Cited by 313Neurotransmitter Receptor Influence on BehaviorPain Mechanisms and TreatmentsPain Management and Placebo Effect

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry

Open access

Navratilova, Edita, Xie, Jennifer Y., Okun, Alec, Qu, Chaoling, Eyde, Nathan, Ci, Shuang, Ossipov, Michael H., King, Tamara, Fields, Howard L., Porreca, Frank·2012·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1214605109PMC PMC3528534

Open this paper in CoChat — free account Open PDF

Abstract

Relief of pain is rewarding. Using a model of experimental postsurgical pain we show that blockade of afferent input from the injury with local anesthetic elicits conditioned place preference, activates ventral tegmental dopaminergic cells, and increases dopamine release in the nucleus accumbens. Importantly, place preference is associated with increased activity in midbrain dopaminergic neurons and blocked by dopamine antagonists injected into the nucleus accumbens. The data directly support the hypothesis that relief of pain produces negative reinforcement through activation of the mesolimbic reward–valuation circuitry.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.1214605109

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Dopamine in motivational control: rewarding, aversive, and alerting
Bromberg-Martin, E. S., Matsumoto, M., & Hikosaka, O. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.022 · Cited by 2,396
Dissociable Roles of Ventral and Dorsal Striatum in Instrumental Conditioning
O'Doherty, J., Dayan, P., Schultz, J., Deichmann, R., Friston, K., & Dolan, R. J. (2004) · Science · doi:10.1126/science.1094285 · Cited by 2,088
Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477
Reward representations and reward-related learning in the human brain: Insights from neuroimaging
O’Doherty, J. P. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.10.016 · Cited by 1,426
Characterization of a rat model of incisional pain
Brennan, T. J., Vandermeulen, E., & Gebhart, G. F. (1996) · Pain · doi:10.1016/0304-3959(95)01441-1 · Cited by 1,101
Dopamine and drug addiction: the nucleus accumbens shell connection
Di Chiara, G., Bassareo, V., Fenu, S., De Luca, M. A., Spina, L., Cadoni, C., Acquas, E., Carboni, E., Valentini, V., & Lecca, D. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.032 · Cited by 935
Projections from the Rat Prefrontal Cortex to the Ventral Tegmental Area: Target Specificity in the Synaptic Associations with Mesoaccumbens and Mesocortical Neurons
Carr, D. B., & Sesack, S. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03864.2000 · Cited by 880
Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking
Stuber, G. D., Sparta, D. R., Stamatakis, A. M., van Leeuwen, W. A., Hardjoprajitno, J. E., Cho, S., Tye, K. M., Kempadoo, K. A., Zhang, F., Deisseroth, K., et al. (2011) · Nature · doi:10.1038/nature10194 · Cited by 878
Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli
Brischoux, F., Chakraborty, S., Brierley, D. I., & Ungless, M. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811507106 · Cited by 801
Dopamine signals for reward value and risk: basic and recent data
Schultz, W. (2010) · Behavioral and Brain Functions · doi:10.1186/1744-9081-6-24 · Cited by 653

Show all 48 references

Research works printed but not linked: 1

10.1016/j.rapm.2007.01.001 · DOI · Paper page

Sorted by citations

Items 101–200 of 313

What does the Fos say? Using Fos-based approaches to understand the contribution of stress to substance use disorders
McReynolds, J. R., Christianson, J. P., Blacktop, J. M., & Mantsch, J. R. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.05.004 · Cited by 49
Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential
Xie, J. Y., Chew, L. A., Yang, X.-F., Wang, Y., Qu, C., Wang, Y., Federici, L. M., Fitz, S. D., Ripsch, M. S., Due, M. R., et al. (2016) · Pain · doi:10.1097/j.pain.0000000000000628 · Cited by 42
Self-citation
