The basolateral amygdala in reward learning and addiction

Wassum, Kate M.; Izquierdo, Alicia

doi:10.1016/j.neubiorev.2015.08.017

Cited by 306Neurotransmitter Receptor Influence on BehaviorMemory and Neural MechanismsNeural and Behavioral Psychology Studies

The basolateral amygdala in reward learning and addiction

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Wassum, Kate M., Izquierdo, Alicia·2015·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2015.08.017PMC PMC4681295

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Abstract

Sophisticated behavioral paradigms partnered with the emergence of increasingly selective techniques to target the basolateral amygdala (BLA) have resulted in an enhanced understanding of the role of this nucleus in learning and using reward information. Due to the wide variety of behavioral approaches many questions remain on the circumscribed role of BLA in appetitive behavior. In this review, we integrate conclusions of BLA function in reward-related behavior using traditional interference techniques (lesion, pharmacological inactivation) with those using newer methodological approaches in experimental animals that allow in vivo manipulation of cell type-specific populations and neural recordings. Secondly, from a review of appetitive behavioral tasks in rodents and monkeys and recent computational models of reward procurement, we derive evidence for BLA as a neural integrator of reward value, history, and cost parameters. Taken together, BLA codes specific and temporally dynamic outcome representations in a distributed network to orchestrate adaptive responses. We provide evidence that experiences with opiates and psychostimulants alter these outcome representations in BLA, resulting in long-term modified action.

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The amygdala plays a crucial role in effort-based decision making in rodents.
“Recent evidence points to the amygdala as playing a crucial role in effort-based decision making in rodents, with neurophysiological data showing that the amygdala plays an important role in valuing effort [40, 41].”
From Neurocomputational mechanisms underlying subjective valuation of effort costs (2017) · cites this paper as [41]
Neurophysiological data show that the amygdala plays an important role in valuing effort.
“Recent evidence points to the amygdala as playing a crucial role in effort-based decision making in rodents, with neurophysiological data showing that the amygdala plays an important role in valuing effort [40, 41].”
From Neurocomputational mechanisms underlying subjective valuation of effort costs (2017) · cites this paper as [41]

