Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians

STAR: ultrafast universal RNA-seq aligner

Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174

Massively parallel digital transcriptional profiling of single cells

Zheng, G. X. Y., Terry, J. M., Belgrader, P., Ryvkin, P., Bent, Z. W., Wilson, R., Ziraldo, S. B., Wheeler, T. D., McDermott, G. P., Zhu, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms14049 · Cited by 7,353

Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing

Zheng, C., Zheng, L., Yoo, J.-K., Guo, H., Zhang, Y., Guo, X., Kang, B., Hu, R., Huang, J. Y., Zhang, Q., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.035 · Cited by 2,152

Single-cell mRNA quantification and differential analysis with Census

Qiu, X., Hill, A. J., Packer, J. S., Lin, D., Ma, Y.-A., & Trapnell, C. (2017) · Nature Methods · doi:10.1038/nmeth.4150 · Cited by 1,904

Single-cell RNA sequencing to explore immune cell heterogeneity

Papalexi, E., & Satija, R. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.76 · Cited by 1,806

HIV Infection, Inflammation, Immunosenescence, and Aging

Deeks, S. G. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-042909-093756 · Cited by 1,349

Cell intrinsic alterations underlie hematopoietic stem cell aging

Rossi, D. J., Bryder, D., Zahn, J. M., Ahlenius, H., Sonu, R., Wagers, A. J., & Weissman, I. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503280102 · Cited by 1,152 · cited 1×

Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer

Chung, W., Eum, H. H., Lee, H.-O., Lee, K.-M., Lee, H.-B., Kim, K.-T., Ryu, H. S., Kim, S., Lee, J. E., Park, Y. H., et al. (2017) · Nature Communications · doi:10.1038/ncomms15081 · Cited by 992 · cited 1×

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

Pang, W. W., Price, E. A., Sahoo, D., Beerman, I., Maloney, W. J., Rossi, D. J., Schrier, S. L., & Weissman, I. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116110108 · Cited by 991

Reading the immune clock: a machine learning model predicts mouse immune age from cellular patterns

Sim, H. B., Jang, J.-H., Mun, S., Ramos, S., Park, D.-H., Choi, Y.-J., Han, J., Lee, J.-B., Chung, H. S., Lee, K., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67393-1 · Cited by 6

Nasal CD4+ tissue-resident memory T cells provide cross-protective immunity to influenza

Mathew, N. R., Gailleton, R., Scharf, L., Schön, K., Enriquez, J., Axelsson, H., Strömberg, A., Lycke, N. Y., Bemark, M., Tang, K., et al. (2026) · The Journal of Experimental Medicine · doi:10.1084/jem.20251793 · Cited by 8

Terminally differentiated cytotoxic CD4 + T cells were clonally expanded in the brain lesion of radiation‐induced brain injury

Ma, X., Zuo, Y., Hu, X., Chen, S., Zhong, K., Xue, R., Gui, S., Liu, K., Li, S., Zhu, X., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14682 · Cited by 6

Targeting PD-1 and CD85j can restore intratumoral CD4 + GzmB + T-cell functions to combat MHC-II-expressing tumors

Wang, B., Wang, X., Wang, T., Meng, K., Yu, T., Xi, Y., Hu, S., Xiong, H., Qu, R., Yuan, Z., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-010890 · Cited by 7

CD4+ T lymphocyte responses to viruses and virus-relevant stimuli in teleost fish

Bela-Ong, D., Thompson, K. D., Kim, H. J., Park, S. B., & Jung, T. S. (2023) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2023.109007 · Cited by 6

Single-Cell RNA Sequencing of Donor-Reactive T Cells Reveals Role of Apoptosis in Donor-Specific Hyporesponsiveness of Kidney Transplant Recipients

van der List, A. C. J., Litjens, N. H. R., Brouwer, R. W. W., Klepper, M., den Dekker, A. T., van IJcken, W. F. J., & Betjes, M. G. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914463 · Cited by 6

Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22 enhances anti-viral immunity

