The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index; none of the 2 sources its claims cite is checked for support yet.
BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.
Open accessAbstract
The BCL2 protooncogene encodes an inner mitochondrial membrane protein that blocks programmed cell death. BCL2 was isolated from the chromosomal breakpoint of follicular B-cell lymphoma. Transgenic mice that overexpress BCL2 display extended survival of resting B cells. In this study we use a monospecific anti-human BCL2 antibody to define the distribution of BCL2 protein within organized tissues. BCL2 is restricted within germinal centers to the follicular mantle and to portions of the light zone implicated in the selection and maintenance of plasma cells and memory B cells. BCL2 is present in the surviving T cells in the thymic medulla. All hematopoietic lineages that derive from a renewing stem cell also display BCL2. A limited number of nonlymphoid tissues demonstrate BCL2 and can be grouped as (i) glandular epithelium in which hormones or growth factors regulate hyperplasia and involution, (ii) complex differentiating epithelium such as skin and intestine characterized by long-lived stem cells, and (iii) long-lived postmitotic cells such as neurons. Within these tissues that demonstrate apoptotic cell turnover, BCL2 is often topographically restricted to long-lived or proliferating cell zones. BCL2's function as an antidote to apoptosis may confer longevity to progenitor and effector cells in these tissues.
Overview
AI snapshot
Written from the paper’s full text.
TL;DR
Using a monospecific anti-human BCL2 antibody, the authors map BCL2 protein across organized tissues and find it topographically restricted to long-lived or proliferating zones in tissues with apoptotic turnover. BCL2 is present in selected lymphoid, hematopoietic, glandular epithelial, complex epithelial, and postmitotic neuronal compartments.
Key findings
- Within germinal centers, BCL2 is restricted to the follicular mantle and portions of the light zone implicated in selection and maintenance of plasma cells and memory B cells.
- BCL2 is present in surviving T cells in the thymic medulla and in all hematopoietic lineages derived from a renewing stem cell.
- A limited set of nonlymphoid tissues shows BCL2: glandular epithelium regulated by hormones/growth factors, complex differentiating epithelium such as skin and intestine with long-lived stem cells, and long-lived postmitotic cells such as neurons.
- In tissues with apoptotic cell turnover, BCL2 is often topographically restricted to long-lived or proliferating cell zones; the authors suggest BCL2 may confer longevity to progenitor and effector cells.
Methods
- The study uses a monospecific anti-human BCL2 antibody to define BCL2 protein distribution within organized tissues.
- The provided text does not report sample sizes, tissue sources, staining protocols, or quantitative analysis details.
Limitations
- The paper’s abstract does not state limitations.
- Evident from the provided text: only the abstract and reference list are available, so sample composition, antibody specificity controls, quantification, and full results cannot be assessed. No quantitative values are reported in the provided text.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
4 Own interpretation · 4 Own result · 2 No full text of the sources · 1 No basis given
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“All hematopoietic lineages that derive from a renewing stem cell also display BCL2.”
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The anti-human BCL2 antibody used in this study is monospecific for BCL2.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“BCL2 is present in the surviving T cells in the thymic medulla.”
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The anti-human BCL2 antibody used in this study is monospecific for BCL2.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“A limited number of nonlymphoid tissues demonstrate BCL2”
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The anti-human BCL2 antibody used in this study is monospecific for BCL2.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“BCL2 is restricted within germinal centers to the follicular mantle and to portions of the light zone implicated in the selection and maintenance of plasma cells and memory B cells.”
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The anti-human BCL2 antibody used in this study is monospecific for BCL2.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Within these tissues that demonstrate apoptotic cell turnover, BCL2 is often topographically restricted to long-lived or proliferating cell zones.”
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The anti-human BCL2 antibody used in this study is monospecific for BCL2.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“glandular epithelium in which hormones or growth factors regulate hyperplasia and involution”
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The anti-human BCL2 antibody used in this study is monospecific for BCL2.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“long-lived postmitotic cells such as neurons”
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The anti-human BCL2 antibody used in this study is monospecific for BCL2.
