The Single Nucleotide Polymorphism Gly482Ser in the PGC-1α Gene Impairs Exercise-Induced Slow-Twitch Muscle Fibre Transformation in Humans
Open accessAbstract
PGC-1α (peroxisome proliferator-activated receptor γ co-activator 1α) is an important regulator of mitochondrial biogenesis and a master regulator of enzymes involved in oxidative phosphorylation. Recent evidence demonstrated that the Gly482Ser single nucleotide polymorphism (SNP) in the PGC-1α gene affects insulin sensitivity, blood lipid metabolism and binding to myocyte enhancer factor 2 (MEF2). Individuals carrying this SNP were shown to have a reduced cardiorespiratory fitness and a higher risk to develop type 2 diabetes. Here, we investigated the responses of untrained men with the Gly482Ser SNP to a 10 week programme of endurance training (cycling, 3 x 60 min/week, heart rate at 70-90% VO2peak). Quantitative data from analysis of biopsies from vastus lateralis muscle revealed that the SNP group, in contrast to the control group, lacked a training-induced increase in content of slow contracting oxidative fibres. Capillary supply, mitochondrial density, mitochondrial enzyme activities and intramyocellular lipid content increased similarly in both groups. These results indicate that the impaired binding of MEF2 to PGC-1α in humans with this SNP impedes exercise-induced fast-to-slow muscle fibre transformation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Skeletal muscle-specific knockout of PGC1α promotes muscle fiber type shift from oxidative to glycolytic.
“In agreement, skeletal muscle-specific knockout of PGC1α promotes muscle fiber type shift from oxidative to glycolytic [33].”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [33]
Activation of PGC1α in skeletal muscle regulates carbohydrate and lipid metabolism and improves oxidative capacity of the muscle fiber by inducing mitochondrial biogenesis.
“Activation of PGC1α in skeletal muscle has been shown to regulate carbohydrate and lipid metabolism and to improve oxidative capacity of the muscle fiber by inducing mitochondrial biogenesis [33].”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · see citing works
Calcium's Role in Mechanotransduction during Muscle Development
Damm, T. B., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,548 · see citing works
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873 · see citing works
Pan, X.-R., Li, G.-W., Hu, Y.-H., Wang, J.-X., Yang, W.-Y., An, Z.-X., Hu, Z.-X., Juan-Lin, Xiao, J.-Z., Cao, H.-B., et al. (1997) · Diabetes Care · doi:10.2337/diacare.20.4.537 · Cited by 4,320 · see citing works
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139 · see citing works
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546 · see citing works
Principles of Exercise Testing and Interpretation.
(1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-106-4-646 · Cited by 2,366 · see citing works
Puigserver, P., & Spiegelman, B. M. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0012 · Cited by 2,076 · see citing works
Mitochondrial dysfunction and type 2 diabetes
Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070 · see citing works
Srere, P. A. (1969) · Methods in Enzymology · doi:10.1016/0076-6879(69)13005-0 · Cited by 2,005 · see citing works
Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952 · see citing works
Waist circumference as a measure for indicating need for weight management
Lean, M. E. J., Han, T. S., & Morrison, C. E. (1995) · BMJ · doi:10.1136/bmj.311.6998.158 · Cited by 1,869 · see citing works
Biochemical Adaptations in Muscle
Holloszy, J. O. (1967) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96046-1 · Cited by 1,517 · see citing works
Practical methods for biological morphometry
Weibel, E. R. (1979) · Academic Press eBooks · Cited by 1,502 · see citing works
Biochemical and molecular investigations in respiratory chain deficiencies
Rustin, P., Chrétien, D., Bourgeron, T., Gérard, B., Rötig, A., Saudubray, J., & Münnich, A. (1994) · Clinica Chimica Acta · doi:10.1016/0009-8981(94)90055-8 · Cited by 1,239 · see citing works
Goodpaster, B. H. (2001) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.12.5755 · Cited by 1,194 · see citing works
Percutaneous Needle Biopsy of Skeletal Muscle in Physiological and Clinical Research
Bergström, J. P. (1975) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517509095787 · Cited by 1,159 · see citing works
Gibala, M. J., Little, J. P., Van Essen, M., Wilkin, G. P., Burgomaster, K. A., Safdar, A., Raha, S., & Tarnopolsky, M. A. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.112094 · Cited by 1,082 · see citing works
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
Arany, Z., Foo, S.-Y., Ma, Y., Ruas, J. L., Bommi-Reddy, A., Girnun, G., Cooper, M., Laznik, D., Chinsomboon, J., Rangwala, S. M., et al. (2008) · Nature · doi:10.1038/nature06613 · Cited by 1,054 · see citing works
Fuel selection in human skeletal muscle in insulin resistance: a reexamination.