Orozco, R. C., Marquardt, K., Pratumchai, I., Shaikh, A. F., Mowen, K. A., Domissy, A., Teijaro, J. R., & Sherman, L. A. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012095 · Cited by 5

Current Trends and Approaches to the Search for Genetic Determinants of Aging and Longevity

Станиславовна, К. С., Volobaev, V. P., Plotnikova, M. Y., Kupriyanova, D. A., Kuznetsova, I. L., Tyazhelova, T. V., & Rogaev, E. I. (2022) · Russian Journal of Genetics · doi:10.1134/s1022795422120067 · Cited by 7

Immune responses in aging adults

Weyand, C. M., & Goronzy, J. J. (2026) · Journal of Clinical Investigation · doi:10.1172/jci206227 · Cited by 5

CD4 CTLs in supercentenarians: Signs of adaptive expansion in healthy aging

Hashimoto, K., Kojima-Ishiyama, M., Inokuchi, H., Tagami, M., Sasaki, T., Mizuguchi, K., Okazaki, Y., Taniuchi, I., Ishigaki, K., Hirose, N., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117728 · Cited by 5

CircRNA expression profiling of PBMCs from patients with hepatocellular carcinoma by RNA‑sequencing

Han, Z., Feng, W., Hu, R., Ge, Q., Sun, X., Ma, W., Zhang, W., Xu, S., Zhan, B., Zhang, L., et al. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10902 · Cited by 5

Re-analysis of single-cell RNA-seq data reveals the origin and roles of cycling myeloid cells

Zhang, J., Shi, J., Wang, L., Liu, X., Cao, Z., Ruan, C., Ning, G., Feng, S., Yao, X. X., & Gao, S. (2024) · Stem Cells · doi:10.1093/stmcls/sxae030 · Cited by 5

Possibilities of using T-cell biophysical biomarkers of ageing

González‐Bermúdez, B., Abarca‐Ortega, A., González-Sánchez, M., la Fuente, M. D., & Plaza, G. R. (2022) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2022.29 · Cited by 4

Dietary restriction in senolysis and prevention and treatment of disease

Aminzadeh-Gohari, S., Kofler, B., & Herzog, C. M. S. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2153355 · Cited by 5

Genetic and Phenotypic Evidence for the Causal Relationship Between Aging and COVID-19Preprint

Ying, K., Zhai, R., Pyrkov, T. V., Mariotti, M., Fedichev, P. O., Shen, X., & Gladyshev, V. N. (2020) · medRxiv · doi:10.1101/2020.08.06.20169854 · Cited by 5

Tumor cell total mRNA expression shapes the molecular and clinical phenotype of cancerPreprint

Cao, S., Wang, J. R., Ji, S., Peng, Y., Montierth, M. D., Guo, S., Shen, J. P., Zhao, X. L., Chen, J., Lee, J. J., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.30.306795 · Cited by 5

Lytic IFNγ is stored in cytotoxic granules and coreleased with granzyme B to mediate cytotoxic T lymphocyte killing

Li, X., Schirra, C., Wirkner, M.-L., Tu, S.-M., Lin, C.-H., Hohmann, M., Gu, Y., Santiago, L., Pardo, J., Arretxe, I., et al. (2026) · Cellular and Molecular Immunology · doi:10.1038/s41423-026-01391-1 · Cited by 4

Expansion of peripheral cytotoxic CD4+ T cells in Alzheimer's disease: New insights from multi-omics evidence

Chen, J., Xie, J., Deng, F., Cai, J., Chen, S., Song, X., Xia, S., Shen, Q., Guo, X., & Tang, Y. (2024) · Genomics · doi:10.1016/j.ygeno.2024.110976 · Cited by 5

Nanotechnological interventions for the detection of pathogens through surface marker recognition

Sharma, C., Verma, M., Randhawa, S., & Acharya, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823426-6.00018-8 · Cited by 4

Central Centrifugal Cicatricial Alopecia Associated With PDL1 Loss and Increased Expression of Caspase 3: A Case Series

Smith, S. D. B., Woddor, N., Cassarino, D. S., Chen, W., Clemetson, N., & Nava, V. E. (2023) · American Journal of Dermatopathology · doi:10.1097/dad.0000000000002428 · Cited by 4

