Cited by 221Neuroscience and Neural EngineeringEEG and Brain-Computer InterfacesStroke Rehabilitation and Recovery

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Restoration of function after brain damage using a neural prosthesis

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Guggenmos, David J., Azin, Meysam, Barbay, Scott, Mahnken, Jonathan D., Dunham, Caleb, Mohseni, Pedram, Nudo, Randolph J.·2013·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1316885110PMC PMC3876197

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Abstract

Significance: Closed-loop systems, or brain–machine–brain interfaces (BMBIs), have not been widely developed for brain repair. In this study, we targeted spared motor and somatosensory regions of the rat brain after traumatic brain injury for establishment of a functional bridge using a battery-powered microdevice. The results show that by using discriminated action potentials as a trigger for stimulating a distant cortical location, rapid recovery of fine motor skills is facilitated. This study provides strong evidence that BMBIs can be used to bridge damaged neural pathways functionally and promote recovery after brain injury. Although this study is restricted to a rodent model of TBI, it is likely that the approach will also be applicable to other types of acquired brain injuries.

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Authors: Guggenmos, D. J., Azin, M., Barbay, S., Mahnken, J. D., Dunham, C., Mohseni, P., & Nudo, R. J.
Affiliations: University of Kansas Medical Center (US)
Case Western Reserve University (US)
Biostatistics, and
ORCID: Guggenmos, David J.
Barbay, Scott
Mohseni, Pedram
Nudo, Randolph J.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2013-12-09
Volume: 110
Issue: 52
Pages: 21177-21182
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1316885110
PMC: PMC3876197
OpenAlex: W2147851954
Cited by: 221
References: 50
Citations by year: 2026: 14 · 2025: 13 · 2024: 8 · 2023: 15 · 2022: 21 · 2021: 19 · 2020: 17 · 2019: 16 · 2018: 27 · 2017: 19 · 2016: 16 · 2015: 21 · 2014: 14
FWCI: 8.34
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: other-oa
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
Keywords: neural prosthesis, neural interfaces, brain injury recovery, focal brain lesions, premotor cortex, somatosensory cortex, microelectrodes, reach-to-grasp, functional connectivity, rat model
MeSH terms: Action Potentials, Animals, Brain Injuries, Male, Motor Cortex, Motor Skills, Neural Pathways, Linear Models, Rats, Long-Evans, Rats, Neural Prostheses, Brain-Computer Interfaces

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Restoration of function after brain damage using a neural prosthesis

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