Neuronal androgen receptor: molecular gateway to polycystic ovary syndrome

Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group

Fauser, B. C. J. M., Tarlatzis, B. C., Rebar, R. W., Legro, R. S., Balen, A. H., Lobo, R., Carmina, E., Chang, J., Yildiz, B. O., Laven, J. S. E., et al. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.09.024 · Cited by 1,976 · see citing works

Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome

Dumesic, D. A., Oberfield, S. E., Stener-Victorin, E., Marshall, J. C., Laven, J. S., & Legro, R. S. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1018 · Cited by 1,020 · see citing works

Assessment of Cardiovascular Risk and Prevention of Cardiovascular Disease in Women with the Polycystic Ovary Syndrome: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society

Wild, R. A., Carmina, E., Diamanti-Kandarakis, E., Dokras, A., Escobar-Morreale, H. F., Futterweit, W., Lobo, R., Norman, R. J., Talbott, E., & Dumesic, D. A. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2724 · Cited by 1,010 · see citing works

The kisspeptin-GnRH pathway in human reproductive health and disease

Skorupskaite, K., George, J. T., & Anderson, R. A. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu009 · Cited by 504 · see citing works

Characterization of Reproductive, Metabolic, and Endocrine Features of Polycystic Ovary Syndrome in Female Hyperandrogenic Mouse Models

Caldwell, A. S. L., Middleton, L. J., Jimenez, M., Desai, R., McMahon, A. C., Allan, C. M., Handelsman, D. J., & Walters, K. A. (2014) · Endocrinology · doi:10.1210/en.2014-1196 · Cited by 338 · see citing works

Hyperandrogenism accompanies increased intra-abdominal fat storage in normal weight polycystic ovary syndrome women

Dumesic, D. A., Akopians, A. L., Madrigal, V. K., Ramirez, E., Margolis, D. J., Sarma, M. K., Thomas, A. M., Grogan, T. R., Haykal, R., Schooler, T. A., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2586 · Cited by 222 · see citing works

Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome

Caldwell, A. S. L., Edwards, M. C., Desai, R., Jimenez, M., Gilchrist, R. B., Handelsman, D. J., & Walters, K. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616467114 · Cited by 222 · see citing works

Neuroendocrine dysfunction in polycystic ovary syndrome

Burt Solorzano, C. M., Beller, J. P., Abshire, M. Y., Collins, J. S., McCartney, C. R., & Marshall, J. C. (2012) · Steroids · doi:10.1016/j.steroids.2011.12.007 · Cited by 173 · see citing works

The Effect of a Pure Antiandrogen Receptor Blocker, Flutamide, on the Lipid Profile in the Polycystic Ovary Syndrome

Diamanti‐Kandarakis, E., Mitrakou, A., Raptis, S. A., Tolis, G., & Dulęba, A. J. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.8.5041 · Cited by 162 · see citing works

Neurokinin B Receptor Antagonism in Women With Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled Trial

George, J. T., Kakkar, R. K., Marshall, J., Scott, M. L., Finkelman, R. D., Ho, T. W., Veldhuis, J. D., Skorupskaite, K., Anderson, R. A., McIntosh, S., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1202 · Cited by 131 · see citing works

Gestational Hyperandrogenism in Developmental Programming

Hakim, C. M., Padmanabhan, V., & Vyas, A. K. (2016) · Endocrinology · doi:10.1210/en.2016-1801 · Cited by 100 · see citing works

Disordered follicle development

Chang, R. J., & Cook‐Andersen, H. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.07.011 · Cited by 97 · see citing works

Haplosufficient Genomic Androgen Receptor Signaling Is Adequate to Protect Female Mice From Induction of Polycystic Ovary Syndrome Features by Prenatal Hyperandrogenization

Caldwell, A. S. L., Eid, S., Kay, C., Jimenez, M., McMahon, A. C., Desai, R., Allan, C. M., Smith, J. T., Handelsman, D. J., & Walters, K. A. (2015) · Endocrinology · doi:10.1210/en.2014-1887 · Cited by 90 · see citing works

Perspectives in polycystic ovary syndrome: From hair to eternity

Dunaif, A. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3780 · Cited by 87 · see citing works

Ovulation induction in polycystic ovary syndrome: Current options

Legro, R. S. (2016) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2016.08.001 · Cited by 86 · see citing works

