Distinct roles for motor neuron autophagy early and late in the SOD1 G93A mouse model of ALS
Open accessAbstract
Significance: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that leads to death of spinal motor neurons and paralysis. Genetic studies of ALS patients have identified mutations in autophagy pathway genes including p62 / SQSTM1 , OPTN , TBK1 , VCP , and C9ORF72 . However, the mechanisms by which these mutations cause ALS are not understood. Here we investigated the role of autophagy in a mouse model of ALS by specifically disrupting the critical autophagy gene Atg7 in motor neurons. We found that inhibition of autophagy in motor neurons accelerated disease onset but prolonged lifespan. This increase in longevity was associated with a reduction in glial inflammation and interneuron pathology, indicating a non–cell-autonomous role for motor neuron autophagy in disease pathogenesis.
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Impaired autophagy sensitizes the nervous system to key pathogenic events occurring early in ALS pathogenesis.
“These findings not only suggest that impaired autophagy sensitizes the nervous system to key pathogenic events occurring early in ALS pathogenesis”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [336]
Conditional deletion of Atg7 in mouse motor neurons accentuates early ALS pathology but mitigates glial inflammation and early death.
“conditional deletion of Atg7 in mouse motor neurons accentuates early ALS pathology but mitigates glial inflammation and early death [336].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [336]
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Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works
Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875 · see citing works
Self-citationCahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129 · see citing works
The Role of Atg Proteins in Autophagosome Formation
Mizushima, N., Yoshimori, T., & Ohsumi, Y. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154005 · Cited by 2,978 · see citing works
Impairment of starvation-induced and constitutive autophagy in <i>Atg7</i> -deficient mice
Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi, Y., Uchiyama, Y., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412022 · Cited by 2,331 · see citing works
Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., & Ohsumi, Y. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0704 · Cited by 2,323 · see citing works
Decoding ALS: from genes to mechanism
Taylor, J. P., Brown, R. H., & Cleveland, D. W. (2016) · Nature · doi:10.1038/nature20413 · Cited by 2,047 · see citing works
Kato, M., Han, T. W., Xie, S., Shi, K., Du, X., Wu, L. C., Mirzaei, H., Goldsmith, E. J., Longgood, J., Pei, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.017 · Cited by 2,012 · see citing works
Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia
Boillée, S., Yamanaka, K., Lobsiger, C. S., Copeland, N. G., Jenkins, N. A., Kassiotis, G., Kollias, G., & Cleveland, D. W. (2006) · Science · doi:10.1126/science.1123511 · Cited by 1,623 · see citing works
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
Kim, H. J., Kim, N. C., Wang, Y., Scarborough, E. A., Moore, J., Diaz, Z., MacLea, K. S., Freibaum, B. D., Li, S., Molliex, A., et al. (2013) · Nature · doi:10.1038/nature11922 · Cited by 1,476 · see citing works
Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits
Tang, G., Gudsnuk, K., Kuo, S.-H., Cotrina, M. L., Rosoklija, G., Sosunov, A., Sonders, M. S., Kanter, E., Castagna, C., Yamamoto, A., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.040 · Cited by 1,146 · see citing works
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
Yamanaka, K., Chun, S. J., Boillee, S., Fujimori-Tonou, N., Yamashita, H., Gutmann, D. H., Takahashi, R., Misawa, H., & Cleveland, D. W. (2008) · Nature Neuroscience · doi:10.1038/nn2047 · Cited by 1,140 · see citing works
Rogov, V., Dötsch, V., Johansen, T., & Kirkin, V. (2014) · Molecular Cell · doi:10.1016/j.molcel.2013.12.014 · Cited by 992 · see citing works
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
Cirulli, E. T., Lasseigne, B. N., Petrovski, S., Sapp, P. C., Dion, P. A., Leblond, C. S., Couthouis, J., Lu, Y.-F., Wang, Q., Krueger, B. J., et al. (2015) · Science · doi:10.1126/science.aaa3650 · Cited by 966 · see citing works
Self-citationAutophagosomes initiate distally and mature during transport toward the cell soma in primary neurons
Maday, S., Wallace, K. E., & Holzbaur, E. L. F. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201106120 · Cited by 681 · cited 1× · see citing works
“It has been demonstrated that autophagosomes can form distally at the synapse and retrogradely transport cargo for degradation (48).”