In the paper
“Transgenic mice that overexpress BCL2 display extended survival of resting B cells.”
What the sources say
- Not checked — no full text of the sourcecites McDonnell et al., 1989 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“complex differentiating epithelium such as skin and intestine characterized by long-lived stem cells”
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The anti-human BCL2 antibody used in this study is monospecific for BCL2.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“BCL2's function as an antidote to apoptosis may confer longevity to progenitor and effector cells in these tissues.”
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The anti-human BCL2 antibody used in this study is monospecific for BCL2.
- It may state two separate claims as one. 1
In the paper
“The BCL2 protooncogene encodes an inner mitochondrial membrane protein that blocks programmed cell death.”
What the sources say
- Not checked — no full text of the sourcecites Hockenbery et al., 1990 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The paper relies on this without support.
The anti-human BCL2 antibody used in this study is monospecific for BCL2.
“we use a monospecific anti-human BCL2 antibody”
Citations
Cites
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
Hockenbery, D., Nuñez, G., Milliman, C., Schreiber, R. D., & Korsmeyer, S. J. (1990) · Nature · doi:10.1038/348334a0 · Cited by 3,720
Self-citationBcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
Vaux, D., Cory, S., & Adams, J. (1988) · Nature · doi:10.1038/335440a0 · Cited by 3,355
Cheng, H., & Leblond, C. P. (1974) · American Journal of Anatomy · doi:10.1002/aja.1001410407 · Cited by 1,737
Savill, J. S., Wyllie, A. H., Henson, J. E., Walport, M. J., Henson, P. M., & Haslett, C. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113970 · Cited by 1,536
Cohen, J., & Duke, R. C. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.132.1.38 · Cited by 1,406
Regressive Events in Neurogenesis
Cowan, W. M., Fawcett, J. W., O'Leary, D. D. M., & Stanfield, B. B. (1984) · Science · doi:10.1126/science.6474175 · Cited by 1,316
McDonnell, T. J., Deane, N., Platt, F. M., Nunez, G., Jaeger, U., McKearn, J. P., & Korsmeyer, S. J. (1989) · Cell · doi:10.1016/0092-8674(89)90174-8 · Cited by 1,213
Self-citationCleary, M. L., Smith, S. D., & Sklar, J. (1986) · Cell · doi:10.1016/0092-8674(86)90362-4 · Cited by 1,212
Bakhshi, A., Jensen, J. P., Goldman, P., Wright, J. J., McBride, O. W., Epstein, A. L., & Korsmeyer, S. J. (1985) · Cell · doi:10.1016/s0092-8674(85)80070-2 · Cited by 1,177
Self-citation
Cited by
Sorted by citations
Items 1,001–1,100 of 1,244
CD4+ T Cells Downregulate Bcl-2 in Germinal Centers
Schenka, A. A., Müller, S., Fournié, J., et al. (2005) · Journal of Clinical Immunology · doi:10.1007/s10875-005-4084-4 · Cited by 8
Manusirivithaya, S., Siriaunkgul, S., Khunamornpong, S., et al. (2006) · Gynecologic Oncology · doi:10.1016/j.ygyno.2005.12.037 · Cited by 8
“It was later shown in subsequent studies that bcl-2 expression is not only specific for this translocation but is also found in normal tissues, long-lived stem cells demonstrating apoptotic turnover, postmitotic cells and in certain tumor [16,17].”