A statistical framework to identify cell types whose genetically regulated proportions are associated with complex diseases

Liu, W., Deng, W., Chen, M., Dong, Z., Zhu, B., Yu, Z., Tang, D., Sauler, M., Lin, C., Wain, L. V., et al. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010825 · Cited by 4

Healthy ageing and the kidney — lessons from centenarians

Arai, Y., & Yanagita, M. (2024) · Nature Reviews Nephrology · doi:10.1038/s41581-024-00860-y · Cited by 4

Combining Single-Cell RNA Sequencing and Mendelian Randomization to Explore Novel Drug Targets for Parkinson’s Disease

Wu, X., Wang, K., Li, Q., Zhang, Y., Wei, P., Shan, Y., & Zhao, G. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04700-3 · Cited by 5

Murine cytotoxic CD4+ T cells in the tumor microenvironment are at a hyper-maturation stage of Th1 CD4+ T cells sustained by IL-12

Lin, Y., Wu, C., Chen, P., Huang, C., Yang, C., Dutta, A., Huang, C., & Lin, C. (2023) · International Immunology · doi:10.1093/intimm/dxad015 · Cited by 5

Dynamic Clonal Hematopoiesis and Functional T-cell Immunity in a Super-centenarianPreprint

van den Akker, E. B., Makrodimitris, S., Hulsman, M., Brugman, M. H., Nikolic, T., Bradley, T., Waisfisz, Q., Baas, F., Jakobs, M. E., de Jong, D., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/788752 · Cited by 4

An atlas of gene regulatory networks for memory CD4 + T cells in youth and old agePreprint

Wayman, J. A., Thomas, A. L., Bejjani, A. T., Katko, A., Almanan, M., Godarova, A., Korinfskaya, S., Cazares, T. A., Yukawa, M., Kottyan, L. C., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.07.531590 · Cited by 4

DECEPTICON: a correlation-based strategy for RNA-seq deconvolution inspired by a variation of the Anna Karenina principle

Deng, F., Zou, J., Wang, M., Gu, Y., Wu, J., Gao, L., Ji, Y., Tong, H. H. Y., Chen, J., Chen, W., et al. (2025) · Briefings in Bioinformatics · doi:10.1093/bib/bbaf234 · Cited by 3

B Cell Levels in Centenarians, Semi-Supercentenarians, and Supercentenarians: Descriptive Analysis by Age, Sex, Cytomegalovirus Status, and Interleukin-6

Bertolazzi, G., Calabrò, A., Accardi, G., Aiello, A., Caruso, C., Corsale, A. M., Simone, M. D., Meraviglia, S., & Candore, G. (2026) · Journal of Ageing and Longevity · doi:10.3390/jal6010009 · Cited by 3

From molecular damage to regulatory constraint: epigenetic and metabolic limits of cellular plasticity in aging

Godlewski, A., & Dziaman, T. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1872180 · Cited by 4

Complete Transcriptome Analysis by 5′-End Single-Cell RNA-Seq with Random Priming

Kouno, T., Carninci, P., & Shin, J. W. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2281-0_11 · Cited by 3

Single-cell sequencing of the vermiform appendix during development identifies transcriptional relationships with appendicitis in preschool children

Meng, L., Yang, Y., He, S., Chen, H., Zhan, Y., Yang, R., Li, Z., Zhu, J., Zhou, J., Li, Y., et al. (2024) · BMC Medicine · doi:10.1186/s12916-024-03611-9 · Cited by 3

Deciphering Novel Communication Patterns in T Regulatory Cells From Very Old Adults

McTaggart, T., Lim, J. X., Smith, K. J., Heaney, B., McDonald, D., Hulme, G., Hussain, R., Coxhead, J. M., Mann, D. A., Sayer, A. A., et al. (2025) · Aging Cell · doi:10.1111/acel.70044 · Cited by 4

Aging and Viral Evolution Impair Immunity Against Dominant Pan‐Coronavirus‐Reactive T Cell Epitope

