Time cells in hippocampal area CA3
Open accessAbstract
UNLABELLED: Studies on time cells in the hippocampus have so far focused on area CA1 in animals performing memory tasks. Some studies have suggested that temporal processing within the hippocampus may be exclusive to CA1 and CA2, but not CA3, and may occur only under strong demands for memory. Here we examined the temporal and spatial coding properties of CA3 and CA1 neurons in rats performing a maze task that demanded working memory and a control task with no explicit working memory demand. In the memory demanding task, CA3 cells exhibited robust temporal modulation similar to the pattern of time cell activity in CA1, and the same populations of cells also exhibited typical place coding patterns in the same task. Furthermore, the temporal and spatial coding patterns of CA1 and CA3 were equivalently robust when animals performed a simplified version of the task that made no demands on working memory. However, time and place coding did differ in that the resolution of temporal coding decreased over time within the delay interval, whereas the resolution of place coding was not systematically affected by distance along the track. These findings support the view that CA1 and CA3 both participate in encoding the temporal and spatial organization of ongoing experience. SIGNIFICANCE STATEMENT: Hippocampal "time cells" that fire at specific moments in a temporally structured memory task have so far been observed only in area CA1, and some studies have suggested that temporal coding within the hippocampus is exclusive to CA1. Here we describe time cells also in CA3, and time cells in both areas are observed even without working memory demands, similar to place cells in these areas. However, unlike equivalent spatial coding along a path, temporal coding is nonlinear, with greater temporal resolution earlier than later in temporally structured experiences. These observations reveal both similarities and differences in temporal and spatial coding within the hippocampus of importance to understanding how these features of memory are represented in the hippocampus.
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Time cells are also identified in the CA3 region.
“Time cells were also identified in the CA3 region (Salz et al., 2016).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Salz et al., 2016
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- Authors
- Salz, D. M., Tiganj, Z., Khasnabish, S., Kohley, A., Sheehan, D., Howard, M. W., & Eichenbaum, H.
- Affiliations
- Boston University (US)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2016-07-13
- Volume
- 36
- Issue
- 28
- Pages
- 7476-7484
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC4945667
- OpenAlex
- W2473196525
- Cited by
- 183
- References
- 23
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 14 · 2023: 16 · 2022: 14 · 2021: 19 · 2020: 24 · 2019: 22 · 2018: 23 · 2017: 18 · 2016: 3
- FWCI
- 14.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (1444389)
- National Institute of Mental Health (MH095297, R01MH095297, R01MH112169)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- time cells, hippocampal CA3, hippocampal CA1, temporal coding, spatial coding, place cells, working memory, maze task, temporal resolution, retention interval
- MeSH terms
- Action Potentials, Animals, Cell Count, Exercise Test, Male, Memory, Short-Term, Models, Neurological, Neurons, Spatial Behavior, Time Factors, Maze Learning, Rats, Long-Evans, Rats, CA1 Region, Hippocampal, CA3 Region, Hippocampal
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