Cited by 313Neurotransmitter Receptor Influence on BehaviorPain Mechanisms and TreatmentsPain Management and Placebo Effect

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry

Open access

Navratilova, Edita, Xie, Jennifer Y., Okun, Alec, Qu, Chaoling, Eyde, Nathan, Ci, Shuang, Ossipov, Michael H., King, Tamara, Fields, Howard L., Porreca, Frank·2012·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1214605109PMC PMC3528534

Open this paper in CoChat — free account Open PDF

Abstract

Relief of pain is rewarding. Using a model of experimental postsurgical pain we show that blockade of afferent input from the injury with local anesthetic elicits conditioned place preference, activates ventral tegmental dopaminergic cells, and increases dopamine release in the nucleus accumbens. Importantly, place preference is associated with increased activity in midbrain dopaminergic neurons and blocked by dopamine antagonists injected into the nucleus accumbens. The data directly support the hypothesis that relief of pain produces negative reinforcement through activation of the mesolimbic reward–valuation circuitry.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.1214605109

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Dopamine in motivational control: rewarding, aversive, and alerting
Bromberg-Martin, E. S., Matsumoto, M., & Hikosaka, O. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.022 · Cited by 2,396
Dissociable Roles of Ventral and Dorsal Striatum in Instrumental Conditioning
O'Doherty, J., Dayan, P., Schultz, J., Deichmann, R., Friston, K., & Dolan, R. J. (2004) · Science · doi:10.1126/science.1094285 · Cited by 2,088
Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477
Reward representations and reward-related learning in the human brain: Insights from neuroimaging
O’Doherty, J. P. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.10.016 · Cited by 1,426
Characterization of a rat model of incisional pain
Brennan, T. J., Vandermeulen, E., & Gebhart, G. F. (1996) · Pain · doi:10.1016/0304-3959(95)01441-1 · Cited by 1,101
Dopamine and drug addiction: the nucleus accumbens shell connection
Di Chiara, G., Bassareo, V., Fenu, S., De Luca, M. A., Spina, L., Cadoni, C., Acquas, E., Carboni, E., Valentini, V., & Lecca, D. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.032 · Cited by 935
Projections from the Rat Prefrontal Cortex to the Ventral Tegmental Area: Target Specificity in the Synaptic Associations with Mesoaccumbens and Mesocortical Neurons
Carr, D. B., & Sesack, S. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03864.2000 · Cited by 880
Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking
Stuber, G. D., Sparta, D. R., Stamatakis, A. M., van Leeuwen, W. A., Hardjoprajitno, J. E., Cho, S., Tye, K. M., Kempadoo, K. A., Zhang, F., Deisseroth, K., et al. (2011) · Nature · doi:10.1038/nature10194 · Cited by 878
Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli
Brischoux, F., Chakraborty, S., Brierley, D. I., & Ungless, M. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811507106 · Cited by 801
Dopamine signals for reward value and risk: basic and recent data
Schultz, W. (2010) · Behavioral and Brain Functions · doi:10.1186/1744-9081-6-24 · Cited by 653

