Cited by 1,129Reproductive tract infections researchGut microbiota and healthOral microbiology and periodontitis research

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Temporal and spatial variation of the human microbiota during pregnancy

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DiGiulio, Daniel B., Callahan, Benjamin J., McMurdie, Paul J., Costello, Elizabeth K., Lyell, Deirdre J., Robaczewska, Anna, Sun, Christine L., Goltsman, Daniela S. A., Wong, Ronald J., Shaw, Gary, Stevenson, David K., Holmes, Susan P., Relman, David A.·2015·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1502875112PMC PMC4568272

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Abstract

Significance: The human indigenous microbial communities (microbiota) play critical roles in health and may be especially important for mother and fetus during pregnancy. Using a case-control cohort of 40 women, we characterized weekly variation in the vaginal, gut, and oral microbiota during and after pregnancy. Microbiota membership remained relatively stable at each body site during pregnancy. An altered vaginal microbial community was associated with preterm birth; this finding was corroborated by an analysis of samples from an additional cohort of nine women. We also discovered an abrupt change in the vaginal microbiota at delivery that persisted in some cases for at least 1 y. Our findings suggest that pregnancy outcomes might be predicted by features of the microbiota early in gestation.

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phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data
McMurdie, P. J., & Holmes, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061217 · Cited by 21,942
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Tibshirani, R., Walther, G., & Hastie, T. (2001) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/1467-9868.00293 · Cited by 6,205
Vaginal microbiome of reproductive-age women
Ravel, J., Gajer, P., Abdo, Z., Schneider, G. M., Koenig, S. S. K., McCulle, S. L., Karlebach, S., Gorle, R., Russell, J., Tacket, C. O., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002611107 · Cited by 4,254
Human Genetics Shape the Gut Microbiome
Goodrich, J. K., Waters, J. L., Poole, A. C., Sutter, J. L., Koren, O., Blekhman, R., Beaumont, M., Van Treuren, W., Knight, R., Bell, J. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.053 · Cited by 3,164
Born Too Soon: The global epidemiology of 15 million preterm births
Blencowe, H. K., Cousens, S. N., Chou, D., Oestergaard, M. Z., Say, L., Moller, A., Kinney, M. V., Lawn, J. E., & the Born Too Soon Preterm Birth Action Group (see acknowledgement for full list) (2013) · Reproductive Health · doi:10.1186/1742-4755-10-s1-s2 · Cited by 2,214
Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy
Koren, O., Goodrich, J. K., Cullender, T. C., Spor, A., Laitinen, K., Kling Bäckhed, H., Gonzalez, A., Werner, J. J., Angenent, L. T., Knight, R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.07.008 · Cited by 2,165
Preterm labor: One syndrome, many causes
Romero, R., Dey, S. K., & Fisher, S. J. (2014) · Science · doi:10.1126/science.1251816 · Cited by 1,984
An ecological and evolutionary perspective on human–microbe mutualism and disease
Dethlefsen, L., McFall-Ngai, M., & Relman, D. A. (2007) · Nature · doi:10.1038/nature06245 · Cited by 1,660
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Gajer, P., Brotman, R. M., Bai, G., Sakamoto, J. M., Schütte, U. M. E., Zhong, X., Koenig, S. S. K., Fu, L., Ma, Z. S., Zhou, X., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003605 · Cited by 1,583

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ERÇELİK, H. C., & Kaya, V. (2023) · Journal of Pediatric Nursing · doi:10.1016/j.pedn.2023.12.019 · Cited by 36
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Rosa, L., Lepanto, M. S., Cutone, A., Ianiro, G., Pernarella, S., Sangermano, R., Musci, G., Ottolenghi, L., & Valenti, P. (2020) · Biochemistry and Cell Biology · doi:10.1139/bcb-2020-0052 · Cited by 33
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Authors: DiGiulio, D. B., Callahan, B. J., McMurdie, P. J., Costello, E. K., Lyell, D. J., Robaczewska, A., Sun, C. L., Goltsman, D. S. A., Wong, R. J., Shaw, G., Stevenson, D. K., Holmes, S. P., & Relman, D. A.
Affiliations: March of Dimes (US)
ORCID: Callahan, Benjamin J.
McMurdie, Paul J.
Costello, Elizabeth K.
Lyell, Deirdre J.
Sun, Christine L.
Goltsman, Daniela S. A.
Wong, Ronald J.
Shaw, Gary
Stevenson, David K.
Holmes, Susan P.
Relman, David A.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2015-08-17
Volume: 112
Issue: 35
Pages: 11060-11065
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1502875112
PMC: PMC4568272
OpenAlex: W1930591173
Cited by: 1,129
References: 35
Citations by year: 2026: 53 · 2025: 90 · 2024: 111 · 2023: 126 · 2022: 133 · 2021: 161 · 2020: 123 · 2019: 118 · 2018: 83 · 2017: 76 · 2016: 48 · 2015: 6
FWCI: 59.83
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: March of Dimes Foundation (Prematurity Research Center of Stanford University)
HHS | NIH | National Center for Advancing Translational Sciences (UL1 TR001085)
HHS | NIH | National Institute of General Medical Sciences (R01 GM086884)
NSF | MPS | Division of Mathematical Sciences (1162538)
Topics: Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: human microbiota, pregnancy, vaginal microbiota, preterm birth, Lactobacillus, Gardnerella, Ureaplasma, gut microbiota, saliva microbiota, community state types, microbial community dynamics, anaerobic bacteria, interpregnancy interval
MeSH terms: Female, Humans, Intestines, Periodontium, Pregnancy, Saliva, Vagina, Microbiota

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Temporal and spatial variation of the human microbiota during pregnancy

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