IL-1β enables CNS access to CCR2 hi monocytes and the generation of pathogenic cells through GM-CSF released by CNS endothelial cells
Open accessAbstract
Significance Multiple sclerosis (MS) is a neuroinflammatory disease characterized by demyelinating plaques in the brain and spinal cord, causing progressive loss of functions. While the causes of MS remain undefined, treatments that target immune cells or their functions greatly improve the clinical outcome. Our laboratory has previously shown that production of the inflammatory cytokine interleukin (IL)-1β by myeloid cells is required for the development of experimental autoimmune encephalomyelitis (EAE), an MS model. Here, we show that activation of central nervous system (CNS) endothelial cells by IL-1β enables inflammatory monocytes to enter the CNS and differentiate into antigen-presenting cells. Additionally, we demonstrate that factors released from the interaction between IL-1β–producing myeloid cells and autoreactive CD4 + T cells are toxic to neurons.
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IL-1β expression was induced in aged choroid plexus macrophages.
“IL-1β expression was induced in aged ChP macrophages”
From A cellular and spatial map of the choroid plexus across brain ventricles and ages (2021) · cites this paper as Paré et al., 2018
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A cellular and spatial map of the choroid plexus across brain ventricles and ages
Dani, N., Herbst, R. H., McCabe, C., Green, G. S., Kaiser, K., Head, J. P., Cui, J., Shipley, F. B., Jang, A., Dionne, D., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.003 · Cited by 388 · see citing works
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- Authors
- Paré, A., Mailhot, B., Lévesque, S. A., Juzwik, C., Ignatius Arokia Doss, P. M., Lécuyer, M.-A., Prat, A., Rangachari, M., Fournier, A., & Lacroix, S.
- Affiliations
- Centre hospitalier universitaire de Québec (CA)
- Montreal Neurological Institute, Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, QC H3A 2B4, Canada;
- Centre de Recherche du Centre Hospitalier Universitaire de Québec, Université Laval, Québec, QC G1V 4G2, Canada;
- Centre Hospitalier de l’Université de Montréal (CA)
- Montreal Neurological Institute and Hospital (CA)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2018-01-22
- Volume
- 115
- Issue
- 6
- Pages
- E1194-E1203
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5819409
- OpenAlex
- W2784643764
- Cited by
- 94
- References
- 41
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 9 · 2023: 7 · 2022: 12 · 2021: 15 · 2020: 22 · 2019: 12 · 2018: 3
- FWCI
- 9.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Multiple Sclerosis Society of Canada (EGID #2446)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- IL-1β, multiple sclerosis, experimental autoimmune encephalomyelitis, CCR2+ monocytes, GM-CSF, myeloid cells, antigen-presenting cells, autoreactive CD4+ T cells, neurotoxicity, neuroinflammation, demyelination, myeloid cell activation
- MeSH terms
- Animals, Central Nervous System, Encephalomyelitis, Autoimmune, Experimental, Inflammation, Monocytes, Neurons, CD4-Positive T-Lymphocytes, Granulocyte-Macrophage Colony-Stimulating Factor, Mice, Knockout, Myeloid Cells, Endothelial Cells, Mice, Interleukin-1beta, Receptors, CCR2
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