Cited by 17Memory Processes and InfluencesMemory and Neural MechanismsPrimate Behavior and Ecology

Location and temporal memory of objects declines in aged marmosets (Callithrix jacchus)

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De Castro, Vanessa, Girard, Pascal·2021·Scientific Reports

Abstract

Episodic memory decline is an early marker of cognitive aging in human. Although controversial in animals and called “episodic-like memory”, several models have been successfully developed, however they rarely focused on ageing. While marmoset is an emerging primate model in aging science, episodic-like memory has never been tested in this species and importantly in aged marmosets. Here, we examined if the recall of the what-when and what-where building blocks of episodic-like memory declines in ageing marmosets. We developed a naturalistic approach using spontaneous exploration of real objects by young and old marmosets in the home cage. We implemented a three-trial task with 1 week inter-trial interval. Two different sets of identical objects were presented in sample trials 1 and 2, respectively. For the test trial, two objects from each set were presented in a former position and two in a new one. We quantified the exploratory behaviour and calculated discrimination indices in a cohort of 20 marmosets. Young animals presented a preserved memory for combined what-where, and what-when components of the experiment, which declined with aging. These findings lead one to expect episodic-like memory deficits in aged marmosets.

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  • Research on memory in rodents and monkeys suggests that both spatial (what-where) and temporal (what-when) elements of memory decline alongside typical age-related changes within the brain.

    “research on memory in rodents and monkeys, although again not strictly in line with episodic-like memory criteria, suggests that both spatial (what–where) [139–142] and temporal (what–when) [142,143] elements of memory decline alongside typical age-related changes within the brain.”

    From Is episodic-like memory <i>like</i> episodic memory? (2024) · cites this paper as [142]

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Research works printed but not linked: 2

  1. [86]McCormack T Attributing Episodic Memory to Animals and Children. Time and Memory: Issues in Philosophy and Psychology 2001 Oxford University Press
  2. [139]Gareth R I Barker, Paul J Banks, Hannah Scott, G Scott Ralph, Kyriacos A Mitrophanous, Liang-Fong Wong, Zafar I Bashir, James B Uney, E Clea Warburton, (2017) Separate elements of episodic memory subserved by distinct hippocampal–prefrontal connections. Nature Neuroscience 20 (2):242-250 28067902

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Authors
De Castro, V., & Girard, P.
Affiliations
Inserm (FR)
Corresponding author
Girard, Pascal
Venue
Scientific Reports
Published
2021-04-28
Volume
11
Issue
1
Pages
9138-9138
ISSN
2045-2322 (ISSN-L)
OpenAlex
W3158658225
Cited by
17
References
143
Citations by year
2026: 4 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 2
FWCI
1.45
Type
journal article
Language
en
Open access
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Agence Nationale de la Recherche (ANR-18-CE37-0022, ANR-14-CE13-0033-02)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
Keywords
episodic-like memory, cognitive aging, marmoset, Callithrix jacchus, object location memory, temporal memory, exploratory behavior, memory discrimination
MeSH terms
Cognitive Aging, Animals, Callithrix, Exploratory Behavior, Female, Male, Discriminant Analysis, Memory, Episodic

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