The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index; none of the 2 sources its claims cite is checked for support yet.
BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.
Open accessAbstract
The BCL2 protooncogene encodes an inner mitochondrial membrane protein that blocks programmed cell death. BCL2 was isolated from the chromosomal breakpoint of follicular B-cell lymphoma. Transgenic mice that overexpress BCL2 display extended survival of resting B cells. In this study we use a monospecific anti-human BCL2 antibody to define the distribution of BCL2 protein within organized tissues. BCL2 is restricted within germinal centers to the follicular mantle and to portions of the light zone implicated in the selection and maintenance of plasma cells and memory B cells. BCL2 is present in the surviving T cells in the thymic medulla. All hematopoietic lineages that derive from a renewing stem cell also display BCL2. A limited number of nonlymphoid tissues demonstrate BCL2 and can be grouped as (i) glandular epithelium in which hormones or growth factors regulate hyperplasia and involution, (ii) complex differentiating epithelium such as skin and intestine characterized by long-lived stem cells, and (iii) long-lived postmitotic cells such as neurons. Within these tissues that demonstrate apoptotic cell turnover, BCL2 is often topographically restricted to long-lived or proliferating cell zones. BCL2's function as an antidote to apoptosis may confer longevity to progenitor and effector cells in these tissues.
Overview
AI snapshot
Written from the paper’s full text.
TL;DR
Using a monospecific anti-human BCL2 antibody, the authors map BCL2 protein across organized tissues and find it topographically restricted to long-lived or proliferating zones in tissues with apoptotic turnover. BCL2 is present in selected lymphoid, hematopoietic, glandular epithelial, complex epithelial, and postmitotic neuronal compartments.
Key findings
- Within germinal centers, BCL2 is restricted to the follicular mantle and portions of the light zone implicated in selection and maintenance of plasma cells and memory B cells.
- BCL2 is present in surviving T cells in the thymic medulla and in all hematopoietic lineages derived from a renewing stem cell.
- A limited set of nonlymphoid tissues shows BCL2: glandular epithelium regulated by hormones/growth factors, complex differentiating epithelium such as skin and intestine with long-lived stem cells, and long-lived postmitotic cells such as neurons.
- In tissues with apoptotic cell turnover, BCL2 is often topographically restricted to long-lived or proliferating cell zones; the authors suggest BCL2 may confer longevity to progenitor and effector cells.
Methods
- The study uses a monospecific anti-human BCL2 antibody to define BCL2 protein distribution within organized tissues.
- The provided text does not report sample sizes, tissue sources, staining protocols, or quantitative analysis details.
Limitations
- The paper’s abstract does not state limitations.
- Evident from the provided text: only the abstract and reference list are available, so sample composition, antibody specificity controls, quantification, and full results cannot be assessed. No quantitative values are reported in the provided text.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
4 Own interpretation · 4 Own result · 2 No full text of the sources · 1 No basis given
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“All hematopoietic lineages that derive from a renewing stem cell also display BCL2.”
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The anti-human BCL2 antibody used in this study is monospecific for BCL2.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“BCL2 is present in the surviving T cells in the thymic medulla.”
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The anti-human BCL2 antibody used in this study is monospecific for BCL2.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“A limited number of nonlymphoid tissues demonstrate BCL2”
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The anti-human BCL2 antibody used in this study is monospecific for BCL2.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“BCL2 is restricted within germinal centers to the follicular mantle and to portions of the light zone implicated in the selection and maintenance of plasma cells and memory B cells.”
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The anti-human BCL2 antibody used in this study is monospecific for BCL2.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Within these tissues that demonstrate apoptotic cell turnover, BCL2 is often topographically restricted to long-lived or proliferating cell zones.”
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The anti-human BCL2 antibody used in this study is monospecific for BCL2.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“glandular epithelium in which hormones or growth factors regulate hyperplasia and involution”
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The anti-human BCL2 antibody used in this study is monospecific for BCL2.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“long-lived postmitotic cells such as neurons”
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The anti-human BCL2 antibody used in this study is monospecific for BCL2.