Kelley, D. E., & Mandarino, L. J. (2000) · Diabetes · doi:10.2337/diabetes.49.5.677 · Cited by 1,017 · see citing works
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber typePreprint
Chin, E. R., Olson, E. N., Richardson, J. A., Yang, Q., Humphries, C. G., Shelton, J. M., Wu, H., Zhu, W., Bassel‐Duby, R., & Williams, R. S. (1998) · Genes & Development · doi:10.1101/gad.12.16.2499 · Cited by 1,015 · see citing works
Optimizing the exercise protocol for cardiopulmonary assessment
Buchfuhrer, M. J., Hansen, J. E., Robinson, T. E., Sue, D. Y., Wasserman, K., & Whipp, B. J. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.55.5.1558 · Cited by 872 · see citing works
Detecting the threshold of anaerobic metabolism in cardiac patients during exercise
Wasserman, K., & McIlroy, M. B. (1964) · The American Journal of Cardiology · doi:10.1016/0002-9149(64)90012-8 · Cited by 864 · see citing works
Transcriptional integration of mitochondrial biogenesis
Scarpulla, R. C., Vega, R. B., & Kelly, D. P. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.06.006 · Cited by 798 · see citing works
Capillary supply of the quadriceps femoris muscle of man: adaptive response to exercise
Andersen, P. H., & Henriksson, J. (1977) · The Journal of Physiology · doi:10.1113/jphysiol.1977.sp011975 · Cited by 749 · see citing works
Handschin, C., Rhee, J., Lin, J., Tarr, P. T., & Spiegelman, B. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1232352100 · Cited by 729 · see citing works
Physical Activity in the Prevention of Type 2 Diabetes
Laaksonen, D. E., Lindström, J., Lakka, T. A., Eriksson, J. G., Niskanen, L., Wikström, K., Aunola, S., Keinänen-Kiukaanniemi, S., Laakso, M., Valle, T. T., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.1.158 · Cited by 614 · see citing works
Handschin, C., Chin, S., Li, P., Liu, F., Maratos-Flier, E., LeBrasseur, N. K., Yan, Z., & Spiegelman, B. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704817200 · Cited by 611 · see citing works
Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1α expression.
