The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
p53 at the endoplasmic reticulum regulates apoptosis in a Ca 2+ -dependent manner
Open accessAbstract
Significance: Accumulating evidence has underscored the role of cytosolic p53 in promoting cell death. Different reports have revealed that p53 participates in apoptosis induction by acting directly at mitochondria. However, because p53 can mediate apoptosis without its DNA-binding domain (the domain proposed to be fundamental for the targeting of p53 to mitochondria), the mitochondrial localization of p53 is likely not the only transcription-independent mechanism by which p53 promotes apoptosis. Here we demonstrate that p53 at the endoplasmic reticulum (ER) and at mitochondria-associated membranes, interacting with sarco/ER Ca 2+ -ATPase pumps, modulates ER–mitochondria cross-talk and, in turn, Ca 2+ -dependent apoptosis.
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Cites
Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607
Clapham, D. E. (2007) · Cell · doi:10.1016/j.cell.2007.11.028 · Cited by 4,175
Haupt, S., Berger, M., Goldberg, Z., & Haupt, Y. (2003) · Journal of Cell Science · doi:10.1242/jcs.00739 · Cited by 1,136
Cytoplasmic functions of the tumour suppressor p53
Green, D. R., & Kroemer, G. (2009) · Nature · doi:10.1038/nature07986 · Cited by 1,106
Endoplasmic reticulum-mitochondria contacts: Function of the junction
Rowland, A. A., & Voeltz, G. K. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3440 · Cited by 1,018 · cited 1×
“ER–mitochondrial cross-talk is fundamental for the upregulation of mitochondrial metabolism in stimulated cells (11) and plays a key role in decoding Ca-mediated apoptotic signals (12– 16).”
BackgroundMonoubiquitylation promotes mitochondrial p53 translocation
Marchenko, N. D., Wolff, S., Erster, S., Becker, K., & Moll, U. M. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601560 · Cited by 286
Intracellular localization of the BCL-2 family member BOK and functional implications
Echeverry, N., Bachmann, D., Ke, F., Strasser, A., Simon, H. U., & Kaufmann, T. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2013.10 · Cited by 137
Cited by
Marchi, S., Giorgi, C., Galluzzi, L., & Pinton, P. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.04.017 · Cited by 235
Self-citationMissiroli, S., Bonora, M., Patergnani, S., Poletti, F., Perrone, M., Gafà, R., Magri, E., Raimondi, A., Lanza, G., Tacchetti, C., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.082 · Cited by 154
Self-citationPhysiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology
Bonora, M., Patergnani, S., Ramaccini, D., Morciano, G., Pedriali, G., Kahsay, A., Bouhamida, E., Giorgi, C., Wieckowski, M., & Pinton, P. (2020) · Biomolecules · doi:10.3390/biom10070998 · Cited by 135
Self-citationER-mitochondria interactions: Both strength and weakness within cancer cells
Doghman-Bouguerra, M., & Lalli, E. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2019.01.009 · Cited by 94
Fang, J., Liu, X., Bolanos, L., Barker, B., Rigolino, C., Cortelezzi, A., Oliva, E. N., Cuzzola, M., Grimes, H. L., Fontanillo, C., et al. (2016) · Nature Medicine · doi:10.1038/nm.4127 · Cited by 83
Metadata
- Authors
- Giorgi, C., Bonora, M., Sorrentino, G., Missiroli, S., Poletti, F., Suski, J. M., Galindo Ramirez, F., Rizzuto, R., Di Virgilio, F., Zito, E., Pandolfi, P. P., Wieckowski, M. R., Mammano, F., Del Sal, G., & Pinton, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-01-26
- Volume
- 112
- Issue
- 6
- Pages
- 1779-1784
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2155353396
- Cited by
- 306
- References
- 7
- FWCI
- 14.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Giorgi, C., Bonora, M., Sorrentino, G., Missiroli, S., Poletti, F., Suski, J. M., Galindo Ramirez, F., Rizzuto, R., Di Virgilio, F., Zito, E., Pandolfi, P. P., Wieckowski, M. R., Mammano, F., Del Sal, G., & Pinton, P. (2015). p53 at the endoplasmic reticulum regulates apoptosis in a Ca 2+ -dependent manner. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1410723112
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