On the role of subsecond dopamine release in conditioned avoidance
Oleson, E. B., & Cheer, J. F. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00096 · Cited by 44
Modulation of salience network intranetwork resting state functional connectivity in women with chronic migraine
Androulakis, X. M., Rorden, C., Peterlin, B. L., & Krebs, K. A. (2017) · Cephalalgia · doi:10.1177/0333102417748570 · Cited by 43
Enrichment of Genomic Pathways Based on Differential DNA Methylation Associated With Chronic Postsurgical Pain and Anxiety in Children: A Prospective, Pilot Study
Chidambaran, V., Zhang, X., Geisler, K. J., Stubbeman, B. L., Chen, X., Weirauch, M. T., Meller, J., & Ji, H. (2019) · Journal of Pain · doi:10.1016/j.jpain.2018.12.008 · Cited by 41
How absent negativity relates to affect and motivation: an integrative relief model
Deutsch, R., Smith, K., Kordts-Freudinger, R., & Reichardt, R. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00152 · Cited by 51
Frontostriatal network dysfunction as a domain‐general mechanism underlying phantom perception
Hullfish, J., Abenes, I., Yoo, H. B., Ridder, D. D., & Vanneste, S. (2019) · Human Brain Mapping · doi:10.1002/hbm.24521 · Cited by 44
Preclinical Assessment of Pain: Improving Models in Discovery Research
King, T. E., & Porreca, F. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_330 · Cited by 43
Self-citation
Behavioral and neurochemical analysis of ongoing bone cancer pain in rats
Remeniuk, B., Sukhtankar, D. D., Okun, A., Navratilova, E., Xie, J. Y., King, T. E., & Porreca, F. (2015) · Pain · doi:10.1097/j.pain.0000000000000218 · Cited by 40
Self-citation
Role of the mesolimbic dopamine system in relief learning
Mayer, D., Kahl, E., Uzuneser, T. C., & Fendt, M. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0020-1 · Cited by 39
Psychosocial intervention and the reward system in pain and opioid misuse: new opportunities and directions
Garland, E. L. (2020) · Pain · doi:10.1097/j.pain.0000000000001988 · Cited by 36
Pain-induced adaptations in the claustro-cingulate pathway
Ntamati, N. R., Acuña, M. A., & Nevian, T. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112506 · Cited by 38
Disease modifying actions of interleukin-6 blockade in a rat model of bone cancer pain
Remeniuk, B., King, T. E., Sukhtankar, D. D., Nippert, A. R., Li, N., Li, F., Cheng, K., Rice, K. C., & Porreca, F. (2017) · Pain · doi:10.1097/j.pain.0000000000001139 · Cited by 38
Self-citation
The rostromedial tegmental nucleus: a key modulator of pain and opioid analgesia
Taylor, N. E., Long, H., Pei, J., Kukutla, P., Phero, A., Hadaegh, F., Abdelnabi, A., Solt, K., & Brenner, G. J. (2019) · Pain · doi:10.1097/j.pain.0000000000001647 · Cited by 41
Dopaminergic modulation of pain signals in the medial prefrontal cortex: Challenges and perspectives
Huang, S., Borgland, S. L., & Zamponi, G. W. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.11.043 · Cited by 38
Elevation of Transient Receptor Potential Vanilloid 1 Function in the Lateral Habenula Mediates Aversive Behaviors in Alcohol-withdrawn Rats
Gregor, D. M., Zuo, W., Fu, R., Bekker, A., & Ye, J.-H. (2019) · Anesthesiology · doi:10.1097/aln.0000000000002615 · Cited by 37
Attenuation of ongoing neuropathic pain by peripheral acting opioid involves activation of central dopaminergic neurocircuitry
Vaidya, S. P., Shantanu, P. A., & Tiwari, V. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135751 · Cited by 37
How Instructions, Learning, and Expectations Shape Pain and Neurobiological Responses
Atlas, L. Y. (2023) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-101822-122427 · Cited by 36
Pain-related cortico-limbic plasticity and opioid signaling
Neugebauer, V., Presto, P., Yakhnitsa, V., Antenucci, N., Mendoza, B., & Ji, G. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109510 · Cited by 38
Brain substrates of reward processing and the μ-opioid receptor: a pathway into pain?
