Cited by 1,443Forensic and Genetic ResearchPleistocene-Era Hominins and ArchaeologyGenomics and Phylogenetic Studies

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Complete mitochondrial genome sequence of a Middle Pleistocene cave bear reconstructed from ultrashort DNA fragments

Open access
Dabney, Jesse, Knapp, Michael, Glocke, Isabelle, Gansauge, Marie-Theres, Weihmann, Antje, Nickel, Birgit, Valdiosera, Cristina, García, Nuria, Pääbo, Svante, Arsuaga, Juan-Luis, Meyer, Matthias·2013·Proceedings of the National Academy of Sciences

Abstract

Significance: Outside of permafrost, no contiguous DNA sequences have been generated from material older than ∼120,000 y. By improving our ability to sequence very short DNA fragments, we have recovered the mitochondrial genome sequence of a >300,000-y-old cave bear from Sima de los Huesos, a Spanish cave site that is famous for its rich collection of Middle Pleistocene human fossils. This finding demonstrates that DNA can survive for hundreds of thousands of years outside of permafrost and opens the prospect of making more samples from this time period accessible to genetic studies.

Overview

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Crossref · 10.1073/pnas.1314445110

Cites

48 of 48 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 2

  1. Garcia N (2004) New results on the remains of Ursidae from Untermassfeld: Comparisons with Ursus dolinensis from Atapuerca and other early and middle Pleistocene sites. Late Neogene and Quaternary Biodiversity and Evolution: Regional Developments and Interregional Correlations Conference 18th International Senckenberg Conference Weimar Germany eds Kahlke R-D Maul LC Mazza PP (Terra Nostra Schriften der Alfred-Wegener-Stiftung Berlin) pp 112–113.
  2. Keis M (2013) Brown bear (Ursus arctos) phylogeography in northern Eurasia. Doctoral dissertation (Univ of Tartu Tartu Estonia).

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Metadata

Authors
Dabney, J., Knapp, M., Glocke, I., Gansauge, M.-T., Weihmann, A., Nickel, B., Valdiosera, C., García, N., Pääbo, S., Arsuaga, J.-L., & Meyer, M.
Affiliations
  • Max Planck Institute for Evolutionary Anthropology (DE)
  • Bangor University (GB)
  • Universidad Complutense de Madrid (ES)
  • Centro de Investigación Sobre la Evolución y Comportamiento Humanos, Universidad Complutense de Madrid–Instituto de Salud Carlos III, 28029 Madrid, Spain;
Venue
Proceedings of the National Academy of Sciences
Published
2013-09-09
Volume
110
Issue
39
Pages
15758-15763
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2050254973
Cited by
1,443
References
48
Citations by year
2026: 128 · 2025: 163 · 2024: 113 · 2023: 117 · 2022: 137 · 2021: 153 · 2020: 161 · 2019: 129 · 2018: 95 · 2017: 96 · 2016: 60 · 2015: 50 · 2014: 34 · 2013: 5
FWCI
32.92
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Library Open Repository (Universidad Complutense Madrid) (submittedVersion, other-oa)
  • Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
  • Social Sciences › Anthropology › Pleistocene-Era Hominins and Archaeology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords
cave bear, Ursus deningeri, mitochondrial genome, ancient DNA, single-stranded DNA library preparation, Sima de los Huesos, Middle Pleistocene, phylogenetic relationships
MeSH terms
Animals, Base Sequence, Ursidae, DNA, Molecular Sequence Data, Phylogeny, Time Factors, Genome, Mitochondrial, Caves

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