Show all 48 references

Research works printed but not linked: 1

10.1016/j.rapm.2007.01.001 · DOI · Paper page

Sorted by citations

Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits
Hashmi, J. A., Baliki, M. N., Huang, L., Baria, A. T., Torbey, S., Hermann, K. M., Schnitzer, T. J., & Apkarian, A. V. (2013) · Brain · doi:10.1093/brain/awt211 · Cited by 762
Neurons for hunger and thirst transmit a negative-valence teaching signal
Betley, J. N., Xu, S., Cao, Z. F. H., Gong, R., Magnus, C. J., Yu, Y., & Sternson, S. M. (2015) · Nature · doi:10.1038/nature14416 · Cited by 704
Endogenous and Exogenous Opioids in Pain
Corder, G. F., Castro, D. C., Bruchas, M. R., & Scherrer, G. (2018) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080317-061522 · Cited by 537
Reward and motivation in pain and pain relief
Navratilova, E., & Porreca, F. (2014) · Nature Neuroscience · doi:10.1038/nn.3811 · Cited by 501
Self-citation
Psychological processing in chronic pain: a neural systems approach
Simons, L. E., Elman, I., & Borsook, D. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.12.006 · Cited by 359
Peripheral input and its importance for central sensitization
Baron, R., Hans, G. H., & Dickenson, A. H. (2013) · Annals of Neurology · doi:10.1002/ana.24017 · Cited by 280
Ventral tegmental area dopamine revisited: effects of acute and repeated stress
Holly, E. N., & Miczek, K. A. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4151-3 · Cited by 265
Distinct Brain Systems Mediate the Effects of Nociceptive Input and Self-Regulation on Pain
Woo, C.-W., Roy, M., Buhle, J. T., & Wager, T. D. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002036 · Cited by 263
The Mesolimbic Dopamine System in Chronic Pain and Associated Affective Comorbidities
Serafini, R. A., Pryce, K. D., & Zachariou, V. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.10.018 · Cited by 252
Predicting transition to chronic pain
Apkarian, A. V., Baliki, M. N., & Farmer, M. A. (2013) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32836336ad · Cited by 250
Mesolimbic dopamine signaling in acute and chronic pain
Taylor, A. M. W., Becker, S., Schweinhardt, P., & Cahill, C. M. (2016) · Pain · doi:10.1097/j.pain.0000000000000494 · Cited by 248
Reward deficiency and anti-reward in pain chronification
Borsook, D., Linnman, C., Faria, V., Strassman, A. M., Becerra, L. R., & Elman, I. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.033 · Cited by 238
Stress-induced plasticity and functioning of ventral tegmental dopamine neurons
Douma, E. H., & de Kloet, E. R. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.015 · Cited by 235
Quantifying cerebral contributions to pain beyond nociception
Woo, C., Schmidt, L., Krishnan, A., Jepma, M., Roy, M., Lindquist, M. A., Atlas, L. Y., & Wager, T. D. (2017) · Nature Communications · doi:10.1038/ncomms14211 · Cited by 233
Brain Circuits Encoding Reward from Pain Relief
Navratilova, E., Atcherley, C. W., & Porreca, F. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.09.003 · Cited by 208
Self-citation
Reward, motivation, and emotion of pain and its relief
Porreca, F., & Navratilova, E. (2017) · Pain · doi:10.1097/j.pain.0000000000000798 · Cited by 210
Self-citation
A dopaminergic switch for fear to safety transitions
Luo, R., Uematsu, A., Weitemier, A. Z., Aquili, L., Koivumaa, J., McHugh, T. J., & Johansen, J. P. (2018) · Nature Communications · doi:10.1038/s41467-018-04784-7 · Cited by 199
Microglia Disrupt Mesolimbic Reward Circuitry in Chronic Pain
Taylor, A. M. W., Castonguay, A., Taylor, A. J., Murphy, N. P., Ghogha, A., Cook, C. P., Xue, L., Olmstead, M. C., Koninck, Y. D., Evans, C. J., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4036-14.2015 · Cited by 196
Endogenous Opioid Activity in the Anterior Cingulate Cortex Is Required for Relief of Pain
Navratilova, E., Xie, J. Y., Meske, D. S., Qu, C., Morimura, K., Okun, A., Arakawa, N., Ossipov, M. H., Fields, H. L., & Porreca, F. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3862-14.2015 · Cited by 195
Self-citation
Activation of cortical somatostatin interneurons prevents the development of neuropathic pain
Cichon, J., Blanck, T. J. J., Gan, W., & Yang, G. (2017) · Nature Neuroscience · doi:10.1038/nn.4595 · Cited by 164
Modulation of pain, nociception, and analgesia by the brain reward center
Mitsi, V., & Zachariou, V. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.017 · Cited by 179
Pain: A Precision Signal for Reinforcement Learning and Control
Seymour, B. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.055 · Cited by 175
