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Cited by 267

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes

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Kuppusamy, Kavitha T., Jones, Daniel C., Sperber, Henrik, Madan, Anup, Fischer, Karin A., Rodriguez, Marita L., Pabon, Lil, Zhu, Wei-Zhong, Tulloch, Nathaniel L., Yang, Xiulan, Sniadecki, Nathan J., Laflamme, Michael A., Ruzzo, Walter L., Murry, Charles E., Ruohola-Baker, Hannele·2015·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1424042112
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Abstract

Significance: The adult human heart is incapable of significant regeneration after injury. Human embryonic stem cells (hESCs) have the capacity to generate an unlimited number of cardiomyocytes (CMs). However, hESC-derived CMs (hESC-CMs) are at a fetal state with respect to their functional and physiological characteristics, diminishing their utility for modeling adult-related heart disease and therapeutic screening. Thus, the potential for hESC-CMs may improve immensely in cardiac-related therapeutic applications if factors that drive their maturation are uncovered. In this study, we show that members of let-7 miRNA family control CM metabolism, cell size, and force contractility, making them one of the best factors identified to date in promoting maturity of stem cell derivatives.

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Metadata

Authors
Kuppusamy, K. T., Jones, D. C., Sperber, H., Madan, A., Fischer, K. A., Rodriguez, M. L., Pabon, L., Zhu, W.-Z., Tulloch, N. L., Yang, X., Sniadecki, N. J., Laflamme, M. A., Ruzzo, W. L., Murry, C. E., & Ruohola-Baker, H.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2015-05-11
Volume
112
Issue
21
Pages
E2785-94
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1424042112
OpenAlex
W2154578855
Cited by
267
References
10
FWCI
11.71
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes. https://app.cochat.ai/papers/10.1073/pnas.1424042112
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Kuppusamy, K. T., Jones, D. C., Sperber, H., Madan, A., Fischer, K. A., Rodriguez, M. L., Pabon, L., Zhu, W.-Z., Tulloch, N. L., Yang, X., Sniadecki, N. J., Laflamme, M. A., Ruzzo, W. L., Murry, C. E., & Ruohola-Baker, H. (2015). Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1424042112

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