Wright, D. C., Han, D.-H., Garcia-Roves, P. M., Geiger, P. C., Jones, T. E., & Holloszy, J. O. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m606116200 · Cited by 488 · see citing works
Functional and structural adaptations of skeletal muscle to microgravity
Fitts, R. H., Riley, D. R., & Widrick, J. J. (2001) · Journal of Experimental Biology · doi:10.1242/jeb.204.18.3201 · Cited by 478 · see citing works
MEF2 responds to multiple calcium‐regulated signals in the control of skeletal muscle fiber type
Wu, H., Naya, F. J., McKinsey, T. A., Mercer, B., Shelton, J. M., Chin, E. R., Simard, A. R., Michel, R. N., Bassel‐Duby, R., Olson, E. N., et al. (2000) · The EMBO Journal · doi:10.1093/emboj/19.9.1963 · Cited by 468 · see citing works
Koves, T. R., Li, P., An, J., Akimoto, T., Slentz, D., Ilkayeva, O., Dohm, G. L., Yan, Z., Newgard, C. B., & Muoio, D. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507621200 · Cited by 464 · see citing works
Tarnopolsky, M. A., Rennie, C. D., Robertshaw, H. A., Fedak-Tarnopolsky, S. N., Devries, M. C., & Hamadeh, M. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00472.2006 · Cited by 457 · see citing works
Skeletal muscle adaptations to endurance training in 60- to 70-yr-old men and women
Coggan, A. R., Spina, R. J., King, D. S., Rogers, M. A., Brown, M., Nemeth, P. M., & Holloszy, J. O. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.72.5.1780 · Cited by 457 · see citing works
HOWALD, H., Hoppeler, H. H., Claassen, H., Mathieu, O., & Straub, R. (1985) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00589248 · Cited by 423 · see citing works
Histone deacetylase degradation andMEF2 activation promote the formation of slow-twitch myofibers
Potthoff, M. J., Wu, H., Arnold, M., Shelton, J. M., Backs, J., McAnally, J., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31960 · Cited by 416 · see citing works
Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance
Amati, F., Dubé, J. J., Alvarez-Carnero, E., Edreira, M. M., Chomentowski, P., Coen, P. M., Switzer, G. E., Bickel, P. E., Stefanovic-Racic, M., Toledo, F. G. S., et al. (2011) · Diabetes · doi:10.2337/db10-1221 · Cited by 395 · see citing works
The transcriptional coactivator PGC-1α mediates exercise-induced angiogenesis in skeletal muscle
Chinsomboon, J., Ruas, J., Gupta, R. K., Thom, R., Shoag, J., Rowe, G. C., Sawada, N., Raghuram, S., & Arany, Z. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909131106 · Cited by 379 · see citing works
Dubé, J. J., Amati, F., Stefanovic-Racic, M., Toledo, F. G. S., Sauers, S. E., & Goodpaster, B. H. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00769.2007 · Cited by 378 · see citing works
Little, J. P., Safdar, A., Bishop, D., Tarnopolsky, M. A., & Gibala, M. J. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00538.2010 · Cited by 342 · see citing works
Yan, Z., Okutsu, M., Akhtar, Y., & Lira, V. A. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00993.2010 · Cited by 338 · see citing works
Ingjer, F. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012938 · Cited by 337 · see citing works
Allhoff, P., Laaser, U., & Heinrich, J. (1991) · Springer eBooks · doi:10.1007/978-3-642-95642-3_32 · Cited by 333 · see citing works
Irrcher, I., Adhihetty, P. J., Sheehan, T. E., Joseph, A.-M., & Hood, D. A. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00409.2002 · Cited by 315 · see citing works
The Finnish Diabetes Prevention Study
Uusitupa, M. I. J., Louheranta, A. M., Lindström, J., Valle, T. T., Sundvall, J., Eriksson, J. G., & Tuomilehto, J. O. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500001070 · Cited by 306 · see citing works
Ek, J., Andersen, G., Urhammer, S. A., Gæde, P. H., Drivsholm, T., Borch-Johnsen, K., Hansen, T., & Pedersen, O. (2001) · Diabetologia · doi:10.1007/s001250100032 · Cited by 293 · see citing works
Effects of Walking on Coronary Heart Disease in Elderly Men: The Honolulu Heart Program
Hakim, A. A., Curb, J. D., Petrovitch, H., Rodriguez, B. L., Yano, K., Ross, G. W., White, L. R., & Abbott, R. D. (1999) · Circulation · doi:10.1161/01.cir.100.1.9 · Cited by 277 · see citing works
Zechner, C., Lai, L., Zechner, J. F., Geng, T., Yan, Z., Rumsey, J. W., Collia, D., Chen, Z., Wozniak, D. F., Leone, T. C., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.008 · Cited by 274 · cited 1× · see citing works
“Interestingly, a similar surplus of slow type I fibres compared to genetically normal controls is known from analyses of fibre type proportions in the gastrocnemius, plantaris and soleusmuscles of PGC-1α knock-out mice [78,87].”