In the paper
“Transgenic mice that overexpress BCL2 display extended survival of resting B cells.”
What the sources say
- Not checked — no full text of the sourcecites McDonnell et al., 1989 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“complex differentiating epithelium such as skin and intestine characterized by long-lived stem cells”
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The anti-human BCL2 antibody used in this study is monospecific for BCL2.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“BCL2's function as an antidote to apoptosis may confer longevity to progenitor and effector cells in these tissues.”
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Rests on an assumption: The anti-human BCL2 antibody used in this study is monospecific for BCL2.
- It may state two separate claims as one. 1
In the paper
“The BCL2 protooncogene encodes an inner mitochondrial membrane protein that blocks programmed cell death.”
What the sources say
- Not checked — no full text of the sourcecites Hockenbery et al., 1990 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The paper relies on this without support.
The anti-human BCL2 antibody used in this study is monospecific for BCL2.
“we use a monospecific anti-human BCL2 antibody”
Citations
Cites
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
Hockenbery, D., Nuñez, G., Milliman, C., Schreiber, R. D., & Korsmeyer, S. J. (1990) · Nature · doi:10.1038/348334a0 · Cited by 3,720
Self-citationBcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
Vaux, D., Cory, S., & Adams, J. (1988) · Nature · doi:10.1038/335440a0 · Cited by 3,355
Cheng, H., & Leblond, C. P. (1974) · American Journal of Anatomy · doi:10.1002/aja.1001410407 · Cited by 1,737
Savill, J. S., Wyllie, A. H., Henson, J. E., Walport, M. J., Henson, P. M., & Haslett, C. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113970 · Cited by 1,536
Cohen, J., & Duke, R. C. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.132.1.38 · Cited by 1,406
Regressive Events in Neurogenesis
Cowan, W. M., Fawcett, J. W., O'Leary, D. D. M., & Stanfield, B. B. (1984) · Science · doi:10.1126/science.6474175 · Cited by 1,316
McDonnell, T. J., Deane, N., Platt, F. M., Nunez, G., Jaeger, U., McKearn, J. P., & Korsmeyer, S. J. (1989) · Cell · doi:10.1016/0092-8674(89)90174-8 · Cited by 1,213
Self-citationCleary, M. L., Smith, S. D., & Sklar, J. (1986) · Cell · doi:10.1016/0092-8674(86)90362-4 · Cited by 1,212
Bakhshi, A., Jensen, J. P., Goldman, P., Wright, J. J., McBride, O. W., Epstein, A. L., & Korsmeyer, S. J. (1985) · Cell · doi:10.1016/s0092-8674(85)80070-2 · Cited by 1,177
Self-citation
Cited by
Sorted by citations
Items 801–900 of 1,244
Influence of the site of small bowel resection on intestinal epithelial cell apoptosis
Haxhija, E. Q., Yang, H., Spencer, A. U., et al. (2005) · Pediatric Surgery International · doi:10.1007/s00383-005-1576-5 · Cited by 23
“Bcl-2 is an anti-apoptotic member of the bcl-2 family and has the capability to prevent cell death [26].”
BackgroundRestoring Apoptosis with BH3 Mimetics in Mature B-Cell Malignancies
Jullien, M., Gomez‐Bougie, P., Chiron, D., & Touzeau, C. (2020) · Cells · doi:10.3390/cells9030717 · Cited by 24
“In normal hematopoietic tissue, BCL-2 expression is mostly found in bone marrow precursor cells, in the mantle zone of germinal centers, as well as in the surviving T cells in the thymic medulla [28].”
BackgroundTopographic Distribution of bcl-2 Protein in Feline Tissues in Health and Neoplasia
Madewell, B. R., Candour-Edwards, R., Edwards, B. F., et al. (1999) · Veterinary Pathology · doi:10.1354/vp.36-6-565 · Cited by 23
Microscopic thymoma and myasthenia gravis.
