Cited by 101Memory Processes and InfluencesMemory and Neural MechanismsCognitive Functions and Memory

The DOI matches its Crossref record; 98 of the 99 references it cites were found in a registry or an index; none of the 79 sources its claims cite is checked for support yet.

Neural mechanisms of reactivation-induced updating that enhance and distort memory

Open access
St. Jacques, Peggy L., Olm, Christopher, Schacter, Daniel L.·2013·Proceedings of the National Academy of Sciences

Abstract

Significance: Reactivation is a key process that updates memory by strengthening existing memories and incorporating relevant new information, thus supporting the dynamic and flexible nature of memory. This adaptive function, however, can sometimes contribute to memory distortions. The current study examines how neural mechanisms that operate during reactivation of memories for a museum tour contribute to enhancement of existing memories, while also supporting integration of novel information that can contribute to false memories. Our results reveal similarities and differences in the neural mechanisms of reactivation associated with subsequent true and false memories for real-world events, thereby illuminating how memories change over time as a consequence of reactivation—a process that has important implications for understanding the unreliability of eyewitness memories.

Overview

AI snapshot

Written from the paper’s full text.

TL;DR

Memory reactivation during fMRI both strengthened later true memories for a museum tour and increased later false memories for novel lure photographs from an alternate tour. The quality of reactivation, indexed by subjective reliving, modulated subsequent true and false memories via partly shared and partly distinct neural recruitment.

Key findings

  • Reactivation increased subsequent hits [t(32) = 6.05, P < 0.0001] and subsequent false alarms [t(32) = 6.67, P < 0.0001] compared with baseline items not shown during scanning.
  • Higher reliving ratings predicted subsequent hits versus misses [t(32) = 13.68, P < 0.0001] and subsequent false alarms versus correct rejections [t(32) = 3.96, P = 0.0003]; trial-by-trial correlations were r = 0.34, P < 0.0001 for true memories and r = 0.09, P = 0.0004 for false memories.
  • Subsequent true and false memory effects both recruited left posterior parahippocampal, bilateral retrosplenial, and bilateral posterior inferior parietal cortices. For true memories, these regions showed greater recruitment during target than lure phases; for false memories, recruitment was equal across target and lure phases.
  • Subsequent hits were associated with greater rostral medial PFC and posterior cingulate recruitment during target versus lure phases for highly relived memories, whereas subsequent false alarms were associated with greater vmPFC, ventrolateral PFC, lateral temporal cortex, and right anterior hippocampus recruitment during target versus lure phases.

Methods

  • Thirty-five participants (18–30 y old, 19 women) completed three sessions separated by 48 h: a self-guided museum tour with a camera taking photographs every 15 s, an fMRI scanning session, and a recognition-memory test. Two participants were excluded for computer issues, and seven additional participants were excluded from fMRI analysis only for quality-control issues.
  • During scanning, participants viewed target photographs from their own tour to reactivate memories, rated reliving, and on full trials then viewed a novel lure photograph from an alternate tour and rated relatedness. Later, they made old/new recognition judgments for reactivated targets and lures and baseline targets and lures.
  • fMRI data were acquired on a 3T scanner and analyzed in SPM8 using a general linear model, a compound-trial approach to separate target and lure phases, subsequent memory contrasts (hits minus misses; false alarms minus correct rejections), and parametric modulation by reliving ratings. Reported analyses used a threshold of P < 0.001, uncorrected, with a cluster size of 10 voxels.

Limitations

  • The paper states that reactivation quality was defined according to subjective recollection, so the findings could also reflect the contribution of memory strength during reactivation.
  • The paper states that it remains an open question whether all varieties of memory distortion can be conceived as costs associated with adaptive features of memory.
  • Evident from the text: fMRI results are reported at an uncorrected threshold of P < 0.001 with a 10-voxel cluster cutoff, and the final fMRI sample was reduced by exclusions, which may limit statistical robustness.

Model-written summary. Check it against the paper before relying on it.

Integrity signals

Registry

Crossref · 10.1073/pnas.1319630110

Cites

98 of 98 references verified0 citation errors · 0 not checkable

Statistics

4 tests recomputed · 0 with the reported and recomputed p on opposite sides of .05

Verification

Claims the paper makes

0 of 79 cited sources checked · 0 supported · 0 flagged

Show all 49 claims

  • It may state two separate claims as one. 22
  • Probably not a substantial claim. 20
38 of 38
  • The authors state this as an assumption.

    Subjective reliving ratings provide a valid index of the quality of memory reactivation.

    “Here we defined reactivation quality according to subjective recollection, and thus, our findings could also reflect the contribution of memory strength during reactivation (68).”
    “using the reliving rating, our putative marker of the quality of reactivation”
1 of 1

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Statistics that don’t add up

Each reported p-value recomputed from its test statistic and degrees of freedom.

  • Inconsistent p-value: t(32) = 3.96, p = .0003

    Minor

    The paper reports p = .0003 here; recomputing from the test statistic and its degrees of freedom gives p < .001 (two-tailed). The check cannot tell whether the statistic or the p-value is the misprint.

    Reported p = .0003 · recomputed p < .001

1 of 1

Statistics recomputed

Every reported test result, recomputed from its test statistic and degrees of freedom. A result shows as not adding up only once an independent check has confirmed it.

  • Doesn’t add upt(32) = 3.96reported p = .0003 · recomputed p < .001

    “t(32) = 3.96, p = .0003”

  • Consistentt(32) = 6.05reported p < .0001 · recomputed p < .001

    “t(32) = 6.05, p < .0001”

  • Consistentt(32) = 6.67reported p < .0001 · recomputed p < .001

    “t(32) = 6.67, p < .0001”

  • Consistentt(32) = 13.68reported p < .0001 · recomputed p < .001

    “t(32) = 13.68, p < .0001”

4 of 4

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

Self-check results appear here once an independent check has confirmed them.

Citations

Cites

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Show all 99 references

1 of the 99 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

  1. FC Bartlett Remembering (Cambridge Univ Press, Cambridge, 1932).
  2. E Loftus Eyewitness Testimony (Harvard Univ Press, Cambridge, 1979).

Cited by

Sorted by citations

Items 101–101 of 101

Metadata

Authors
St. Jacques, P. L., Olm, C., & Schacter, D. L.
Affiliations
  • Department of Psychology and
  • Harvard University (US)
Venue
Proceedings of the National Academy of Sciences
Published
2013-11-04
Volume
110
Issue
49
Pages
19671-19678
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2045390639
Cited by
99
References
99
Citations by year
2026: 5 · 2025: 8 · 2024: 9 · 2023: 10 · 2022: 3 · 2021: 11 · 2020: 6 · 2019: 8 · 2018: 9 · 2017: 13 · 2016: 8 · 2015: 5 · 2014: 4
FWCI
3.11
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Sussex Research Online (University of Sussex) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
Funders
  • National Institute on Aging (AG038079, F32AG038079)
  • National Institute of Mental Health (MH 060941, R01MH060941)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
memory reactivation, false memory, memory distortion, retrosplenial cortex, subsequent memory, event memory
MeSH terms
Adult, Analysis of Variance, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Memory Disorders, Photic Stimulation, Mental Recall, Time Factors, Recognition, Psychology

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