The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior
Open accessAbstract
A large number of studies have demonstrated that the nucleus accumbens (NAC) is a critical site in the neuronal circuits controlling reward responses, motivation, and mood, but the neuronal cell type(s) underlying these processes are not yet known. Identification of the neuronal cell types that regulate depression-like states will guide us in understanding the biological basis of mood and its regulation by diseases like major depressive disorder. Taking advantage of recent findings demonstrating that the serotonin receptor chaperone, p11, is an important molecular regulator of depression-like states, here we identify cholinergic interneurons (CINs) as a primary site of action for p11 in the NAC. Depression-like behavior is observed in mice after decrease of p11 levels in NAC CINs. This phenotype is recapitulated by silencing neuronal transmission in these cells, demonstrating that accumbal cholinergic neuronal activity regulates depression-like behaviors and suggesting that accumbal CIN activity is crucial for the regulation of mood and motivation.
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In the citing paper
“Mice lacking p11 [162], p11 reductions in NAc [163], or p11 knockout in NAc ChIs [158] is sufficient to reduce sucrose preference and increase forced-swim immobility (Fig. 2, top).”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [158]
In the citing paper
“Silencing NAc cholinergic interneurons (ChIs) results in anhedonia and increases immobility in the forced-swim and tail-suspension tests [158].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [158]
In the citing paper
“a recent study has shown that decreasing striatal cholinergic tone in the mouse can lead to depression-like symptoms, likely through interneuron-dependent disinhibition of striatal neurons (Warner-Schmidt et al., 2012)”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Warner-Schmidt et al., 2012
In the citing paper
“decreasing cholinergic transmission in the striatum can induce depression-like effects in mice through disinhibition of medium spiny neurons (Warner-Schmidt et al., 2012)”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as Warner-Schmidt et al., 2012
In the citing paper
“numerous studies have now demonstrated that alterations of neuronal activity in the mesolimbic system can result in antidepressant-like effects (Nestler, 2014; Nestler and Carlezon, 2006; Warner-Schmidt et al., 2012)”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as Warner-Schmidt et al., 2012
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Citations
Cites
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Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059
Habits, Rituals, and the Evaluative Brain
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Neurocircuitry of Mood Disorders
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The ascent of mouse: advances in modelling human depression and anxiety
Cryan, J. F., & Holmes, A. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1825 · Cited by 1,198
Putting a spin on the dorsal-ventral divide of the striatum
Voorn, P., Vanderschuren, L. J. M. J., Groenewegen, H. J., Robbins, T. W., & Pennartz, C. M. A. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.06.006 · Cited by 1,188
A cholinergic-adrenergic hypothesis of mania and depression
Janowsky, D., Davis, J., El-Yousef, M. K., & Sekerke, H. J. (1972) · The Lancet · doi:10.1016/s0140-6736(72)93021-8 · Cited by 1,134
A translational profiling approach for the molecular characterization of CNS cell types
Heiman, M., Schaefer, A., Gong, S., Peterson, J. D., Day, M., Ramsey, K. E., Suárez-Fariñas, M., Schwarz, C., Stephan, D. A., Surmeier, D. J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.028 · Cited by 1,134
Self-citationDeep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression
Schlaepfer, T. E., Cohen, M. X., Frick, C., Kosel, M., Brodesser, D., Axmacher, N., Joe, A. Y., Kreft, M., Lenartz, D., & Sturm, V. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301408 · Cited by 1,027
Gong, S., Doughty, M., Harbaugh, C. R., Cummins, A., Hatten, M. E., Heintz, N., & Gerfen, C. R. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2707-07.2007 · Cited by 977
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Cited by
Sorted by citations
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870
Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior
Picciotto, M. R., Higley, M. J., & Mineur, Y. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.036 · Cited by 1,404
“…striatal cholinergic tone in the mouse can lead to depression-like symptoms, likely through interneuron-dependent disinhibition of striatal neurons (Warner-Schmidt et al., 2012), highlighting the fact that ACh can induce heterogeneous effects in different brain areas that appear to have opposite…”
BackgroundMineur, Y. S., Obayemi, A., Wigestrand, M. B., Fote, G. M., Calarco, C. A., Li, A. M., & Picciotto, M. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219731110 · Cited by 375
“pha-helical CRF(9-41), reverses nicotine-induced conditioned, but not unconditioned,”
BackgroundInfluentialWalczak, Ł. J., & Herbet, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179290 · Cited by 376
“These interneurons are also the main source of ACh in the nucleus accumbens [183,184].”
BackgroundNakajima, M., Görlich, A., & Heintz, N. (2014) · Cell · doi:10.1016/j.cell.2014.09.020 · Cited by 262
“To do so, we chose the viral-mediated tethered toxin (t-toxin) strategy for chronic inhibition of neurotransmission (Auer et al., 2010; Warner-Schmidt et al., 2012) in mPFC OxtrCre interneurons and the three chamber mouse social interaction test (Moy et al., 2004).”
MethodSelf-citation
Metadata
- Authors
- Warner-Schmidt, J. L., Schmidt, E. F., Marshall, J. J., Rubin, A. J., Arango-Lievano, M., Kaplitt, M. G., Ibañez-Tallon, I., Heintz, N., & Greengard, P.
- Affiliations
- Laboratories of aMolecular and Cellular Neuroscience and
- Howard Hughes Medical Institute (US)
- Weill Cornell Medicine (US)
- Molecular Biology and Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065;
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2012-06-25
- Volume
- 109
- Issue
- 28
- Pages
- 11360-11365
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3396525
- OpenAlex
- W2004051792
- Cited by
- 163
- References
- 37
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 8 · 2023: 11 · 2022: 14 · 2021: 20 · 2020: 11 · 2019: 13 · 2018: 9 · 2017: 14 · 2016: 11 · 2015: 13 · 2014: 11 · 2013: 11 · 2012: 5
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute on Aging (AG09464, P01AG009464)
- National Institute of Mental Health (P50MH090963, MH090963)
- National Institute on Drug Abuse (RC2DA028968)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cholinergic interneurons, nucleus accumbens, depression-like behavior, p11, major depressive disorder, mood regulation, motivation, neuronal silencing, neural transmission
- MeSH terms
- S100 Calcium Binding Protein A10, Acetylcholine, Animals, Antidepressive Agents, Behavior, Animal, Depression, Immunohistochemistry, Interneurons, Male, Mice, Inbred C57BL, Models, Biological, S100 Proteins, Neurons, Nucleus Accumbens, Phenotype, Receptors, Cholinergic, Annexin A2, Mice, Knockout, Neurotransmitter Agents, Molecular Chaperones, Mice
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