Stretchable multichannel antennas in soft wireless optoelectronic implants for optogenetics
Open accessAbstract
Significance: Soft, multichannel antennas enable wireless, battery-free operation of fully implantable optoelectronic systems designed for use in studies of brain function. These systems support independent, remote control of multiple light-emitting diodes that inject into targeted regions of the deep brain, where they separately stimulate activity in genetically and spatially discrete neural circuits, via the use of the techniques of optogenetics. These capabilities represent significant advancements over alternative technology approaches for this important branch of neuroscience research. In vivo studies using optimized systems demonstrate wireless control of two different brain regions and distinct activation of subpopulations of neurons using separately activated light sources associated with these subdermal devices.
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Flexible LEDs and microscale inorganic LEDs with biocompatibility have been reported to facilitate optogenetic stimulation of the central and peripheral nervous system.
“With the advances of materials science and manufacturing technologies, flexible light-emitting diodes (LED) [562] and microscale, inorganic LED (μ-ILED)[563] with biocompatibility have been reported to facilitate the progress in optogenetic stimulation for central and peripheral nervous system.”
From Flexible Electronics and Devices as Human–Machine Interfaces for Medical Robotics (2022) · cites this paper as [562]
The paper describes implantable microscale inorganic LEDs for wireless optogenetic stimulation in the brain, and its Optoelectronic Design section describes soft components intended to minimize tissue damage. Its introduction also mentions optoelectronic stimulation of peripheral nerves, but does not establish that the μ-ILED devices reported here were used for peripheral stimulation. (LLM, conf=0.82)
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Self-citation
- Authors
- Park, S. I., Shin, G., McCall, J. G., Al-Hasani, R., Norris, A., Xia, L., Brenner, D. S., Noh, K. N., Bang, S. Y., Bhatti, D. L., Jang, K.-I., Kang, S.-K., Mickle, A. D., Dussor, G., Price, T. J., Gereau, R. W., Bruchas, M. R., & Rogers, J. A.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Washington University in St. Louis (US)
- Washington University Pain Center, Washington University School of Medicine, St. Louis, MO 63130;
- The University of Texas at Dallas (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-11-28
- Volume
- 113
- Issue
- 50
- Pages
- E8169-E8177
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5167187
- OpenAlex
- W2557453416
- Semantic Scholar
- 89b33555e97eabedfd1f12ef37c7fd9a9fbc39c7
- Cited by
- 135
- References
- 34
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 15 · 2023: 13 · 2022: 13 · 2021: 21 · 2020: 18 · 2019: 16 · 2018: 17 · 2017: 12
- FWCI
- 8.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- OakTrust (Texas A&M University Libraries) (submittedVersion)
- Funders
- HHS | NIH | Office of Behavioral and Social Sciences Research (NS081707)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Wireless Power Transfer Systems
- Physical Sciences › Engineering › Biomedical Engineering › Wireless Body Area Networks
- Keywords
- stretchable antennas, optogenetics, micro-LEDs, capacitive coupling, wireless power transfer, locus coeruleus, nucleus accumbens, sleep arousal, psychobiology
- MeSH terms
- Animals, Arousal, Behavior, Animal, Equipment Design, Locus Coeruleus, Male, Models, Theoretical, Reward, Prostheses and Implants, Deep Brain Stimulation, Mice, Electromagnetic Phenomena, Wireless Technology, Adrenergic Neurons, Optogenetics
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