Clustering of PCOS-like traits in naturally hyperandrogenic female rhesus monkeys

Abbott, D. H., Rayome, B. H., Dumesic, D. A., Lewis, K. C., Edwards, A. K., Wallen, K., Wilson, M. E., Appt, S. E., & Levine, J. E. (2017) · Human Reproduction · doi:10.1093/humrep/dex036 · Cited by 66 · see citing works

Both Estrogen and Androgen Modify the Response to Activation of Neurokinin-3 and κ-Opioid Receptors in Arcuate Kisspeptin Neurons From Male Mice

Ruka, K. A., Burger, L. L., & Moenter, S. M. (2015) · Endocrinology · doi:10.1210/en.2015-1688 · Cited by 52 · see citing works

Prenatal Programming by Testosterone of Hypothalamic Metabolic Control Neurones in the Ewe

Sheppard, K. M., Padmanabhan, V., Coolen, L. M., & Lehman, M. N. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02126.x · Cited by 51 · see citing works

Characterizing the neuroendocrine and ovarian defects of androgen receptor-knockout female mice

Cheng, X. B., Jimenez, M., Desai, R., Middleton, L. J., Joseph, S. R., Ning, G., Allan, C. M., Smith, J. T., Handelsman, D. J., & Walters, K. A. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00263.2013 · Cited by 50 · see citing works

Evidence for Increased 5α-Reductase Activity During Early Childhood in Daughters of Women With Polycystic Ovary Syndrome

Torchen, L. C., Idkowiak, J., Fogel, N. R., O’Neil, D. M., Shackleton, C. H. L., Arlt, W., & Dunaif, A. E. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3926 · Cited by 49 · see citing works

A talk between fat tissue, gut, pancreas and brain to control body weight

Wilson, J. L., & Enriori, P. J. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.08.022 · Cited by 45 · see citing works

Androgens in polycystic ovary syndrome

Walters, K. A. (2016) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000245 · Cited by 39 · see citing works

Cellular and subcellular localization of androgen receptor immunoreactivity relative to C1 adrenergic neurons in the rostral ventrolateral medulla of male and female rats

Milner, T. A., Hernandez, F. J., Herrick, S. P., Pierce, J. P., Iadecola, C., & Drake, C. T. (2007) · Synapse · doi:10.1002/syn.20370 · Cited by 22 · see citing works

Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls

Witchel, S. F., Oberfield, S. E., & Peña, A. S. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00078 · Cited by 653 · see citing works

New Perspectives on the Pathogenesis of PCOS: Neuroendocrine Origins

Walters, K. A., Gilchrist, R. B., Ledger, W. L., Teede, H. J., Handelsman, D. J., & Campbell, R. E. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2018.08.005 · Cited by 186 · see citing works

Androgens and ovarian function: translation from basic discovery research to clinical impact

Walters, K. A., Rodriguez Paris, V, Aflatounian, A., & Handelsman, D. J. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0096 · Cited by 104 · see citing works

The Impact of Obesity and Chronic Hyperinsulinemia on Gonadotropin Release and Gonadal Steroid Secretion in the Polycystic Ovary Syndrome*

Dunaif, A. E., Mandeli, J., Fluhr, H., & Dobrjansky, A. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-1-131 · Cited by 160 · see citing works

Endogenous inhibitors of 11β–hydroxysteroid dehydrogenase type 1 do not explain abnormal cortisol metabolism in polycystic ovary syndrome

Walker, B. R., Rodin, A., Taylor, N., & Clayton, R. N. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.00893.x · Cited by 21 · see citing works

Increased circulating levels of immunoreactive β-endorphin in polycystic ovary syndrome is not caused by increased pituitary secretion

Carmina, E., Ditkoff, E. C., Malizia, G., Vijod, A. G., Janni, A., & Lobo, R. A. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(92)91781-5 · Cited by 27 · see citing works

Insulin resistance in polycystic ovary syndrome: decreased expression of GLUT-4 glucose transporters in adipocytes

ROSENBAUM, D. S., Haber, R. S., & Dunaif, A. E. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.264.2.e197 · Cited by 223 · see citing works

EFFECTS OF LH SUPPRESSION IN POLYCYSTIC OVARY SYNDROME

Fleming, R., Black, W. P., & Coutts, J. R. T. (1985) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1985.tb01129.x · Cited by 20 · see citing works