Basolateral amygdala to orbitofrontal cortex projections enable cue-triggered reward expectations
Open accessAbstract
To make an appropriate decision, one must anticipate potential future rewarding events, even when they are not readily observable. These expectations are generated by using observable information (e.g., stimuli or available actions) to retrieve often quite detailed memories of available rewards. The basolateral amygdala (BLA) and orbitofrontal cortex (OFC) are two reciprocally connected key nodes in the circuitry supporting such outcome-guided behaviors. But there is much unknown about the contribution of this circuit to decision making, and almost nothing known about the whether any contribution is via direct, monosynaptic projections, or the direction of information transfer. Therefore, here we used designer receptor-mediated inactivation of OFC→BLA or BLA→OFC projections to evaluate their respective contributions to outcome-guided behaviors in rats. Inactivation of BLA terminals in the OFC, but not OFC terminals in the BLA, disrupted the selective motivating influence of cue-triggered reward representations over reward-seeking decisions as assayed by Pavlovian-to-instrumental transfer. BLA→OFC projections were also required when a cued reward representation was used to modify Pavlovian conditional goal-approach responses according to the reward9s current value. These projections were not necessary when actions were guided by reward expectations generated based on learned action-reward contingencies, or when rewards themselves, rather than stored memories, directed action. These data demonstrate that BLA→OFC projections enable the cue-triggered reward expectations that can motivate the execution of specific action plans and allow adaptive conditional responding. SIGNIFICANCE STATEMENT Deficits anticipating potential future rewarding events are associated with many psychiatric diseases. Presently, we know little about the neural circuits supporting such reward expectation. Here we show that basolateral amygdala to orbitofrontal cortex projections are required for expectations of specific available rewards to influence reward seeking and decision making. The necessity of these projections was limited to situations in which expectations were elicited by reward-predictive cues. These projections therefore facilitate adaptive behavior by enabling the orbitofrontal cortex to use environmental stimuli to generate expectations of potential future rewarding events.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The amygdala encodes reward value and deviations between expected and actual outcomes through its projections to the prefrontal cortex.
“Reward value and deviations of expected and actual outcomes are encoded via the amygdala through its projections to the PFC (Lichtenberg et al., 2017; Wassum and Izquierdo, 2015).”
From The effects of early life stress on reward processing (2018) · cites this paper as Lichtenberg et al., 2017
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,497 · see citing works
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
Goldstein, R. Z., & Volkow, N. D. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3119 · Cited by 2,749 · see citing works
Ongur, D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.206 · Cited by 2,627 · see citing works
Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046 · see citing works
Neurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606 · cited 1× · see citing works
“Disrupted amygdala and OFC activity and connectivity have also been associated with these diseases (Ressler and Mayberg, 2007; Price and Drevets, 2010; Goldstein and Volkow, 2011; Passamonti et al., 2012; Liu et al., 2014; Sladky et al., 2015).”
Goal-directed instrumental action: contingency and incentive learning and their cortical substrates
Balleine, B. W., & Dickinson, A. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00033-1 · Cited by 1,541 · see citing works
Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys
Carmichael, S. T., & Price, J. L. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903630408 · Cited by 1,197 · see citing works
Encoding Predictive Reward Value in Human Amygdala and Orbitofrontal Cortex
Gottfried, J. A., O'Doherty, J., & Dolan, R. J. (2003) · Science · doi:10.1126/science.1087919 · Cited by 1,165 · see citing works
Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic
Ressler, K. J., & Mayberg, H. S. (2007) · Nature Neuroscience · doi:10.1038/nn1944 · Cited by 1,007 · see citing works
The primate amygdala represents the positive and negative value of visual stimuli during learning
Paton, J. J., Belova, M. A., Morrison, S. E., & Salzman, C. D. (2006) · Nature · doi:10.1038/nature04490 · Cited by 917 · cited 2× · see citing works
“That BLA→OFC projections are vital for cue-triggered reward expectations 551 is consistent with evidence that reward cues activate BLA neurons (Paton et al., 2006; Tye and 552 Janak, 2007; Ambroggi et al., 2008; Sangha et al., 2013; Beyeler et al., 2016) and that the OFC 553 specializes in stimulus-outcome representat…”
Orbitofrontal Cortex as a Cognitive Map of Task Space
Wilson, R. C., Takahashi, Y. K., Schoenbaum, G., & Niv, Y. (2014) · Neuron · doi:10.1016/j.neuron.2013.11.005 · Cited by 885 · see citing works
Orbitofrontal cortex and basolateral amygdala encode expected outcomes during learning
