Cited by 199Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorAmino Acid Enzymes and Metabolism

A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex

Open access
Wang, Huaixing, Stradtman, George G., Wang, Xiao-Jing, Gao, Wen-Jun·2008·Proceedings of the National Academy of Sciences

Abstract

In the prefrontal cortex, NMDA receptors are important for normal prefrontal functions such as working memory, and their dysfunction plays a key role in the pathological processes of psychiatric disorders such as schizophrenia. Little is known, however, about the synaptic properties of NMDA receptors in the local circuits of recurrent excitation, a leading candidate mechanism underlying working memory. We investigated the NMDA receptor-mediated currents at monosynaptic connections between pairs of layer 5 pyramidal neurons. We found that NMDA receptor-mediated currents at prefrontal synapses in the adult, but not young, rats exhibit a twofold longer decay time-constant and temporally summate a train of stimuli more effectively, compared to those in the primary visual cortex. Experiments with pharmacological, immunocytochemical, and biochemical approaches further suggest that, in the adult animals, neurons express significantly more NR2B subunits in the prefrontal cortex than the visual cortex. The NR2B-rich synapses in the prefrontal circuitry may be critically implicated in online cognitive computations and plasticity in learning, as well as psychiatric disorders.

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Crossref · 10.1073/pnas.0804318105

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Authors
Wang, H., Stradtman, G. G., Wang, X.-J., & Gao, W.-J.
Affiliations
  • Drexel University (US)
  • Yale University (US)
Venue
Proceedings of the National Academy of Sciences
Published
2008-10-28
Volume
105
Issue
43
Pages
16791-16796
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2064286037
Cited by
199
References
39
Citations by year
2026: 7 · 2025: 3 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 15 · 2020: 12 · 2019: 9 · 2018: 15 · 2017: 10 · 2016: 16 · 2015: 14 · 2014: 20 · 2013: 17 · 2012: 11
FWCI
3.85
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Drexel University
  • National Alliance for Research on Schizophrenia and Depression
  • National Institutes of Health (NIH-R01)
  • College of Medicine, Drexel University
  • National Institute of Mental Health (R21MH079117, R01MH062349, MH232307, R01MH085666)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords
NMDA receptor, prefrontal cortex, layer 5 pyramidal neurons, monosynaptic connections, NR2B subunit, synaptic plasticity, working memory, temporal summation, primary visual cortex, schizophrenia, adult rats
MeSH terms
Animals, Synaptic Transmission, Synapses, Receptors, N-Methyl-D-Aspartate, Prefrontal Cortex, Pyramidal Cells, Rats

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