Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry

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Dopamine and drug addiction: the nucleus accumbens shell connection

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Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking

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Metabotropic Glutamate Receptors 7 within the Nucleus Accumbens are Involved in Relief Learning in Rats

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Positive allosteric modulators of nonbenzodiazepine γ-aminobutyric acidA receptor subtypes for the treatment of chronic pain

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Behavior and Medical Problems in Pet Animals

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Deficits in neuronal cytochrome P450 activity attenuate opioid analgesia but not opioid side effects

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Nortriptyline Enhances Morphine-Conditioned Place Preference in Neuropathic Rats: Role of the Central Noradrenergic System

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Aberrant functional and effective connectivity of the frontostriatal network in unilateral acute tinnitus patients with hearing loss

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Conditioned Place Preference as a Preclinical Model for Screening Pharmacotherapies for Drug Abuse

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The bivalent ligand, MMG22, reduces neuropathic pain after nerve injury without the side effects of traditional opioids

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Persistent neuropathic pain increases synaptic GluA1 subunit levels in core and shell subregions of the nucleus accumbens

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Pain And Opioid Systems, Implications In The Opioid Epidemic

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The interaction effects between opioidergic and D1-like dopamine receptors in the nucleus accumbens on pain-related behaviors in the animal model of acute pain

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VTA dopaminergic neurons involved in chronic spared nerve injury pain-induced depressive-like behavior

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Influence of Inflammatory Pain and Dopamine on Synaptic Transmission in the Mouse ACC

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Neuroanatomy of the nociceptive system: From nociceptors to brain networks

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Pain, negative affective states and opioid-based analgesics: Safer pain therapies to dampen addiction

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AMPAkines potentiate the corticostriatal pathway to reduce acute and chronic pain

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The role of the anterior pretectal nucleus in pain modulation: A comprehensive review

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Anterior Insular-nucleus Accumbens Pathway Controls Refeeding-induced Analgesia under Chronic Inflammatory Pain Condition

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Interactive Mechanisms of Supraspinal Sites of Opioid Analgesic Action: A Festschrift to Dr. Gavril W. Pasternak

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Internet-based cognitive behavioural therapy for insomnia comorbid with chronic benign pain – A randomized controlled trial

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Interaction of opioid and D2-like dopamine receptors in the nucleus accumbens modulate acute pain-related behaviors

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Serotonin release mediates analgesia via opioidergic system and withdrawal symptoms in chronic kratom extract-treated mice

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Relationship between behavioral and mood responses to monetary rewards in a sample of Indian students with and without reported pain

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Acupuncture for the relief of chronic pain: Regulating negative emotions and reward/motivation circuits based on the theory of “spirit-regulation with acupuncture”☆ 针灸改善慢性疼痛的新视角:“针灸治神”调控负性情绪及奖赏/动机环路

Xia-li, W. E. I., Jun, T. I. A. N., Shao-hui, J. I. A., & Shu, Q. (2022) · 世界针灸杂志：英文版 · doi:10.1016/j.wjam.2022.10.001 · Cited by 6

Interhemispheric neural characteristics of noxious mechano-nociceptive stimulation in the anterior cingulate cortex

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Pain Resilience and Coping Behaviors in Individuals in a Collectivist Social Context

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The medial shell of nucleus accumbens regulates chronic pain and comorbid depression via separate downstream targets in male mice

Xia, X.-X., Wang, Y., Wang, X.-Y., Liu, X., Hu, W., Liu, X., & Zhang, Y. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116716 · Cited by 6

Differential Roles of the D1- and D2-Like Dopamine Receptors Within the Ventral Tegmental Area in Modulating the Antinociception Induced by Forced Swim Stress in the Rat

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Perception of repeated pain relief with controllable and uncontrollable pain

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Ventral tegmental area dopaminergic circuits participates in stress-induced chronic postsurgical pain in male mice

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Dynamics of Lateral Habenula–Ventral Tegmental Area Microcircuit on Pain-Related Cognitive Dysfunctions

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The Self-administration of Analgesic Drugs in Experimentally Induced Chronic Pain

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Pain catastrophizing is associated with reduced neural response to monetary reward

Cooke, M. E., Edwards, R. R., Wheeler, G. L., Schmitt, W. A., Nielsen, L., Streck, J. M., Schuster, R. M., Potter, K. W., Evins, A. E., & Gilman, J. M. (2023) · Frontiers in Pain Research · doi:10.3389/fpain.2023.1129353 · Cited by 4

Serotonin circuits act cooperatively with pathophysiology of opioid use disorder

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Sex and Strain Differences in Analgesic and Hyperlocomotor Effects of Morphine and μ‐Opioid Receptor Expression in Mice

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Functional connectivity between the nucleus accumbens and amygdala underlies avoidance learning during adolescence: Implications for developmental psychopathology

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The Influence of Pain on Reward Processing: Current Literature and Prospects

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Pain and depression

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Microinjection of morphine into the nucleus accumbens and CA1 modulates pain-related behaviors in an animal model of inflammatory pain in male rats

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Longitudinal analysis of pain-induced brain activations in post-traumatic headache

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Dopamine and Its Actions in the Basal Ganglia System

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Intra-accumbal blockade of endocannabinoid CB1 receptors impairs learning but not retention of conditioned relief

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Approach Behavior Induced by 10.6-μm Laser Stimulation at Acupoint ST36 in a Rat Model of Incisional Pain

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Function of Excitatory Periaqueductal Gray Synapses in the Ventral Tegmental Area following Inflammatory Injury