Pun, S., Santos, A. F., Saxena, S., Xu, L., & Caroni, P. (2006) · Nature Neuroscience · doi:10.1038/nn1653 · Cited by 659 · see citing works
Chiu, I. M., Morimoto, E. T. A., Goodarzi, H., Liao, J. T., O’Keeffe, S., Phatnani, H. P., Muratet, M., Carroll, M. C., Levy, S., Tavazoie, S., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.06.018 · Cited by 651 · see citing works
Self-citationCell-to-cell transmission of pathogenic proteins in neurodegenerative diseases
Guo, J. L., & Lee, V. M. Y. (2014) · Nature Medicine · doi:10.1038/nm.3457 · Cited by 641 · see citing works
Komatsu, M., Wang, Q. J., Holstein, G. R., Friedrich, V. L., Iwata, J.-I., Kominami, E., Chait, B. T., Tanaka, K., & Yue, Z. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701311104 · Cited by 614 · see citing works
ALS motor phenotype heterogeneity, focality, and spread
Ravits, J., & Spada, A. R. L. (2009) · Neurology · doi:10.1212/wnl.0b013e3181b6bbbd · Cited by 602 · see citing works
Lithium delays progression of amyotrophic lateral sclerosis
Fornai, F., Longone, P., Cafaro, L., Kastsiuchenka, O., Ferrucci, M., Manca, M. L., Lazzeri, G., Spalloni, A., Bellio, N., Lenzi, P., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708022105 · Cited by 550 · see citing works
Amyotrophic lateral sclerosis—a model of corticofugal axonal spread
Braak, H., Brettschneider, J., Ludolph, A. C., Lee, V. M., Trojanowski, J. Q., & Tredici, K. D. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.221 · Cited by 524 · see citing works
Motor Neuron Diversity in Development and Disease
Kanning, K. C., Kaplan, A., & Henderson, C. E. (2010) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135722 · Cited by 472 · see citing works
Aβ Secretion and Plaque Formation Depend on Autophagy
Nilsson, P., Loganathan, K., Sekiguchi, M., Matsuba, Y., Hui, K., Tsubuki, S., Tanaka, M., Iwata, N., Saito, T., & Saido, T. C. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.042 · Cited by 459 · see citing works
Exosomes and Autophagy: Coordinated Mechanisms for the Maintenance of Cellular Fitness
Baixauli, F., López-Otı́n, C., & Mittelbrunn, M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00403 · Cited by 443 · see citing works
A Cluster of Cholinergic Premotor Interneurons Modulates Mouse Locomotor Activity
Zagoraiou, L., Akay, T., Martin, J. F., Brownstone, R. M., Jessell, T. M., & Miles, G. B. (2009) · Neuron · doi:10.1016/j.neuron.2009.10.017 · Cited by 429 · see citing works
The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy
Webster, C. P., Smith, E. F., Bauer, C. S., Moller, A., Hautbergue, G. M., Ferraiuolo, L., Myszczynska, M. A., Higginbottom, A., Walsh, M. J., Whitworth, A. J., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201694401 · Cited by 404 · see citing works
Zhang, X., Li, L., Chen, S., Yang, D., Wang, Y., Zhang, X., Wang, Z., & Le, W. (2011) · Autophagy · doi:10.4161/auto.7.4.14541 · Cited by 364 · see citing works
Regulation of Presynaptic Neurotransmission by Macroautophagy
Hernandez, D., Torres, C. A., Setlik, W., Cebrián, C., Mosharov, E. V., Tang, G., Cheng, H., Kholodilov, N. G., Yarygina, O., Burke, R. E., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.020 · Cited by 348 · see citing works
Castillo, K., Nassif, M., Valenzuela, V., Rojas, F., Matus, S., Mercado, G., Court, F. A., van Zundert, B., & Hetz, C. A. (2013) · Autophagy · doi:10.4161/auto.25188 · Cited by 338 · see citing works
Nuclear and cytosolic JNK signalling in neurons
Coffey, E. T. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3729 · Cited by 336 · see citing works
Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration
Kaplan, A., Spiller, K. J., Towne, C. L., Kanning, K. C., Choe, G. T., Geber, A. B., Akay, T., Aebischer, P., & Henderson, C. E. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.009 · Cited by 309 · see citing works
High-contrast en bloc staining of neuronal tissue for field emission scanning electron microscopy
Tapia, J. C., Kasthuri, N., Hayworth, K. J., Schalek, R., Lichtman, J. W., Smith, S. J., & Buchanan, J. (2012) · Nature Protocols · doi:10.1038/nprot.2011.439 · Cited by 296 · see citing works
Self-citationSullivan, P. M., Zhou, X., Robins, A. M., Paushter, D. H., Kim, D., Smolka, M. B., & Hu, F. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0324-5 · Cited by 295 · see citing works
Zhang, X., Chen, S., Song, L., Tang, Y., Shen, Y., Li, J. X., & Le, W. (2014) · Autophagy · doi:10.4161/auto.27710 · Cited by 256 · see citing works