Nees, F., Becker, S., Millenet, S., Banaschewski, T., Poustka, L., Bokde, A. L. W., Bromberg, U., Büchel, C., Conrod, P., Desrivières, S., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000000720 · Cited by 35
The Role of Ventral Tegmental Area Gamma-Aminobutyric Acid in Chronic Neuropathic Pain after Spinal Cord Injury in Rats
Ko, M. Y., Jang, E. Y., Lee, J. Y., Kim, S. P., Whang, S. H., Lee, B. H., Kim, H. Y., Yang, C. H., Cho, H. J., & Gwak, Y. S. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5381 · Cited by 36
On‐Demand Printing of Wearable Thermotherapy Pad
Moon, D., Plečkaitytė, G., Choi, T., Seol, M., Kim, B., Lee, D. I., Han, J., & Meyyappan, M. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.201901575 · Cited by 35
Toward Composite Pain Biomarkers of Neuropathic Pain—Focus on Peripheral Neuropathic Pain
Diaz, M. M., Caylor, J. R., Strigo, I. A., Lerman, I. R., Henry, B. L., López, E., Wallace, M. S., Ellis, R. J., Simmons, A. N., & Keltner, J. R. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.869215 · Cited by 38
Relief learning is distinguished from safety learning by the requirement of the nucleus accumbens.
Mohammadi, M., Bergado-Acosta, J. R., & Fendt, M. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.06.053 · Cited by 35
Reinforcement signaling of punishment versus relief in fruit fliesPreprint
König, C., Khalili, A., Ganesan, M., Nishu, A. P., Garza, A. P., Niewalda, T., Gerber, B., Aso, Y., & Yarali, A. (2018) · Learning & Memory · doi:10.1101/lm.047308.118 · Cited by 40
Pain relief by supraspinal gabapentin requires descending noradrenergic inhibitory controls
Juarez-Salinas, D. L., Braz, J. M., Hamel, K. A., & Basbaum, A. I. (2018) · PAIN Reports · doi:10.1097/pr9.0000000000000659 · Cited by 33
Brain Reward Circuit and Pain
Watanabe, M., & Narita, M. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1756-9_17 · Cited by 34
Sensory neuropathy and nociception in rodent models of Parkinson's disease
Valek, L., Auburger, G. W. J., & Tegeder, I. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.039396 · Cited by 33
The effect of electroacupuncture on regulating pain and depression-like behaviors induced by chronic neuropathic pain
Cong, W., Yu, P., Meng, B., Jia, X., & Jin, Z. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-20-1900 · Cited by 34
Opioid analgesia and the somatosensory memory of neonatal surgical injury in the adult rat
Moriarty, O., Harrington, L., Beggs, S., & Walker, S. M. (2018) · British Journal of Anaesthesia · doi:10.1016/j.bja.2017.11.111 · Cited by 32
RGS9-2 Modulates Responses to Oxycodone in Pain-Free and Chronic Pain States
Gaspari, S., Cogliani, V., Manouras, L., Anderson, E. M., Mitsi, V., Avrampou, K., Carr, F. B., & Zachariou, V. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.4 · Cited by 32
Effects of craving on opioid use are attenuated after pain coping counseling in adults with chronic pain and prescription opioid addiction.
