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Cited by 77

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response

Sitz, Justine, Blanchet, Sophie Anne, Gameiro, Steven F., Biquand, Elise, Morgan, Tia M., Galloy, Maxime, Dessapt, Julien, Lavoie, Elise G., Blondeau, Andréanne, Smith, Brandon C., Mymryk, Joe S., Moody, Cary A., Fradet-Turcotte, Amélie·2019·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1906102116
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Abstract

Significance: Human papillomaviruses (HPVs) cause 5% of all cancers, including cervical cancers and a growing number of oropharyngeal cancers, which are reaching epidemic proportion. While HPV oncogenes promote the acquisition of cancer hallmarks such as sustained proliferation and resistance to cell death by targeting the p53 and pRb pathways, the mechanism by which they induce genomic instability leading to cellular transformation remains largely unknown. This paper describes how the HPV oncoprotein E7 directly impedes the cellular response to DNA double-strand breaks by interacting with a previously uncharacterized domain of the E3 ubiquitin ligase RNF168. As the function of RNF168 is essential for proper DNA repair, our findings reveal a mechanism by which HPV induces genomic instability and fuels cancer progression.

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Metadata

Authors
Sitz, J., Blanchet, S. A., Gameiro, S. F., Biquand, E., Morgan, T. M., Galloy, M., Dessapt, J., Lavoie, E. G., Blondeau, A., Smith, B. C., Mymryk, J. S., Moody, C. A., & Fradet-Turcotte, A.
Affiliations
  • Oncology Division, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval Research Center, Québec, QC, Canada G1R 1S3;
  • Department of Microbiology & Immunology, The University of Western Ontario, London, ON, Canada N6A 3K7;
  • Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;
  • Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
ORCID
Fradet-Turcotte, Amélie
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2019-09-09
Volume
116
Issue
39
Pages
19552-19562
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.1906102116
Cited by
77
References
9
Language
en
Licence
www.pnas.org/site/aboutpnas/licenses.xhtml (vor, 182 d)
Funders
  • Gouvernement du Canada | CIHR | Institute of Cancer Research (152948)
  • Gouvernement du Canada | CIHR | Institute of Infection and Immunity (142491)
  • Cancer Research Society (19590)
  • HHS | NIH | National Cancer Institute (CA181581, CA226523)

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CoChat. (2026). Citation check: Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response. https://app.cochat.ai/papers/10.1073/pnas.1906102116
The paper
Sitz, J., Blanchet, S. A., Gameiro, S. F., Biquand, E., Morgan, T. M., Galloy, M., Dessapt, J., Lavoie, E. G., Blondeau, A., Smith, B. C., Mymryk, J. S., Moody, C. A., & Fradet-Turcotte, A. (2019). Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1906102116