Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240 · see citing works

α-Synuclein Locus Triplication Causes Parkinson's Disease

Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., et al. (2003) · Science · doi:10.1126/science.1090278 · Cited by 4,383 · see citing works

AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998) · Nature Genetics · doi:10.1038/ng0298-106 · Cited by 3,836 · see citing works

The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia

Zarranz, J. J., Alegre, J., Gómez‐Esteban, J. C., Lezcano, E., Ros, R., Ampuero, I., Vidal, L., Hoenicka, J., Rodriguez, O., Atarés, B., et al. (2004) · Annals of Neurology · doi:10.1002/ana.10795 · Cited by 2,737 · see citing works

α-synuclein locus duplication as a cause of familial Parkinson's disease

Chartier-Harlin, M.-C., Kachergus, J., Roumier, C., Mouroux, V., Douay, X., Lincoln, S., Levecque, C., Larvor, L., Andrieux, J., Hulihan, M., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17103-1 · Cited by 2,029 · see citing works

Genome-wide association study reveals genetic risk underlying Parkinson's disease

Simón‐Sánchez, J., Schulte, C., Brás, J., Sharma, M., Gibbs, J. R., Berg, D., Paisán‐Ruiz, C., Lichtner, P., Scholz, S. W., Hernandez, D. G., et al. (2009) · Nature Genetics · doi:10.1038/ng.487 · Cited by 1,916 · see citing works

Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-Lundberg, D., Ho, W.-H., Castillo, P. E., Shinsky, N., Verdugo, J. M. G., Armanini, M., Ryan, A., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)80886-7 · Cited by 1,722 · see citing works

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

Satake, W., Nakabayashi, Y., Mizuta, I., Hirota, Y., Ito, C., Kubo, M., Kawaguchi, T., Tsunoda, T., Watanabe, M., Takeda, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.485 · Cited by 1,308 · see citing works

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

Nemani, V. M., Lü, W., Berge‐Seidl, V., Nakamura, K., Onoa, B., Lee, M. K., Chaudhry, F. A., Nicoll, R. A., & Edwards, R. H. (2010) · Neuron · doi:10.1016/j.neuron.2009.12.023 · Cited by 1,051 · see citing works

Striatal Dopamine Release Is Triggered by Synchronized Activity in Cholinergic Interneurons

Threlfell, S., Lalic, T., Platt, N. J., Jennings, K. A., Deisseroth, K., & Cragg, S. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.04.038 · Cited by 845 · see citing works

GABAA receptor-mediated inhibition of rat substantia nigra dopaminergic neurons by pars reticulata projection neurons

Tepper, J. M., Martin, L., & Anderson, D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-04-03092.1995 · Cited by 362 · see citing works

α-Synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication

Miller, D. W., Hague, S., Clarimón, J., Baptista, M., Gwinn, K. A., Cookson, M., & Singleton, A. (2004) · Neurology · doi:10.1212/01.wnl.0000127517.33208.f4 · Cited by 356 · see citing works

Misfolded proteinase K–resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies

Neumann, M., Kahle, P. J., Giasson, B. I., Ozmen, L., Borroni, E., Spooren, W. P. J. M., Müller, V., Odoy, S., Fujiwara, H., Hasegawa, M., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15777 · Cited by 351 · see citing works

Anatomy of the dopamine system in the basal ganglia

Smith, Y., & Kieval, J. Z. (2000) · Trends in Neurosciences · doi:10.1016/s1471-1931(00)00023-9 · Cited by 320 · see citing works

α-Synuclein and dopamine at the crossroads of Parkinson's disease

Venda, L. L., Cragg, S. J., Buchman, V. L., & Wade‐Martins, R. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.09.004 · Cited by 288 · see citing works

Nonmotor Symptoms of Parkinson's Disease Revealed in an Animal Model with Reduced Monoamine Storage Capacity