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Morphological changes of the limbic system associated with acute and chronic low‐back pain: A UK biobank imaging study

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Managing Pain in Patients With Comorbid Alcohol Use Disorder and Chronic Pain

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Withdrawal-associated injury site pain prevalence and correlates among opioid-using people who inject drugs in Vancouver, Canada

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Foot shock facilitates reward seeking in an experience-dependent manner

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Chronic post-ICU pain: A review of the mechanism and the rehabilitation management

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The Role of Dopamine in Chronic Pain: Neuroinflammation and Neurogenesis

Vetlugina, А., Фокеева, Н. О., Kochneva, A., Kalueff, A. V., Евгеньевич, М. П., & Gerasimova, E. (2025) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093025020097 · Cited by 2

Neurobiological convergence of pain and substance use disorders: A focus on opioidergic and mesolimbic circuitry

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Withdrawal-Induced Delirium in Opioid Dependence: A Systematic Review

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Behavioral assessment of pain in rodents: advances from evoked responses to spontaneous states and multimodal approaches

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Methylphenidate as a Novel Adjunct in Opioid-Taking Patients: Insights into Dopaminergic Neuroadaptation and Hypoactive Delirium

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Network analysis of depressive symptoms in Chinese outpatients with somatic symptom disorder

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Ghrelin mechanisms of food reward. Part 2. Interaction of ghrelin with hormones, neuropeptides and other endogenous ligands

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Animal Models for Studying Substance Use Disorder: Place and Taste Conditioning

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Contextual determinants of reinforcement: A motivational analysis.

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It all began in Issaquah 50 years ago

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Behavioral Tests for Assessing Pain and Nociception: Relationship with the Brain Reward System

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Cerebral hemodynamics as biomarkers for neuropathic pain in rats: a longitudinal study using a spinal nerve ligation model

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Aged mice exhibit faster acquisition of intravenous opioid self-administration with variable effects on intake

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TMEM251 loss-induced autophagy dysfunction in the anterior cingulate cortex contributes to chronic postoperative pain

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Cognitive, Emotional, and Social Factors in the Modulation of Pain Perception

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Endocannabinoid-Dopamine Interactions Shape Ethologically Relevant Behavior through Computation of Conditioned Stimuli

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Introduction to chronic pain

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Exercise and Diet in the Control of Inflammation and Pain

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Pain and Value-Based Decision-Making: An Introduction and Implications for Neuroeconomics

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Neural similarities and differences between pain and itch: Reception, transmission and modulation

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Dynamic modulation of synaptic transmission in the mouse ACC by inflammatory pain and dopaminePreprint

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TARGETING METHYLGLYOXAL AND PPAR GAMMA TO ALLEVIATE NEUROPATHIC PAIN ASSOCIATED WITH TYPE 2 DIABETES

Griggs, R. B. (2015) · UKnowledge (University of Kentucky)

Probing Neural Communication by Expanding In Vivo Electrochemical and Electrophysiological Measurements

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Neural and Computational Mechanisms of Reward and Aversion

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Behavioral Insights into Nociceptor Function: A Systematic Approach to Understanding Postsurgical and Neuropathic Pain Mechanisms in Rats

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ELECTROPHYSIOLOGICAL ANALYSIS ASSESSING THE ANALGESIC NATURE OF THE LATERAL HABENULA (LHb)

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Association of Lowering Default Pill Counts in Electronic Medical Record Systems With Postoperative Opioid Prescribing After Cardiac Surgery

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A diencephalic circuit for opioid analgesia but not positive reinforcementPreprint

Waung, M. W., Maanum, K. A., Cirino, T. J., Driscoll, J. R., OʼBrien, C., Bryant, S., Mansourian, K. A., Morales, M., Barker, D. J., & Margolis, E. B. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.15.422931

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Faculty Opinions recommendation of Activation of cortical somatostatin interneurons prevents the development of neuropathic pain.

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The Relationship between Behavioral and Mood Responses to Monetary Rewards in a Sample of Indian Students with and without Reported PainPreprint

Tandon, T., Piccolo, M., Ledermann, K., Gupta, R., Morina, N., & Martin-Söelch, C. (2022) · Research Square · doi:10.21203/rs.3.rs-1972688/v1

Canabidiol em modelo pré-clínico de dor neuropática: uma avaliação dos aspectos sensoriais, emocionais e inflamatórios relacionados com a modulação da sensibilidade dolorosa

Cardoso, G. K. R. D. S. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.59.2022.tde-01092022-134636

How instructions, learning, and expectations shape pain and clinical outcomesPreprint

Atlas, L. Y. (2022) · doi:10.31234/osf.io/qhkat

Glutamatergic neurons in the infralimbic cortex for motivational response of pain relief induced by electroacupuncturePreprint

Liu, H., Chen, M., Lü, J., Qin, C., Wang, C., & Liu, S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.02.530902

The Role of VTA Dopaminergic Neurons in Chronic Peripheral Neuropathic Pain- induced Depressive-like BehaviorPreprint

Zhang, L., Sun, Y., Ji, M., Wang, S., Sun, H., Zhang, H., & Huang, D. (2023) · Research Square · doi:10.21203/rs.3.rs-3288809/v1

Investigating the interaction between opioidergic and D1-like dopamine receptors in the nucleus accumbens on pain-related behaviors in the animal model of acute painPreprint

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Effect of Raha syrup on the motivational effects of morphine and CSF serotonin levels in rats

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Additional file 1 of Ventral tegmental area dopaminergic circuits participates in stress-induced chronic postsurgical pain in male mice

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