Role of nucleus accumbens in neuropathic pain: Linked multi-scale evidence in the rat transitioning to neuropathic pain
Chang, P.-C., Pollema-Mays, S. L., Centeno, M. V., Procissi, D., Contini, M., Baria, A. T., Martina, M., & Apkarian, A. V. (2014) · Pain · doi:10.1016/j.pain.2014.02.019 · Cited by 161
Studying ongoing and spontaneous pain in rodents – challenges and opportunities
Tappe‐Theodor, A., & Kuner, R. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12643 · Cited by 152
Evaluation of reward from pain relief
Navratilova, E., Xie, J. Y., King, T. E., & Porreca, F. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12095 · Cited by 152
Self-citation
Parceling Human Accumbens into Putative Core and Shell Dissociates Encoding of Values for Reward and Pain
Baliki, M. N., Mansour, A. R., Baria, A. T., Huang, L., Berger, S., Fields, H. L., & Apkarian, A. V. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1731-13.2013 · Cited by 161
Self-citation
Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states
Little, J. W., Ford, A., Symons-Liguori, A. M., Chen, Z., Janes, K., Doyle, T. M., Xie, J. Y., Luongo, L., Tosh, D. K., Maione, S., et al. (2014) · Brain · doi:10.1093/brain/awu330 · Cited by 144
Self-citation
Calcium-Permeable AMPA Receptors in the Nucleus Accumbens Regulate Depression-Like Behaviors in the Chronic Neuropathic Pain State
Goffer, Y., Xu, D., Eberle, S. E., D’amour, J. A., Lee, M., Tukey, D. S., Froemke, R. C., Ziff, E. B., & Wang, J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2454-13.2013 · Cited by 147
Pain-relief learning in flies, rats, and man: basic research and applied perspectivesPreprint
Gerber, B., Yarali, A., Diegelmann, S., Wotjak, C. T., Pauli, P., & Fendt, M. (2014) · Learning & Memory · doi:10.1101/lm.032995.113 · Cited by 145
Mapping Cortical Integration of Sensory and Affective Pain Pathways
Singh, A., Patel, D. J., Li, A., Hu, L., Zhang, Q., Liu, Y., Guo, X., Robinson, E. J., Martinez, E., Doan, L., et al. (2020) · Current Biology · doi:10.1016/j.cub.2020.02.091 · Cited by 136
Altered periaqueductal gray resting state functional connectivity in migraine and the modulation effect of treatment
Li, Z., Liu, M., Lan, L., Zeng, F., Makris, N., Liang, Y., Guo, T., Wu, F., Gao, Y., Dong, M., et al. (2016) · Scientific Reports · doi:10.1038/srep20298 · Cited by 127
Acute stress selectively reduces reward sensitivity
Berghorst, L. H., Bogdan, R., Frank, M. J., & Pizzagalli, D. A. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00133 · Cited by 131
Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior
Markovic, T., Pedersen, C. E., Massaly, N., Vachez, Y. M., Ruyle, B. C., Murphy, C. A., Abiraman, K., Shin, J. H., Garcia, J. J., Yoon, H. J., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00924-3 · Cited by 129
Cognition in the Chronic Pain Experience: Preclinical Insights
Phelps, C. E., Navratilova, E., & Porreca, F. (2021) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2021.01.001 · Cited by 126
Self-citation
Current evidence of cannabinoid‐based analgesia obtained in preclinical and human experimental settings
Lötsch, J., Weyer-Menkhoff, I., & Tegeder, I. (2017) · European Journal of Pain · doi:10.1002/ejp.1148 · Cited by 123
Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area μ Opioid Receptors
Hipólito, L., Wilson‐Poe, A. R., Campos‐Jurado, Y., Zhong, E., González-Romero, J. L., Virag, L., Whittington, R. A., Comer, S. D., Carlton, S. M., Walker, B. M., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1053-15.2015 · Cited by 114
Neural mechanisms of pain and alcohol dependence
Apkarian, A. V., Neugebauer, V., Koob, G. F., Edwards, S., Levine, J. D., Ferrari, L. F., Egli, M., & Regunathan, S. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.09.008 · Cited by 114
Pain modulates dopamine neurons via a spinal–parabrachial–mesencephalic circuit
Yang, H., de Jong, J. W., Cerniauskas, I., Peck, J. R., Lim, B. K., Gong, H., Fields, H. L., & Lammel, S. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00903-8 · Cited by 120
Self-citation
Lost but making progress—Where will new analgesic drugs come from?
Borsook, D., Hargreaves, R. J., Bountra, C., & Porreca, F. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008320 · Cited by 116
Self-citation
Development of CGRP-dependent pain and headache related behaviours in a rat model of concussion: Implications for mechanisms of post-traumatic headache
Bree, D., & Levy, D. (2016) · Cephalalgia · doi:10.1177/0333102416681571 · Cited by 112
A functional subdivision within the somatosensory system and its implications for pain research
Ma, Q. (2022) · Neuron · doi:10.1016/j.neuron.2021.12.015 · Cited by 112
Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex
Zhou, H., Zhang, Q., Martinez, E., Dale, J., Hu, S., Zhang, E., Liu, K. G., Huang, D., Yang, G., Chen, Z. S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06295-x · Cited by 113
Evidence and explanation for the involvement of the nucleus accumbens in pain processing
Harris, H. N., & Peng, Y. B. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.266909 · Cited by 108
Neural circuits and motivational processes for hunger
Sternson, S. M., Nicholas Betley, J., & Cao, Z. F. H. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.04.006 · Cited by 108
Rapid treatment-induced brain changes in pediatric CRPS
Erpelding, N., Simons, L., Lebel, A., Serrano, P., Pielech, M., Prabhu, S., Becerra, L., & Borsook, D. (2016) · Brain Structure and Function · doi:10.1007/s00429-014-0957-8 · Cited by 108
Does the kappa opioid receptor system contribute to pain aversion?
Cahill, C. M., Taylor, A. M. W., Cook, C., Ong, E., MorÃ³n, J. A., & Evans, C. J. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00253 · Cited by 105
Central Processing of Itch in the Midbrain Reward Center
Su, X., Chen, M., Yuan, Y., Li, Y., Guo, S.-S., Luo, H., Huang, C., Sun, W., Li, Y., Zhu, M. X., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.030 · Cited by 107
Animal models for the study of depressive disorder
Song, J., & Kim, Y. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13622 · Cited by 112
Positive emotions and brain reward circuits in chronic pain
Navratilova, E., Morimura, K., Xie, J. Y., Atcherley, C. W., Ossipov, M. H., & Porreca, F. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.23968 · Cited by 100
Self-citation
Brain-Derived Neurotrophic Factor in the Mesolimbic Reward Circuitry Mediates Nociception in Chronic Neuropathic Pain
Zhang, H., Qian, Y., Li, C., Liu, D., Wang, L., Wang, X., Liu, M., Liu, H., Zhang, S., Guo, X.-Y., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.1180 · Cited by 105
Capturing the aversive state of cephalic pain preclinically
Felice, M. D., Eyde, N., Dodick, D. W., Dussor, G. O., Ossipov, M. H., Fields, H. L., & Porreca, F. (2013) · Annals of Neurology · doi:10.1002/ana.23922 · Cited by 99
Self-citation
Analogous responses in the nucleus accumbens and cingulate cortex to pain onset (aversion) and offset (relief) in rats and humans
Becerra, L. R., Navratilova, E., Porreca, F., & Borsook, D. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00284.2013 · Cited by 99
Self-citation
Chronic pain induces generalized enhancement of aversion
Zhang, Q., Manders, T. R., Tong, A. P., Yang, R., Garg, A., Martinez, E., Zhou, H., Dale, J., Goyal, A., Urien, L., et al. (2017) · eLife · doi:10.7554/elife.25302 · Cited by 101
Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain
Bannister, K., Qu, C., Navratilova, E., Oyarzo, J. N., Xie, J. Y., King, T. E., Dickenson, A. H., & Porreca, F. (2017) · Pain · doi:10.1097/j.pain.0000000000001040 · Cited by 97
Self-citation
Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain
Makary, M. M., Polosecki, P. I., Cecchi, G., DeAraujo, I. E., Barron, D. S., Constable, R. T., Whang, P. G., Thomas, D.-A. M., Mowafi, H. O., Small, D. M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1918682117 · Cited by 96
Monoamines as Drug Targets in Chronic Pain: Focusing on Neuropathic Pain
Bravo, L., Llorca-Torralba, M., Berrocoso, E., & Micó, J. A. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01268 · Cited by 89
Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids
Leitl, M. D., Onvani, S., Bowers, M. S., Cheng, K., Rice, K. C., Carlezon, W. A., Banks, M. L., & Negus, S. S. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.236 · Cited by 87
Scaling Up Cortical Control Inhibits Pain
Dale, J., Zhou, H., Zhang, Q., Martinez, E., Hu, S., Liu, K., Urien, L., Chen, Z. S., & Wang, J. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.139 · Cited by 87
A neurobehavioral approach to addiction: implications for the opioid epidemic and the psychology of addiction
Bechara, A., Berridge, K. C., Bickel, W. K., Morón, J. A., Williams, S. B., & Stein, J. S. (2019) · Psychological Science in the Public Interest · doi:10.1177/1529100619860513 · Cited by 82
Neuroinflammation—a co-occurring phenomenon linking chronic pain and opioid dependence
Cahill, C. M., & Taylor, A. M. W. (2017) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.12.003 · Cited by 84
Brain-derived neurotrophic factor–mediated projection-specific regulation of depressive-like and nociceptive behaviors in the mesolimbic reward circuitry
