Architecture of the cerebral cortical association connectome underlying cognition
Open accessAbstract
Cognition presumably emerges from neural activity in the network of association connections between cortical regions that is modulated by inputs from sensory and state systems and directs voluntary behavior by outputs to the motor system. To reveal global architectural features of the cortical association connectome, network analysis was performed on >16,000 reports of histologically defined axonal connections between cortical regions in rat. The network analysis reveals an organization into four asymmetrically interconnected modules involving the entire cortex in a topographic and topologic core-shell arrangement. There is also a topographically continuous U-shaped band of cortical areas that are highly connected with each other as well as with the rest of the cortex extending through all four modules, with the temporal pole of this band (entorhinal area) having the most cortical association connections of all. These results provide a starting point for compiling a mammalian nervous system connectome that could ultimately reveal novel correlations between genome-wide association studies and connectome-wide association studies, leading to new insights into the cellular architecture supporting cognition.
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Neural tracer data is the gold standard for mesoscale connectivity studies in a number of model organisms.
“Neural tracer data is the gold standard for mesoscale connectivity studies in a number of model organisms (Bota et al., 2015; Girard et al., 2020; Jbabdi et al., 2015; Markov et al., 2014; 2013; Oh et al., 2014).”
From The role of spatial embedding in mouse brain networks constructed from diffusion tractography and tracer injections (2021) · cites this paper as Bota et al., 2015
The Abstract says animal histological pathway-tracing data are needed to validate diffusion tractography, and Materials and Methods describes using tracing reports for a rat cortical connectome. But the paper studies regional macroconnections, while the Discussion describes a neuron-type mesoconnectome as future work; it does not establish tracer data as the gold standard for mesoscale studies across multiple model organisms. Page numbers are unavailable in our copy. (LLM, conf=0.85)
Experimental — accuracy not yet measuredThe LEC is a functional hub for integrating multisensory information, including both spatial and non-spatial characteristics, probably even time.
“This matches the anatomical features of LEC, as being a functional hub for integrating multisensory information (Bota et al., 2015), including both spatial and non-spatial characteristics, probably even time (Tsao et al., 2018).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Bota et al., 2015
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- Authors
- Bota, M., Sporns, O., & Swanson, L. W.
- Affiliations
- University of Southern California (US)
- Indiana University Bloomington (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-04-06
- Volume
- 112
- Issue
- 16
- Pages
- E2093-101
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4413280
- OpenAlex
- W2069755236
- Cited by
- 231
- References
- 47
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 14 · 2023: 19 · 2022: 26 · 2021: 18 · 2020: 24 · 2019: 20 · 2018: 24 · 2017: 22 · 2016: 28 · 2015: 12
- FWCI
- 17.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Institute of Neurological Disorders and Stroke (NS050792)
- James S. McDonnell Foundation (220020255)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- cerebral cortex, cortical connectivity, network architecture, entorhinal cortex, temporal pole, topographic connectivity, cognitive function, rat brain, genome-wide association study
- MeSH terms
- Algorithms, Animals, Cerebral Cortex, Cognition, Humans, Nerve Net, Rats, Connectome
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