Loyal, L., Jürchott, K., Reimer, U., Meyer‐Arndt, L., Henze, L., Mages, N., Kostrzanowski, J., Reus, B., Mangold, M., Kruse, B., et al. (2025) · European Journal of Immunology · doi:10.1002/eji.202551888 · Cited by 3

FCRL3 is an immunoregulatory receptor that restrains the activation of human memory T lymphocytes

Bianchi, N., Foli, E., Mostanfar, M., Marzi, R., Spinella, M. C., Polletti, S., Pecoraro, M., Cassotta, A., Thakur, R. S., Jarrossay, D., et al. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20242474 · Cited by 3

Healthy aging—would cytotoxic T lymphocytes stand out?

Zhang, T., Zhang, J., & Wang, S. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01699-1 · Cited by 3

Expression of most retrotransposons in human blood correlates with biological aging

Tsai, Y.-T., Seymen, N., Thompson, I. R., Zou, X., Mumtaz, W., Gerlevik, S., Mufti, G. J., & Karimi, M. M. (2024) · eLife · doi:10.1101/2024.02.09.579582 · Cited by 2

Analysis of Target Molecules towards Anti-cancer Therapeutic Antibodies

Masuko, T. (2020) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.20-00183 · Cited by 3

Correction to: High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges

Nikolaou, C., Mühle, K., Schlickeiser, S., Japp, A. S., Matzmohr, N., Kunkel, D., Frentsch, M., & Thiel, A. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00235-y · Cited by 3

Memory cytotoxic SARS-CoV-2 spike protein-specific CD4+ T cells associate with viral controlPreprint

Dong, T., Liu, G., Felce, S. L., Yao, X., Yin, Z., Fries, A., Mentzer, A. J., Dong, D., Wang, W., Dejnirattisai, W., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1317569/v1 · Cited by 3

Healthy aging and aging-related kidney diseases: lessons from centenarians

Yamamoto, S., Arai, Y., Kosaka, T., Matsumoto, M., Yamada, R., Yoshikawa, T., & Yanagita, M. (2025) · Clinical Kidney Journal · doi:10.1093/ckj/sfaf284 · Cited by 2

Single-cell aging clocks: A precision tool for dissecting and targeting the aging process

Hao, Y., Xie, S., Wei, Y., Sun, X., Xiao, Y., Xie, X., Han, K., Wang, T., Wang, Z., Zhang, L., et al. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103040 · Cited by 2

Aging diminishes thymic output, reduces naive T cells, promotes memory T-cell accumulation, and impairs thymic regeneration

Konovalova, D. M., Cooper, M. D., Huang, S., Shane, D. X., Mulhern, J. S., Chiao, Y. A., Yuan, S. Y., & Ma, Y. (2026) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00242.2025 · Cited by 3

The immunology behind inflammaging—causes, sources, and mechanisms

Sturmlechner, I., LeBrasseur, N. K., Weyand, C. M., & Goronzy, J. J. (2026) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2026.05.031 · Cited by 3

IDEAL-Age: an interpretable deep learning framework for single-cell resolution profiling of immunological aging

Xu, Y., Luo, Z., He, K., Zhang, F., Zhang, Y., Wang, J., Wen, H., Li, Y., & Han, D. (2026) · Genome biology · doi:10.1186/s13059-026-04188-7 · Cited by 2

Unveiling aging dynamics in the hematopoietic system insights from single-cell technologies

Jin, X., Zhang, R., Fu, Y., Zhu, Q., Hong, L., Wu, A., & Wang, H. (2024) · Briefings in Functional Genomics · doi:10.1093/bfgp/elae019 · Cited by 2

QSAR Based Drug Repurposing: A New Paradigm in Breast Cancer Research

Mohapatra, R., Panda, P., & Rout, S. S. (2024) · Indian Journal of Pharmaceutical Education and Research · doi:10.5530/ijper.58.3.78 · Cited by 2

Co-expression of B7-H3 and LAG3 represents cytotoxicity of CD4+ T cells in humans