Taylor, T. N., Caudle, W. M., Shepherd, K. R., Noorian, A. R., Jackson, C. R., Iuvone, P. M., Weinshenker, D., Greene, J. G., & Miller, G. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1495-09.2009 · Cited by 278 · see citing works

Striatal Muscarinic Receptors Promote Activity Dependence of Dopamine Transmission via Distinct Receptor Subtypes on Cholinergic Interneurons in Ventral versus Dorsal Striatum

Threlfell, S., Clements, M. A., Khodai, T., Pienaar, I. S., Exley, R. A., Wess, J., & Cragg, S. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5620-09.2010 · Cited by 224 · see citing works

Functional Alterations to the Nigrostriatal System in Mice Lacking All Three Members of the Synuclein Family

Anwar, S., Peters, O. M., Millership, S. J., Ninkina, N. N., Doig, N. M., Connor‐Robson, N., Threlfell, S., Kooner, G., Deacon, R. M. J., Bannerman, D. M., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6194-10.2011 · Cited by 200 · see citing works

Modelling of Parkinson's disease in mice

Chesselet, M., & Richter, F. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70227-7 · Cited by 192 · see citing works

A Dopaminergic Axon Lattice in the Striatum and Its Relationship with Cortical and Thalamic Terminals

Moss, J., & Bolam, J. P. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2780-08.2008 · Cited by 190 · see citing works

Elevated α-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease

Gründemann, J., Schlaudraff, F., Haeckel, O., & Liss, B. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn084 · Cited by 174 · see citing works

Increased striatal dopamine release and hyperdopaminergic‐like behaviour in mice lacking both alpha‐synuclein and gamma‐synuclein

Senior, S. L., Ninkina, N. N., Deacon, R. M. J., Bannerman, D. M., Buchman, V. L., Cragg, S. J., & Wade‐Martins, R. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06055.x · Cited by 164 · see citing works

Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of γ‐synuclein, α‐synuclein and double α/γ‐synuclein null mutant mice

Robertson, D. C., Schmidt, O., Ninkina, N. N., Jones, P. A., Sharkey, J., & Buchman, V. L. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02378.x · Cited by 154 · see citing works

Comparative Analysis of an Improved Thioflavin-S Stain, Gallyas Silver Stain, and Immunohistochemistry for Neurofibrillary Tangle Demonstration on the Same Sections

Sun, A.-Y., Nguyen, X. V., & Bing, G. (2002) · Journal of Histochemistry and Cytochemistry · doi:10.1177/002215540205000403 · Cited by 146 · see citing works

Absence of α-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice

Al-Wandi, A., Ninkina, N. N., Millership, S. J., Williamson, S. J. M., Jones, P. A., & Buchman, V. L. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.11.001 · Cited by 129 · see citing works

Histamine H3Receptors Inhibit Serotonin Release in Substantia Nigra Pars Reticulata

Threlfell, S., Cragg, S. J., Kalló, I., Turi, G. F., Coen, C. W., & Greenfield, S. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2690-04.2004 · Cited by 118 · see citing works

Activity of Neurochemically Heterogeneous Dopaminergic Neurons in the Substantia Nigra during Spontaneous and Driven Changes in Brain State

Brown, M. T. C., Henny, P., Bolam, J. P., & Magill, P. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4423-08.2009 · Cited by 106 · see citing works

Non‐linear relationship between 5‐HT transporter gene expression and frequency sensitivity of 5‐HT signals

Jennings, K. A., Lesch, K., Sharp, T., & Cragg, S. J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07001.x · Cited by 41 · see citing works

Different basal levels of CaMKII phosphorylated at Thr286/287 at nociceptive and low‐threshold primary afferent synapses

Larsson, M., & Broman, J. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04081.x · Cited by 34 · see citing works

MK-801 interaction with the 5-HT transporter: a real-time study in brain slices using fast cyclic voltammetry

Iravani, M. M., Muscat, R., & Kruk, Z. L. (1999) · Synapse · doi:10.1002/(sici)1098-2396(19990601)32:3 · Cited by 27 · see citing works

