The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Tumor necrosis factor-α triggers a cytokine cascade yielding postoperative cognitive decline
Open accessAbstract
Cognitive decline following surgery in older individuals is a major clinical problem of uncertain mechanism; a similar cognitive decline also follows severe infection, chemotherapy, or trauma and is currently without effective therapy. A variety of mechanisms have been proposed, and exploring the role of inflammation, we recently reported the role of IL-1β in the hippocampus after surgery in mice with postoperative cognitive dysfunction. Here, we show that TNF-α is upstream of IL-1 and provokes its production in the brain. Peripheral blockade of TNF-α is able to limit the release of IL-1 and prevent neuroinflammation and cognitive decline in a mouse model of surgery-induced cognitive decline. TNF-α appears to synergize with MyD88, the IL-1/TLR superfamily common signaling pathway, to sustain postoperative cognitive decline. Taken together, our results suggest a unique therapeutic potential for preemptive treatment with anti-TNF antibody to prevent surgery-induced cognitive decline.
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Metadata
- Authors
- Terrando, N., Monaco, C., Ma, D., Foxwell, B. M. J., Feldmann, M., & Maze, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-11
- Volume
- 107
- Issue
- 47
- Pages
- 20518-20522
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2135735522
- Cited by
- 726
- References
- 14
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- green
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