Schoenbaum, G. M., Chiba, A. A., & Gallagher, M. (1998) · Nature Neuroscience · doi:10.1038/407 · Cited by 849 · see citing works
Human orbitofrontal cortex represents a cognitive map of state space
Schuck, N. W., Cai, M. B., Wilson, R. C., & Niv, Y. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.019 · Cited by 602 · see citing works
Orbitofrontal Cortex and Representation of Incentive Value in Associative Learning
Gallagher, M., McMahan, R. W., & Schoenbaum, G. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-15-06610.1999 · Cited by 593 · see citing works
Corbit, L. H., & Balleine, B. W. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4507-04.2005 · Cited by 589 · see citing works
Izquierdo, A., Suda, R. K., & Murray, E. A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1921-04.2004 · Cited by 588 · see citing works
Baxter, M. G., Parker, A., Lindner, C. C. C., Izquierdo, A. D., & Murray, E. A. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04311.2000 · Cited by 582 · see citing works
Ambroggi, F., Ishikawa, A., Fields, H. L., & Nicola, S. M. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.004 · Cited by 488 · see citing works
Schoenbaum, G., Setlow, B., Saddoris, M. P., & Gallagher, M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00474-4 · Cited by 484 · see citing works
Stachniak, T. J., Ghosh, A., & Sternson, S. M. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.008 · Cited by 427 · see citing works
Divergent routing of positive and negative information from the amygdala during memory retrieval
Beyeler, A., Namburi, P., Glober, G. F., Simonnet, C., Calhoon, G. G., Conyers, G. F., Luck, R., Wildes, C. P., & Tye, K. M. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.004 · Cited by 412 · see citing works
PRICE, J. L. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.008 · Cited by 395 · see citing works
The Role of Learning in the Operation of Motivational Systems
Dickinson, A., & Balleine, B. W. (2002) · Wiley eBooks · doi:10.1002/0471214426.pas0312 · Cited by 387 · see citing works
A thalamic input to the nucleus accumbens mediates opiate dependence
Zhu, Y., Wienecke, C. F. R., Nachtrab, G. T., & Chen, X. (2016) · Nature · doi:10.1038/nature16954 · Cited by 386 · see citing works
Different Roles for Orbitofrontal Cortex and Basolateral Amygdala in a Reinforcer Devaluation Task
Pickens, C. L., Saddoris, M. P., Setlow, B., Gallagher, M., Holland, P. C., & Schoenbaum, G. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11078.2003 · Cited by 379 · see citing works
Orbitofrontal Cortex Mediates Outcome Encoding in Pavlovian But Not Instrumental Conditioning
Ostlund, S. B., & Balleine, B. W. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5443-06.2007 · Cited by 379 · cited 5× · see citing works
“…that reward cues activate BLA neurons (Paton et al., 2006; Tye and Janak, 2007; Ambroggi et al., 2008; Sangha et al., 2013; Beyeler et al., 2016) and that the OFC specializes in stimulus– outcome representations (Ostlund and Balleine, 2007a, b; Rudebeck et al., 2008, 2017; Camille et al., 2011).”
InfluentialDecoding subjective decisions from orbitofrontal cortex
Rich, E. L., & Wallis, J. D. (2016) · Nature Neuroscience · doi:10.1038/nn.4320 · Cited by 360 · see citing works
The effect of lesions of the basolateral amygdala on instrumental conditioning
Balleine, B. W., Killcross, A. S., & Dickinson, A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-02-00666.2003 · Cited by 355 · see citing works
Amygdaloid projections to the frontal cortex and the striatum in the rat
Kita, H., & Kitai, S. T. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902980104 · Cited by 351 · see citing works
Frontal cortex subregions play distinct roles in choices between actions and stimuli
Rudebeck, P. H., Behrens, T. E., Kennerley, S. W., Baxter, M. G., Buckley, M. J., Walton, M. E., & Rushworth, M. F. S. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3541-08.2008 · Cited by 350 · see citing works
Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking
Mahler, S. V., Vazey, E. M., Beckley, J. T., Keistler, C., McGlinchey, E. M., Kaufling, J., Wilson, S. P., Deisseroth, K. A., Woodward, J. J., & Aston‐Jones, G. (2014) · Nature Neuroscience · doi:10.1038/nn.3664 · Cited by 344 · see citing works
Orbitofrontal Cortex Supports Behavior and Learning Using Inferred But Not Cached Values
Jones, J. L., Esber, G. R., McDannald, M. A., Gruber, A. J., Hernández, A., Mirenzi, A., & Schoenbaum, G. M. (2012) · Science · doi:10.1126/science.1227489 · Cited by 332 · see citing works
Emotion, decision making, and the amygdala.
Seymour, B., & Dolan, R. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.020 · Cited by 324 · see citing works
The basolateral amygdala in reward learning and addiction
Wassum, K. M., & Izquierdo, A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.017 · Cited by 306 · see citing works
Self-citationGore, F., Schwartz, E. C., Brangers, B. C., Aladi, S., Stujenske, J. M., Likhtik, E., Russo, M. J., Gordon, J. A., Salzman, C. D., & Axel, R. (2015) · Cell · doi:10.1016/j.cell.2015.06.027 · Cited by 256 · see citing works
A controlled, powerful multiple-comparison strategy for several situations.
Levin, J. R., Serlin, R. C., & Seaman, M. A. (1994) · Psychological Bulletin · doi:10.1037/0033-2909.115.1.153 · Cited by 246 · see citing works
DREADDS: Use and application in behavioral neuroscience.
