Feasibility of long-term storage of graded information by the Ca2+/calmodulin-dependent protein kinase molecules of the postsynaptic density.
Open accessAbstract
The feasibility of long-term information storage by brain type II Ca2+/calmodulin-dependent protein kinase molecules is explored. Recent evidence indicates that this protein has switch-like properties. Equations are derived showing that a single kinase holoenzyme could form a bistable switch having the stability necessary to encode long-term memory, and that a group of kinase molecules, such as that contained within the postsynaptic density, could form a device capable of storing graded information.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Crick and Lisman proposed a molecular model for information storage that could withstand molecular turnover.
“As discussed above, they proposed a molecular model for information storage that could withstand molecular turnover.”
From Synaptic memory and CaMKII (2023) · cites this paper as [70]
Cites
MacDermott, A. B., Mayer, M. L., Westbrook, G. L., Smith, S. J., & Barker, J. L. (1986) · Nature · doi:10.1038/321519a0 · Cited by 1,835 · see citing works
Intracellular injections of EGTA block induction of hippocampal long-term potentiation
Lynch, G., Larson, J., Kelso, S., Barrionuevo, G., & Schottler, F. (1983) · Nature · doi:10.1038/305719a0 · Cited by 1,116 · see citing works
Neurobiology: Memory and molecular turnover
Crick, F. (1984) · Nature · doi:10.1038/312101a0 · Cited by 392 · see citing works
Lai, Y., Nairn, A. C., & Greengard, P. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4253 · Cited by 292 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The molecular basis of CaMKII function in synaptic and behavioural memory
Lisman, J., Schulman, H., & Cline, H. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn753 · Cited by 1,860 · see citing works
Self-citationStress, Depression, and Neuroplasticity: A Convergence of Mechanisms
Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795 · see citing works
Structure–function of the multifunctional Ca2+/calmodulin-dependent protein kinase II
HUDMON, A., & SCHULMAN, H. (2002) · Biochemical Journal · doi:10.1042/bj20020228 · Cited by 615 · see citing works
How does PKMζ maintain long-term memory?
Sacktor, T. C. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2949 · Cited by 431 · see citing works
Pettit, D. L., Perlman, S., & Malinow, R. (1994) · Science · doi:10.1126/science.7997883 · Cited by 329 · see citing works
Brody, C. D., Romo, R., & Kepecs, A. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00050-3 · Cited by 284 · see citing works
Mechanism of Graded Persistent Cellular Activity of Entorhinal Cortex Layer V Neurons
Fransén, E., Tahvildari, B., Egorov, A. V., Hasselmo, M. E., & Alonso, A. A. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.036 · Cited by 279 · see citing works
Boeckers, T. M., Kreutz, M. R., Winter, C., Zuschratter, W., Smalla, K.-H., Sanmarti-Vila, L., Wex, H., Langnaese, K., Bockmann, J., Garner, C. C., et al. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-15-06506.1999 · Cited by 257 · see citing works
Miller, P., Zhabotinsky, A. M., Lisman, J. E., & Wang, X.-J. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030107 · Cited by 199 · see citing works
Self-citationLearning mechanisms: the case for CaM-KII
Lisman, J., Malenka, R. C., Nicoll, R. A., & Malinow, R. (1997) · Science · doi:10.1126/science.276.5321.2001 · Cited by 147 · see citing works
Self-citationNicoll, R. A., & Schulman, H. (2023) · Physiological Reviews · doi:10.1152/physrev.00034.2022 · Cited by 126 · see citing works
“This immediately suggested a role in information storage (15, 70).”
BackgroundCalcium dynamics of spines depend on their dendritic location
Holthoff, K., Tsay, D., & Yuste, R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00576-7 · Cited by 117 · see citing works
CA1 Long-Term Potentiation Is Diminished but Present in Hippocampal Slices from α-CaMKII Mutant Mice
Hinds, H. L., Tonegawa, S., & Malinow, R. (1998) · Learning & Memory · doi:10.1101/lm.5.4.344 · Cited by 86 · see citing works
Cooke, S. F., Wu, J., Plattner, F., Errington, M., Rowan, M., Peters, M., Hirano, A., Bradshaw, K. D., Anwyl, R., Bliss, T. V. P., et al. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.111559 · Cited by 77 · see citing works
Synaptic memory survives molecular turnover
Lee, J., Chen, X., & Nicoll, R. A. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2211572119 · Cited by 27 · see citing works
- Authors
- Lisman, J. E., & Goldring, M. A.
- Affiliations
- Brandeis University (US)
- ORCID
- Lisman, J E
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1988-07
- Volume
- 85
- Issue
- 14
- Pages
- 5320-5324
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC281742
- OpenAlex
- W2087445908
- Cited by
- 257
- References
- 4
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 4 · 2019: 4 · 2018: 8 · 2017: 3 · 2016: 3 · 2015: 7 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 9.59
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- calcium/calmodulin-dependent protein kinase, postsynaptic density, long-term memory, bistable switch, switch-like behavior, holoenzyme, synaptic plasticity, computational model of memory
- MeSH terms
- Calcium, Calmodulin, Humans, Kinetics, Memory, Models, Biological, Phosphorylation, Protein Kinases, Synapses
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