Tamura, Y., Ohki, S., Nagai, H., Yoshizato, R., Nishi, S., Jin, Y., Kitajima, Y., Guo, Y., Ichinohe, T., Okada, S., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1560383 · Cited by 3

Potential role of mesenchymal stem cells in T cell aging

Zhong, X., Chen, J., Bo, W., Wu, X., Li, M., Du, F., Chen, Y., Deng, S., Zhao, Y., Shen, J., et al. (2023) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02371-y · Cited by 4

The Genomic Loci of Specific Human tRNA Genes Exhibit Ageing-Related DNA HypermethylationPreprint

Acton, R., Yuan, W., Gao, F., Xia, Y., Bourne, E., Woźniak, E. L., Bell, J. T., Lillycrop, K. A., Wang, J., Dennison, E. M., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/870352 · Cited by 2

Portrayal of the human blood transcriptome of 3,388 adults and its relation to ageing and healthPreprint

Schmidt, M., Loeffler‐Wirth, H., Hopp, L., Arakelyan, A., Kirsten, H., Krohn, K., Burkhardt, R., Wirkner, K., Thiery, J., Engel, C., et al. (2019) · doi:10.21203/rs.2.19387/v1 · Cited by 2

Nasal tissue-resident memory CD4 + T cells persist after influenza A virus infection and provide heterosubtypic protectionPreprint

Mathew, N. R., Gailleton, R., Scharf, L., Schön, K., Enriquez, J., Axelsson, H., Strömberg, A., Lycke, N. Y., Bemark, M., Tang, K., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.06.602325 · Cited by 2

Integrating multi-omic QTLs and predictive models reveals regulatory architectures at immune related GWAS loci in CD4+ T cellsPreprint

Matos, M. R., Ghatan, S., Bankier, S., Thompson, T. V., Lundy, K., Suzuki, M., Doña-Termine, R., Stauber, J., Reynolds, D. M., Rosales, K., et al. (2026) · medRxiv · doi:10.64898/2026.01.27.26344979 · Cited by 3

If Jeanne Calment Were 122, That Is All the More Reason for Biosampling

Young, R. D. (2020) · Rejuvenation Research · doi:10.1089/rej.2020.2303 · Cited by 1

Special Issue “Centenarians—A Model to Study the Molecular Basis of Lifespan and Healthspan 2.0”

Caruso, C., & Puca, A. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713180 · Cited by 1

Is End-Stage Renal Disease Tumor Suppressive? Dispelling the Myths

Migita, T. (2024) · Cancers · doi:10.3390/cancers16183135 · Cited by 1

Osteoblast‐CD4 + CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age‐Related Bone Loss

Yang, B., Zhang, G., Zhu, Y., Wang, J., Feng, X., Fei, W., Dai, J., Hu, L., Zhang, Y., Cai, J., et al. (2025) · Advanced Science · doi:10.1002/advs.202501170 · Cited by 3

Cavitation bubble-assisted high-intensity focused ultrasound induces abscopal immune responses

Tada, R., Yamaguchi, T., Kanno, T., Endo‐Takahashi, Y., Hayakawa, M., Togashi, Y., Yoshizawa, S., Adachi, Y., & Negishi, Y. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115565 · Cited by 1

Analysis of immune cell remodeling and functional alterations induced by aging and obesity in mice

Sim, H. B., Choi, Y.-J., Mun, S., Ramos, S., Park, D.-H., Lee, J.-B., Jeong, S., & Kim, J.-J. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115735 · Cited by 1

Splicing-aware scRNA-Seq resolution reveals execution-ready programs in effector Tregs

Lukyanov, D. K., Egorov, E. S., Kriukova, V., Syrko, D., Kotliar, V., Ladell, K., Price, D. A., Franke, A., & Chudakov, D. M. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1013682 · Cited by 1

Household mold exposure and arthritis in older Chinese adults: evidence from the Chinese Longitudinal Healthy Longevity Survey (CLHLS)

Yu, G., Jiang, K., Chen, W., Tan, T., & Cong, L. (2026) · BMC Geriatrics · doi:10.1186/s12877-026-07096-4 · Cited by 1