Smith, K. S., Bucci, D. J., Luikart, B. W., & Mahler, S. V. (2016) · Behavioral Neuroscience · doi:10.1037/bne0000135 · Cited by 237 · see citing works
Pavlovian conditioned stimulus effects upon instrumental choice behavior are reinforcer specific
Kruse, J. M., Overmier, J., Konz, W., & Rokke, E. (1983) · Learning and Motivation · doi:10.1016/0023-9690(83)90004-8 · Cited by 226 · see citing works
Identity-specific coding of future rewards in the human orbitofrontal cortex
Howard, J. D., Gottfried, J. A., Tobler, P. N., & Kahnt, T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1503550112 · Cited by 222 · see citing works
Lesions of the Basolateral Amygdala Disrupt Selective Aspects of Reinforcer Representation in Rats
Blundell, P., Hall, G., & Killcross, S. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-22-09018.2001 · Cited by 219 · see citing works
Rapid Associative Encoding in Basolateral Amygdala Depends on Connections with Orbitofrontal Cortex
Saddoris, M. P., Gallagher, M., & Schoenbaum, G. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.018 · Cited by 214 · see citing works
Contributions of the Amygdala to Reward Expectancy and Choice Signals in Human Prefrontal Cortex
Hampton, A. N., Adolphs, R., Tyszka, J. M., & O'Doherty, J. P. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.022 · Cited by 213 · see citing works
Medial Orbitofrontal Cortex Mediates Outcome Retrieval in Partially Observable Task Situations
Bradfield, L. A., Dezfouli, A., van Holstein, M., Chieng, B. C. H., & Balleine, B. W. (2015) · Neuron · doi:10.1016/j.neuron.2015.10.044 · Cited by 206 · see citing works
Associative learning mechanisms underpinning the transition from recreational drug use to addiction
Hogarth, L., Balleine, B. W., Corbit, L. H., & Killcross, S. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06768.x · Cited by 204 · see citing works
Ostlund, S. B., & Balleine, B. W. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5472-07.2008 · Cited by 198 · see citing works
Corticostriatal Control of Goal-Directed Action Is Impaired in Schizophrenia
Morris, R. W., Quail, S., Griffiths, K. R., Green, M. J., & Balleine, B. W. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.06.005 · Cited by 197 · see citing works
Camille, N., Tsuchida, A., & Fellows, L. K. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3164-11.2011 · Cited by 195 · see citing works
Selective synaptic remodeling of amygdalocortical connections associated with fear memory
Yang, Y., Liu, D., Huang, W., Deng, J., Sun, Y.-G., Zuo, Y., & Poo, M. (2016) · Nature Neuroscience · doi:10.1038/nn.4370 · Cited by 187 · see citing works
Distinct opioid circuits determine the palatability and the desirability of rewarding events
Wassum, K. M., Ostlund, S. B., Maidment, N. T., & Balleine, B. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905874106 · Cited by 182 · see citing works
Self-citationEffects of Amygdala Lesions on Reward-Value Coding in Orbital and Medial Prefrontal Cortex
Rudebeck, P. H., Mitz, A. R., Chacko, R. V., & Murray, E. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.036 · Cited by 178 · see citing works
What and when to "want"? Amygdala-based focusing of incentive salience upon sugar and sex
Mahler, S. V., & Berridge, K. C. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2588-6 · Cited by 170 · see citing works
Corbit, L. H., & Janak, P. H. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07153.x · Cited by 159 · see citing works
Orbitofrontal Lesions Impair Use of Cue-Outcome Associations in a Devaluation Task.
Pickens, C. L., Saddoris, M. P., Gallagher, M., & Holland, P. C. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.1.317 · Cited by 155 · see citing works
Sladky, R., Höflich, A., Küblböck, M., Kraus, C., Baldinger, P., Moser, E., Lanzenberger, R., & Windischberger, C. (2015) · Cerebral Cortex · doi:10.1093/cercor/bht279 · Cited by 152 · see citing works
Transient Inactivation of Orbitofrontal Cortex Blocks Reinforcer Devaluation in Macaques
West, E. A., DesJardin, J. T., Gale, K., & Málková, L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3295-11.2011 · Cited by 137 · see citing works
Parkes, S. L., & Balleine, B. W. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5071-12.2013 · Cited by 136 · see citing works
Johnson, A. W., Gallagher, M., & Holland, P. C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3758-08.2009 · Cited by 132 · see citing works
Safety Encoding in the Basal Amygdala
Sangha, S., Chadick, J. Z., & Janak, P. H. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3302-12.2013 · Cited by 131 · see citing works
Howard, J. D., & Kahnt, T. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3473-16.2017 · Cited by 131 · see citing works
Amygdala Neurons Differentially Encode Motivation and Reinforcement
Tye, K. M., & Janak, P. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5281-06.2007 · Cited by 130 · cited 2× · see citing works
“That BLA¡OFC projections are vital for cue-triggered reward expectations is consistent with evidence that reward cues activate BLA neurons (Paton et al., 2006; Tye and Janak, 2007; Ambroggi et al., 2008; Sangha et al., 2013; Beyeler et al., 2016) and that the OFC specializes in stimulus– outcome representations (Ostlu…”
Klein-Flügge, M. C., Barron, H. C., Brodersen, K. H., Dolan, R. J., & Behrens, T. E. J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2532-12.2013 · Cited by 128 · see citing works
GABA<sub>A</sub>-Mediated Inhibition of Basolateral Amygdala Blocks Reward Devaluation in Macaques
Wellman, L. L., Gale, K., & Malkova, L. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2257-04.2005 · Cited by 126 · see citing works
Abnormal Anatomical Connectivity between the Amygdala and Orbitofrontal Cortex in Conduct Disorder
Passamonti, L., Fairchild, G., Fornito, A., Goodyer, I. M., Nimmo-Smith, I., Hagan, C. C., & Calder, A. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048789 · Cited by 123 · see citing works
The Origins and Organization of Vertebrate Pavlovian ConditioningPreprint
Fanselow, M., & Wassum, K. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021717 · Cited by 123 · see citing works
Self-citationMachado, C. J., & Bachevalier, J. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05525.x · Cited by 120 · see citing works