BackgroundGeng, T., Li, P., Okutsu, M., Yin, X., Kwek, J., Zhang, M., & Yan, Z. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00481.2009 · Cited by 263 · see citing works
PGC-1α-mediated adaptations in skeletal muscle
Olesen, J., Kiilerich, K., & Pilegaard, H. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0834-0 · Cited by 244 · see citing works
Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state
van Loon, L. J. C., & Goodpaster, B. H. (2006) · Pflügers Archiv · doi:10.1007/s00424-005-1509-0 · Cited by 232 · see citing works
Fibre types in skeletal muscle: a personal account
Schiaffino, S. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02130.x · Cited by 227 · see citing works
Hara, K., Tobe, K., Okada, T., Kadowaki, H., Akanuma, Y., Ito, C., Kimura, S., & Kadowaki, T. (2002) · Diabetologia · doi:10.1007/s00125-002-0803-z · Cited by 224 · see citing works
Regulation by exercise of skeletal muscle content of mitochondria and GLUT4.
Holloszy, J. O. (2008) · PubMed · Cited by 202 · see citing works
Jansson, E., Sjödin, B., & Tesch, P. A. (1978) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1978.tb06272.x · Cited by 188 · see citing works
Hata, Y., Mabuchi, H., Saitō, Y., Itakura, H., Egusa, G., Ito, H., Teramoto, T., Tsushima, M., Tada, N., Oikawa, S., et al. (2002) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.9.1 · Cited by 188 · see citing works
Effects of Obesity on Substrate Utilization during Exercise
Goodpaster, B. H., Wolfe, R. R., & Kelley, D. E. (2002) · Obesity Research · doi:10.1038/oby.2002.78 · Cited by 169 · see citing works
Decrease of mitochondrial DNA content and energy metabolism in renal cell carcinoma
Meierhofer, D. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh104 · Cited by 164 · see citing works
Putman, C. T., Xu, X., Gillies, E. M., MacLean, I. M., & Bell, G. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-004-1104-7 · Cited by 159 · see citing works
Rapid exercise-induced changes in PGC-1α mRNA and protein in human skeletal muscle
Mathai, A. S., Bonen, A., Benton, C. R., Robinson, D. L., & Graham, T. E. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00847.2007 · Cited by 158 · see citing works
Pilegaard, H., Osada, T., Andersen, L. T., Helge, J. W., Saltin, B., & Neufer, P. D. (2005) · Metabolism · doi:10.1016/j.metabol.2005.03.008 · Cited by 154 · see citing works
PGC-1α regulates a HIF2α-dependent switch in skeletal muscle fiber types
Rasbach, K. A., Gupta, R. K., Ruas, J. L., Wu, J., Naseri, E., Estall, J. L., & Spiegelman, B. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016089107 · Cited by 142 · see citing works
Stefan, N., Thamer, C., Staiger, H., Machicao, F. E., Machann, J., Schick, F., Venter, C., Niess, A. M., Laakso, M., Fritsche, A., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1785 · Cited by 141 · see citing works
Network distribution of mitochondria and lipid droplets in human muscle fibres
Shaw, C. S., Jones, D. A., & Wagenmakers, A. J. M. (2007) · Histochemistry and Cell Biology · doi:10.1007/s00418-007-0349-8 · Cited by 140 · see citing works
Ahmetov, I. I., Williams, A. G., Викторович, П. Д., Lyubaeva, E. V., Hakimullina, A. M., Fedotovskaya, O. N., Mozhayskaya, I. A., Виноградова, О. Л., Astratenkova, I. V., Montgomery, H., et al. (2009) · Human Genetics · doi:10.1007/s00439-009-0728-4 · Cited by 135 · see citing works
A forty-year memoir of research on the regulation of glucose transport into muscle
Holloszy, J. O. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00463.2002 · Cited by 135 · see citing works
PPARGC1Agenotype (Gly482Ser) predicts exceptional endurance capacity in European men
Lucía, A., Gómez‐Gallego, F., Barroso, I., Rabadán, M., Bandrés, F., Juan, A. F. S., Chicharro, J. L., Ekelund, U., Brage, S., Earnest, C. P., et al. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00037.2005 · Cited by 134 · see citing works
PGC-1α mediates exercise-induced skeletal muscle VEGF expression in mice
