Plasma membrane insertion of the AMPA receptor GluA2 subunit is regulated by NSF binding and Q/R editing of the ion pore
Open accessAbstract
The delivery of AMPA receptors to the plasma membrane is a critical step both for the synaptic delivery of these receptors and for the regulation of synaptic transmission. To directly visualize fusion events of transport vesicles containing the AMPA receptor GluA2 subunit with the plasma membrane we used pHluorin-tagged GluA2 subunits and total internal reflection fluorescence microscopy. We demonstrate that the plasma membrane insertion of GluA2 requires the NSF binding site within its intracellular cytoplasmic domain and that RNA editing of the Q/R site in the ion channel region plays a key role in GluA2 plasma membrane insertion. Finally, we show that plasma membrane insertion of heteromeric GluA2/3 receptors follows the same rules as homomeric GluA2 receptors. These results demonstrate that the plasma membrane delivery of GluA2 containing AMPA receptors is regulated by its unique structural elements.
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GluA2-containing receptors (likely GluA2/3 heteromers) undergo spontaneous and constitutive exocytosis, but these events are much smaller, containing an estimated 2-5 receptors.
“GluA2-containing receptors (likely GluA2/3 heteromers) undergo spontaneous and constitutive exocytosis, but these events are much smaller, containing an estimated 2-5 receptors (Araki et al., 2010, Gu et al., 2016, Lin et al., 2009).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Araki et al., 2010
The Discussion reports that GluA2 exocytosis is largely constitutive (approximately 70%) and that its insertion events contain only a few receptors compared with GluA1; it also discusses GluA2/3 heteromers. The Results report lower fluorescence intensity for GluA2 events, but our copy does not give the claimed estimate of 2–5 receptors per event. (LLM, conf=0.87)
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- Authors
- Araki, Y., Lin, D.-T., & Huganir, R. L.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-06
- Volume
- 107
- Issue
- 24
- Pages
- 11080-11085
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2890737
- OpenAlex
- W2083767904
- Cited by
- 92
- References
- 37
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 6 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 3 · 2014: 10 · 2013: 6 · 2012: 7
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Neurological Disorders and Stroke (R01NS036715)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- AMPA receptors, GluR2 subunit, plasma membrane insertion, RNA editing, ion channel pore, vesicle fusion
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Binding Sites, Cell Membrane, Cells, Cultured, Hippocampus, Molecular Sequence Data, Neuronal Plasticity, Neurons, Recombinant Proteins, RNA Editing, DNA Primers, Receptors, AMPA, Protein Subunits, Rats, N-Ethylmaleimide-Sensitive Proteins, Protein Multimerization
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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