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

Peelaerts, W., Bousset, L., Van der Perren, A., Moskalyuk, A., Pulizzi, R., Giugliano, M., Van den Haute, C., Melki, R., & Baekelandt, V. (2015) · Nature · doi:10.1038/nature14547 · Cited by 1,130 · see citing works

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

Wong, Y. C., & Krainc, D. (2017) · Nature Medicine · doi:10.1038/nm.4269 · Cited by 897 · see citing works

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

Ryan, B. J., Hoek, S., Fon, E. A., & Wade-Martins, R. (2015) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.02.003 · Cited by 524 · see citing works

Striatal dopamine neurotransmission: Regulation of release and uptake

Sulzer, D., Cragg, S. J., & Rice, M. E. (2016) · Basal Ganglia · doi:10.1016/j.baga.2016.02.001 · Cited by 382 · see citing works

Synaptopathies: synaptic dysfunction in neurological disorders – A review from students to students

Lepeta, K., Lourenco, M. V., Schweitzer, B. C., Martino Adami, P. V., Banerjee, P., Catuara‐Solarz, S., de La Fuente Revenga, M., Guillem, A. M., Haidar, M., Ijomone, O. M., et al. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13713 · Cited by 386 · see citing works

Impaired dopamine release in Parkinson’s disease

Cramb, K. M. L., Beccano-Kelly, D., Cragg, S. J., & Wade-Martins, R. (2023) · Brain · doi:10.1093/brain/awad064 · Cited by 207 · see citing works

Fluid Biomarkers for Synaptic Dysfunction and Loss

Camporesi, E., Nilsson, J., Brinkmalm, A., Becker, B., Ashton, N. J., Blennow, K., & Zetterberg, H. (2020) · Biomarker Insights · doi:10.1177/1177271920950319 · Cited by 165 · see citing works

Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration

Gómez de San José, N., Massa, F., Halbgebauer, S., Oeckl, P., Steinacker, P., & Otto, M. (2022) · Journal of Neural Transmission · doi:10.1007/s00702-021-02411-2 · Cited by 112 · see citing works

Neuroinflammation in Parkinson’s Disease Animal Models: A Cell Stress Response or a Step in Neurodegeneration?

Cebrián, C., Loike, J. D., & Sulzer, D. (2014) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2014_356 · Cited by 65 · see citing works

Impairment of macroautophagy in dopamine neurons has opposing effects on parkinsonian pathology and behavior

Hunn, B. H. M., Vingill, S., Threlfell, S., Alegre-Abarrategui, J., Magdelyns, M., Deltheil, T., Bengoa-Vergniory, N., Oliver, P. L., Cioroch, M., Doig, N. M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.029 · Cited by 38 · see citing works

Morphological parameters of the heterogeneity of the substantia nigra in elderly men and women

Николаевич, С. В., Худоерков, Р. М., Воронков, Д. Н., et al. (2015) · Russian Journal of Archive of Pathology · doi:10.17116/patol201577451-54 · Cited by 3 · see citing works

Co-Expression of Nogo-A in Dopaminergic Neurons of the Human Substantia Nigra Pars Compacta Is Reduced in Parkinson’s Disease

Eyer, G.-C., Santo, S. D., Hewer, E., et al. (2021) · Cells · doi:10.3390/cells10123368 · Cited by 7 · see citing works

Dopaminergic neurons

Chinta, S. J., & Andersen, J. K. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.09.009 · Cited by 341 · see citing works

Tenuigenin Protects Dopaminergic Neurons from Inflammation‐Mediated Damage Induced by the Lipopolysaccharide

Yuan, H., Li, B., Xu, J., et al. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2012.00347.x · Cited by 42 · see citing works

Caspase inhibition protects nigral neurons against 6-OHDA-induced retrograde degeneration

Cutillas, B., Espejo, M., Gil, J., et al. (1999) · Neuroreport · doi:10.1097/00001756-199908200-00030 · Cited by 46 · see citing works