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Stress Impairs 5-HT2A Receptor-Mediated Serotonergic Facilitation of GABA Release in Juvenile Rat Basolateral Amygdala
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Dopamine D1and NMDA Receptors Mediate Potentiation of Basolateral Amygdala-Evoked Firing of Nucleus Accumbens Neurons
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Interactions between the prefrontal cortex and amygdala during delay discounting and reversal.
Churchwell, J. C., Morris, A. M., Heurtelou, N. M., & Kesner, R. P. (2009) · Behavioral Neuroscience · doi:10.1037/a0017734 · Cited by 141 · see citing works
The amygdala and emotion: a view through fear
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Incentive Memory: Evidence the Basolateral Amygdala Encodes and the Insular Cortex Retrieves Outcome Values to Guide Choice between Goal-Directed Actions
Parkes, S. L., & Balleine, B. W. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5071-12.2013 · Cited by 136 · see citing works
The monoaminergic innervation of the amygdala in the squirrel monkey: An immunohistochemical study
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Sidman Instrumental Avoidance Initially Depends on Lateral and Basal Amygdala and Is Constrained by Central Amygdala-Mediated Pavlovian Processes
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The basolateral amygdala is critical to the expression of Pavlovian and instrumental outcome-specific reinforcer devaluation effects
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Amygdala and bed nucleus of the stria terminalis circuitry: Implications for addiction-related behaviors
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Safety Encoding in the Basal Amygdala
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Amygdala Neurons Differentially Encode Motivation and Reinforcement
Tye, K. M., & Janak, P. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5281-06.2007 · Cited by 130 · cited 1× · see citing works
“…this idea, BLA neurons fire in response to reward-predictive cues during learning (Ambroggi et al., 2008; Paton et al., 2006; Schoenbaum et al., 1999; Tye and Janak, 2007; Uwano et al., 1995) and in anticipation of reward in an olfactory instrumental discrimination task (Schoenbaum et al., 1998).”
Background
Interaction of the Amygdala with the Frontal Lobe in Reward Memory
Gaffan, D., Murray, E. A., & Fabre‐Thorpe, M. (1993) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1993.tb00948.x · Cited by 128 · see citing works
Distinct Subtypes of Basolateral Amygdala Taste Neurons Reflect Palatability and Reward
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GABA<sub>A</sub>-Mediated Inhibition of Basolateral Amygdala Blocks Reward Devaluation in Macaques
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Consolidation and Reconsolidation of Incentive Learning in the Amygdala
Wang, S., Ostlund, S. B., Nader, K., & Balleine, B. W. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4716-04.2005 · Cited by 126 · see citing works
Effects of excitotoxic lesions of the basolateral amygdala on cocaine-seeking behavior and cocaine conditioned place preference in rats
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Dissociable Roles for the Basolateral Amygdala and Orbitofrontal Cortex in Decision-Making under Risk of Punishment
Orsini, C. A., Trotta, R. T., Bizon, J. L., & Setlow, B. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3586-14.2015 · Cited by 123 · see citing works
The Origins and Organization of Vertebrate Pavlovian ConditioningPreprint
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Self-citation
Selective bilateral amygdala lesions in rhesus monkeys fail to disrupt object reversal learning
Izquierdo, A., & Murray, E. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3616-06.2007 · Cited by 121 · see citing works
Self-citation
Functional Disconnection of the Orbitofrontal Cortex and Basolateral Amygdala Impairs Acquisition of a Rat Gambling Task and Disrupts Animals' Ability to Alter Decision-Making Behavior after Reinforcer Devaluation
Zeeb, F. D., & Winstanley, C. A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3971-12.2013 · Cited by 120 · see citing works
Dissociable contributions of anterior cingulate cortex and basolateral amygdala on a rodent cost/benefit decision-making task of cognitive effort
Hosking, J. G., Cocker, P. J., & Winstanley, C. A. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.27 · Cited by 119 · see citing works
Emotion dysregulation in schizophrenia: Reduced amplification of emotional expression is associated with emotional blunting
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Basolateral Amygdala Modulates Terminal Dopamine Release in the Nucleus Accumbens and Conditioned Responding
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Motivational control of heterogeneous instrumental chains.
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Encoding of the unconditioned stimulus in Pavlovian conditioning
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Differential roles of the prefrontal cortical subregions and basolateral amygdala in compulsive cocaine seeking and relapse after voluntary abstinence in rats
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The Contribution of Orbitofrontal Cortex to Action Selection
Ostlund, S. B., & Balleine, B. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.033 · Cited by 102 · see citing works
Opposing effects of amygdala and orbital prefrontal cortex lesions on the extinction of instrumental responding in macaque monkeys
Izquierdo, A., & Murray, E. A. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04434.x · Cited by 96 · see citing works
Learning about Multiple Attributes of Reward in Pavlovian Conditioning
Delamater, A. R., & Oakeshott, S. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1390.008 · Cited by 95 · see citing works
Inactivation of Basolateral Amygdala Specifically Eliminates Palatability-Related Information in Cortical Sensory Responses
Piette, C. E., Baez-Santiago, M. A., Reid, E. E., Katz, D. B., & Moran, A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0669-12.2012 · Cited by 93 · see citing works
Effects of chronic administration of drugs of abuse on impulsive choice (delay discounting) in animal models
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On the Nature of CS and US Representations in Pavlovian Learning
Delamater, A. (2011) · Learning & Behavior · doi:10.3758/s13420-011-0036-4 · Cited by 88 · see citing works
Changes in reinforcing properties of stimuli following ablation of the amygdaloid complex in monkeys.
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Role of Central Serotonin in Anticipation of Rewarding and Punishing Outcomes: Effects of Selective Amygdala or Orbitofrontal 5-HT Depletion
Rygula, R., Clarke, H. F., Cardinal, R. N., Cockcroft, G. J., Xia, J., Dalley, J. W., Robbins, T. W., & Roberts, A. C. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu102 · Cited by 85 · see citing works
Selective reinstatement of instrumental performance depends on the discriminative stimulus properties of the mediating outcome
Ostlund, S. B., & Balleine, B. W. (2007) · Animal Learning & Behavior · doi:10.3758/bf03196073 · Cited by 82 · see citing works
Amygdala Neural Encoding of the Absence of Reward during Extinction
Tye, K. M., Cone, J. J., Schairer, W. W., & Janak, P. H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4240-09.2010 · Cited by 81 · see citing works
Enhancement of Inhibitory Avoidance and Conditioned Taste Aversion Memory With Insular Cortex Infusions of 8-Br-cAMP: Involvement of the Basolateral AmygdalaPreprint
Miranda, M. I., & McGaugh, J. L. (2004) · Learning & Memory · doi:10.1101/lm.72804 · Cited by 81 · see citing works
Evidence for model-based computations in the human amygdala during Pavlovian conditioning
Prévost, C., McNamee, D., Jessup, R. K., Bossaerts, P., & O'Doherty, J. P. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002918 · Cited by 79 · see citing works
Prediction of economic choice by primate amygdala neurons
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Amygdala modulates memory for changes in reward magnitude: reversible post-training inactivation with lidocaine attenuates the response to a reduction in reward.
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The Basolateral Amygdala Is Critical for the Acquisition and Extinction of Associations between a Neutral Stimulus and a Learned Danger Signal But Not between Two Neutral Stimuli
Parkes, S. L., & Westbrook, R. F. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2949-10.2010 · Cited by 76 · see citing works
The Role of the Amygdala-Striatal Pathway in the Acquisition and Performance of Goal-Directed Instrumental Actions
