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Cell population structure prior to bifurcation predicts efficiency of directed differentiation in human induced pluripotent cells
Abstract
Significance: Induced pluripotent stem cells (iPSCs) open new possibilities for generating personalized disease models and drug testing. However, iPSC differentiation to a specific cell type can take weeks to complete, delaying the optimization process (maximize yield of desired cell types) for each patient’s iPSC. This task can be accelerated if the destination cell type can be determined early during cell lineage trajectory before cells manifest the desired phenotype. Our results indicate such a possibility: by quantifying the cell population structure during a critical state transition, we identified key regulators of lineages commitment and predicted the percentage of desired cell types for several protocol variations 2 wk in advance.
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“This concept has been demonstrated for cell fate decisions by cytokines in cell differentiation (25, 75), and we suggest that analogous dynamics also may play a role in brain development.”
From Behavior-related gene regulatory networks: A new level of organization in the brain (2020) · cites this paper as [75]
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Cited by
Behavior-related gene regulatory networks: A new level of organization in the brain
Sinha, S., Jones, B. M., Traniello, I. M., Bukhari, S. A., Halfon, M. S., Hofmann, H. A., Huang, S., Katz, P. S., Keagy, J., Lynch, V. J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1921625117 · Cited by 85
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Metadata
- Authors
- Bargaje, R., Trachana, K., Shelton, M. N., McGinnis, C. S., Zhou, J. X., Chadick, C., Cook, S., Cavanaugh, C., Huang, S., & Hood, L.
- Affiliations
- Institute for Systems Biology, Seattle, WA 98109;
- Institute for Stem Cell & Regenerative Medicine, University of Washington Medicine Research, Seattle, WA 98109
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-02-06
- Volume
- 114
- Issue
- 9
- Pages
- 2271-2276
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 115
- References
- 34
- Language
- en
- Funders
- HHS | NIH | National Institute of General Medical Sciences (2P50GM076547-06A1)
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