Uncovering residual effects of chronic sleep loss on human performance
Open accessAbstract
Sleep loss leads to profound performance decrements. Yet many individuals believe they adapt to chronic sleep loss or that recovery requires only a single extended sleep episode. To evaluate this, we designed a protocol whereby the durations of sleep and wake episodes were increased to 10 and 32.85 hours, respectively, to yield a reduced sleep-to-wake ratio of 1:3.3. These sleep and wake episodes were distributed across all circadian phases, enabling measurement of the effects of acute and chronic sleep loss at different times of the circadian day and night. Despite recurrent acute and substantial chronic sleep loss, 10-hour sleep opportunities consistently restored vigilance task performance during the first several hours of wakefulness. However, chronic sleep loss markedly increased the rate of deterioration in performance across wakefulness, particularly during the circadian "night." Thus, extended wake during the circadian night reveals the cumulative detrimental effects of chronic sleep loss on performance, with potential adverse health and safety consequences.
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The detrimental effects of sustained and prolonged chronic sleep may not be reversible, leading to long-term adverse health and safety consequences.
“The detrimental effects of sustained and prolonged chronic sleep however, may not be reversible leading to long term adverse health and safety consequences.79”
From Sleep duration and incidence of obesity in infants, children, and adolescents: a systematic review and meta-analysis of prospective studies (2018) · cites this paper as [79]
The adverse effects of limited sleep time are especially severe at circadian times when sleep propensity is high.
“the adverse effects of limited sleep time are especially severe at circadian times when sleep propensity is high.”
Forced desynchrony protocols reveal the variance in neurobehavioral functions attributable primarily to endogenous circadian control and the variance attributable primarily to the sleep homeostatic drive.
“Recent forced desynchrony protocols, which serve to experimentally reveal the variance in neurobehavioral functions attributable primarily to endogenous circadian control and the variance attributable primarily to the sleep homeostatic drive, have revealed that circadian dynamics can expose large neurobehavioral vulnerability during chronic sleep restriction.26,27”
From Circadian rhythms, sleep deprivation, and human performance (2013) · cites this paper as [26]
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- Authors
- Cohen, D. A., Wang, W., Wyatt, J. K., Kronauer, R. E., Dijk, D.-J., Czeisler, C. A., & Klerman, E. B.
- Affiliations
- Brigham and Women's Hospital (US)
- Rush University Medical Center (US)
- Harvard University (US)
- University of Surrey (GB)
- Corresponding author
- Cohen, Daniel A.
- Venue
- Science Translational Medicine
- Published
- 2010-01-13
- Volume
- 2
- Issue
- 14
- Pages
- 14ra3-14ra3
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC2892834
- OpenAlex
- W2147523200
- Cited by
- 236
- References
- 35
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 8 · 2023: 14 · 2022: 14 · 2021: 16 · 2020: 16 · 2019: 18 · 2018: 13 · 2017: 13 · 2016: 15 · 2015: 18 · 2014: 18 · 2013: 18 · 2012: 21
- FWCI
- 23.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Funders
- National Institute on Aging (P01AG009975)
- National Heart, Lung, and Blood Institute (T32HL007901)
- National Center for Research Resources (M01RR002635)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K02HD045459)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- chronic sleep loss, sleep deprivation, sustained attention, cognitive performance, circadian rhythm, extended wakefulness, performance recovery
- MeSH terms
- Adult, Attention, Circadian Rhythm, Female, Humans, Male, Psychomotor Performance, Reaction Time, Sleep, Wakefulness, Work Schedule Tolerance, Models, Statistical
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