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Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells
Open accessAbstract
Significance: This study opens avenues to improve the ability of adult skin cells to form a fully functional skin, with clinical applications. Our investigation elucidates a relay of molecular events and biophysical processes at the core of the self-organization process during tissue morphogenesis. Molecules key to the multistage morphological transition are identified and can be added or inhibited to restore the stalled process in adult cells. The principles uncovered here are likely to function in other organ systems and will inspire us to view organoid morphogenesis, embryogenesis, and regeneration differently. The application of these findings will enable rescue of robust hair formation in adult skin cells, thus eventually helping patients in the context of regenerative medicine.
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“However, it remains challenging to induce hair neogenesis in in vitro culture, including the generation of matured hair follicles (e.g., dermal papilla and the bulge region) and the extension of long hair shafts (11).”
From Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction (2022) · cites this paper as [11]
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Metadata
- Authors
- Lei, M., Schumacher, L. J., Lai, Y.-C., Juan, W.-T., Yeh, C.-Y., Wu, P., Jiang, T.-X., Baker, R. E., Widelitz, R. B., Yang, L., & Chuong, C.-M.
- Affiliations
- University of Southern California (US)
- University of Oxford (GB)
- China Medical University (TW)
- Chongqing University (CN)
- Corresponding author
- Chuong, Cheng-Ming
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-08-10
- Volume
- 114
- Issue
- 34
- Pages
- E7101-E7110
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5576784
- OpenAlex
- W2742248339
- Cited by
- 142
- References
- 44
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 13 · 2023: 13 · 2022: 14 · 2021: 19 · 2020: 17 · 2019: 13 · 2018: 18 · 2017: 4
- FWCI
- 17.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR42177, AR60306)
- Topics
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- skin organoids, self-organization, hair regrowth, hair follicle morphogenesis, tissue morphogenesis, biophysical processes, molecular signaling, regenerative medicine, organoid formation
- MeSH terms
- Animals, Animals, Newborn, Female, Hair, Male, Mice, Nude, Morphogenesis, Organoids, Regeneration, Skin, Skin Physiological Phenomena, Stem Cells, Matrix Metalloproteinases, Mice
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