Messina, B. G., & Worley, M. J. (2019) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000399 · Cited by 32
Engaging endogenous opioid circuits in pain affective processes
Kimmey, B. A., McCall, N. M., Wooldridge, L. M., Satterthwaite, T. D., & Corder, G. F. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24762 · Cited by 31
Lack of effect of different pain-related manipulations on opioid self-administration, reinstatement of opioid seeking, and opioid choice in rats
Reiner, D. J., Townsend, E. A., Orihuel, J., Applebey, S. V., Claypool, S. M., Banks, M. L., Shaham, Y., & Negus, S. S. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05816-9 · Cited by 29
Dopaminergic Regulation of Reward System Connectivity Underpins Pain and Emotional Suffering in Migraine
Kim, D. J., Jassar, H., Lim, M., Nascimento, T. D., & DaSilva, A. F. M. (2021) · Journal of Pain Research · doi:10.2147/jpr.s296540 · Cited by 31
Pain, from perception to action: A computational perspective
Chen, Z. S., & Wang, J. (2022) · iScience · doi:10.1016/j.isci.2022.105707 · Cited by 38
Are psychedelic medicines the reset for chronic pain? Preliminary findings and research needs
Zia, F. Z., Baumann, M. H., Belouin, S. J., Dworkin, R. H., Ghauri, M. H., Hendricks, P. S., Henningfield, J. E., Lanier, R. K., Ross, S., & Berger, A. M. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109528 · Cited by 33
Acute orofacial pain leads to prolonged changes in behavioral and affective pain components
Araya, E. I., Baggio, D. F., Koren, L. D. O., Andreatini, R., Schwarting, R. K. W., Zamponi, G. W., & Chichorro, J. G. (2020) · Pain · doi:10.1097/j.pain.0000000000001970 · Cited by 30
Intranasal Oxytocin Attenuates Reactive and Ongoing, Chronic Pain in a Model of Mild Traumatic Brain Injury
Meidahl, A. C., Eisenried, A., Klukinov, M., Cao, L., Tzabazis, A., & Yeomans, D. C. (2017) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13248 · Cited by 30
Pain modulates neural responses to reward in the medial prefrontal cortex
Wang, C., Bao, C., Gao, J., Gu, Y., & Dong, X. (2019) · Human Brain Mapping · doi:10.1002/hbm.24882 · Cited by 31
Early Life Stress and Risks for Opioid Misuse: Review of Data Supporting Neurobiological Underpinnings
Oswald, L. M., Dunn, K. E., Seminowicz, D. A., & Storr, C. L. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11040315 · Cited by 29
Alterations in pain processing circuitries in episodic migraine
Mungoven, T. J., Marciszewski, K. K., Macefield, V. G., Macey, P. M., Henderson, L. A., & Meylakh, N. (2022) · The Journal of Headache and Pain · doi:10.1186/s10194-021-01381-w · Cited by 28
Neurobiological Correlates of Pain Avoidance-Like Behavior in Morphine-Dependent and Non-Dependent Rats
Pahng, A. R., Paulsen, R. I., McGinn, M. A., Edwards, K. N., & Edwards, S. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.09.055 · Cited by 29
Emotion dysregulation as a transdiagnostic mechanism of opioid misuse and suicidality among chronic pain patients
Riquino, M. R., Priddy, S. E., Howard, M. O., & Garland, E. L. (2018) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/s40479-018-0088-6 · Cited by 28
Gabapentin regulates dopaminergic neuron firing and theta oscillation in the ventral tegmental area to reverse depression-like behavior in chronic neuropathic pain state
Fu, B., Wen, S., Wang, B., Wang, K., Zhang, J., Weng, X., & Liu, S.-J. (2018) · Journal of Pain Research · doi:10.2147/jpr.s170167 · Cited by 31
Viewing Nonsuicidal Self-Injury in Adolescence Through a Developmental Neuroscience Lens: The Impact of Neural Sensitivity to Socioaffective Pain and Reward
Cummings, L. R., Mattfeld, A. T., Pettit, J. W., & McMakin, D. L. (2021) · Clinical Psychological Science · doi:10.1177/2167702621989323 · Cited by 33
Corticolimbic circuitry in the modulation of chronic pain and substance abuse
Taylor, A. M. W. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.05.009 · Cited by 26
Chronic inflammatory pain alters alcohol-regulated frontocortical signaling and associations between alcohol drinking and thermal sensitivity
McGinn, M. A., Edwards, K. N., & Edwards, S. (2020) · Neurobiology of Pain · doi:10.1016/j.ynpai.2020.100052 · Cited by 27
Free-Operant Avoidance Behavior by Rats after Reinforcer Revaluation Using Opioid Agonists and d-Amphetamine
Fernando, A. B. P., Urcelay, G. P., Mar, A. C., Dickinson, A., & Robbins, T. W. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4146-13.2014 · Cited by 26
Stimulation of the ventral tegmental area increased nociceptive thresholds and decreased spinal dorsal horn neuronal activity in rat
Li, A.-L., Sibi, J. E., Yang, X., Chiao, J. ‐., & Peng, Y. B. (2016) · Experimental Brain Research · doi:10.1007/s00221-016-4558-z · Cited by 31
Use of the Exponential and Exponentiated Demand Equations to Assess the Behavioral Economics of Negative Reinforcement
Fragale, J. E. C., Beck, K. D., & Pang, K. C. H. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00077 · Cited by 26
The risk for problematic opioid use in chronic pain: What can we learn from studies of pain and reward?
