The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
RETRACTED: Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging
Open accessAbstract
Aging is a major risk factor for metabolic disease and loss of skeletal muscle mass and strength, a condition known as sarcopenia. Both conditions present a major health burden to the elderly population. Here, we analyzed the effect of mildly increased PGC-1α expression in skeletal muscle during aging. We found that transgenic MCK-PGC-1α animals had preserved mitochondrial function, neuromuscular junctions, and muscle integrity during aging. Increased PGC-1α levels in skeletal muscle prevented muscle wasting by reducing apoptosis, autophagy, and proteasome degradation. The preservation of muscle integrity and function in MCK-PGC-1α animals resulted in significantly improved whole-body health; both the loss of bone mineral density and the increase of systemic chronic inflammation, observed during normal aging, were prevented. Importantly, MCK-PGC-1α animals also showed improved metabolic responses as evident by increased insulin sensitivity and insulin signaling in aged mice. Our results highlight the importance of intact muscle function and metabolism for whole-body homeostasis and indicate that modulation of PGC-1α levels in skeletal muscle presents an avenue for the prevention and treatment of a group of age-related disorders.
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“On the other hand, sarcopenia involves autophagy of muscle structural components, and attenuation of autophagy with PPARGC1A overexpression mitigates sarcopenia [495].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [495]
In the citing paper
“forced overexpression of this gene in muscle attenuates mitochondrial dysfunction and the associated muscle atrophy in aging animals.(Wenz, Rossi, Rotundo, Spiegelman, and Moraes 2009)”
From Successful aging: Advancing the science of physical independence in older adults (2015) · cites this paper as Wenz et al. 2009
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Metadata
- Authors
- Wenz, T., Rossi, S. G., Rotundo, R. L., Spiegelman, B. M., & Moraes, C. T.
- Affiliations
- Departments of aNeurology and
- University of Miami (US)
- Harvard University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-12
- Volume
- 106
- Issue
- 48
- Pages
- 20405-20410
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2787152
- OpenAlex
- W2171217650
- Cited by
- 600
- References
- 38
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 11 · 2023: 8 · 2022: 18 · 2021: 23 · 2020: 23 · 2019: 21 · 2018: 23 · 2017: 33 · 2016: 61 · 2015: 68 · 2014: 67 · 2013: 85 · 2012: 75
- FWCI
- 19.71
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG0005917, R01AG005917)
- National Eye Institute (EY10804, R01EY010804)
- National Cancer Institute (CA 85700, R01CA085700)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK54477, R56DK054477, R01DK061562, R01DK054477, DK 61562)
- National Institute of Neurological Disorders and Stroke (R56NS041777, R01NS041777, NS-041777)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- PGC-1α, sarcopenia, skeletal muscle aging, metabolic disorders, mitochondrial function, neuromuscular junction, muscle atrophy, apoptosis, autophagy, proteasomal degradation, bone mineral density, chronic inflammation, insulin sensitivity, insulin signaling, transgenic mice, retraction
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Aging, Animals, Body Composition, Body Constitution, Body Weight, Metabolic Diseases, Mice, Inbred C57BL, Mice, Transgenic, Mitochondria, Transcription Factors, Trans-Activators, Muscle, Skeletal, Mice, Sarcopenia
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