Storage-inducing Transmembrane Protein 2 Is Required for Normal Fat Storage in Adipose Tissue

Miranda, D. A., Kim, J.-H., Nguyen, L. N., Cheng, W., Tan, B. C., Goh, V. J., Tan, J. S. Y., Yaligar, J., KN, B. P., Velan, S. S., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.547687 · Cited by 71

Fat storage-inducing transmembrane (FIT or FITM) proteins are related to lipid phosphatase/phosphotransferase enzymes

Hayes, M. J., Choudhary, V., Ojha, N., Shin, J. J. H., Han, G., Carman, G. M., Loewen, C. J. R., Prinz, W. A., & Levine, T. P. (2018) · Microbial Cell · doi:10.15698/mic2018.02.614 · Cited by 71

Lipid droplet biogenesis: A mystery “unmixing”?

Renne, M. F., Klug, Y. A., & Carvalho, P. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.03.001 · Cited by 71

FIT2 is an acyl–coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis

Becuwe, M., Bond, L. M., Pinto, A. F. M., Boland, S., Mejhert, N., Elliott, S. D., Cicconet, M., Graham, M. M., Liu, X. N., Ilkayeva, O., et al. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.202006111 · Cited by 69

Lipid Droplets: Formation to Breakdown

Meyers, A., Weisskittel, T., & Dalhaimer, P. (2017) · Lipids · doi:10.1007/s11745-017-4263-0 · Cited by 68

Reducing microglial lipid load enhances β amyloid phagocytosis in an Alzheimer’s disease mouse model

Wu, X., Miller, J. A., Lee, B. T. K., Wang, Y., & Ruedl, C. (2025) · Science Advances · doi:10.1126/sciadv.adq6038 · Cited by 67

Born this way – Biogenesis of lipid droplets from specialized ER subdomains

Nettebrock, N. T., & Bohnert, M. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.04.008 · Cited by 72

Lipid Droplets Big and Small: Basic Mechanisms That Make Them All

Klemm, R. W., & Carvalho, P. (2024) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-012624-031419 · Cited by 72

Mature lipid droplets are accessible to ER luminal proteins

Mishra, S., Khaddaj, R., Cottier, S., Strádalová, V., Jacob, C., & Schneiter, R. (2016) · Journal of Cell Science · doi:10.1242/jcs.189191 · Cited by 65

Lipid droplet‐mediated lipid and protein homeostasis in budding yeast

Graef, M. (2018) · FEBS Letters · doi:10.1002/1873-3468.12996 · Cited by 65

Come a little bit closer! Lipid droplet-ER contact sites are getting crowded

Hugenroth, M., & Bohnert, M. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2019.118603 · Cited by 62

Origin and Development of the Adipose Tissue, a Key Organ in Physiology and Disease

Parra-Peralbo, E., Talamillo, A., & Barrio, R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.786129 · Cited by 66

Double function at the blood–brain barrier

Betsholtz, C. (2014) · Nature · doi:10.1038/nature13339 · Cited by 63

A critical role of VMP1 in lipoprotein secretion

Morishita, H., Zhao, Y. G., Tamura, N., Nishimura, T., Kanda, Y., Sakamaki, Y., Okazaki, M., Li, D., & Mizushima, N. (2019) · eLife · doi:10.7554/elife.48834 · Cited by 62

Manipulation of Host Cell Organelles by Intracellular Pathogens

Kellermann, M., Scharte, F., & Hensel, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126484 · Cited by 63

Moving out but keeping in touch: contacts between endoplasmic reticulum and lipid droplets

Salo, V. T., & Ikonen, E. (2018) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2018.11.002 · Cited by 62

Wnt Signaling: From Mesenchymal Cell Fate to Lipogenesis and Other Mature Adipocyte Functions

Bagchi, D. P., & MacDougald, O. A. (2021) · Diabetes · doi:10.2337/dbi20-0015 · Cited by 65

Structural Insights into Triglyceride Storage Mediated by Fat Storage-Inducing Transmembrane (FIT) Protein 2

Gross, D. A., Snapp, E. L., & Silver, D. L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010796 · Cited by 60

Lipid droplets: FSP27 knockout enhances their sizzle

Puri, V., & Czech, M. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36554 · Cited by 62

Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implications

Rakotonirina-Ricquebourg, R., Costa, V., & Teixeira, V. (2021) · Progress in Lipid Research · doi:10.1016/j.plipres.2021.101141 · Cited by 63

The SR-BI Partner PDZK1 Facilitates Hepatitis C Virus Entry

Eyre, N. S., Drummer, H. E., & Beard, M. R. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001130 · Cited by 59

SCS3 and YFT2 Link Transcription of Phospholipid Biosynthetic Genes to ER Stress and the UPR

Moir, R. D., Gross, D. A., Silver, D. L., & Willis, I. M. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002890 · Cited by 59

A whole-genome sequence based association study on pork eating quality traits and cooking loss in a specially designed heterogeneous F6 pig population

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