Autophagy promotes synapse development in <i>Drosophila</i>
Shen, W., & Ganetzky, B. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200907109 · Cited by 252 · see citing works
A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis
Schaefer, A. M., Sanes, J. R., & Lichtman, J. W. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20620 · Cited by 250 · see citing works
Ejlerskov, P., Rasmussen, I., Nielsen, T. T., Bergström, A., Tohyama, Y., Jensen, P. H., & Vilhardt, F. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.401174 · Cited by 236 · see citing works
Human TBK1: A Gatekeeper of Neuroinflammation
Ahmad, L., Zhang, S.-Y., Casanova, J.-L., & Sancho-Shimizu, V. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.04.006 · Cited by 208 · see citing works
Tashiro, Y., Urushitani, M., Inoue, H., Koike, M., Uchiyama, Y., Komatsu, M., Tanaka, K., Yamazaki, M., Abe, M., Misawa, H., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.417600 · Cited by 194 · see citing works
Sun, S., Sun, Y., Ling, S., Ferraiuolo, L., McAlonis‐Downes, M., Zou, Y., Drenner, K., Wang, Y., Ditsworth, D., Tokunaga, S., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520639112 · Cited by 194 · see citing works
Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin‐independent mechanism
Gal, J., Ström, A., Kwinter, D. M., Kilty, R., Zhang, J., Shi, P., Fu, W., Wooten, M. W., & Zhu, H. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06388.x · Cited by 187 · see citing works
Mizuno, Y., Amari, M., Takatama, M., Aizawa, H., Mihara, B., & Okamoto, K. (2006) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2006.05.060 · Cited by 158 · see citing works
Xie, Y., Zhou, B., Lin, M.-Y., Wang, S., Foust, K. D., & Sheng, Z. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.026 · Cited by 148 · see citing works
Intricate interplay between astrocytes and motor neurons in ALS
Phatnani, H. P., Guarnieri, P., Friedman, B. A., Carrasco, M. A., Muratet, M. A., O’Keeffe, S., Nwakeze, C. L., Pauli, F., Newberry, K. M., Meadows, S. K., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222361110 · Cited by 146 · see citing works
Self-citationPizzasegola, C., Caron, I., Daleno, C., Ronchi, A., Minoia, C., Carrı̀, M. T., & Bendotti, C. (2009) · Amyotrophic Lateral Sclerosis · doi:10.1080/17482960902803440 · Cited by 132 · see citing works
Common Molecular Pathways in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Weishaupt, J. H., Hyman, T., & Đikić, I. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.07.005 · Cited by 128 · see citing works
Vlug, A. S., Teuling, E., Haasdijk, E. D., et al. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04389.x · Cited by 110 · see citing works
Glazner, G. W., Mu, X., & Springer, J. E. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980202)391:1 · Cited by 110 · see citing works
Williams, E. R., & Baker, S. N. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0272-09.2009 · Cited by 103 · see citing works
Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis
Nassif, M., Valenzuela, V., Rojas-Rivera, D., Vidal, R., Matus, S., Castillo, K., Fuentealba, Y., Kroemer, G., Levine, B., & Hetz, C. (2014) · Autophagy · doi:10.4161/auto.28784 · Cited by 100 · see citing works
Li, Y., Guo, Y., wang, X., Yu, X., Duan, W., Hong, K., Wang, J., Han, H., & Li, C. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.061 · Cited by 98 · see citing works
Self-citationStephens, B., Guiloff, R. J., Navarrete, R., Newman, P., Nikhar, N., & Lewis, P. D. (2006) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.12.003 · Cited by 95 · see citing works
Gill, A., Kidd, J. D., Vieira, F. G., Thompson, K., & Perrin, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006489 · Cited by 83 · see citing works
Alterations in the motor neuron–renshaw cell circuit in the Sod1G93A mouse model
Wootz, H., FitzSimons‐Kantamneni, E., Larhammar, M., Rotterman, T. M., Enjin, A., Patra, K., André, E., van Zundert, B., Kullander, K., & Álvarez, F. J. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23266 · Cited by 81 · see citing works
Hultborn, H., Katz, R., & Mackel, R. G. (1988) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1988.tb08503.x · Cited by 71 · see citing works
RNA-Seq Profiling of Spinal Cord Motor Neurons from a Presymptomatic SOD1 ALS Mouse
Bandyopadhyay, U., Cotney, J. L., Nagy, M., Oh, S., Leng, J., Mahajan, M. C., Mane, S., Fenton, W. A., Noonan, J. P., & Horwich, A. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053575 · Cited by 64 · see citing works
