Defining hair follicles in the age of stem cell bioengineering
Open accessAbstract
One challenge faced by stem cell biologists is the bioengineering of an organ. Ehama et al. (2007, this issue) used cells derived from human and rodent epidermis and dermal papilla to reconstitute hair-follicle mini-organs. Some result in hair follicles; others are hair follicle-like. The challenge calls for the development of a set of criteria to define a hair follicle so that bioengineered products in the future can be evaluated.
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In animal models, rodent and human skin with hair follicles can be reconstituted by co-culturing mesenchymal cells with epithelial cells or HF-initiating dermal papilla cells.
“In animal models, rodent and human skin with HFs can be reconstituted by co-culturing mesenchymal cells with epithelial cells or, specifically, HF initiating dermal papilla (DP) cells (Asakawa et al., 2012; Chuong et al., 2007; Ehama et al., 2007; Ikeda et al., 2009; Nakao et al., 2007; Takagi et al., 2016; Toyoshima et al., 2012; Zheng et al., 2005a).”
From Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids (2018) · cites this paper as Chuong et al., 2007
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- Authors
- Chuong, C.-M., Cotsarelis, G., & Stenn, K.
- Affiliations
- University of Southern California (US)
- University of Pennsylvania (US)
- Corresponding author
- Chuong, Cheng-Ming
- ORCID
- Cotsarelis, George
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2007-09
- Volume
- 127
- Issue
- 9
- Pages
- 2098-2100
- ISSN
- 0022-202X (ISSN-L)
- PMC
- PMC4388139
- OpenAlex
- W2004056485
- Cited by
- 56
- References
- 25
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 6
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR042177, R01AR047364)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- hair follicle, dermal papilla, epidermal cells, skin regeneration
- MeSH terms
- Animals, Biomedical Engineering, Epidermis, Humans, Models, Biological, Organ Culture Techniques, Stem Cells, Hair Follicle, Embryonic Development, Mice
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