BackgroundAnalysis of a regulatory element in the 5′‐untranslated region of the bcl‐2 gene
Körner, I., Weber-Nordt, R., Pfaff, P., et al. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00229-9 · Cited by 8
Inoue, T., Yoneda, K., Kakurai, M., et al. (2002) · Journal of Cutaneous Pathology · doi:10.1034/j.1600-0560.2002.290509.x · Cited by 8
O’Connor, L., & Strasser, A. (1999) · Results and problems in cell differentiation · doi:10.1007/978-3-540-69184-6_9 · Cited by 8
Expression and function of Fas and Fas ligand on peripheral blood lymphocytes in normal subjects
Kawakami, A., Eguchi, K., Matsuoka, N., et al. (1998) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(98)90111-1 · Cited by 8
Effects of Altered Bcl‐2 Expression on B Lymphocyte Selectiona
Mandik, L., Katsumata, M., & Erikson, J. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb52043.x · Cited by 8
Evaluation of bcl-2 gene expression in papilloma of larynx in children
Niedzielska, G., & Kocki, J. (2000) · International Journal of Pediatric Otorhinolaryngology · doi:10.1016/s0165-5876(00)00305-0 · Cited by 8
Takano, Y., Saegusa, M., Masuda, M., et al. (1997) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf01240123 · Cited by 8
Primary non‐Hodgkin lymphoma of the humerus following traumatic injury: case report
Stemberga, V., Dobi-Babić, R., Bosnar, A., et al. (2003) · Hematological Oncology · doi:10.1002/hon.713 · Cited by 8
Goumenos, D. S., Tsamandas, A. C., Kalliakmani, P., et al. (2004) · Renal Failure · doi:10.1081/jdi-120039818 · Cited by 8
Distribution of Bcl-2 gene expression and its prognostic value in non-small cell lung cancer.
Yilmaz, A., Savaş, İ., Sak, S. D., et al. (2005) · PubMed · Cited by 8
Expression of Bcl-2 Oncogene Product in Primary Non-Hodgkin's Malignant Lymphoma of the Oral Cavity
Takahashi, H., Kawazoe, K., Fujita, S., et al. (1996) · Pathology - Research and Practice · doi:10.1016/s0344-0338(96)80129-4 · Cited by 8
The Polymerase Chain Reaction: Its use in the Molecular Characterization and Diagnosis of Cancers
Kawasaki, E. S. (1992) · Cancer Investigation · doi:10.3109/07357909209024799 · Cited by 8
Mutant Glucocorticoid Receptors in Lymphomaa
Ip, M. M., Shea, W., & Rowan, B. G. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb32274.x · Cited by 8
Lymphocyte Programmed Cell Death
Ashwell, J. D. (1994) · Elsevier eBooks · doi:10.1016/b978-0-12-653955-4.50006-3 · Cited by 8
Regulation of Apoptosis by the Transforming Gene Products of Adenovirus
White, E., Rao, L., Chiou, S., Tseng, C.-C., Sabbatini, P., Gonzalez, M., & Verwaerde, P. (1994) · Springer eBooks · doi:10.1007/978-1-4757-9217-1_4 · Cited by 8
Tissue array analysis for the differentiation of gliosis from gliomas
Villaamil, V. M. (2011) · Molecular Medicine Reports · doi:10.3892/mmr.2011.462 · Cited by 7
Insights into Canine Infertility: Apoptosis in Chronic Asymptomatic Orchitis
Morawietz, J., Körber, H., Packeiser, E., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076083 · Cited by 7
“Bcl-2 protein expression in immune cells under physiological and pathological conditions is well known in B and T lymphocytes [72,73].”
BackgroundFuentes, M., Andrews, M., & Arredondo, M. (2013) · Biological Trace Element Research · doi:10.1007/s12011-013-9666-z · Cited by 7
“These studies showed that in the presence of elevated glucose concentrations, an increase in Bax expression is observed, and hence the increased apoptosis in human and animal tissues [27].”
BackgroundDifferent Mechanisms of Drug Resistance in Myelodysplastic Syndromes and Acute Myeloid Leukemia
Messingerová, L., Imrichova, D., Coculova, M., Zelina, M., Pavlíková, L., Kavcová, H., Šereš, M., Boháčová, V., Lakatoš, B., Sulová, Z., et al. (2016) · InTech eBooks · doi:10.5772/63483 · Cited by 9
“Bcl-2 was shown to be restricted in tissues character‐ ized by apoptotic cell death [45].”