Finan, P. H., Remeniuk, B., & Dunn, K. E. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.029 · Cited by 27
Neuropathy following spinal nerve injury shares features with the irritable nociceptor phenotype: A back‐translational study of oxcarbazepine
Patel, R., Kucharczyk, M. W., Montagut‐Bordas, C., Lockwood, S., & Dickenson, A. H. (2018) · European Journal of Pain · doi:10.1002/ejp.1300 · Cited by 26
A critical evaluation of validity and utility of translational imaging in pain and analgesia: Utilizing functional imaging to enhance the process
Upadhyay, J., Geber, C., Hargreaves, R. J., Birklein, F., & Borsook, D. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.004 · Cited by 26
Conditioned place preference and spontaneous dorsal horn neuron activity in chronic constriction injury model in rats
Dalm, B., Reddy, C. G., Howard, M. A., Kang, S., & Brennan, T. J. (2015) · Pain · doi:10.1097/j.pain.0000000000000365 · Cited by 25
Chronic low back pain: a mini-review on pharmacological management and pathophysiological insights from clinical and pre-clinical data
Park, T. S. W., Kuo, A., & Smith, M. T. (2018) · Inflammopharmacology · doi:10.1007/s10787-018-0493-x · Cited by 26
AMPAkines Target the Nucleus Accumbens to Relieve Postoperative Pain
Su, C. H., Lin, H. Y., Yang, R., Xu, D., Lee, M., Pawlak, N., Norcini, M., Sideris, A., Recio‐Pinto, E., Huang, D., et al. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001336 · Cited by 25
Mechanisms of postoperative pain
Kang, S., & Brennan, T. J. (2016) · Anesthesia and Pain Medicine · doi:10.17085/apm.2016.11.3.236 · Cited by 23
Melanocortin-4 receptor regulation of pain
Li, Z., Liu, B., He, Z., & Xiang, H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.05.021 · Cited by 23
Pain predictability reverses valence ratings of a relief-associated stimulus
Andreatta, M., Mühlberger, A., Glotzbach-Schoon, E., & Pauli, P. (2013) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2013.00053 · Cited by 26
Uncovering the analgesic effects of a pH-dependent mu-opioid receptor agonist using a model of nonevoked ongoing pain
Massaly, N., Temp, J., Machelska, H., & Stein, C. (2020) · Pain · doi:10.1097/j.pain.0000000000001968 · Cited by 21
The lateral habenula is a common target of cocaine and dexamethasone
Zhang, C., Zhang, H., Xu, H., Li, M., & Wang, S. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.09.019 · Cited by 22
Endogenous opioids contribute to the feeling of pain relief in humans
Sirucek, L., Price, R. C., Gandhi, W., Hoeppli, M., Fahey, E., Qu, A., Becker, S., & Schweinhardt, P. (2021) · Pain · doi:10.1097/j.pain.0000000000002285 · Cited by 24
Cannabidiol modulates chronic neuropathic pain aversion behavior by attenuation of neuroinflammation markers and neuronal activity in the corticolimbic circuit in male Wistar rats.