Zeeb, F. D., & Winstanley, C. A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3971-12.2013 · Cited by 120 · see citing works
Corbit, L. H., & Balleine, B. W. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_388 · Cited by 118 · see citing works
Encoding of the unconditioned stimulus in Pavlovian conditioning
Colwill, R. M., & Motzkin, D. K. (1994) · Animal Learning & Behavior · doi:10.3758/bf03209158 · Cited by 107 · see citing works
Farovik, A., Place, R., McKenzie, S., Porter, B. S., Munro, C. E., & Eichenbaum, H. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0134-15.2015 · Cited by 105 · see citing works
Liu, H., Tang, Y., Womer, F. Y., Fan, G., Lu, T., Driesen, N. R., Ren, L., Wang, Y., Yong He, A., Blumberg, H. P., et al. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt044 · Cited by 105 · see citing works
The Contribution of Orbitofrontal Cortex to Action Selection
Ostlund, S. B., & Balleine, B. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.033 · Cited by 102 · see citing works
Specialized areas for value updating and goal selection in the primate orbitofrontal cortex
Murray, E. A., Moylan, E. J., Saleem, K. S., Basile, B. M., & Turchi, J. N. (2015) · eLife · doi:10.7554/elife.11695 · Cited by 102 · see citing works
Rhodes, S. E. V., & Murray, E. A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4374-12.2013 · Cited by 96 · see citing works
Learning about Multiple Attributes of Reward in Pavlovian Conditioning
Delamater, A. R., & Oakeshott, S. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1390.008 · Cited by 95 · see citing works
On the Nature of CS and US Representations in Pavlovian Learning
Delamater, A. (2011) · Learning & Behavior · doi:10.3758/s13420-011-0036-4 · Cited by 88 · see citing works
The Role of Orbitofrontal–Amygdala Interactions in Updating Action–Outcome Valuations in Macaques
Fiuzat, E. C., Rhodes, S. E. V., & Murray, E. A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1839-16.2017 · Cited by 85 · see citing works
Rudebeck, P. H., Ripple, J. A., Mitz, A. R., Averbeck, B. B., & Murray, E. A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0933-16.2017 · Cited by 83 · see citing works
Neural Estimates of Imagined Outcomes in the Orbitofrontal Cortex Drive Behavior and Learning
Takahashi, Y. K., Chang, C. Y., Lucantonio, F., Haney, R. Z., Berg, B. A., Yau, H., Bonci, A., & Schoenbaum, G. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.008 · Cited by 81 · see citing works
The orbitofrontal cortex, predicted value and choice
Balleine, B. W., Leung, B. K., & Ostlund, S. B. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06270.x · Cited by 80 · see citing works
Wassum, K. M., Cely, I., Balleine, B. W., & Maidment, N. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3102-10.2011 · Cited by 67 · see citing works
Self-citationDelamater, A. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.030 · Cited by 67 · see citing works
Alvares, G. A., Balleine, B. W., & Guastella, A. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094778 · Cited by 63 · see citing works
Orbitofrontal neurons acquire responses to ‘valueless’ Pavlovian cues during unblocking
McDannald, M. A., Esber, G. R., Wegener, M. A., Wied, H. M., Liu, T., Stalnaker, T. A., Jones, J. L., Trageser, J. C., & Schoenbaum, G. M. (2014) · eLife · doi:10.7554/elife.02653 · Cited by 63 · see citing works
Back to basics: Making predictions in the orbitofrontal–amygdala circuit
Sharpe, M. J., & Schoenbaum, G. M. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.04.009 · Cited by 61 · see citing works
Malvaez, M., Greenfield, V. Y., Wang, A. S., Yorita, A. M., Feng, L., Linker, K. E., Monbouquette, H. G., & Wassum, K. M. (2015) · Scientific Reports · doi:10.1038/srep12511 · Cited by 61 · see citing works
Self-citationThinking Outside the Box: Orbitofrontal Cortex, Imagination, and How We Can Treat Addiction
Schoenbaum, G. M., Chang, C.-Y., Lucantonio, F., & Takahashi, Y. K. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.147 · Cited by 53 · see citing works
Arguello, A. A., Richardson, B. D., Hall, J. L., Wang, R., Hodges, M., Mitchell, M., Stuber, G. D., Rossi, D. J., & Fuchs, R. A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.157 · Cited by 48 · see citing works
Rudell, J. B., Rechs, A. J., Kelman, T. J., Ross‐Inta, C., Hao, S., & Gietzen, D. W. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4934-10.2011 · Cited by 46 · see citing works
Keiflin, R., Reese, R. M., Woods, C. A., & Janak, P. H. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0026-13.2013 · Cited by 35 · see citing works
Lopatina, N., McDannald, M. A., Styer, C. V., Sadacca, B. F., Cheer, J. F., & Schoenbaum, G. M. (2015) · eLife · doi:10.7554/elife.11299 · Cited by 35 · see citing works
Neural Estimates of Imagined Outcomes in Basolateral Amygdala Depend on Orbitofrontal Cortex
Lucantonio, F., Gardner, M., Mirenzi, A., Newman, L. E., Takahashi, Y. K., & Schoenbaum, G. M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3126-15.2015 · Cited by 34 · see citing works
Gilroy, K. E., Everett, E. M., & Delamater, A. R. (2014) · International Journal of Comparative Psychology · doi:10.46867/ijcp.2014.27.04.02 · Cited by 16 · see citing works
Inflated reward value in early opiate withdrawal
Wassum, K. M., Greenfield, V. Y., Linker, K. E., Maidment, N. T., & Ostlund, S. B. (2014) · Addiction Biology · doi:10.1111/adb.12172 · Cited by 16 · see citing works
Self-citationScarlet, J., Delamater, A. R., Campese, V. D., Fein, M., & Wheeler, D. S. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08113.x · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Functional Heterogeneity within Rat Orbitofrontal Cortex in Reward Learning and Decision Making
Izquierdo, A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1678-17.2017 · Cited by 251 · see citing works
The effects of early life stress on reward processing
Novick, A. M., Levandowski, M. L., Laumann, L. E., Philip, N. S., Price, L. H., & Tyrka, A. R. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.02.002 · Cited by 192 · see citing works
“Taken together, connections between midbrain dopamine cells, the basal ganglia (including structures within ventral striatum, such as the nucleus accumbens) and the PFC, with input from other structures, including the amygdala, thus form a reward circuit.”