Leick, L., Hellsten, Y., Fentz, J., Lyngby, S. S., Wojtaszewski, J. F. P., Hidalgo, J., & Pilegaard, H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00076.2009 · Cited by 124 · see citing works
Summermatter, S., Baum, O., Santos, G., Hoppeler, H. H., & Handschin, C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.145995 · Cited by 114 · see citing works
Mora, S., & Pessin, J. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910259199 · Cited by 111 · see citing works
Oberkofler, H., Schraml, E., Krempler, F., & Patsch, W. (2003) · Biochemical Journal · doi:10.1042/bj20021665 · Cited by 100 · see citing works
Exercise increases MEF2‐ and GEF DNA‐binding activities in human skeletal muscle
McGee, S. L., Sparling, D., Olson, A., & Hargreaves, M. (2006) · The FASEB Journal · doi:10.1096/fj.05-4671fje · Cited by 100 · see citing works
Human skeletal muscle fibre type variations correlate with PPARα, PPARδ and PGC‐1α mRNA
Kramer, D., Ahlsén, M., Norrbom, J., Jansson, E., Hjeltnes, N., Gustafsson, T. P., & Krook, A. (2006) · Acta Physiologica · doi:10.1111/j.1748-1716.2006.01620.x · Cited by 99 · see citing works
Koves, T. R., Sparks, L. M., Kovalik, J., Mosedale, M., Arumugam, R., DeBalsi, K. L., Everingham, K., Thorne, L. B., Esther Phielix, E., Meex, R. C. R., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.p028910 · Cited by 95 · see citing works
Severe depletion of mitochondrial DNA in spinal muscular atrophy
Berger, A., Mayr, J. A., Meierhofer, D., Fötschl, U., Bittner, R. E., Budka, H., Grethen, C., Huemer, M., Kofler, B., & Sperl, W. (2003) · Acta Neuropathologica · doi:10.1007/s00401-002-0638-1 · Cited by 82 · see citing works
Self-citationTimmons, J. A., Norrbom, J., Schéele, C., Thonberg, H., Wahlestedt, C., & Tesch, P. (2006) · Genomics · doi:10.1016/j.ygeno.2005.09.007 · Cited by 79 · see citing works
Low aerobic mitochondrial energy metabolism in poorly- or undifferentiated neuroblastoma
Feichtinger, R. G., Zimmermann, F., Mayr, J. A., Neureiter, D., Hauser‐Kronberger, C., Schilling, F. H., Jones, N., Sperl, W., & Kofler, B. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-149 · Cited by 78 · see citing works
Self-citationSuccessive bouts of cycling stimulates genes associated with mitochondrial biogenesis
Dumke, C. L., Davis, J. M., Murphy, E. A., Nieman, D. C., Carmichael, M. D., Quindry, J. C., Triplett, N. T., Utter, A. C., Gross, S. J., Henson, D. A., et al. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1143-1 · Cited by 72 · see citing works
Andrulionytė, L., Peltola, P., Chiasson, J., Laakso, M., & for the STOP-NIDDM Study Group (2006) · Diabetes · doi:10.2337/db05-1629 · Cited by 68 · see citing works
Cobley, J. N., Bartlett, J. D., Kayani, A., Murray, S. W., Louhelainen, J., Donovan, T., Waldron, S., Gregson, W., Burniston, J. G., Morton, J. P., et al. (2012) · Biogerontology · doi:10.1007/s10522-012-9408-1 · Cited by 58 · see citing works
Steinbacher, P., Tauber, M., Kogler, S., Stoiber, W., Resch, H., & Sänger, A. M. (2009) · Tissue and Cell · doi:10.1016/j.tice.2009.07.001 · Cited by 58 · see citing works
Self-citationChoi, Y.-S., Hong, J.-M., Lim, S., Ko, K. S., & Pak, Y. K. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.03.193 · Cited by 50 · see citing works
Attenuated respiratory compensation during rapidly incremented ramp exercise
Scheuermann, B. W., & Kowalchuk, J. M. (1998) · Respiration Physiology · doi:10.1016/s0034-5687(98)00097-8 · Cited by 48 · see citing works
Shono, N., Urata, H., Saltin, B., Mizuno, M., Harada, T., Shindo, M., & Tanaka, H. (2002) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.9.78 · Cited by 45 · see citing works
Comparison of different definitions of the metabolic syndrome
Sandhofer, A., Iglseder, B., Paulweber, B., Ebenbichler, C. F., & Patsch, J. R. (2007) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2007.01751.x · Cited by 41 · see citing works
Self-citationA decade of aerobic endurance training: histological evidence for fibre type transformation.