The AICL-KLRF1 axis supports CD4-CD8 T cell communication and cytokine competence in pre-exhausted CD8+ T cells

Barone, M., Peidli, S., Neuschulz, A., Riesterer, K., Iwert, C., Junquera, L., Sai, S., Bolaji, O., Bakoueva, D., Appelt, C., et al. (2026) · EMBO Reports · doi:10.1038/s44319-026-00732-5 · Cited by 1

Blood as the mirror and modulator of aging: mechanistic insights and rejuvenation strategies

Kim, E., Kang, J. S., & Yang, Y. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01688-1 · Cited by 1

Genetic, Socioecological, and Health Research on Extreme Longevity in Semisupercentenarians and Supercentenarians: A Scoping Review

Abdelraheem, O. M., Kheir‐Mataria, W. A. E., & Chun, S. (2026) · Journal of Aging Research · doi:10.1155/jare/1605361 · Cited by 1

How Big Data and AI are revolutionizing human immunology

Teichmann, S. A. (2026) · Nature reviews. Immunology · doi:10.1038/s41577-026-01340-z · Cited by 1

Mito-Omics and immune function: Applying novel mitochondrial omic techniques to the context of the aging immune system

Silverstein, A. R., Flores, M. K., Miller, B., Kim, S., Yen, K., Mehta, H. H., & Cohen, P. (2020) · Translational Medicine of Aging · doi:10.1016/j.tma.2020.08.001 · Cited by 1

2) Frailty and Sarcopenia in Centenarians

Arai, Y., & Hirose, N. (2020) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.109.427 · Cited by 1

Therapeutic Potential

Maru, Y. (2021) · Springer eBooks · doi:10.1007/978-981-16-1757-7_16 · Cited by 1

Biomarkers of Healthy Longevity: Lessons from Supercentenarians in Japan

Arai, Y., & Hirose, N. (2022) · Springer eBooks · doi:10.1007/978-981-16-7977-3_3 · Cited by 1

SARS-CoV-2 Vaccination Responses in Anti-CD20-Treated Progressive Multiple Sclerosis Patients Show Immunosenescence in Antigen-Specific B and T Cells

Biasi, S. D., Ciobanu, A. L., Santacroce, E., Tartaro, D. L., Degliesposti, G., D’Angerio, M., Leccese, M., Cardi, M., Trenti, T., Cuccorese, M., et al. (2024) · Vaccines · doi:10.3390/vaccines12080924 · Cited by 1

Dissecting the landscape of activated CMV-stimulated CD4+ T cells in human by linking single-cell RNA-seq with T-cell receptor sequencingPreprint

Lyu, M., Wang, S., Gao, K., Wang, L., Li, B., & Tian, L. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.30.268433 · Cited by 1

Master Transcription Factors Regulate the DNA Methylation Landscape During Hepatocyte DifferentiationPreprint

Suzuki, T., Furuhata, E., Maeda, S., Kishima, M., Miyajima, Y., Tanaka, Y., Lim, J., Nishimura, H., Nakanish, Y., Shojima, A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.16.423165 · Cited by 1

慶應義塾大学医学部百寿総合研究センター

新井, 康. (2023) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.60.89 · Cited by 1

Scanpro: robust proportion analysis for single cell resolution dataPreprint

Alayoubi, Y., Bentsen, M. S., & Looso, M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.14.553234 · Cited by 1

Cytotoxic CD4 + T cells in the bone marrow compromise healthy ageing by enhancing granulopoiesisPreprint

Gabandé‐Rodríguez, E., Soto‐Heredero, G., Carrasco, E., Anerillas, C., Escrig-Larena, J. I., Delgado-Pulido, S., Francos-Quijorna, I., Heras, M. M. G. D. L., Fernández-Almeida, Á., Blanco, E. M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.26.577360 · Cited by 1

Expression of Most Retrotransposons in Human Blood Correlates with Biological AgingPreprint

Tsai, Y.-T., Seymen, N., Thompson, I. R., Zou, X., Mumtaz, W., Gerlevik, S., Mufti, G. J., & Karimi, M. M. (2024) · eLife · doi:10.7554/elife.96575.2 · Cited by 2