Liu, D., Tang, Q., Cui, Y., Song, Y., Liu, Y., Yang, J., Liu, H., Zhang, Y., Wu, S., Song, Y., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000001083 · Cited by 81
The Roles of Phasic and Tonic Dopamine in Tic Learning and Expression
Maia, T. V., & Conceição, V. A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.05.025 · Cited by 78
Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: A potential biomarker of efficacy
Xie, J. Y., Qu, C., Patwardhan, A. M., Ossipov, M. H., Navratilova, E., Becerra, L. R., Borsook, D., & Porreca, F. (2014) · Pain · doi:10.1016/j.pain.2014.05.018 · Cited by 80
Self-citation
Cues conditioned to withdrawal and negative reinforcement: Neglected but key motivational elements driving opioid addiction
Pantazis, C. B., Gonzalez, L. A., Tunstall, B. J., Carmack, S. A., Koob, G. F., & Vendruscolo, L. F. (2021) · Science Advances · doi:10.1126/sciadv.abf0364 · Cited by 74
Dopamine: from prediction error to psychotherapy
Papalini, S., Beckers, T., & Vervliet, B. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0814-x · Cited by 75
John J. Bonica Award Lecture: Peripheral neuronal hyperexcitability: the “low-hanging” target for safe therapeutic strategies in neuropathic pain
Raja, S. N., Ringkamp, M., Guan, Y., & Campbell, J. N. (2020) · Pain · doi:10.1097/j.pain.0000000000001838 · Cited by 71
Synapse-specific opioid modulation of thalamo-cortico-striatal circuits
Birdsong, W. T., Jongbloets, B. C., Engeln, K. A., Wang, D., Scherrer, G., & Mao, T. (2019) · eLife · doi:10.7554/elife.45146 · Cited by 67
BDNF as a biomarker for neuropathic pain: Consideration of mechanisms of action and associated measurement challenges
Thakkar, B., & Acevedo, E. O. (2023) · Brain and Behavior · doi:10.1002/brb3.2903 · Cited by 75
Acute stress-induced cortisol elevations mediate reward system activity during subconscious processing of sexual stimuli
Oei, N. Y. L., Both, S., van Heemst, D., & van der Grond, J. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.10.005 · Cited by 73
Impaired mesocorticolimbic connectivity underlies increased pain sensitivity in chronic low back pain
Yu, S., Li, W., Shen, W., Edwards, R. R., Gollub, R. L., Wilson, G., Park, J., Ortiz, A., Cao, J., Gerber, J. A., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116969 · Cited by 73
Acupuncture Treatment Modulates the Connectivity of Key Regions of the Descending Pain Modulation and Reward Systems in Patients with Chronic Low Back Pain
Yu, S., Ortiz, A., Gollub, R. L., Wilson, G., Gerber, J. A., Park, J., Huang, Y., Shen, W., Chan, S., Wasan, A. D., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061719 · Cited by 71
Stress relief as a natural resilience mechanism against depression-like behaviors
Dong, Y., Li, Y., Xiang, X., Xiao, Z.-C., Hu, J., Li, Y., Li, H., & Hu, H. (2023) · Neuron · doi:10.1016/j.neuron.2023.09.004 · Cited by 73
The altered right frontoparietal network functional connectivity in migraine and the modulation effect of treatment
Li, Z., Lan, L., Zeng, F., Makris, N., Hwang, J., Guo, T., Wu, F., Gao, Y., Dong, M., Liu, M., et al. (2016) · Cephalalgia · doi:10.1177/0333102416641665 · Cited by 67
Inhibition of the Prefrontal Projection to the Nucleus Accumbens Enhances Pain Sensitivity and Affect
Zhou, H., Martinez, E., Lin, H. H., Yang, R., Dale, J., Liu, K., Huang, D., & Wang, J. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00240 · Cited by 70
The Role of Dopamine in Associative Learning in Drosophila: An Updated Unified Model
Adel, M., & Griffith, L. C. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00665-0 · Cited by 64
Decreased dopaminergic inhibition of pyramidal neurons in anterior cingulate cortex maintains chronic neuropathic pain
Lançon, K., Qu, C., Navratilova, E., Porreca, F., & Séguéla, P. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109933 · Cited by 60
Self-citation
Closed-loop stimulation using a multiregion brain-machine interface has analgesic effects in rodents
Sun, G., Zeng, F., McCartin, M., Zhang, Q., Xu, H., Liu, Y., Chen, Z. S., & Wang, J. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abm5868 · Cited by 63
Re-examining the Mysterious Role of the Cerebellum in Pain
Li, C. N., Keay, K. A., Henderson, L. A., & Mychasiuk, R. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1538-23.2024 · Cited by 65
From Pleasure to Pain, and Back Again: The Intricate Relationship Between Alcohol and Nociception
Robins, M. T., Heinricher, M. M., & Ryabinin, A. E. (2019) · Alcohol and Alcoholism · doi:10.1093/alcalc/agz067 · Cited by 63
A trigger for opioid misuse: chronic pain and stress dysregulate the mesolimbic pathway and kappa opioid system