Corbit, L. H., Leung, B. K., & Balleine, B. W. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3271-13.2013 · Cited by 75 · see citing works
Functional Circuits and Anatomical Distribution of Response Properties in the Primate Amygdala
Zhang, W., Schneider, D. M., Belova, M. A., Morrison, S. E., Paton, J. J., & Salzman, C. D. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2970-12.2013 · Cited by 74 · see citing works
Transient Extracellular Glutamate Events in the Basolateral Amygdala Track Reward-Seeking Actions
Wassum, K. M., Tolosa, V., Tseng, T. T. ‐., Balleine, B. W., Monbouquette, H. G., & Maidment, N. T. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5780-11.2012 · Cited by 74 · see citing works
Self-citation
Optogenetic dissection of amygdala functioning
LaLumiere, R. T. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00107 · Cited by 71 · see citing works
An Adaptive Response to Uncertainty Generates Positive and Negative Contrast Effects
McNamara, J. M., Fawcett, T. W., & Houston, A. I. (2013) · Science · doi:10.1126/science.1230599 · Cited by 68 · see citing works
Roles of nucleus accumbens and basolateral amygdala in autoshaped lever pressing
Chang, S. E., Wheeler, D. S., & Holland, P. C. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.03.008 · Cited by 68 · see citing works
Target-Specific Suppression of GABA Release from Parvalbumin-Interneurons in the Basolateral Amygdala by Dopamine
Chu, H.-Y., Ito, W., Li, J., & Morozov, A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2997-12.2012 · Cited by 67 · see citing works
μ-Opioid Receptor Activation in the Basolateral Amygdala Mediates the Learning of Increases But Not Decreases in the Incentive Value of a Food Reward
Wassum, K. M., Cely, I., Balleine, B. W., & Maidment, N. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3102-10.2011 · Cited by 67 · see citing works
Self-citation
Goal-directed responding is sensitive to lesions to the prelimbic cortex or basolateral nucleus of the amygdala but not to their disconnection.
Coutureau, É., Marchand, A. R., & Scala, G. D. (2009) · Behavioral Neuroscience · doi:10.1037/a0014818 · Cited by 66 · see citing works
Basolateral amygdala lesions facilitate reward choices after negative feedback in rats
Izquierdo, A., Darling, C., Manos, N., Pozos, H., Kim, C., Ostrander, S., Cazares, V., Stepp, H., & Rudebeck, P. H. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4942-12.2013 · Cited by 63 · see citing works
μ Opioid Receptor Activation Inhibits GABAergic Inputs to Basolateral Amygdala Neurons Through Kv1.1/1.2 Channels
Finnegan, T. F., Chen, S.-R., & Pan, H. (2005) · Journal of Neurophysiology · doi:10.1152/jn.01004.2005 · Cited by 61 · see citing works
Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions
Malvaez, M., Greenfield, V. Y., Wang, A. S., Yorita, A. M., Feng, L., Linker, K. E., Monbouquette, H. G., & Wassum, K. M. (2015) · Scientific Reports · doi:10.1038/srep12511 · Cited by 61 · see citing works
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Anatomy and computational modeling of networks underlying cognitive-emotional interaction
John, Y. J., Bullock, D. H., Zikopoulos, B., & Barbas, H. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00101 · Cited by 59 · see citing works
Responses of Amygdala Neurons to Positive Reward-Predicting Stimuli Depend on Background Reward (Contingency) Rather Than Stimulus-Reward Pairing (Contiguity)
Bermúdez, M. A., & Schultz, W. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00933.2009 · Cited by 56 · see citing works
Assignment of Model Amygdala Neurons to the Fear Memory Trace Depends on Competitive Synaptic Interactions
Kim, D., Paré, D., & Nair, S. S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2430-13.2013 · Cited by 56 · see citing works
Memory for Magnitude of Reinforcement: Dissociation between the Amygdala and Hippocampus
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Planning activity for internally generated reward goals in monkey amygdala neurons
Hernádi, I., Fabian Grabenhorst, B., & Schultz, W. (2015) · Nature Neuroscience · doi:10.1038/nn.3925 · Cited by 46 · see citing works
Temporary basolateral amygdala lesions disrupt acquisition of socially transmitted food preferences in ratsPreprint
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Transient inactivation of basolateral amygdala during selective satiation disrupts reinforcer devaluation in rats.