BackgroundLack of Bcl-2 expression in feline follicular lymphomas
Henrich, M., Bauknecht, A., Hecht, W., et al. (2019) · Journal of Veterinary Diagnostic Investigation · doi:10.1177/1040638719877916 · Cited by 7
“In contrast, proliferative zones of spleen, lymph nodes, and tonsils lack the expression of Bcl-2, except for single nonproliferating positive cells.(13,23,29) A few non-lymphoid tissues with high rates of apoptosis also express Bcl-2, such as glandular epithelium regulated by hormones or growth factors, complex diffe…”
BackgroundBostwick, D. G., & Liang Cheng, C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-54941-7.00009-8 · Cited by 7
Prostate Stem Cells and Cancer in Animals
Nikitin, A. Y., Nafus, M. G., Zhou, Z., et al. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-933-8_16 · Cited by 7
Apoptotic Events in Male Germ Cells and in Mature Mammalian Spermatozoa
Tapia, J. A., & Peña, F. J. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9873-4_8 · Cited by 7
Interleukin-12 Inhibits Apoptosis in Chronic Lymphatic Leukemia (CLL) B Cells
Schuhknecht, S., Duensing, A. U., Dallmann, I., et al. (2002) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/108497802760804718 · Cited by 7
Aluminum Trichloride Disorders Bile Acid Secretion and Induces Hepatocyte Apoptosis in Rats
She, Y., Zhao, H., Zhu, Y., et al. (2015) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-014-0380-z · Cited by 7
INTERLEUKIN-7 RECEPTOR α CHAIN–DEPENDENT SIGNALING IS REQUIRED FOR T-CELL DEVELOPMENT
Puel, A., & Leonard, W. J. (2000) · Immunology and Allergy Clinics of North America · doi:10.1016/s0889-8561(05)70133-8 · Cited by 7
Apoptosis and Gastrointestinal Disease
Palejwala, A. A., & Watson, A. J. M. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/j.1536-4801.2000.tb07138.x · Cited by 7
Fujisawa, M., Kanzaki, M., Tatsumi, N., et al. (2000) · Endocrine Research · doi:10.1080/07435800009040146 · Cited by 7
Biopathologic Features of Hodgkin's Disease
Chilosi, M., & Pizzolo, G. (1995) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199509054424 · Cited by 7
Bostwick, D. G., & Meiers, I. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-3966-2.00032-1 · Cited by 7
Apoptosis in Alphavirus Encephalitis
Griffin, D. E., & Hardwick, J. M. (1998) · Seminars in Virology · doi:10.1006/smvy.1998.0152 · Cited by 7
DeFranco, A. L. (1992) · Current Biology · doi:10.1016/0960-9822(92)90227-2 · Cited by 7
Tosi, P., Visani, G., Ottaviani, E., et al. (1996) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1996.tb01351.x · Cited by 7
“As overexpression of bcl-2 gene has been reported to be connected with resistance to apoptosis both in normal (34) and in neoplastic models (35) and has been described as playing a role in protecting leukaemic cells from drug-induced apoptosis (36), we quantitated bcl-2 protein in ALL cells in order to evaluate whethe…”
BackgroundHuang, Y., He, Z., Zhou, H., et al. (2023) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010234591230919074245 · Cited by 6
Chromosomal abnormalities, p53 and Bcl-2 expression and clinical outcome in choroidal melanoma
Erol, N., ??ner, ?., Artan, S., et al. (2004) · Melanoma Research · doi:10.1097/00008390-200412000-00006 · Cited by 6
Immunohistochemical markers in lymphoid malignancies: Protein correlates of molecular alterations
Ho, C., & Rodig, S. J. (2015) · Seminars in Diagnostic Pathology · doi:10.1053/j.semdp.2015.02.016 · Cited by 7
Expression Analysis of p53, Ki-67 and bcl-2 in Pre-Malignant Lesions of the Cervix
Godoy, A. E. G., Bazzo, K. O., Moura, L. B. D., et al. (2014) · Open Journal of Obstetrics and Gynecology · doi:10.4236/ojog.2014.48067 · Cited by 6
El-Domyati, M. M., Ahmad, H., Nagy, I. V., et al. (2007) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2006.02090.x · Cited by 6
You, Y., Durán, R. C., Jiang, L., Dong, X., Zong, S., Snyder, M. P., & Wu, J. Q. (2018) · Integrative Biology · doi:10.1039/c8ib00059j · Cited by 6
Expression of bcl-2 in the Epithelial Lining of Odontogenic Keratocysts
Jahanshahi, G., Talebi, A., & Shirvani, A. (2006) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 6
Cell Death in HIV Pathogenesis and Its Modulation by Retinoids
Szondy, Z., Tóth, R., Szegezdi, É., et al. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03905.x · Cited by 6
The synthesis of Bcl-2 and other proteins in the neoplastic follicles of follicular lymphoma.
