Corticotropin-releasing hormone: An autocrine hormone that promotes lipogenesis in human sebocytes
Open accessAbstract
Sebaceous glands may be involved in a pathway conceptually similar to that of the hypothalamic-pituitary-adrenal (HPA) axis. Such a pathway has been described and may occur in human skin and lately in the sebaceous glands because they express neuropeptide receptors. Corticotropin-releasing hormone (CRH) is the most proximal element of the HPA axis, and it acts as central coordinator for neuroendocrine and behavioral responses to stress. To further examine the probability of an HPA equivalent pathway, we investigated the expression of CRH, CRH-binding protein (CRH-BP), and CRH receptors (CRH-R) in SZ95 sebocytes in vitro and their regulation by CRH and several other hormones. CRH, CRH-BP, CRH-R1, and CRH-R2 were detectable in SZ95 sebocytes at the mRNA and protein levels: CRH-R1 was the predominant type (CRH-R1/CRH-R2 = 2). CRH was biologically active on human sebocytes: it induced biphasic increase in synthesis of sebaceous lipids with a maximum stimulation at 10 −7 M and up-regulated mRNA levels of 3β- hydroxysteroid dehydrogenase/Δ 5–4 isomerase, although it did not affect cell viability, cell proliferation, or IL-1β-induced IL-8 release. CRH, dehydroepiandrosterone, and 17β-estradiol did not modulate CRH-R expression, whereas testosterone at 10 −7 M down-regulated CRH-R1 and CRH-R2 mRNA expression at 6 to 24 h, and growth hormone (GH) switched CRH-R1 mRNA expression to CRH-R2 at 24 h. Based on these findings, CRH may be an autocrine hormone for human sebocytes that exerts homeostatic lipogenic activity, whereas testosterone and growth hormone induce CRH negative feedback. The findings implicate CRH in the clinical development of acne, seborrhea, androgenetic alopecia, skin aging, xerosis, and other skin disorders associated with alterations in lipid formation of sebaceous origin.
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Corticotropin-releasing hormone is expressed in human sebocytes and augments the synthesis of sebaceous lipids in vitro.
“Corticotropin-releasing hormone is expressed in human sebocytes and augments the synthesis of sebaceous lipids in vitro.85,79”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [85]
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- Authors
- Zouboulis, C. C., Seltmann, H., Hiroi, N., Chen, W., Young, M., Oeff, M., Scherbaum, W. A., Orfanos, C. E., McCann, S. M., & Bornstein, S. R.
- Affiliations
- National Institutes of Health (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2002-05-14
- Volume
- 99
- Issue
- 10
- Pages
- 7148-7153
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC124543
- OpenAlex
- W1990641016
- Cited by
- 290
- References
- 4
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 9 · 2023: 5 · 2022: 7 · 2021: 11 · 2020: 15 · 2019: 12 · 2018: 8 · 2017: 14 · 2016: 11 · 2015: 7 · 2014: 24 · 2013: 13 · 2012: 11
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Site cant be reached (submittedVersion)
- Funders
- Sonnenfeld Stiftung
- Deutsche Forschungsgemeinschaft
- National Science Council
- Freie Universität Berlin
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Keywords
- corticotropin-releasing factor, sebocytes, sebaceous glands, lipogenesis, hypothalamic-pituitary-adrenal axis, CRH receptors, CRH-binding protein, testosterone, growth hormone, sebaceous lipids, acne, seborrhea, androgenetic alopecia, skin aging
- MeSH terms
- Carrier Proteins, Cell Division, Cell Line, Cell Survival, Corticotropin-Releasing Hormone, Humans, Interleukin-1, Lipids, RNA, Messenger, Sebaceous Glands, Growth Hormone, Testosterone, 3-Hydroxysteroid Dehydrogenases, Up-Regulation, Gene Expression, Interleukin-8, Receptors, Corticotropin-Releasing Hormone
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