Thayer, R., Collins, J. M., Noble, E. G., et al. (2000) · PubMed · Cited by 40 · see citing works
Role of PGC-1α in muscle function and aging
Kang, C., & Ji, L. L. (2013) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2013.03.005 · Cited by 37 · see citing works
Zhang, S., Lu, W., Yan, L., Mu-chao, W., Xu, M., Chen, L., & Cheng, H. (2007) · PubMed · Cited by 35 · see citing works
Vohl, M., Houde, A., Lebel, S., Hould, F., & Marceau, P. (2005) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2005.07.002 · Cited by 34 · see citing works
ZHANG, S.-L., Lu, W., Yan, L., Mu-chao, W., Xu, M.-T., Li-hong, C. H. E. N., & Cheng, H. (2007) · Chinese Medical Journal · doi:10.1097/00029330-200711010-00005 · Cited by 31 · see citing works
Alterations of respiratory chain complexes in sporadic pheochromocytoma
Kofler, B. (2010) · Frontiers in Bioscience-Elite · doi:10.2741/e233 · Cited by 17 · see citing works
Self-citationRing‐Dimitriou, S., Kedenko, L., Kedenko, I., et al. (2014) · Cited by 13 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [54]Srere PA. Citrate synthase. Methods Enzymol. 1969; 13: 3– 11.
Cited by
Sorted by citations
Jun, L., Tao, Y.-X., Geetha, T., & Babu, J. R. (2024) · Current Nutrition Reports · doi:10.1007/s13668-024-00555-7 · Cited by 27 · see citing works
Responses to Maximal Strength Training in Different Age and Gender Groups
Kittilsen, H. T., Goleva-Fjellet, S., Freberg, B. I., Nicolaisen, I., Støa, E. M., Bratland-Sanda, S., Helgerud, J., Wang, E., Sæbø, M., & Støren, Ø. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.636972 · Cited by 26 · see citing works
- Authors
- Steinbacher, P., Feichtinger, R. G., Kedenko, L., Kedenko, I., Reinhardt, S., Schönauer, A.-L., Leitner, I., Sänger, A. M., Stoiber, W., Kofler, B., Förster, H., Paulweber, B., & Ring-Dimitriou, S.
- Affiliations
- University of Salzburg (AT)
- Paracelsus Medical University (AT)
- Corresponding author
- Steinbacher, Peter
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-04-17
- Volume
- 10
- Issue
- 4
- Pages
- e0123881
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4401702
- OpenAlex
- W2077084368
- Cited by
- 33
- References
- 92
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 3 · 2019: 6 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 1
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Oesterreichische Nationalbank
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- PGC-1α, slow-twitch muscle fibres, endurance training, vastus lateralis, mitochondrial biogenesis, oxidative phosphorylation, MEF2, intramyocellular lipid, capillary supply, mitochondrial enzyme activity
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Adult, Humans, Male, Physical Endurance, Transcription Factors, Exercise, Muscle, Skeletal, Muscle Fibers, Slow-Twitch, Polymorphism, Single Nucleotide, MEF2 Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