Lampert, I. A. (1999) · Molecular Pathology · doi:10.1136/mp.52.1.29 · Cited by 6
Haemopoietic growth factors in acute myeloblastic and lymphoblastic leukaemia
Löwenberg, B., & Touw, I. P. (1992) · Baillière s Clinical Haematology · doi:10.1016/s0950-3536(11)80009-0 · Cited by 6
Jacysyn, J. F., Conde-Moscatelli, M., Barrichello, C., et al. (2002) · Experimental Cell Research · doi:10.1006/excr.2001.5406 · Cited by 6
“In this regard, DP thymocytes are the most sensitive cells and express the lowest Bcl-2 level among all thymocyte subpopulations [22].”
BackgroundRatech, H. (1993) · American Journal of Clinical Pathology · doi:10.1093/ajcp/99.4.381 · Cited by 6
Overexpressed Bcl-xL prevents bacterial superantigen-induced apoptosis of thymocytes in vitro
Takahashi, T., Honda, H., Hirai, H., et al. (1997) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400214 · Cited by 6
Glick, S. H., Howell, L. P., & White, R. D. (1996) · The Journal of Urology · doi:10.1097/00005392-199605000-00071 · Cited by 6
Ito, Y., Hayashi, N., Sasaki, Y., et al. (1996) · International Hepatology Communications · doi:10.1016/0928-4346(96)00263-0 · Cited by 6
Evidence for trans regulation of apoptosis in intertypic somatic cell hybrids.
Gourdeau, H., & Walker, P. R. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.6125 · Cited by 6
Differential expression of CD95, Bcl‐2, and Bax in rat gastric chief and parietal cells
Neu, B., Herrmuth, H., Ernst, F., et al. (2001) · Microscopy Research and Technique · doi:10.1002/jemt.1106 · Cited by 6
“In contrast to our findings, earlier immunohistochemical studies indicated that Bcl-2 expression is restricted to stem cells and proliferative zones in the gastrointestinal tract (Hockenbery et al., 1991; Tsujimoto and Croce, 1986).”
Overview of Germinal Center Function and Structure in Normal and Genetically Engineered Mice
Tsiagbe, V. K., & Thorbecke, G. J. (1998) · Springer eBooks · doi:10.1007/978-3-662-13141-1_1 · Cited by 6
Lequarré, A., Feugang, J. M., Malhomme, O., Donnay, I., Massip, A., Dessy, F., & Langendonckt, A. V. (2000) · Molecular Reproduction and Development · doi:10.1002/1098-2795(200101)58:1 · Cited by 72
Genomic Abnormalities as Biomarkers and Therapeutic Targets in Acute Myeloid Leukemia
Ribeiro, S., Eiring, A. M., & Khorashad, J. S. (2021) · Cancers · doi:10.3390/cancers13205055 · Cited by 5
“The BCL-2 protein is expressed by hematopoietic lineages and various other normal tissues such as the epithelium and neurons [95].”
