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Increased thermogenesis by a noncanonical pathway in ANGPTL3/8-deficient mice

Banfi, Serena, Gusarova, Viktoria, Gromada, Jesper, Cohen, Jonathan C., Hobbs, Helen H.·2018·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1717420115PMC PMC5819435
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Abstract

Significance: White adipose tissue (WAT) serves as an energy reservoir during fasting and is replenished with fatty acids from circulating triglycerides upon refeeding. We showed previously that postprandial partitioning of fatty acids between oxidative and storage tissues is mediated by angiopoietin-like proteins 3 (A3) and 8 (A8). Here, we show that disruption of both Angptl3 and Angptl8 in mice causes striking alterations in energy metabolism: reduced fat mass, hyperthermia, increased metabolic rate, and beiging of subcutaneous WAT. The hypermetabolic features of the A3 −/− A8 −/− mice were most pronounced in fed animals, and attenuated with fasting and β3-adrenergic receptor blockade. These data indicate that A3 and A8 promote efficient energy utilization by tissues and limit the increase in energy expenditure associated with food intake.

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Metadata

Authors
Banfi, S., Gusarova, V., Gromada, J., Cohen, J. C., & Hobbs, H. H.
Affiliations
  • Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390;
  • Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591;
  • Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390;
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2018-01-22
Volume
115
Issue
6
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.1717420115
PMC
PMC5819435
Cited by
56
References
5
Language
en
Licence
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Funders
HHS | National Institutes of Health (5 PO1 HL20948.)

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