Lytic IFNγ is stored in granzyme B-containing cytotoxic granules and co-secreted by effector CD8⁺ T cellsPreprint

Li, X., Schirra, C., Wirkner, M.-L., Tu, S.-M., Lin, C.-H., Hohmann, M., Alawar, N., Chouaib, A. A., Becherer, U., Pattu, V., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.29.635520 · Cited by 1

Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosusPreprint

Trzupek, D., Lee, M., Hamey, F., Wicker, L. S., Todd, J. A., & Ferreira, R. C. (2021) · medRxiv · doi:10.1101/2021.04.27.21256106

Skin immunity in protection against Staphylococcus aureus infections

Mnich, M. E. (2022) · doi:10.33540/938

Discovering Molecular Regulators of Ageing Using Mixture Models With RNA-sequencing DataPreprint

Loganathan, S., Kulkarni, A. S., Fard, A. T., & Mar, J. C. (2022) · Research Square · doi:10.21203/rs.3.rs-1390473/v1

Correlation of Peripheral CD4+GranzB+CTLs with Disease Severity in Patients with Primary Sjögren’s SyndromePreprint

Wang, Q., Che, N., Lu, C., Sun, X., Wang, Y., Wang, Q., Tan, W., Zhou, L., Zhang, X., Xu, D., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-564919/v1

Integrated single-cell sequencing analysis reveals peripheral immune landscape across the human lifespanPreprint

Tong, R., Li, R., Zhao, Y., Luo, L., Zhong, J., Li, Z., Lin, W., Chen, Y., Shi, J., Gao, Y., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.11.498621 · Cited by 1

Bayesian differential analysis of cell type proportions: opinion

Karagiannis, T. T., Monti, S., & Paola Sebastiani, B. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1205499

Autoimmunity associated allele of tyrosine phosphatase gene PTPN22 enhances anti-viral immunityPreprint

Orozco, R. C., Marquardt, K., Pratumchai, I., Mowen, K. A., Domissy, A., Teijaro, J. R., & Sherman, L. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.28.546768

Can modulation of autophagy reinvigorate T cells in the elderly?

Inderberg, E. M., & Wälchli, S. (2023) · Ageing and Cancer Research & Treatment · doi:10.37155/2972-4759-2023-01-01-6

Supercentenarians

Kondapaka, M., & Kheirbek, R. (2023) · International perspectives on aging · doi:10.1007/978-3-031-30915-1_15

Scanpro: robust proportion analysis for single cell resolution dataPreprint

Looso, M., Alayoubi, Y., & Bentsen, M. S. (2023) · Research Square · doi:10.21203/rs.3.rs-3375942/v1

Blood mononuclear cell molecular landscape associated with tumor progression in triple-negative breast cancer

Patysheva, M. R., Frolova, A. A., Bragina, O., Fedorov, A. A., Александровна, В. М., Garbukov, Е. Y., Iamshchikov, P. S., Vashisth, M., Чердынцева, Н. В., & Gerashchenko, T. S. (2023) · Siberian Journal of Oncology · doi:10.21294/1814-4861-2023-22-5-197-204

Immune Cell Senescence and body Aging

Yoshimura, A. (2023) · Personalized Medicine Universe · doi:10.46459/pmu.2023006

Investigation and description of the New Brain and New Mind hypotheses

Klinedinst, B. S. (2021) · doi:10.31274/td-20240329-457

Splicing-aware resolution of scRNA-Seq dataPreprint

Lukyanov, D., Egorov, E., Kriukova, V., Ladell, K., Price, D., Franke, A., & Chudakov, D. (2024) · bioRxiv · doi:10.1101/2024.03.25.586675

Spatial analysis of the bone microenvironment reveals a novel osteoblast-CD4+ CTL crosstalk mediated by the SIRT1/DAAM2 axisPreprint

wang, Y.-X., Wang, L., Chen, H., Yang, B., zhang, G.-F., Wang, J., Fei, W., Cai, J., Ruan, B., Liu, Z., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4143931/v1