Virgo, L., & de Belleroche, J. (1995) · Brain Research · doi:10.1016/0006-8993(95)00052-r · Cited by 62 · see citing works
Hossaini, M., Cano, S. C., van Dis, V., Haasdijk, E. D., Hoogenraad, C. C., Holstege, J. C., & Jaarsma, D. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31822581ac · Cited by 56 · see citing works
Wang, X., Engisch, K. L., Li, Y., Pinter, M. J., Cope, T. C., & Rich, M. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2755-04.2004 · Cited by 53 · see citing works
Self-citationExpressionPlot: a web-based framework for analysis of RNA-Seq and microarray gene expression data
Friedman, B. A., & Maniatis, T. (2011) · Genome biology · doi:10.1186/gb-2011-12-7-r69 · Cited by 45 · see citing works
Self-citationGrand, J. N. L., Bon, K., Fraîchard, A., Zhang, J., Jouvenot, M., Risold, P., Boyer‐Guittaut, M., & Delage-Mourroux, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063133 · Cited by 29 · see citing works
Inoue, K., Rispoli, J. M., Yang, L., MacLeod, D., Beal, M. F., Klann, E., & Abeliovich, A. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003845 · Cited by 22 · see citing works
Distribution and ultrastructural localization of GEC1 in the rat CNS
Wang, Y., Dun, S. L., Huang, P., et al. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.03.013 · Cited by 13 · see citing works
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Maniatis, S., Äijö, T., Vickovic, S., Braine, C., Kang, K., Mollbrink, A., Fagegaltier, D., Andrusivová, Ž., Saarenpää, S., Saiz-Castro, G., et al. (2019) · Science · doi:10.1126/science.aav9776 · Cited by 429 · see citing works
Tam, O. H., Rozhkov, N. V., Shaw, R., Kim, D., Hubbard, I., Fennessey, S., Propp, N., Phatnani, H., Kwan, J., Sareen, D., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.066 · Cited by 327 · see citing works
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Chua, J. P., De Calbiac, H., Kabashi, E., & Barmada, S. J. (2022) · Autophagy · doi:10.1080/15548627.2021.1926656 · Cited by 189 · see citing works
Gerbino, V., Kaunga, E., Ye, J., Canzio, D., O’Keeffe, S., Rudnick, N. D., Guarnieri, P., Lutz, C. M., & Maniatis, T. (2020) · Neuron · doi:10.1016/j.neuron.2020.03.005 · Cited by 102 · see citing works
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Brenner, D., Sieverding, K., Bruno, C., Lüningschrör, P., Buck, E., Mungwa, S., Fischer, L., Brockmann, S. J., Ulmer, J., Bliederhäuser, C., et al. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20180729 · Cited by 83 · see citing works
Wu, J. J., Cai, A., Greenslade, J. E., Higgins, N. R., Fan, C., Le, N. T. T., Tatman, M., Whiteley, A. M., Prado, M. A., Dieriks, B. V., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1917371117 · Cited by 86 · see citing works
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Dutta, K., Patel, P., & Julien, J.-P. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.08.008 · Cited by 56 · see citing works
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- Authors
- Rudnick, N. D., Griffey, C. J., Guarnieri, P., Gerbino, V., Wang, X., Piersaint, J. A., Tapia, J. C., Rich, M. M., & Maniatis, T.
- Affiliations
- Columbia University Irving Medical Center (US)
- Wright State University (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-09-13
- Volume
- 114
- Issue
- 39
- Pages
- E8294-E8303
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5625902
- OpenAlex
- W2755399567
- Cited by
- 189
- References
- 64
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 14 · 2023: 17 · 2022: 18 · 2021: 35 · 2020: 26 · 2019: 27 · 2018: 21 · 2017: 4
- FWCI
- 14.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CORE Scholar (Wright State University) (submittedVersion)
- Funders
- HHS | NIH | NIH Office of the Director (DP1 OD003930)
- HHS | NIH | National Institute of Neurological Disorders and Stroke (F31 NS089131, R01 NS082354)
- HHS | NIH | National Institute of General Medical Sciences (T32 GM007367)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Keywords
- amyotrophic lateral sclerosis, ATG7, SOD1 G93A mouse model, autophagy inhibition, glial inflammation, lifespan extension, motor neuron degeneration
- MeSH terms
- Autophagy-Related Protein 7, Superoxide Dismutase-1, Amyotrophic Lateral Sclerosis, Animals, Autophagy, Disease Models, Animal, Motor Neurons, Superoxide Dismutase, Mice, Knockout, Mice
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