Silva-Cardoso, G. K., Lazarini-Lopes, W., Primini, E. O., Hallak, J. E., Crippa, J., Zuardi, A., Garcia-Cairasco, N., & Leite-Panissi, C. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114588 · Cited by 20
A diencephalic circuit in rats for opioid analgesia but not positive reinforcement
Waung, M. W., Maanum, K. A., Cirino, T. J., Driscoll, J. R., OʼBrien, C., Bryant, S., Mansourian, K. A., Morales, M., Barker, D. J., & Margolis, E. B. (2022) · Nature Communications · doi:10.1038/s41467-022-28332-6 · Cited by 19
Dopamine receptor D2, but not D1, mediates the reward circuit from the ventral tegmental area to the central amygdala, which is involved in pain relief
Huang, M., Wang, G., Lin, Y., Guo, Y., Jin, H., Ren, X., Cao, J., Cao, J., Weidong, Z., & Li, Z. (2022) · Molecular Pain · doi:10.1177/17448069221145096 · Cited by 19
Training endogenous pain modulation: a preliminary investigation of neural adaptation following repeated exposure to clinically-relevant pain
Sevel, L. S., Boissoneault, J., Alappattu, M. J., Bishop, M. D., & Robinson, M. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-018-0033-8 · Cited by 19
Attenuated dopamine receptor signaling in nucleus accumbens core in a rat model of chemically-induced neuropathy
Selley, D. E., Lazenka, M. F., Sim‐Selley, L. J., McVoy, J. R. S., Potter, D. N., Chartoff, E. H., Carlezon, W. A., & Negus, S. S. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.107935 · Cited by 19
Peripheral nerve injury promotes morphine-seeking behavior in rats during extinction
Gutierrez, T., Oliva, I., Crystal, J. D., & Hohmann, A. G. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113601 · Cited by 18
Lateral Hypothalamic Orexin Neurons Mediate the Reward Effects of Pain Relief Induced by Electroacupuncture
Wang, C., Chen, M., Qin, C., Qu, X., Shen, X., & Liu, S. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.812035 · Cited by 18
Evidence for dopaminergic involvement in endogenous modulation of pain relief
Desch, S., Schweinhardt, P., Seymour, B., Flor, H., & Becker, S. (2023) · eLife · doi:10.7554/elife.81436 · Cited by 19
Characterization of the Affective Component of Acute Postoperative Pain Associated with a Novel Rat Model of Inguinal Hernia Repair Pain
Bree, D., Moriarty, O., Broom, D. C., Kelly, J. P., Roche, M., & Finn, D. P. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12483 · Cited by 18
Emotional Modulation of Pain
Rhudy, J. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800538-5.00003-0 · Cited by 22
Role of VVZ-149, a Novel Analgesic Molecule, in the Affective Component of Pain: Results from an Exploratory Proof-of-Concept Study of Postoperative Pain following Laparoscopic and Robotic-Laparoscopic Gastrectomy
Song, I., Cho, S., Nedeljković, S. S., Lee, S. R., Lee, C., Kim, J., & Bai, S. J. (2021) · Pain Medicine · doi:10.1093/pm/pnab066 · Cited by 17
The Role of the Kappa Opioid System in Comorbid Pain and Psychiatric Disorders: Function and Implications
Ji, M., Yang, J., Gao, Z., Zhang, L., & Liu, C. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.642493 · Cited by 17
Electroacupuncture effects on trigeminal neuralgia with comorbid anxiety and depression: The role of frequency and acupoint specificity
Shen, Z., Chang, W., Liang, L., Zhang, J., Wang, Y., Yin, X., Xu, S., Li, W., & Yu, J. M. (2025) · The FASEB Journal · doi:10.1096/fj.202402461rr · Cited by 18
Doubling Your Payoff: Winning Pain Relief Engages Endogenous Pain Inhibition
Becker, S., Gandhi, W., Kwan, S., Ahmed, A., & Schweinhardt, P. (2015) · eNeuro · doi:10.1523/eneuro.0029-15.2015 · Cited by 19
Bridging the Translational Divide in Pain Research: Biological, Psychological and Social Considerations