Massaly, N., Morón, J. A., & Al-Hasani, R. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00480 · Cited by 59
A new aspect of chronic pain as a lifestyle-related disease
Senba, E., & Kami, K. (2017) · Neurobiology of Pain · doi:10.1016/j.ynpai.2017.04.003 · Cited by 57
Top-Down Cortical Control of Acute and Chronic Pain
Urien, L., & Wang, J. (2019) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000744 · Cited by 56
Parallels and Overlap: The Integration of Homeostatic Signals by Mesolimbic Dopamine Neurons
Hsu, T. M., McCutcheon, J. E., & Roitman, M. F. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00410 · Cited by 59
Emotional and Motivational Pain Processing: Current State of Knowledge and Perspectives in Translational Research
Becker, S., Navratilova, E., Nees, F., & Damme, S. V. (2018) · Pain Research and Management · doi:10.1155/2018/5457870 · Cited by 59
Self-citation
Inhibition of TRPV1 by SHP-1 in nociceptive primary sensory neurons is critical in PD-L1 analgesia
Liu, B., Cao, Q.-L., Zhao, X., Liu, H.-Z., & Zhang, Y. (2020) · JCI Insight · doi:10.1172/jci.insight.137386 · Cited by 55
Cannabidiol Is a Potential Therapeutic for the Affective-Motivational Dimension of Incision Pain in Rats
Genaro, K., Fabris, D., Arantes, A. L. F., Zuardi, A. W., Crippa, J. A. S., & Prado, W. A. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00391 · Cited by 55
Aversive Motivation and Cognitive ControlPreprint
Yee, D. M., Leng, X., Shenhav, A., & Braver, T. S. (2021) · PsyArXiv (OSF Preprints) · doi:10.1016/j.neubiorev.2021.12.016 · Cited by 59
Lysergic Acid Diethylamide and Psilocybin for the Management of Patients with Persistent Pain: a Potential Role?
Whelan, A., & Johnson, M. I. (2018) · Pain Management · doi:10.2217/pmt-2017-0068 · Cited by 51
Persistent pain alters AMPA receptor subunit levels in the nucleus accumbens
Su, C. H., D’amour, J. A., Lee, M. S., Lin, H.-Y., Manders, T. R., Xu, D., Eberle, S. E., Goffer, Y., Zou, A., Rahman, M., et al. (2015) · Molecular Brain · doi:10.1186/s13041-015-0140-z · Cited by 52
The dynamic interaction between pain and opioid misuse
Wilson‐Poe, A. R., & Morón, J. A. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13873 · Cited by 49
CRMP2 and voltage-gated ion channels: potential roles in neuropathic pain
Chew, L. A., & Khanna, R. (2018) · Neuronal Signaling · doi:10.1042/ns20170220 · Cited by 50
Pain relief induces dopamine release in the rat nucleus accumbens during the early but not late phase of neuropathic pain
Kato, T., Ide, S., & Minami, M. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.06.060 · Cited by 49
Psychological Processes in Chronic Pain: Influences of Reward and Fear Learning as Key Mechanisms – Behavioral Evidence, Neural Circuits, and Maladaptive Changes
Nees, F., & Becker, S. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.051 · Cited by 49
Understanding the role of dopamine in conditioned and unconditioned fear
Brandão, M. L., & Coimbra, N. C. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0023 · Cited by 49
Temporal pain processing in the primary somatosensory cortex and anterior cingulate cortex
Sun, G., McCartin, M., Liu, W., Zhang, Q., Kenefati, G., Chen, Z. S., & Wang, J. (2023) · Molecular Brain · doi:10.1186/s13041-022-00991-y · Cited by 47
Downregulation of M-channels in lateral habenula mediates hyperalgesia during alcohol withdrawal in rats
Kang, S., Li, J., Zuo, W., Chen, P., Gregor, D., Fu, R., Han, X., Bekker, A., & Ye, J.-H. (2019) · Scientific Reports · doi:10.1038/s41598-018-38393-7 · Cited by 47
Ghrelin attenuated hyperalgesia induced by chronic nitroglycerin: CGRP and TRPV1 as targets for migraine management
Farajdokht, F., Mohaddes, G., Shanehbandi, D., Karimi, P., & Babri, S. (2017) · Cephalalgia · doi:10.1177/0333102417748563 · Cited by 47
Generality and opponency of rostromedial tegmental (RMTg) roles in valence processing
Li, H., Pullmann, D., Cho, J. Y., Eid, M., & Jhou, T. C. (2019) · eLife · doi:10.7554/elife.41542 · Cited by 50
Selective modulation of tonic aversive qualities of neuropathic pain by morphine in the central nucleus of the amygdala requires endogenous opioid signaling in the anterior cingulate cortex
Navratilova, E., Nation, K., Remeniuk, B., Neugebauer, V., Bannister, K., Dickenson, A. H., & Porreca, F. (2019) · Pain · doi:10.1097/j.pain.0000000000001748 · Cited by 47
Self-citation
Corticostriatal circuits in the transition to chronic back pain: The predictive role of reward learning
Löffler, M., Levine, S. M., Usai, K., Desch, S., Mišić, M., Nees, F., & Flor, H. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100677 · Cited by 45