BackgroundNormal Lymphoid Organs and Tissues
Campo, E., Jaffe, E. S., & Harris, N. L. (2011) · Elsevier eBooks · doi:10.1016/b978-0-7216-0040-6.00008-3 · Cited by 5
B Cell Activation and Apoptosis
Sarthou, P., Benhamou, L. E., & Cazenave, P. (1995) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-79437-7_2 · Cited by 5
Epidermal growth factor receptor, somatostatin and Bcl-2 in human pancreatic tumor xenografts
Zalatnai, A. (1999) · Pathology & Oncology Research · doi:10.1053/paor.1999.0176 · Cited by 5
Bursch, W. (1994) · Springer eBooks · doi:10.1007/978-3-642-79088-1_7 · Cited by 5
HARMON, B. V., & Allan, D. J. (1997) · Advances in genetics · doi:10.1016/s0065-2660(08)60447-2 · Cited by 5
Rhouma, K. B., Schimchowitsch, S., Stoeckel, M. E., et al. (1997) · Archives of Physiology and Biochemistry · doi:10.1076/apab.105.2.216.12919 · Cited by 5
Control of histone modifications
Davie, J., & Spencer, V. A. (1999) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(1999)75:32+ · Cited by 146
Disturbance of plasma and platelet thrombospondin levels in sickle cell disease
Browne, P., Mosher, D. F., Steinberg, M. H., & Hebbel, R. P. (1996) · American Journal of Hematology · doi:10.1002/(sici)1096-8652(199604)51:4 · Cited by 97
Mini-Review: Cellular Mechanisms of Disease Series Bcl-2 and the Regulation of Programmed Cell Death
Reed, J. C. (2013) · Cited by 5
Synthetic Estrogen-Mediated Alterations in Uterine Cell Fate
Hendry, W. J., Zheng, X. L., Leavitt, W. W., et al. (1997) · Springer eBooks · doi:10.1007/978-1-4612-1944-6_20 · Cited by 5
Necrospermia: Etiology and Management
Lecomte, P. J., Barthélémy, C., Nduwayo, L., et al. (1999) · Springer eBooks · doi:10.1007/978-1-4612-1522-6_6 · Cited by 4
Indolent lymphoma: follicular lymphoma and the microenvironment—insights from the microscope
Harris, N. L. (2014) · Hematology · doi:10.1182/asheducation-2014.1.158 · Cited by 4
A case report: Spindle cell lipoma in the floor of mouth
Takeda, Y., Nogami, S., Iwama, R., et al. (2020) · Journal of Oral and Maxillofacial Surgery Medicine and Pathology · doi:10.1016/j.ajoms.2020.03.006 · Cited by 4
Al-Harmooshee, M. B. H. (2011) · Medical Journal of Babylon · Cited by 4
D'Herde, K. G. M. A., Diez‐Fraile, A., & Lammens, T. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9293-0_2 · Cited by 4
Importance of Stromal Stem Cells in Prostate Carcinogenesis Process
Asadi, F., Lazennec, G., & Jorgense, C. (2011) · InTech eBooks · doi:10.5772/14879 · Cited by 3
“In adult, BCL-2 expression is limited to renewing stem cell populations such as those found in prostatic glandular epithelia (Hockenbery et al, 1991).”
