The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Restoration of function after brain damage using a neural prosthesis
Open accessAbstract
Significance: Closed-loop systems, or brain–machine–brain interfaces (BMBIs), have not been widely developed for brain repair. In this study, we targeted spared motor and somatosensory regions of the rat brain after traumatic brain injury for establishment of a functional bridge using a battery-powered microdevice. The results show that by using discriminated action potentials as a trigger for stimulating a distant cortical location, rapid recovery of fine motor skills is facilitated. This study provides strong evidence that BMBIs can be used to bridge damaged neural pathways functionally and promote recovery after brain injury. Although this study is restricted to a rodent model of TBI, it is likely that the approach will also be applicable to other types of acquired brain injuries.
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“This cooperation probably plays an essential role in the reorganization of neuronal pathways that mediate neurological recovery in response to neurorehabilitation with the BSI.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [40]
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Items 201–221 of 221
Role of Brain Cortex Plasticity in the Use of Neural Interfaces
Badakva, A. M., Miller, N. V., Zobova, L. N., & Roshchin, V. Y. (2020) · Human Physiology · doi:10.1134/s0362119720070026
Shevchenko, A., Shevchenko, A. A., Tyatyushkina, O., & Ulyanov, S. V. (2020) · System Analysis in Science and Education · doi:10.37005/2071-9612-2020-4-90-134
Optimizing Neuroprosthetic Therapies via Autonomous Learning AgentsPreprint
Bonizzato, M., Côté, S. L., Massai, E., Hottin, R. G., Laferrière, S., Quessy, S., Lajoie, G., Martinez, M., & Dancause, N. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3925256
Electrical Conditioning for Spike-Timing-Dependent Plasticity of Neural Circuits
Moorjani, S. G., McPherson, J. G., & Perlmutter, S. I. (2022) · Springer eBooks · doi:10.1007/978-1-0716-1006-0_100700
Brain-Machine Interfaces: From Restoring Sensorimotor Control to Augmenting Cognition
Moxon, K. A., Kong, Z., & Ditterich, J. (2022) · Handbook of Neuroengineering · doi:10.1007/978-981-15-2848-4_36-1
Brain Co-processors: Ethical and Social Implications
Rao, R. P. N., & Schönau, A. (2023) · Advances in neuroethics · doi:10.1007/978-3-031-26801-4_10 · Cited by 1
Enabling Model-based Design for closed-loop applications in neuroengineeringPreprint
Florio, M. D., Bornat, Y., Carè, M., Cota, V. R., Buccelli, S., & Chiappalone, M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.11.557151
Rhesus monkeys learn to control a directional-key inspired brain machine interface via bio-feedback
Zhang, C., Wang, H., Tang, S., & Li, Z. (2024) · PLoS ONE · doi:10.1371/journal.pone.0286742
SSVEP modulation via non-volitional neurofeedback: an in silico proof of concept
Estiveira, J., Soares, E. S., Pires, G., Nunes, U., Sousa, T., Ribeiro, S. T. G., & Castelo-Branco, M. S. (2024) · Journal of Neural Engineering · doi:10.1088/1741-2552/ad94a5
Absence of cortical reorganization following an internal capsule stroke in rodentsPreprint
Cettina, P. E., Guggenmos, D. J., Sivakumar, S. S., Murphy, M. D., Barbay, H. S., Nudo, R. J., & Bundy, D. T. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.31.685962
Self-citationLearning Temporal Basis Vectors for Closed-Loop Neural Stimulation
Bryan, M. J., Schwock, F., Yazdan-Shahmorad, A., & Rao, R. P. N. (2025) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc58623.2025.11254522
Unveiling Changes in Sleep-Wake Neural Activity and Behavior After a Cortical Lesion In Vivo
Corso, S. D., Barban, F., Cota, V. R., & Chiappalone, M. (2025) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc58623.2025.11252625
A Proof-of-Concept Spike Based Neuromorphic Brain-Computer Interface
Dijkema, E. B., Pennartz, C. M. A., & Olcese, U. (2025) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc58623.2025.11253485
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Shared somatosensory–motor neural population dynamics track motor recovery after strokePreprint
Heimbuch, I. S., Khanna, P., Novik, L., Morecraft, R. J., & Ganguly, K. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.10.705199
Peripheral nerve pathway reconnections promote the reorganization of central motor representations
Feng, J., Li, P., Fang, W., Li, Q., Meng, Y., Ren, H., Chen, W., Guan, C., Qiao, Z., Shen, Y., et al. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3205-6
Albrecht, S., Vandevelde, J. R., Vecchi, E., Berra, G., Bassetti, D., Stüttgen, M. C., Luhmann, H. J., & Horenko, I. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1605209
Negri, F., Guggenmos, D. J., & Barban, F. (2026) · Journal of Neural Engineering · doi:10.1088/1741-2552/ae5f4b
Self-citationEngineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation
Kumar, S. S., Bossard, Y., Sava, R., Gänswein, T., Sadiraj, L., Dupré, J.-S., Schröter, M. S., Camp, J. G., Cardes, F., Bartram, J., et al. (2026) · Advanced Science · doi:10.1002/advs.75473
Jia, F., Jia, C., Wan, C., Chen, D., Gao, S., Gong, J., & Guo, Y. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115990
Early premotor–somatosensory remodeling after primary motor cortex injury
Nudo, R. J., Barbay, S., Frost, S. B., Taylor, M., Hudson, H. M., & Guggenmos, D. J. (2026) · Cerebral Cortex · doi:10.1093/cercor/bhag145
Self-citation
Metadata
- Authors
- Guggenmos, D. J., Azin, M., Barbay, S., Mahnken, J. D., Dunham, C., Mohseni, P., & Nudo, R. J.
- Affiliations
- University of Kansas Medical Center (US)
- Case Western Reserve University (US)
- Biostatistics, and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-12-09
- Volume
- 110
- Issue
- 52
- Pages
- 21177-21182
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3876197
- OpenAlex
- W2147851954
- Cited by
- 221
- References
- 50
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 8 · 2023: 15 · 2022: 21 · 2021: 19 · 2020: 17 · 2019: 16 · 2018: 27 · 2017: 19 · 2016: 16 · 2015: 21 · 2014: 14
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- other-oa
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Keywords
- neural prosthesis, neural interfaces, brain injury recovery, focal brain lesions, premotor cortex, somatosensory cortex, microelectrodes, reach-to-grasp, functional connectivity, rat model
- MeSH terms
- Action Potentials, Animals, Brain Injuries, Male, Motor Cortex, Motor Skills, Neural Pathways, Linear Models, Rats, Long-Evans, Rats, Neural Prostheses, Brain-Computer Interfaces
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