Contributions of primate prefrontal cortex and medial temporal lobe to temporal-order memory
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Neuropsychological and neurophysiological studies have emphasized the role of the prefrontal cortex (PFC) in maintaining information about the temporal order of events or items for upcoming actions. However, the medial temporal lobe (MTL) has also been considered critical to bind individual events or items to their temporal context in episodic memory. Here we characterize the contributions of these brain areas by comparing single-unit activity in the dorsal and ventral regions of macaque lateral PFC (d-PFC and v-PFC) with activity in MTL areas including the hippocampus (HPC), entorhinal cortex, and perirhinal cortex (PRC) as well as in area TE during the encoding phase of a temporal-order memory task. The v-PFC cells signaled specific items at particular time periods of the task. By contrast, MTL cortical cells signaled specific items across multiple time periods and discriminated the items between time periods by modulating their firing rates. Analysis of the temporal dynamics of these signals showed that the conjunctive signal of item and temporal-order information in PRC developed earlier than that seen in v-PFC. During the delay interval between the two cue stimuli, while v-PFC provided prominent stimulus-selective delay activity, MTL areas did not. Both regions of PFC and HPC exhibited an incremental timing signal that appeared to represent the continuous passage of time during the encoding phase. However, the incremental timing signal in HPC was more prominent than that observed in PFC. These results suggest that PFC and MTL contribute to the encoding of the integration of item and timing information in distinct ways.
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Both the PFC and medial temporal lobe are involved in the integration of temporal-context memory.
“both regions are involved in the integration of temporal-context memory”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Naya et al., 2017
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- Authors
- Naya, Y., Chen, H., Yang, C., & Suzuki, W. A.
- Affiliations
- Peking University (CN)
- New York University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-11-30
- Volume
- 114
- Issue
- 51
- Pages
- 13555-13560
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5754788
- OpenAlex
- W2775146878
- Cited by
- 62
- References
- 51
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 2 · 2023: 6 · 2022: 7 · 2021: 10 · 2020: 17 · 2019: 8 · 2018: 3
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Institute of Mental Health (MH086563)
- National Natural Science Foundation of China (31421003)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- temporal order memory, prefrontal cortex, medial temporal lobe, hippocampus, entorhinal cortex, perirhinal cortex, temporal coding, single-unit activity, macaque, delay activity, episodic memory
- MeSH terms
- Animals, Macaca mulatta, Male, Memory, Short-Term, Temporal Lobe, Prefrontal Cortex, Memory, Episodic
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