Opposing roles of primate areas 25 and 32 and their putative rodent homologs in the regulation of negative emotion
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Significance: Affective disorders are associated with increased cardiovascular mortality and enhanced negative emotion. Although neuroimaging studies of such disorders reveal dysregulation in numerous frontal brain regions, including the subgenual/perigenual cingulate cortices (areas 25 and 32), the causal involvement of this dysregulation is unknown, and translation from rodent studies is limited. Here we demonstrate that, in the marmoset monkey, inactivation of area 25 increases parasympathetic modulation of resting cardiovascular function and decreases the cardiovascular and behavioral correlates of negative emotion. In contrast, area 32 inactivation increases these correlates. These findings provide causal evidence that these primate areas differentially regulate negative emotion, and link the cardiovascular symptomatology of affective disorders to central neural, rather than peripheral cardiac, dysfunction.
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Medial aspects of PFC have very differing organizations between rodents and primates.
“even the medial aspects of PFC have recently been found to have very differing organizations (Wallis, Cardinal, Alexander, Roberts, & Clarke, 2017)”
From Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species (2020) · cites this paper as Wallis, Cardinal, Alexander, Roberts, & Clarke, 2017
The Significance and Discussion sections describe opposing effects of putatively corresponding medial PFC regions on negative emotion in rodents and primates, supporting a difference in functional organization. But the Significance section says their anatomical connectivity is very similar, so the paper does not support an unqualified claim that their organizations differ greatly. (LLM, conf=0.84)
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- Authors
- Wallis, C. U., Cardinal, R. N., Alexander, L., Roberts, A. C., & Clarke, H. F.
- Affiliations
- University of Cambridge (GB)
- National Health Service (GB)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-05
- Volume
- 114
- Issue
- 20
- Pages
- E4075-E4084
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5441783
- OpenAlex
- W2611279297
- Cited by
- 117
- References
- 13
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 11 · 2023: 5 · 2022: 8 · 2021: 23 · 2020: 31 · 2019: 15 · 2018: 9
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- Funders
- Medical Research Council (RG62920)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- ventromedial prefrontal cortex, negative emotion regulation, fear extinction, fear conditioning, heart rate variability, marmoset monkey, pharmacological inactivation, anxiety, depression, autonomic arousal
- MeSH terms
- Animals, Callithrix, Conditioning, Psychological, Fear, Female, Heart Rate, Male, Parasympathetic Nervous System, Prefrontal Cortex
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