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Restoration of function after brain damage using a neural prosthesis
Open accessAbstract
Significance: Closed-loop systems, or brain–machine–brain interfaces (BMBIs), have not been widely developed for brain repair. In this study, we targeted spared motor and somatosensory regions of the rat brain after traumatic brain injury for establishment of a functional bridge using a battery-powered microdevice. The results show that by using discriminated action potentials as a trigger for stimulating a distant cortical location, rapid recovery of fine motor skills is facilitated. This study provides strong evidence that BMBIs can be used to bridge damaged neural pathways functionally and promote recovery after brain injury. Although this study is restricted to a rodent model of TBI, it is likely that the approach will also be applicable to other types of acquired brain injuries.
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“This cooperation probably plays an essential role in the reorganization of neuronal pathways that mediate neurological recovery in response to neurorehabilitation with the BSI.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [40]
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Pankovski, T. (2018) · Biologically Inspired Cognitive Architectures · doi:10.1016/j.bica.2018.04.004
Assessing Perturbations to Neural Spiking Response Dynamics Caused By Electrical Microstimulation
Murphy, M. D., Dunham, C., Nudo, R. J., Guggenmos, D. J., & Averna, A. (2018) · IEEE International Symposium on Circuits and Systems proceedings · doi:10.1109/iscas.2018.8351872
Self-citationA Closed-Loop Neural Prosthesis for Restoration of Function after Traumatic Brain Injury
Mohseni, P., Nudo, R. J., & Guggenmos, D. J. (2017)
Self-citationA Multimodular System to Study the Impact of a Focal Lesion in Neuronal Cell Cultures
Averna, A., Carè, M., Buccelli, S., Semprini, M., Difato, F., & Chiappalone, M. (2019) · Lecture notes in computer science · doi:10.1007/978-3-030-28042-0_1
McNeal, D. W., Barbay, S., Frost, S. B., Taylor, M., Guggenmos, D. J., & Nudo, R. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.12.148494
Self-citationJiang, Z., Li, J., Chundi, P. K., Kim, S. J., Yang, M., Kang, J., Jung, S., Kim, S. J., & Seok, M. (2020) · arXiv (Cornell University) · doi:10.48550/arxiv.2009.05210
Metadata
- Authors
- Guggenmos, D. J., Azin, M., Barbay, S., Mahnken, J. D., Dunham, C., Mohseni, P., & Nudo, R. J.
- Affiliations
- University of Kansas Medical Center (US)
- Case Western Reserve University (US)
- Biostatistics, and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-12-09
- Volume
- 110
- Issue
- 52
- Pages
- 21177-21182
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3876197
- OpenAlex
- W2147851954
- Cited by
- 221
- References
- 50
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 8 · 2023: 15 · 2022: 21 · 2021: 19 · 2020: 17 · 2019: 16 · 2018: 27 · 2017: 19 · 2016: 16 · 2015: 21 · 2014: 14
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- other-oa
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Keywords
- neural prosthesis, neural interfaces, brain injury recovery, focal brain lesions, premotor cortex, somatosensory cortex, microelectrodes, reach-to-grasp, functional connectivity, rat model
- MeSH terms
- Action Potentials, Animals, Brain Injuries, Male, Motor Cortex, Motor Skills, Neural Pathways, Linear Models, Rats, Long-Evans, Rats, Neural Prostheses, Brain-Computer Interfaces
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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