Cho, C., Deol, H. K., & Martin, L. J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.603186 · Cited by 18
Possible contributions of a novel form of synaptic plasticity inAplysiato reward, memory, and their dysfunctions in mammalian brainPreprint
Hawkins, R. D. (2013) · Learning & Memory · doi:10.1101/lm.031237.113 · Cited by 17
Anterior cingulate cortex regulates pain catastrophizing-like behaviors in rats
Jee, H. J., Zhu, E., Sun, M., Liu, W., Zhang, Q., & Wang, J. (2023) · Molecular Brain · doi:10.1186/s13041-023-01060-8 · Cited by 17
Transcranial Direct Current Stimulation (tDCS) Induces Analgesia in Rats with Neuropathic Pain and Alcohol Abstinence
Santos, D. S., Lopes, B. C., Medeiros, L. F., Assumpção, J. A. F., de Souza, A., Salvi, A. A., da Silva, L. S., Fregni, F., Caumo, W., & Torres, I. L. D. S. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03116-w · Cited by 16
Altered Reward Processing and Sex Differences in Chronic Pain
Baker, A. K., Ericksen, L. C., Koppelmans, V., Mickey, B. J., Martucci, K. T., Zubieta, J.-K., & Love, T. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.889849 · Cited by 16
Pramipexole treatment attenuates mechanical hypersensitivity in male rats experiencing chronic inflammatory pain
Edwards, S., Callicoatte, C. N., Barattini, A. E., Cucinello‐Ragland, J. A., Melain, A., Edwards, K. N., Gilpin, N. W., Avegno, E. M., & Pahng, A. R. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.108976 · Cited by 16
Separating analgesia from reward within the ventral tegmental area
Schifirnet, E., Bowen, S. E., & Borszcz, G. S. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.009 · Cited by 15
Relief learning requires a coincident activation of dopamine D1 and NMDA receptors within the nucleus accumbens
Bergado-Acosta, J. R., Kahl, E., Kogias, G., Uzuneser, T. C., & Fendt, M. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.11.022 · Cited by 15
Assessment of Behavioral Disruption in Rats with Abdominal Inflammation Using Visual Cue Titration and the Five-choice Serial-reaction Time Task
Martin, T. J., Strassburg, T. J., Grigg, A. L., Kim, S. A., Ririe, D. G., & Eisenach, J. C. (2017) · Anesthesiology · doi:10.1097/aln.0000000000001702 · Cited by 15
The α2/α3GABAA receptor modulator TPA023B alleviates not only the sensory but also the tonic affective component of chronic pain in mice
Neumann, E., Küpfer, L., & Zeilhofer, H. U. (2020) · Pain · doi:10.1097/j.pain.0000000000002030 · Cited by 14
Operant and classical learning principles underlying mind–body interaction in pain modulation: a pilot fMRI study
Lee, I., Jung, W.-M., Lee, Y., Wallraven, C., & Chae, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-81134-6 · Cited by 16
Pharmacological modulation of ventral tegmental area neurons elicits changes in trigeminovascular sensory processing and is accompanied by glycemic changes: Implications for migraine
Martins-Oliveira, M., Akerman, S., Holland, P. R., Tavares, I., & Goadsby, P. J. (2022) · Cephalalgia · doi:10.1177/03331024221110111 · Cited by 15
Pregabalin induces conditioned place preference in the rat during the early, but not late, stage of neuropathic pain
Asaoka, Y., Kato, T., Ide, S., Amano, T., & Minami, M. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.01.029 · Cited by 15
Forebrain medial septum sustains experimental neuropathic pain
Ariffin, M. Z., Ibrahim, K. M., Lee, A. T.-H., Lee, R. Z., Poon, S. Y., Thong, H. K., Liu, E. H. C., Low, C., & Khanna, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-30177-3 · Cited by 15
μ-opioid receptor agonists and psychedelics: pharmacological opportunities and challenges