Expression of Most Retrotransposons in Human Blood Correlates with Biological AgingPreprint

Tsai, Y.-T., Seymen, N., Thompson, I. R., Zou, X., Mumtaz, W., Gerlevik, S., Mufti, G. J., & Karimi, M. M. (2024) · eLife · doi:10.7554/elife.96575.1

Intracellular cytokines in peritoneal leukocytes relate to lifespan in aging and long-lived female mice

de Toda, I. M., Félix, J., Cerro, E. D., & la Fuente, M. D. (2024) · Biogerontology · doi:10.1007/s10522-024-10110-0

Author response: Expression of Most Retrotransposons in Human Blood Correlates with Biological Aging

Tsai, Y.-T., Seymen, N., Thompson, I. R., Zou, X., Mumtaz, W., Gerlevik, S., Mufti, G. J., & Karimi, M. M. (2024) · eLife · doi:10.7554/elife.96575.2.sa0

eLife Assessment: Expression of Most Retrotransposons in Human Blood Correlates with Biological Aging

Ginhoux, F. (2024) · eLife · doi:10.7554/elife.96575.2.sa2

Reviewer #1 (Public Review): Expression of Most Retrotransposons in Human Blood Correlates with Biological Aging

Tsai, Y.-T., Seymen, N., Thompson, I. R., et al. (2024) · eLife · doi:10.7554/elife.96575.2.sa1

A Case of Spontaneous Regression of Lung Cancer After Biopsy

Saito, Y., Nishimura, K., Higashi, M., Arakawa, N., Abe, K., Matsui, N., Toriyama, M., Fujimoto, S., Nagai, T., & Oyama, K. (2024) · Haigan · doi:10.2482/haigan.64.310

Expression of Most Retrotransposons in Human Blood Correlates with Biological AgingPreprint

Tsai, Y.-T., Seymen, N., Thompson, I. R., Zou, X., Mumtaz, W., Gerlevik, S., Mufti, G. J., & Karimi, M. M. (2024) · eLife · doi:10.7554/elife.96575.3

Protocol for mapping T cell activation using single-cell RNA-seq

Li, H., Liu, Y., Wang, X., Yu, S., Wang, J., Hu, Y., Hong, N., & Jin, W. (2024) · STAR Protocols · doi:10.1016/j.xpro.2024.103409

Adaptive immune responses against common viruses are sustained and functional in end-of-life patients

Olofsson, A., Humbert, M., Rekha, R. S., Frankling, M. H., Lund‐Johansen, F., Bergman, P., Björkhem‐Bergman, L., & Karlsson, A. C. (2025) · iScience · doi:10.1016/j.isci.2025.112082 · Cited by 1

CD4 CTLs in supercentenarians: Signs of adaptive expansion in healthy aging

Hashimoto, K., Kojima-Ishiyama, M., Inokuchi, H., Tagami, M., Sasaki, T., Mizuguchi, K., Okazaki, Y., Taniuchi, I., Ishigaki, K., Hirose, N., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117728 · Cited by 5

Single‐Cell Transcriptomics Reveals Longevity Immune Remodeling Features Shared by Centenarians and Their Offspring

Dong, C., Miao, Y., Zhao, R. Z., Yang, M., Guo, A., Xue, Z., Li, T., Zhang, Q., Bao, Y., Shen, C., et al. (2022) · Advanced Science · doi:10.1002/advs.202204849 · Cited by 16

Uncovering an adaptive immune hallmark of extreme longevity

Wang, P. (2026) · Trends in Genetics · doi:10.1016/j.tig.2026.07.009

Single-cell analysis of human peripheral blood reveals high immune response activity in successful ageing individuals

Wang, Y., Zhang, Y., Gong, G., Liu, Q., Li, L., Zhang, M., Shen, S., Wang, R., Wu, J., & Xu, W. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.112011 · Cited by 10

Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity

Karagiannis, T. T., Dowrey, T. W., Villacorta-Martín, C., Montano, M. A., Reed, E. R., Belkina, A. C., Andersen, S. L., Perls, T. T., Monti, S., Murphy, G. J., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104514 · Cited by 88