BackgroundLima, M. A. V. C., & da Silva, B. B. (2011) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-011-1932-8 · Cited by 4
Intermittent Hormone Therapy in Nonmetastatic Prostate Cancer
Opfermann, K. J., Lai, Z., Essenmacher, L., et al. (2006) · Clinical Genitourinary Cancer · doi:10.3816/cgc.2006.n.030 · Cited by 4
Tubular Cell Apoptosis and Proliferation in the Early Phase of Renal Damage in Uninephrectomized SHR
Rodrı́guez-López, A. M., Flores, O., Arévalo, M. A., et al. (2002) · Kidney & Blood Pressure Research · doi:10.1159/000049430 · Cited by 4
Conhecimentos atuais sobre a biologia dos melanócitos no folículo piloso humano
Oliveira, I. O., & de Almeida, H. L. (2003) · Anais Brasileiros de Dermatologia · doi:10.1590/s0365-05962003000300010 · Cited by 4
Kasprzak, A., Hausmann, M., Małkowska-Lanzafame, A., et al. (2014) · Journal of Medical Science · doi:10.20883/medical.e42 · Cited by 4
Falco, M. D., Laforgia, V., Fedele, V., et al. (2001) · The Histochemical Journal · doi:10.1023/a:1016302400996 · Cited by 4
“A role for Bcl-2 in regulating the naturally occurring cell death that takes place in tissues of all organisms, is suggested by the topographic distribution of the Bcl-2 protein (Hockenbery et al. 1991).”
Derossi, D. R., Ito, K., Filho, J. D. C., et al. (2003) · Jornal Brasileiro de Patologia e Medicina Laboratorial · doi:10.1590/s1676-24442003000300010 · Cited by 4
“(16) observaram a expressão de bcl2 em vários tecidos humanos adultos e a classificaram em três categorias:”
BackgroundRadioprotective effects of the immunostimulating lauroylpeptide LtriP (RP 56142)
Migliore-Samour, D., Bousseau, A., Caillaud, J., et al. (1993) · Cellular and Molecular Life Sciences · doi:10.1007/bf01989422 · Cited by 4
Subcellular localization of Bcl‐2 protein in synovial sarcoma
Kawauchi, S., Noguchi, S., Fukuda, T., et al. (1997) · Pathology International · doi:10.1111/j.1440-1827.1997.tb03717.x · Cited by 4
Pantazis, P., Chatterjee, D., Han, Z., Wyche, J. H., DeJesus, A., & Giovanella, B. C. (1996) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1996.tb00494.x · Cited by 4
Angermüller, S., Schumann, J., Fahimi, H. D., et al. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07918.x · Cited by 4
Lebedeva, I. V., & Stein, C. A. (2000) · Molecular Biology · doi:10.1023/a:1026679826610 · Cited by 4
Insights from transgenic mice regarding the role of bcl-2 in normal and neoplastic lymphoid cells
Cory, S., Harris, A. W., & Strasser, A. (1995) · Springer eBooks · doi:10.1007/978-94-011-0553-8_10 · Cited by 4
Spatial omics representation and functional tissue module inference using graph Fourier transformPreprint
Chang, Y., Liu, J., Ma, A., Jiang, S., Krull, J. E., Yeo, Y. Y., Liu, Y., Rodig, S. J., Barouch, D. H., Fan, R., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.10.519929 · Cited by 3
“As a result, CD20 confirmed the MZ structure, and the expression of BCL-2 suggested a novel marker on MZ structures 53 .”
BackgroundDNA Ploidy and Proliferative Activity in bcl-2 Expressed Non-small Cell Lung Cancer
Kim, Y., Park, K. O., Kim, H. J., et al. (1996) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.1996.11.2.101 · Cited by 4
Pathogenesis of Fulminant Hepatic Failure
Soultati, A. S., & Dourakis, S. P. (2007) · Annals of Gastroenterology · Cited by 3
Long, R. M., Morrissey, C. M., Walsh, S. E., et al. (2007) · British Journal of Urology · doi:10.1111/j.1464-410x.2007.06932.x · Cited by 3
New classification of low-grade lymphoma
Grogan, T. M. (1996) · Annals of Oncology · doi:10.1093/annonc/7.suppl_6.s3 · Cited by 3
Increased Apoptosis Associated with Depressed Type of Early Intestinal Gastric Cancer
Masutani, M., Suzuki, J., Matsuda, T., et al. (2001) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2001.tb02142.x · Cited by 3
The Bak protein expression in germinal centers of hypertrophied adenoids in children
Musiatowicz, M., Koda, M., & Sulkowski, S. (2007) · International Journal of Pediatric Otorhinolaryngology · doi:10.1016/j.ijporl.2007.09.020 · Cited by 3
Effects of BCL-2 over-expression on B cells in transgenic rats and rat hybridomas
Iscache, A.-L., Ménoret, S., Tesson, L., Remy, S., Usal, C., Pedros, C., Saoudi, A., Buelow, R., & Anegón, I. (2011) · International Immunology · doi:10.1093/intimm/dxr071 · Cited by 3
Suprabasal BCL-2 expression does not sensitize to chemically-induced skin cancer in transgenic mice.
