Location and temporal memory of objects declines in aged marmosets (Callithrix jacchus)
Open accessAbstract
Episodic memory decline is an early marker of cognitive aging in human. Although controversial in animals and called “episodic-like memory”, several models have been successfully developed, however they rarely focused on ageing. While marmoset is an emerging primate model in aging science, episodic-like memory has never been tested in this species and importantly in aged marmosets. Here, we examined if the recall of the what-when and what-where building blocks of episodic-like memory declines in ageing marmosets. We developed a naturalistic approach using spontaneous exploration of real objects by young and old marmosets in the home cage. We implemented a three-trial task with 1 week inter-trial interval. Two different sets of identical objects were presented in sample trials 1 and 2, respectively. For the test trial, two objects from each set were presented in a former position and two in a new one. We quantified the exploratory behaviour and calculated discrimination indices in a cohort of 20 marmosets. Young animals presented a preserved memory for combined what-where, and what-when components of the experiment, which declined with aging. These findings lead one to expect episodic-like memory deficits in aged marmosets.
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Research on memory in rodents and monkeys suggests that both spatial (what-where) and temporal (what-when) elements of memory decline alongside typical age-related changes within the brain.
“research on memory in rodents and monkeys, although again not strictly in line with episodic-like memory criteria, suggests that both spatial (what–where) [139–142] and temporal (what–when) [142,143] elements of memory decline alongside typical age-related changes within the brain.”
From Is episodic-like memory <i>like</i> episodic memory? (2024) · cites this paper as [142]
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Flagged first, then by citations
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Sorted by citations
Is episodic-like memory <i>like</i> episodic memory?
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- Authors
- De Castro, V., & Girard, P.
- Affiliations
- Inserm (FR)
- Corresponding author
- Girard, Pascal
- Venue
- Scientific Reports
- Published
- 2021-04-28
- Volume
- 11
- Issue
- 1
- Pages
- 9138-9138
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC8080792
- OpenAlex
- W3158658225
- Cited by
- 17
- References
- 143
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 2
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Agence Nationale de la Recherche (ANR-18-CE37-0022, ANR-14-CE13-0033-02)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Keywords
- episodic-like memory, cognitive aging, marmoset, Callithrix jacchus, object location memory, temporal memory, exploratory behavior, memory discrimination
- MeSH terms
- Cognitive Aging, Animals, Callithrix, Exploratory Behavior, Female, Male, Discriminant Analysis, Memory, Episodic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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