BackgroundInfluentialSpecializations for reward-guided decision-making in the primate ventral prefrontal cortex
Murray, E. A., & Rudebeck, P. H. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0013-4 · Cited by 169 · see citing works
The Meaning of Behavior: Discriminating Reflex and Volition in the Brain
Balleine, B. W. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.024 · Cited by 172 · see citing works
Namboodiri, V. M. K., Otis, J. M., van Heeswijk, K., Voets, E. S., Alghorazi, R. A., Rodriguez-Romaguera, J., Mihalas, S., & Stuber, G. D. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0408-1 · Cited by 150 · see citing works
Orbitofrontal Circuits Control Multiple Reinforcement-Learning Processes
Groman, S. M., Keistler, C., Keip, A. J., Hammarlund, E., Dileone, R., Pittenger, C., Lee, D., & Taylor, J. R. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.042 · Cited by 142 · see citing works
CNO Evil? Considerations for the Use of DREADDs in Behavioral Neuroscience
Mahler, S. V., & Aston‐Jones, G. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.299 · Cited by 141 · see citing works
Campbell, E. J., & Marchant, N. J. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14146 · Cited by 140 · see citing works
Prefrontal projections to the thalamic nucleus reuniens mediate fear extinction
Ramanathan, K. R., Jin, J., Giustino, T. F., Payne, M. R., & Maren, S. (2018) · Nature Communications · doi:10.1038/s41467-018-06970-z · Cited by 140 · see citing works
Distinct cortical–amygdala projections drive reward value encoding and retrieval
Malvaez, M., Shieh, C., Murphy, M. D., Greenfield, V. Y., & Wassum, K. M. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0374-7 · Cited by 130 · see citing works
Self-citationEstrogen-sensitive medial preoptic area neurons coordinate torpor in mice
Zhang, Z., Reis, F. M., He, Y., Park, J. W., DiVittorio, J. R., Sivakumar, N., van Veen, J. E., Maesta‐Pereira, S., Shum, M., Nichols, I., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-20050-1 · Cited by 138 · see citing works
Connectivity characterization of the mouse basolateral amygdalar complex
Hintiryan, H., Bowman, I., Johnson, D. L., Korobkova, L., Zhu, M., Khanjani, N., Gou, L., Gao, L., Yamashita, S., Bienkowski, M. S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22915-5 · Cited by 121 · see citing works
The role of the orbitofrontal cortex in alcohol use, abuse, and dependence
Moorman, D. E. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.010 · Cited by 109 · see citing works
A thalamic bridge from sensory perception to cognition
Wolff, M., Morceau, S., Folkard, R., Martín-Cortecero, J., & Groh, A. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.11.013 · Cited by 114 · see citing works
Nucleus Accumbens Cholinergic Interneurons Oppose Cue-Motivated Behavior
Collins, A. L., Aitken, T. J., Huang, I.-W., Shieh, C., Greenfield, V. Y., Monbouquette, H. G., Ostlund, S. B., & Wassum, K. M. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.02.014 · Cited by 104 · see citing works
Self-citationCortico-Limbic Interactions Mediate Adaptive and Maladaptive Responses Relevant to Psychopathology
Kovner, R., Oler, J. A., & Kalin, N. H. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.19101064 · Cited by 103 · see citing works
Alcaraz, F., Fresno, V., Marchand, A. R., Kremer, E. J., Coutureau, É., & Wolff, M. (2018) · eLife · doi:10.7554/elife.32517 · Cited by 97 · see citing works
Mahler, S. V., Brodnik, Z. D., Cox, B. M., Buchta, W. C., Bentzley, B. S., Quintanilla, J., Cope, Z. A., Lin, E. C., Riedy, M. D., Scofield, M. D., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0537-18.2018 · Cited by 101 · see citing works
Howard, J. D., & Kahnt, T. (2018) · Nature Communications · doi:10.1038/s41467-018-04055-5 · Cited by 96 · see citing works
The orbitofrontal cortex, food intake and obesity
Seabrook, L. T., & Borgland, S. L. (2020) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.190163 · Cited by 88 · see citing works
Prefrontal Pathways Provide Top-Down Control of Memory for Sequences of Events
Jayachandran, M., Linley, S. B., Schlecht, M., Mahler, S. V., Vertes, R. P., & Allen, T. A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.053 · Cited by 84 · see citing works
Millard, S. J., Bearden, C. E., Karlsgodt, K. H., & Sharpe, M. J. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01188-y · Cited by 79 · see citing works
Neural Substrates and Circuits of Drug AddictionPreprint
Feltenstein, M. W., See, R. E., & Fuchs, R. A. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039628 · Cited by 88 · see citing works
Food cue reactivity: Neurobiological and behavioral underpinnings
Kanoski, S. E., & Boutelle, K. N. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09724-x · Cited by 78 · see citing works
Amygdala-cortical collaboration in reward learning and decision making
Wassum, K. M. (2022) · eLife · doi:10.7554/elife.80926 · Cited by 76 · see citing works
Self-citationSias, A. C., Jafar, Y., Goodpaster, C. M., Ramírez-Armenta, K., Wrenn, T. M., Griffin, N. K., Patel, K., Lamparelli, A. C., Sharpe, M. J., & Wassum, K. M. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01586-7 · Cited by 73 · see citing works
Self-citationBradfield, L. A., & Hart, G. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.11.009 · Cited by 64 · see citing works
