Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 641

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis

Open access
Kurowska-Stolarska, Mariola, Alivernini, Stefano, Ballantine, Lucy E., Asquith, Darren L., Millar, Neal L., Gilchrist, Derek S., Reilly, James, Ierna, Michelle, Fraser, Alasdair R., Stolarski, Bartosz, McSharry, Charles, Hueber, Axel J., Baxter, Derek, Hunter, John, Gay, Steffen, Liew, Foo Y., McInnes, Iain B.·2011·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1019536108
Open this paper in CoChat — free account

Abstract

MicroRNA (miRNA) species (miR) regulate mRNA translation and are implicated as mediators of disease pathology via coordinated regulation of molecular effector pathways. Unraveling miR disease-related activities will facilitate future therapeutic interventions. miR-155 recently has been identified with critical immune regulatory functions. Although detected in articular tissues, the functional role of miR-155 in inflammatory arthritis has not been defined. We report here that miR-155 is up-regulated in synovial membrane and synovial fluid (SF) macrophages from patients with rheumatoid arthritis (RA). The increased expression of miR-155 in SF CD14 + cells was associated with lower expression of the miR-155 target, Src homology 2-containing inositol phosphatase-1 (SHIP-1), an inhibitor of inflammation. Similarly, SHIP-1 expression was decreased in CD68 + cells in the synovial lining layer in RA patients as compared with osteoarthritis patients. Overexpression of miR-155 in PB CD14 + cells led to down-regulation of SHIP-1 and an increase in the production of proinflammatory cytokines. Conversely, inhibition of miR-155 in RA synovial CD14 + cells reduced TNF-α production. Finally, miR-155–deficient mice are resistant to collagen-induced arthritis, with profound suppression of antigen-specific Th17 cell and autoantibody responses and markedly reduced articular inflammation. Our data therefore identify a role of miR-155 in clinical and experimental arthritis and suggest that miR-155 may be an intriguing therapeutic target.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1073/pnas.1019536108

Cites

9 of 9 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 9 references

Research works printed but not linked: 28

  1. 10.1038/nri2094 · DOI · Paper page
  2. 10.1038/nri2708 · DOI · Paper page
  3. 10.1016/j.tcb.2006.12.007 · DOI · Paper page
  4. 10.1038/ni1575 · DOI · Paper page
  5. 10.1126/science.1141229 · DOI · Paper page
  6. 10.1038/nature03702 · DOI · Paper page
  7. 10.1186/ar2493 · DOI · Paper page
  8. 10.1186/ar3006 · DOI · Paper page
  9. 10.1002/art.23386 · DOI · Paper page
  10. 10.1002/art.23429 · DOI · Paper page
  11. 10.1002/art.24762 · DOI
  12. 10.1002/art.24140 · DOI · Paper page
  13. 10.1002/art.22423 · DOI
  14. 10.1172/JCI200316913 · doi:10.1172/jci200316913 · Paper page
  15. 10.1182/blood-2005-01-0191 · DOI · Paper page
  16. 10.1038/nprot.2008.19 · DOI · Paper page
  17. 10.1007/978-1-59745-402-5_16 · DOI
  18. 10.1073/pnas.1009798107 · DOI · Paper page
  19. 10.1073/pnas.0811073106 · DOI · Paper page
  20. 10.1016/j.immuni.2008.11.010 · DOI · Paper page
  21. 10.1016/j.immuni.2007.10.009 · DOI · Paper page
  22. 10.1007/s12026-008-8078-1 · DOI
  23. 10.1046/j.1365-2249.1998.00529.x · DOI · Paper page
  24. 10.1186/ar1478 · DOI
  25. IK Campbell, et al., Protection from collagen-induced arthritis in granulocyte-macrophage colony-stimulating factor-deficient mice. J Immunol 161, 3639–3644 (1998). · DOI · Paper page
  26. B Manoury-Schwartz, et al., High susceptibility to collagen-induced arthritis in mice lacking IFN-gamma receptors. J Immunol 158, 5501–5506 (1997). · DOI · Paper page
  27. 10.4049/jimmunol.181.6.3733 · DOI · Paper page
  28. 10.1002/art.30281 · DOI · Paper page

Cited by

See all 641

Metadata

Authors
Kurowska-Stolarska, M., Alivernini, S., Ballantine, L. E., Asquith, D. L., Millar, N. L., Gilchrist, D. S., Reilly, J., Ierna, M., Fraser, A. R., Stolarski, B., McSharry, C., Hueber, A. J., Baxter, D., Hunter, J., Gay, S., Liew, F. Y., & McInnes, I. B.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2011-06-20
Volume
108
Issue
27
Pages
11193-11198
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1019536108
OpenAlex
W2059695215
Cited by
641
References
9
FWCI
41.64
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. https://app.cochat.ai/papers/10.1073/pnas.1019536108
The paper
Kurowska-Stolarska, M., Alivernini, S., Ballantine, L. E., Asquith, D. L., Millar, N. L., Gilchrist, D. S., Reilly, J., Ierna, M., Fraser, A. R., Stolarski, B., McSharry, C., Hueber, A. J., Baxter, D., Hunter, J., Gay, S., Liew, F. Y., & McInnes, I. B. (2011). MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1019536108

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.