Authors: Navratilova, E., Xie, J. Y., Okun, A., Qu, C., Eyde, N., Ci, S., Ossipov, M. H., King, T., Fields, H. L., & Porreca, F.
Affiliations: University of Arizona (US)
University of New England (US)
University of California, San Francisco (US)
ORCID: Navratilova, Edita
Xie, Jennifer Y.
Ossipov, Michael H.
King, Tamara
Fields, Howard L.
Porreca, Frank
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2012-11-26
Volume: 109
Issue: 50
Pages: 20709-20713
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1214605109
PMC: PMC3528534
OpenAlex: W2052380247
Cited by: 313
References: 48
Citations by year: 2026: 17 · 2025: 17 · 2024: 19 · 2023: 23 · 2022: 22 · 2021: 28 · 2020: 28 · 2019: 23 · 2018: 29 · 2017: 32 · 2016: 17 · 2015: 21 · 2014: 19 · 2013: 17
FWCI: 7.51
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute on Drug Abuse (R01DA034975)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Keywords: analgesia, negative reinforcement, mesolimbic reward circuitry, postoperative pain, conditioned place preference, ventral tegmental area, dopaminergic neurons, nucleus accumbens, dopamine release, local anesthetics, dopamine antagonists
MeSH terms: Afferent Pathways, Anesthetics, Local, Animals, Disease Models, Animal, Limbic System, Male, Models, Neurological, Nerve Block, Nucleus Accumbens, Pain, Pain, Postoperative, Postoperative Pain, Reinforcement, Psychology, Reward, Rats, Sprague-Dawley, Ventral Tegmental Area, Dopamine Antagonists, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks