Social interaction-mediated lifespan extension of Drosophila Cu/Zn superoxide dismutase mutants
Open accessAbstract
Beneficial effects of social interaction on aging have been studied in humans and other species. We found that short-lived Drosophila mutants of the antioxidant enzyme Cu/Zn superoxide dismutase displayed a robust lifespan extension, with improved stress resistance and motor ability, upon cohousing with active flies of longer lifespan or younger age. Genetic, surgical, and environmental manipulations revealed motor and sensory components in behavioral interactions required for the lifespan extension induced by cohousing. Our results provide a definitive case of beneficial social interaction on lifespan and a useful entry point for analyzing the underlying molecular networks and physiological mechanisms.
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Social isolation shortens lifespan in Drosophila melanogaster.
“social isolation decreases the lifespan of the fruit fly, Drosophila melanogaster;12”
From Social isolation (2011) · cites this paper as [12]
Experimental studies in nonhuman social species show that isolation has direct harmful physiological effects.
“experimental studies in nonhuman social species indicate that isolation has direct, deleterious physiological effects.”
From Social isolation (2011) · cites this paper as [12]
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Self-citation
- Authors
- Ruan, H., & Wu, C.-F.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Wu, Chun-Fang
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2008-05-27
- Volume
- 105
- Issue
- 21
- Pages
- 7506-7510
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2396722
- OpenAlex
- W2148972618
- Cited by
- 112
- References
- 31
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 3 · 2023: 9 · 2022: 6 · 2021: 8 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 6 · 2016: 6 · 2015: 8 · 2014: 4 · 2013: 5 · 2012: 5
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS026528, NS-26528)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- social interaction, lifespan extension, aging, Cu/Zn superoxide dismutase, mutant SOD1, Drosophila, cohousing, stress tolerance, motor abilities, behavioral interactions, antioxidant enzymes
- MeSH terms
- Alleles, Animals, Animal Communication, Drosophila, Female, Longevity, Male, Mutation, Social Behavior, Superoxide Dismutase, Drosophila Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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