West, E. A., Forcelli, P. A., Murnen, A. T., McCue, D. L., Gale, K., & Málková, L. (2012) · Behavioral Neuroscience · doi:10.1037/a0029080 · Cited by 45 · see citing works
Lesions of the Basolateral Amygdala Disrupt Conditioning Based on the Retrieved Representations of Motivationally Significant Events
Dwyer, D. M., & Killcross, S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1647-06.2006 · Cited by 44 · see citing works
Dissociable effects of basolateral amygdala lesions on decision making biases in rats when loss or gain is emphasized
Tremblay, M., Cocker, P. J., Hosking, J. G., Zeeb, F. D., Rogers, R. D., & Winstanley, C. A. (2014) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-014-0271-1 · Cited by 42 · see citing works
Sensitivity to Temporal Reward Structure in Amygdala Neurons
Bermúdez, M. A., Göbel, C., & Schultz, W. (2012) · Current Biology · doi:10.1016/j.cub.2012.07.062 · Cited by 40 · see citing works
Orbitofrontal cortex and basolateral amygdala lesions result in suboptimal and dissociable reward choices on cue-guided effort in rats.
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Effect of 6-hydroxydopamine lesions of the amygdala on intravenous cocaine self-administration under a progressive ratio schedule of reinforcement
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An assessment of the reinforcing properties of foods after amygdaloid lesions in rhesus monkeys.
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Effects of lesions of the amygdala central nucleus on autoshaped lever pressing
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Amygdala stimulation disrupts the magnitude of reinforcement contribution to long-term memory
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Positive and negative feedback learning and associated dopamine and serotonin transporter binding after methamphetamine
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Odor-mediated taste learning requires dorsal hippocampus, but not basolateral amygdala activity
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Reductions in Frontocortical Cytokine Levels are Associated with Long-Lasting Alterations in Reward Valuation after Methamphetamine
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d-cycloserine in the basolateral amygdala prevents extinction and enhances reconsolidation of odor-reward associative learning in rats
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Cocaine-induced Impulsive Choices Are Accompanied by Impaired Delay-dependent Anticipatory Activity in Basolateral Amygdala
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The basolateral amygdala is necessary for negative prediction errors to enhance cue salience, but not to produce conditioned inhibition
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Normal Aging Alters Learning and Attention-Related Teaching Signals in Basolateral Amygdala
Roesch, M. R., Esber, G. R., Bryden, D. W., Cerri, D. H., Haney, Z. R., & Schoenbaum, G. M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2393-12.2012 · Cited by 19 · see citing works
Distinct patterns of outcome valuation and amygdala-prefrontal cortex synaptic remodeling in adolescence and adulthood
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Inflated reward value in early opiate withdrawal
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Self-citation
The basolateral amygdala mediates the effects of cues associated with meal interruption on feeding behavior
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Basolateral amygdala inactivation by muscimol, but not ERK/MAPK inhibition, impairs the use of reward expectancies during working memory
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Effects of context‐drug learning on synaptic connectivity in the basolateral nucleus of the amygdala in rats
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The effect of probability discounting on reward seeking: a three-dimensional perspective
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Amygdala function in positive reinforcement: Contributions from studies of nonhuman primates.
Murray, E. A., Izquierdo, A., & Málková, L. (2009) · Cited by 9 · see citing works
Post-training depletions of basolateral amygdala serotonin fail to disrupt discrimination, retention, or reversal learning
Ochoa, J. G., Stolyarova, A., Kaur, A., Hart, E. E., Bugarin, A., & Izquierdo, A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00155 · Cited by 8 · see citing works