Halbout, B., Marshall, A. T., Azimi, A., Liljeholm, M., Mahler, S. V., Wassum, K. M., & Ostlund, S. B. (2019) · eLife · doi:10.7554/elife.43551 · Cited by 67 · see citing works
Self-citationLocal modulation by presynaptic receptors controls neuronal communication and behaviour
Lovinger, D. M., Mateo, Y., Johnson, K. A., Engi, S. A., Antonazzo, M., & Cheer, J. F. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00561-0 · Cited by 66 · see citing works
The Limbic and Sensorimotor Pathways of the Human Amygdala: A Structural Connectivity Study
Rizzo, G., Milardi, D., Bertino, S., Basile, G. A., Mauro, D. D., Calamuneri, A., Chillemi, G., Silvestri, G., Anastasi, G., Bramanti, A., et al. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.05.051 · Cited by 66 · see citing works
Prefrontal cortex interactions with the amygdala in primates
Murray, E. A., & Fellows, L. K. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01128-w · Cited by 65 · see citing works
Enhanced incentive motivation in obesity-prone rats is mediated by NAc core CP-AMPARs
Derman, R. C., & Ferrario, C. R. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.039 · Cited by 59 · see citing works
Prefrontal circuit organization for executive control
Kamigaki, T. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.08.017 · Cited by 65 · see citing works
A bidirectional corticoamygdala circuit for the encoding and retrieval of detailed reward memories
Sias, A. C., Morse, A. K., Wang, S. C., Greenfield, V. Y., Goodpaster, C. M., Wrenn, T. M., Wikenheiser, A. M., Holley, S. M., Cepeda, C., Levine, M. S., et al. (2021) · eLife · doi:10.7554/elife.68617 · Cited by 60 · see citing works
Self-citationIs the core function of orbitofrontal cortex to signal values or make predictions?
Zhou, J., Gardner, M. P., & Schoenbaum, G. (2021) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2021.02.011 · Cited by 57 · see citing works
To be specific: The role of orbitofrontal cortex in signaling reward identity.
Howard, J. D., & Kahnt, T. (2021) · Behavioral Neuroscience · doi:10.1037/bne0000455 · Cited by 57 · see citing works
Lichtenberg, N. T., Sepe-Forrest, L., Pennington, Z. T., Lamparelli, A. C., Greenfield, V. Y., & Wassum, K. M. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0901-21.2021 · Cited by 57 · see citing works
Self-citationThe orbitofrontal cartographer.
Gardner, M., & Schoenbaum, G. M. (2021) · Behavioral Neuroscience · doi:10.1037/bne0000463 · Cited by 56 · see citing works
Grund, T., Tang, Y., Benusiglio, D., Althammer, F., Probst, S., Oppenländer, L., Neumann, I. D., & Grinevich, V. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.03.019 · Cited by 53 · see citing works
Barreiros, I. V., Panayi, M. C., & Walton, M. E. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.02.017 · Cited by 51 · see citing works
Foraging with the frontal cortex: A cross-species evaluation of reward-guided behavior
Rudebeck, P. H., & Izquierdo, A. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01140-0 · Cited by 48 · see citing works
Kuniishi, H., Yamada, D., Wada, K., Yamada, M., & Sekiguchi, M. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0837-3 · Cited by 47 · see citing works
Value-free reinforcement learning: policy optimization as a minimal model of operant behavior
Bennett, D., Niv, Y., & Langdon, A. (2021) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2021.04.020 · Cited by 46 · see citing works
Sign-tracking is an expectancy-mediated behavior that relies on prediction error mechanismsPreprint
Derman, R. C., Schneider, K. N., Juarez, S., & Delamater, A. R. (2018) · Learning & Memory · doi:10.1101/lm.047365.118 · Cited by 46 · see citing works
Nicotine excites VIP interneurons to disinhibit pyramidal neurons in auditory cortex
Askew, C. E., López, A. J., Wood, M. A., & Metherate, R. (2019) · Synapse · doi:10.1002/syn.22116 · Cited by 41 · see citing works
Gentry, R. N., Schuweiler, D. R., & Roesch, M. R. (2018) · Brain Research · doi:10.1016/j.brainres.2018.10.008 · Cited by 40 · see citing works
Simmler, L. D., & Ozawa, T. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104464 · Cited by 40 · see citing works
Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity
Zhan, J. J., Komal, R., Keenan, W. T., Hattar, S. S., & Fernandez, D. C. (2019) · Journal of Visualized Experiments · doi:10.3791/59439 · Cited by 39 · see citing works
Keefer, S. E., Bacharach, S. Z., Kochli, D. E., Chabot, J. M., & Calu, D. J. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00003 · Cited by 40 · see citing works
Multiple Memory Subsystems: Reconsidering Memory in the Mind and Brain
Sherman, B. E., Turk‐Browne, N. B., & Goldfarb, E. V. (2023) · Perspectives on Psychological Science · doi:10.1177/17456916231179146 · Cited by 42 · see citing works
Gardner, M., Sanchez, D. C., Conroy, J. C., Wikenheiser, A. M., Zhou, J., & Schoenbaum, G. M. (2020) · Neuron · doi:10.1016/j.neuron.2020.08.010 · Cited by 37 · see citing works
Inactivation of the Ventrolateral Orbitofrontal Cortex Impairs Flexible Use of Safety Signals
Sarlitto, M. C., Foilb, A. R., & Christianson, J. P. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.03.037 · Cited by 36 · see citing works
Servonnet, A., Hernandez, G., Hage, C. E., Rompré, P., & Samaha, A. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2196-19.2020 · Cited by 33 · see citing works
mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking
Morisot, N., Berger, A. L., Phamluong, K., Laguesse, S., Moffat, J. J., & Dorit Ron, A. (2019) · eLife · doi:10.7554/elife.51333 · Cited by 35 · see citing works
Schalbetter, S. M., Mueller, F. S., Scarborough, J., Richetto, J., Weber‐Stadlbauer, U., Meyer, U., & Notter, T. (2021) · Lab Animal · doi:10.1038/s41684-021-00723-0 · Cited by 34 · see citing works
Value-Related Neuronal Responses in the Human Amygdala during Observational Learning
Aquino, T. G., Minxha, J., Dunne, S., Ross, I. B., Mamelak, A. N., Rutishauser, U., & O’Doherty, J. P. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2897-19.2020 · Cited by 28 · see citing works
Disinhibition of the orbitofrontal cortex biases decision-making in obesity
Seabrook, L. T., Naef, L., Baimel, C., Judge, A., Kenney, T., Ellis, M., Tayyab, T., Armstrong, M., Qiao, M., Floresco, S., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01210-6 · Cited by 32 · see citing works
Zimmerman, E. C., & Grace, A. A. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14111 · Cited by 31 · see citing works
Rodrigues, B., Coelho, A., Portugal‐Nunes, C., Magalhães, R. J. D. S., Moreira, P. S., Castanho, T. C., Amorim, L., Marques, P., Soares, J. M., Sousa, N., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00786 · Cited by 32 · see citing works
West, E. A., Niedringhaus, M. S., Ortega, H. K., Haake, R. M., Frӧhlich, F., & Carelli, R. M. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.027 · Cited by 29 · see citing works
Ozawa, A., & Arakawa, H. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113234 · Cited by 28 · see citing works
Walters, C. J., Jubran, J., Sheehan, A., Erickson, M. T., & Redish, A. D. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05197-0 · Cited by 28 · see citing works
Derman, R. C., Bass, C. E., & Ferrario, C. R. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05453-8 · Cited by 28 · see citing works
Keefer, S. E., Gyawali, U., & Calu, D. J. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113306 · Cited by 27 · see citing works
Roles of the prefrontal cortex in learning to time the onset of pre-existing motor programs
Lee, B.-C., Choi, J., & Martin, B. J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241562 · Cited by 26 · see citing works
Fraser, K. M., & Janak, P. H. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06227-0 · Cited by 26 · see citing works
Hernaus, D., Frank, M. J., Brown, E. C., Brown, J. K., Gold, J. M., & Waltz, J. A. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.11.011 · Cited by 26 · see citing works
Review of Orbitofrontal Cortex in Alcohol Dependence: A Disrupted Cognitive Map?
Shields, C. N., & Gremel, C. M. (2020) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14441 · Cited by 25 · see citing works
Instrumental and Pavlovian Mechanisms in Alcohol Use Disorder
Doñamayor, N., Ebrahimi, C., Garbusow, M., Wedemeyer, F., Schlagenhauf, F., & Heinz, A. (2020) · Current Addiction Reports · doi:10.1007/s40429-020-00333-9 · Cited by 22 · see citing works
Randall, P. A., McElligott, Z. A., & Besheer, J. (2019) · Addiction Biology · doi:10.1111/adb.12782 · Cited by 22 · see citing works
Barreiros, I. V., Ishii, H., Walton, M. E., & Panayi, M. C. (2021) · Behavioral Neuroscience · doi:10.1037/bne0000442 · Cited by 22 · see citing works
Shipman, M. L., Johnson, G. C., Bouton, M. E., & Green, J. T. (2019) · eNeuro · doi:10.1523/eneuro.0125-19.2019 · Cited by 20 · see citing works
Different methods of fear reduction are supported by distinct cortical substrates
Lay, B. P. P., Pitaru, A. A., Boulianne, N., Esber, G. R., & Iordanova, M. D. (2020) · eLife · doi:10.7554/elife.55294 · Cited by 21 · see citing works
Cao, L., Li, H., Hu, X., Liu, J., Gao, Y., Liang, K., Zhang, L., Hu, X., Bu, X., Lu, L., et al. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.11.005 · Cited by 20 · see citing works
Deffains, M., Nguyen, T. H., Orignac, H., Biendon, N., Doveró, S., Bézard, E., & Boraud, T. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14746 · Cited by 20 · see citing works
Insights into the Neurobiology of Craving in Opioid Use Disorder
Lueptow, L. M., Shashkova, E., Miller, M. G., Evans, C. J., & Cahill, C. M. (2020) · Current anesthesiology reports · doi:10.1007/s40140-020-00420-7 · Cited by 19 · see citing works
Kietzman, H. W., Trinoskey-Rice, G., Blumenthal, S. A., Guo, J., & Gourley, S. L. (2022) · Nature Communications · doi:10.1038/s41467-022-32388-9 · Cited by 19 · see citing works
Srivastava, H. K., & Bandyopadhyay, S. (2020) · eNeuro · doi:10.1523/eneuro.0121-20.2020 · Cited by 19 · see citing works
Pujara, M. S., Ciesinski, N. K., Reyelts, J. F., Rhodes, S. E. V., & Murray, E. A. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0794-21.2022 · Cited by 19 · see citing works
Mindfulness Meditation and Network Neuroscience: Review, Synthesis, and Future Directions
Prakash, R. S., Shankar, A., Tripathi, V., Yang, W. F. Z., Fisher, M. E., Bauer, C. C. C., Betzel, R. F., & Sacchet, M. D. (2024) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2024.11.005 · Cited by 23 · see citing works
Cross-species studies on orbitofrontal control of inference-based behavior.
Kahnt, T., & Schoenbaum, G. M. (2021) · Behavioral Neuroscience · doi:10.1037/bne0000401 · Cited by 17 · see citing works
Nasser, H. M., Lafferty, D. S., Lesser, E. N., Bacharach, S. Z., & Calu, D. J. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.11.010 · Cited by 17 · see citing works
Keefer, S. E., Kochli, D. E., & Calu, D. J. (2022) · eNeuro · doi:10.1523/eneuro.0156-22.2022 · Cited by 16 · see citing works
Prediction errors and valence: From single units to multidimensional encoding in the amygdala
Brockett, A. T., Vázquez, D., & Roesch, M. R. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113176 · Cited by 13 · see citing works
A hippocampo-cortical pathway detects changes in the validity of an action as a predictor of reward
Piquet, R., Faugère, A., & Parkes, S. L. (2023) · Current Biology · doi:10.1016/j.cub.2023.11.036 · Cited by 14 · see citing works
Hathaway, B. A., Schumacher, J. D., Hrelja, K. M., & Winstanley, C. A. (2021) · eNeuro · doi:10.1523/eneuro.0341-21.2021 · Cited by 14 · see citing works
Aguirre, C. G., Woo, J. H., Romero-Sosa, J. L., Rivera, Z. M., Tejada, A. N., Munier, J. J., Perez, J., Goldfarb, M., Das, K., Gomez, M., et al. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0622-23.2023 · Cited by 14 · see citing works
Watve, A., Haugg, A., Frei, N., Koush, Y., Willinger, D., Brühl, A. B., Stämpfli, P., Scharnowski, F., & Sladky, R. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1286665 · Cited by 14 · see citing works
Prelimbic cortex neural encoding dynamically tracks expected outcome value
Niedringhaus, M. S., & West, E. A. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113938 · Cited by 16 · see citing works
Quantity versus quality: Convergent findings in effort-based choice tasks
Hart, E. E., & Izquierdo, A. (2019) · Behavioural Processes · doi:10.1016/j.beproc.2019.05.009 · Cited by 14 · see citing works
Representation of foreseeable choice outcomes in orbitofrontal cortex triplet-wise interactions
Balaguer‐Ballester, E., Nogueira, R., Abofalia, J. M., Moreno‐Bote, R., & Sanchez-Vives, M. V. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007862 · Cited by 13 · see citing works
Regulation of dendritic spines in the amygdala following sleep deprivation
Rexrode, L., Tennin, M., Babu, J., Young, C., Bollavarapu, R., Lawson, L. A., Valeri, J., Pantazopoulos, H., & Gisabella, B. (2023) · Frontiers in Sleep · doi:10.3389/frsle.2023.1145203 · Cited by 12 · see citing works
Whyte, A. J., Trinoskey-Rice, G., Davies, R. A., Woon, E. P., Foster, S. L., Shapiro, L. P., Li, D. C., Srikanth, K. D., Gil-Henn, H., & Gourley, S. L. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0781-20.2021 · Cited by 12 · see citing works
Mechanisms of higher-order learning in the amygdala
Gostolupce, D., Iordanova, M. D., & Lay, B. P. P. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113435 · Cited by 12 · see citing works
Fisher, H., Pajser, A., & Pickens, C. L. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112159 · Cited by 12 · see citing works
Seabrook, L. T., Peterson, C., Noble, D., Sobey, M., Tayyab, T., Kenney, T., Judge, A., Armstrong, M., Lin, S., & Borgland, S. L. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0831-23.2023 · Cited by 11 · see citing works
Ghobadi‐Azbari, P., Khayati, R. M., Sangchooli, A., & Ekhtiari, H. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.899605 · Cited by 10 · see citing works
Sequeira, S. L., Silk, J. S., Jones, N. P., Forbes, E. E., Hanson, J. L., Hallion, L. S., & Ladouceur, C. D. (2024) · Development and Psychopathology · doi:10.1017/s0954579424001068 · Cited by 10 · see citing works
Rutherford, L. G., & Milton, A. L. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.104514 · Cited by 10 · see citing works
Garceau, C., Samaha, A., Cordahi, T., Servonnet, A., & Khoo, S. Y. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05907-7 · Cited by 9 · see citing works
- Authors
- Lichtenberg, N. T., Pennington, Z. T., Holley, S. M., Greenfield, V. Y., Cepeda, C., Levine, M. S., & Wassum, K. M.
- Affiliations
- University of California, Los Angeles (US)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2017-07-25
- Volume
- 37
- Issue
- 35
- Pages
- 8374-8384
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC5577854
- OpenAlex
- W2736491203
- Cited by
- 171
- References
- 95
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 14 · 2023: 13 · 2022: 18 · 2021: 37 · 2020: 22 · 2019: 24 · 2018: 18 · 2017: 3
- FWCI
- 10.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (DA024635)
- University of California, Los Angeles
- National Institute on Drug Abuse (T32DA024635, R01DA035443)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- basolateral amygdala, orbitofrontal cortex, reward anticipation, Pavlovian-to-instrumental transfer, decision-making, reward seeking, goal-directed behavior, monosynaptic connectivity
- MeSH terms
- Animals, Conditioning, Operant, Cues, Decision Making, Extinction, Psychological, Male, Motivation, Neural Pathways, Reward, Prefrontal Cortex, Rats, Long-Evans, Rats, Anticipation, Psychological, Basolateral Nuclear Complex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