Schenkel, J., Weiher, H., Fürstenberger, G., et al. (2008) · PubMed · Cited by 3
T11TS repress gliomagenic apoptosis of bone marrow hematopoietic stem cells
Mondal, S., Hazra, I., Datta, A., Sk, O. F., Moitra, S., Tripathi, S. K., & Chaudhuri, S. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25874 · Cited by 3
Dysregulation of Programmed Cell Death in Cancer toward a Molecular Understanding of Bcl-2
Reed, J. C. (1998) · Springer eBooks · doi:10.1007/978-1-4899-1352-4_13 · Cited by 3
The BCL-2 Gene: A Regulator of Programmed Cell Death
Hockenbery, D. M. (1994) · Springer eBooks · doi:10.1007/978-1-4757-9217-1_10 · Cited by 3
Self-citationApoptosis in Hematopoiesis and Leukemogenesis
Chapman, R. S., Gregory, C. D., & Dive, C. (1996) · Blood cell biochemistry · doi:10.1007/978-0-585-31728-1_7 · Cited by 3
Apoptosis: Signal Transduction and Modes of Activation
Caron‐Leslie, L. M., & Cidlowski, J. A. (1993) · Springer eBooks · doi:10.1007/978-1-4613-8336-9_1 · Cited by 3
Coppock, D. L., & Nathanson, L. (1993) · Cancer treatment and research · doi:10.1007/978-1-4615-3080-0_10 · Cited by 3
“Apoptosis may be induced by chemotherapeutic agents [16] and, interestingly, may be controlled by oncogenes, including bcl-2 [17,18] and myc [19].”
BackgroundIn Vivo Patterns of Apoptosis-Regulating Protein Expression in Kaposi's Sarcoma
Montmayeur, F., Krajewski, S., Bejui-Thivolet, F. O., et al. (1997) · Applied Immunohistochemistry · doi:10.1097/00022744-199706000-00005 · Cited by 3
Metadata
- Authors
- Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M., & Korsmeyer, S. J.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1991-08-15
- Volume
- 88
- Issue
- 16
- Pages
- 6961-6965
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC52213
- OpenAlex
- W1970629830
- Semantic Scholar
- d825dc162ad208c572711f59c9aa1c7974e89492
- Cited by
- 1,252
- References
- 40
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 9 · 2022: 4 · 2021: 5 · 2020: 10 · 2019: 9 · 2018: 9 · 2017: 9 · 2016: 7 · 2015: 10 · 2014: 15 · 2013: 10 · 2012: 12
- FWCI
- 26.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- Bcl-2, apoptosis, germinal center, light zone, plasma cells, memory B cells, thymic medulla, hematopoietic stem cells, tissue distribution, epithelial stem cells, follicular B-cell lymphoma, transgenic mice
- MeSH terms
- Adult, Bone Marrow, Breast, Cell Survival, Digestive System, Female, Humans, Immunoenzyme Techniques, Male, Neurons, Pancreas, Prostate, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Proto-Oncogenes, Skin, Thymus Gland, Palatine Tonsil, Proto-Oncogene Proteins c-bcl-2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-18, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-18 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