Salinsky, L. M., Merritt, C. R., Zamora, J. C., Giacomini, J. L., Anastasio, N. C., & Cunningham, K. A. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1239159 · Cited by 14
An Ascending Excitatory Circuit from the Dorsal Raphe for Sensory Modulation of Pain
Liu, D., Hu, S.-W., Wang, D., Zhang, Q., Zhang, X. L., Ding, H., & Cao, J. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0869-23.2023 · Cited by 14
Stress-induced overeating behaviors explained from a (transitory) relief-learning perspective
Papalini, S. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114707 · Cited by 17
Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: Analysis using a microdialysis/mass spectrometry integrated system
Watanabe, M., Sugiura, Y., Sugiyama, E., Narita, M., Navratilova, E., Kondo, T., Uchiyama, N., Yamanaka, A., Kuzumaki, N., Porreca, F., et al. (2018) · Molecular Pain · doi:10.1177/1744806918754934 · Cited by 14
Self-citation
Multidimensional Pain Modulation by Acupuncture Analgesia: The Reward Effect of Acupuncture on Pain Relief
Pan, S., Wang, S., Xue, X., Yuan, H.-Y., Li, J., Liu, Y., & Yue, Z. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/3759181 · Cited by 13
Deep Brain Stimulation of the Subgenual Cingulate Cortex for the Treatment of Chronic Low Back Pain
Kashanian, A., Tsolaki, E. C., Pouratian, N., & Bari, A. (2021) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13388 · Cited by 15
Nerve growth factor, brain-derived neurotrophic factor, and the chronobiology of mood: a new insight into the "neurotrophic hypothesis"
Tirassa, P., Quartini, A., & Iannitelli, A. (2015) · ChronoPhysiology and Therapy · doi:10.2147/cpt.s54526 · Cited by 12
Inflammatory Pain Alters Dopaminergic Modulation of Excitatory Synapses in the Anterior Cingulate Cortex of Mice
Darvish-Ghane, S., Lyver, B., Facciol, A., Chatterjee, D., & Martin, L. J. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.07.010 · Cited by 10
Lateral preoptic area glutamate neurons relay nociceptive information to the ventral tegmental area
Barker, D. J., Zhang, S., Wang, H., Estrin, D. J., Miranda-Barrientos, J. A., Liu, B., Kulkarni, R. J., de Deus, J. L., & Morales, M. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113029 · Cited by 12

Authors: Navratilova, E., Xie, J. Y., Okun, A., Qu, C., Eyde, N., Ci, S., Ossipov, M. H., King, T., Fields, H. L., & Porreca, F.
Affiliations: University of Arizona (US)
University of New England (US)
University of California, San Francisco (US)
ORCID: Navratilova, Edita
Xie, Jennifer Y.
Ossipov, Michael H.
King, Tamara
Fields, Howard L.
Porreca, Frank
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2012-11-26
Volume: 109
Issue: 50
Pages: 20709-20713
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1214605109
PMC: PMC3528534
OpenAlex: W2052380247
Cited by: 313
References: 48
Citations by year: 2026: 17 · 2025: 17 · 2024: 19 · 2023: 23 · 2022: 22 · 2021: 28 · 2020: 28 · 2019: 23 · 2018: 29 · 2017: 32 · 2016: 17 · 2015: 21 · 2014: 19 · 2013: 17
FWCI: 7.51
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute on Drug Abuse (R01DA034975)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Keywords: analgesia, negative reinforcement, mesolimbic reward circuitry, postoperative pain, conditioned place preference, ventral tegmental area, dopaminergic neurons, nucleus accumbens, dopamine release, local anesthetics, dopamine antagonists
MeSH terms: Afferent Pathways, Anesthetics, Local, Animals, Disease Models, Animal, Limbic System, Male, Models, Neurological, Nerve Block, Nucleus Accumbens, Pain, Pain, Postoperative, Postoperative Pain, Reinforcement, Psychology, Reward, Rats, Sprague-Dawley, Ventral Tegmental Area, Dopamine Antagonists, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks