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Behavioral tagging is a general mechanism of long-term memory formation
Open accessAbstract
In daily life, memories are intertwined events. Little is known about the mechanisms involved in their interactions. Using two hippocampus-dependent (spatial object recognition and contextual fear conditioning) and one hippocampus-independent (conditioned taste aversion) learning tasks, we show that in rats subjected to weak training protocols that induce solely short term memory (STM), long term memory (LTM) is promoted and formed only if training sessions took place in contingence with a novel, but not familiar, experience occurring during a critical time window around training. This process requires newly synthesized proteins induced by novelty and reveals a general mechanism of LTM formation that begins with the setting of a "learning tag" established by a weak training. These findings represent the first comprehensive set of evidences indicating the existence of a behavioral tagging process that in analogy to the synaptic tagging and capture process, need the creation of a transient, protein synthesis-independent, and input specific tag.
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Non-Hebbian plasticity transforms transient experiences into lasting memoriesPreprint
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Unravelling the neurocognitive mechanisms underlying counterconditioning in humansPreprint
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Unravelling the neurocognitive mechanisms underlying counterconditioning in humansPreprint
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“This asymmetry contrasts with rodent studies, which have established that novelty can enhance memory both proactively and ret-roactively (Ballarini et al., 2009; Frey & Morris, 1998).”
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Premature release of action sequences in adolescent male rats
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Triggering hippocampal LTP and learning by dopamine : a teaching signal
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Metadata
- Authors
- Ballarini, F., Moncada, D., Martinez, M. C., Alen, N., & Viola, H.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Instituto de Biología Celular y Neurociencias, Facultad de Medicina, Universidad de Buenos Aires-CONICET, Paraguay 2155, 3° Piso, CP 1121, Buenos Aires, Argentina; and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-08-25
- Volume
- 106
- Issue
- 34
- Pages
- 14599-14604
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2732837
- OpenAlex
- W2146205533
- Cited by
- 301
- References
- 39
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 38 · 2023: 23 · 2022: 15 · 2021: 18 · 2020: 22 · 2019: 15 · 2018: 22 · 2017: 14 · 2016: 24 · 2015: 18 · 2014: 23 · 2013: 13 · 2012: 9
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires) (publishedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- long-term memory formation, synaptic tagging and capture, short-term memory, hippocampal-dependent memory, contextual fear conditioning, conditioned taste aversion, protein synthesis, memory consolidation, rats
- MeSH terms
- Animals, Behavior, Animal, Conditioning, Psychological, Discrimination Learning, Fear, Hippocampus, Learning, Male, Memory, Memory, Short-Term, Neuronal Plasticity, Psychomotor Performance, Saccharin, Sodium Chloride, Spatial Behavior, Taste, Time Factors, Rats, Wistar, Long-Term Potentiation, Neocortex, Rats
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