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The effects of early life stress on reward processing
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“Taken together, connections between midbrain dopamine cells, the basal ganglia (including structures within ventral striatum, such as the nucleus accumbens) and the PFC, with input from other structures, including the amygdala, thus form a reward circuit.”
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Basolateral amygdala to orbitofrontal cortex projections enable cue-triggered reward expectations
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Multidimensional processing in the amygdala
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Projection-Target-Defined Effects of Orexin and Dynorphin on VTA Dopamine Neurons
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Meta-analysis reveals a lack of sexual dimorphism in human amygdala volume
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Optogenetic Central Amygdala Stimulation Intensifies and Narrows Motivation for Cocaine
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The Developing Brain in the Digital Era: A Scoping Review of Structural and Functional Correlates of Screen Time in Adolescence
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The neuroscience of morality and social decision-making
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Distinct Transcriptomic Cell Types and Neural Circuits of the Subiculum and Prosubiculum along the Dorsal-Ventral Axis
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Functional Contribution of the Medial Prefrontal Circuitry in Major Depressive Disorder and Stress-Induced Depressive-Like Behaviors
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Defining the place of habit in substance use disorders
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Reciprocal cortico-amygdala connections regulate prosocial and selfish choices in mice
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Ongoing behavioral state information signaled in the lateral habenula guides choice flexibility in freely moving rats
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From controlled to compulsive drug-taking: The role of the habenula in addiction
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Circuits Regulating Pleasure and Happiness: The Evolution of the Amygdalar-Hippocampal-Habenular Connectivity in Vertebrates
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The cue-reactivity paradigm: An ensemble of networks driving attention and cognition when viewing drug and natural reward-related stimuli
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Subcortical Dopamine and Cognition in Schizophrenia: Looking Beyond Psychosis in Preclinical Models
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Regulation of Alcohol Extinction and Cue-Induced Reinstatement by Specific Projections among Medial Prefrontal Cortex, Nucleus Accumbens, and Basolateral Amygdala
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Optogenetic Inhibition Reveals Distinct Roles for Basolateral Amygdala Activity at Discrete Time Points during Risky Decision Making
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Depletion of the Microbiome Alters the Recruitment of Neuronal Ensembles of Oxycodone Intoxication and Withdrawal
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Reinforcement Learning in Autism Spectrum Disorder
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A dimensional approach to modeling symptoms of neuropsychiatric disorders in the marmoset monkey
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Adverse Childhood Experiences and Amygdalar Reduction: High-Resolution Segmentation Reveals Associations With Subnuclei and Psychiatric Outcomes
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Amygdala: Neuroanatomical and Morphophysiological Features in Terms of Neurological and Neurodegenerative Diseases
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The link between optimism bias and attention bias: A neurocognitive perspective
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The Human Basolateral Amygdala Is Indispensable for Social Experiential Learning
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Genesis and Maintenance of Attentional Biases: The Role of the Locus Coeruleus-Noradrenaline System
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Glutamatergic basolateral amygdala to anterior insular cortex circuitry maintains rewarding contextual memory
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Altering D1 receptor activity in the basolateral amygdala impairs fear suppression during a safety cue
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Control of behavioral flexibility by the lateral habenula
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Infralimbic medial prefrontal cortex signalling to calbindin 1 positive neurons in posterior basolateral amygdala suppresses anxiety- and depression-like behaviours
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Intensive whole-brain 7T MRI case study of volitional control of brain activity in deep absorptive meditation states
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Transcranial Magnetic Stimulation for Post-traumatic Stress Disorder
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Sex specific recruitment of a medial prefrontal cortex-hippocampal-thalamic system during context-dependent renewal of responding to food cues in rats
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Complementary contributions of basolateral amygdala and orbitofrontal cortex to value learning under uncertainty
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Oxytocin administration in the basolateral and central nuclei of amygdala moderately suppresses food intake
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Multiple Memory Subsystems: Reconsidering Memory in the Mind and Brain
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Chemogenetic Stimulation and Silencing of the Insula, Amygdala, Nucleus Accumbens, and Their Connections Differentially Modulate Alcohol Drinking in Rats
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Probabilistic Reinforcement Learning and Anhedonia
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Incidental rewarding cues influence economic decisions in people with obesity
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Prefrontal Cortex and Amygdala Subregion Morphology Are Associated With Obesity and Dietary Self-control in Children and Adolescents
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A Role for Serotonin in Modulating Opposing Drive and Brake Circuits of Impulsivity
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Sex differences, learning flexibility, and striatal dopamine D1 and D2 following adolescent drug exposure in rats
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Choose your path: Divergent basolateral amygdala efferents differentially mediate incentive motivation, flexibility and decision-making
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Amygdala dynorphin/κ opioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress
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Deconstructing value-based decision making via temporally selective manipulation of neural activity: Insights from rodent models
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Estradiol and progesterone in female reward-learning, addiction, and therapeutic interventions
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Cocaine, nicotine, and their conditioned contexts enhance consolidation of object memory in ratsPreprint
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Investigation of reward learning and feedback sensitivity in non-clinical participants with a history of early life stress
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Self-citation

Authors: Wassum, K. M., & Izquierdo, A.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Izquierdo, Alicia
ORCID: Wassum, Kate M.
Izquierdo, Alicia
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2015-10
Volume: 57
Pages: 271-283
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2015.08.017
PMC: PMC4681295
OpenAlex: W1489713305
Cited by: 306
References: 182
Citations by year: 2026: 31 · 2025: 24 · 2024: 26 · 2023: 28 · 2022: 36 · 2021: 44 · 2020: 22 · 2019: 25 · 2018: 17 · 2017: 35 · 2016: 15 · 2015: 3
FWCI: 2.81
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by)
eScholarship (California Digital Library) (submittedVersion)
Funders: NIH (DA035443)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: basolateral amygdala, reward learning, addiction, appetitive behavior, opioid use disorder, stimulant use disorder
MeSH terms: Animals, Appetitive Behavior, Humans, Learning, Reward, Behavior, Addictive, Basolateral Nuclear Complex

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The basolateral amygdala in reward learning and addiction

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