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Cited by 132Cellular transport and secretionNeuroscience and Neuropharmacology ResearchExtracellular vesicles in disease

Mechanisms and Function of Dendritic Exocytosis

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Kennedy, Matthew J., Ehlers, Michael D.·2011·Neuron
DOI 10.1016/j.neuron.2011.02.032PMC PMC3073864
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Abstract

Dendritic exocytosis is required for a broad array of neuronal functions including retrograde signaling, neurotransmitter release, synaptic plasticity, and establishment of neuronal morphology. While the details of synaptic vesicle exocytosis from presynaptic terminals have been intensely studied for decades, the mechanisms of dendritic exocytosis are only now emerging. Here we review the molecules and mechanisms of dendritic exocytosis and discuss how exocytosis from dendrites influences neuronal function and circuit plasticity.

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  • The insertion and removal of AMPARs during LTP and LTD, respectively, is believed to involve classical mechanisms of SNARE protein-mediated exocytosis and dynamin-dependent endocytosis via clathrin-coated vesicles.

    “The insertion and removal of AMPARs during LTP and LTD, respectively, is believed to involve classical mechanisms of SNARE protein -mediated exocytosis and dynamin-dependent endocytosis via clathrin-coated vesicles (Lu ¨scher et al. 1999;Carroll et al. 2001;Kennedy and Ehlers 2011).”

    From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Kennedy and Ehlers 2011

    The section “Postsynaptic Exocytosis and Synaptic Plasticity” describes SNARE-mediated postsynaptic fusion as a mechanism implicated in AMPA-receptor insertion during LTP. Our copy does not substantiate the other half of the claim: AMPA-receptor removal during LTD by dynamin-dependent endocytosis through clathrin-coated vesicles. (LLM, conf=0.88)

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Authors
Kennedy, M. J., & Ehlers, M. D.
Affiliations
  • Duke University (US)
  • Pfizer (United States) (US)
Corresponding author
  • Kennedy, Matthew J.
  • Ehlers, Michael D.
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2011-03
Volume
69
Issue
5
Pages
856-875
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2011.02.032
PMC
PMC3073864
OpenAlex
W2136622247
Cited by
132
References
20
Citations by year
2026: 7 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 12 · 2021: 13 · 2020: 8 · 2019: 7 · 2018: 7 · 2017: 7 · 2016: 4 · 2015: 4 · 2014: 14 · 2013: 13 · 2012: 16
FWCI
1.39
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institute of Mental Health (R01MH064748)
  • National Institute of Neurological Disorders and Stroke (R01NS047574)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords
synaptic vesicle exocytosis, retrograde signaling, neurotransmitter release, synaptic plasticity, neuronal morphology, dendritic transport, circuit plasticity, neuronal function
MeSH terms
Animals, Dendrites, Exocytosis, Synaptic Transmission, Neuronal Plasticity, Neurons, Synapses, Synaptic Vesicles

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