Puglisi, F., Finato, N., Mariuzzi, L., et al. (1995) · Journal of Clinical Pathology · doi:10.1136/jcp.48.7.682 · Cited by 23
Apoptosis in the mammary gland and breast cancer
Hahm, H. A., & Davidson, N. E. (1998) · Endocrine Related Cancer · doi:10.1677/erc.0.0050199 · Cited by 23
“Several members of the bcl-2 family including bcl-2, bax, and bcl-xL are expressed by normal mammary epithelial cells in culture and breast tissue (Hockenbery et al. 1991, Leek et al. 1994, Sabourin et al. 1994, Bargou et al. 1995, Ferrieres et al. 1997).”
BackgroundNiwa, M., Hara, A., Iwai, T., Sassa, T., & Mori, H. (1997) · Neurological Research · doi:10.1080/01616412.1997.11740872 · Cited by 23
Hsu, H., Mountz, J. D., Williams, R. W., Shelton, B. J., Yang, P., Matsuki, Y., Xu, X., Dodd, C. H., Li, L., Geiger, H., et al. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00004-0 · Cited by 23
Effect of Hypertrophic Scar Fibroblast-Derived Exosomes on Keratinocytes of Normal Human Skin
Cui, H. S., Joo, S. Y., Lee, S. Y., Cho, Y. S., Kim, D. H., & Seo, C. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076132 · Cited by 23
“For example, proliferating basal keratinocytes highly express Bcl-2, which is absent in suprabasal keratinocytes [47]; a gra-”
BackgroundExpression of bcl-2 in Papillary Thyroid Cancers and its Prognostic Value
Aksoy, M., Giles, Y., Kapran, Y., et al. (2005) · Acta chirurgica Belgica · doi:10.1080/00015458.2005.11679794 · Cited by 22
Expression of Bcl-2 and p53 at the fetal-maternal interface of rhesus monkey.
Wei, P., Jin, X. S., Zhang, X., et al. (2005) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-3-4 · Cited by 22
Izawa, H., Yonemitsu, N., Shin, T., & Sugihara, H. (1999) · Auris Nasus Larynx · doi:10.1016/s0385-8146(99)00005-x · Cited by 23
Apoptosis of Villous Epithelial Cells and Follicle-Associated Epithelial Cells in Chicken Cecum.
Takeuchi, T., Kitagawa, H., Imagawa, T., & Uehara, M. (1999) · Journal of Veterinary Medical Science · doi:10.1292/jvms.61.149 · Cited by 22
“In mouse small intestines, apoptosis of the epithelial cells is regulated by the bcl-2 gene [2, 8, 11].”
BackgroundMarone, M., Bonanno, G., Rutella, S., et al. (2002) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190210195 · Cited by 22
The Diagnostic and Prognostic Value of Bone Marrow Immunostaining in Myelodysplastic Syndromes
Deliliers, G. L., Annaloro, C., Soligo, D. V., et al. (1998) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199809092679 · Cited by 22
Meda, B. A., Frost, M., Newell, J., et al. (2003) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200307000-00003 · Cited by 22
“BCL-2 is expressed in a range of nonneoplastic tissues, including subsets of lymphocytes and nonlymphoid cells such as glandular epithelium and postmitotic cells such as neurons.(8) Fetal tissues display a wider range of BCL-2 expression than adult tissues, and its topographic distribution in this setting suggests a r…”
BackgroundOldenburg, N. B. E., Evans-Storms, R. B., & Cidlowski, J. A. (1997) · Endocrinology · doi:10.1210/en.138.2.810 · Cited by 22
Regulators of apoptosis in human breast cancer
Eissa, S., Labib, R. A., Khalifa, A., et al. (1999) · Clinical Biochemistry · doi:10.1016/s0009-9120(99)00025-9 · Cited by 22
Hague, A. (1998) · Carcinogenesis · doi:10.1093/carcin/19.9.1691 · Cited by 22
Gupta, A. (2016) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2016/13899.8157 · Cited by 21
González‐González, R., Molina‐Frechero, N., Damián‐Matsumura, P., et al. (2015) · Disease Markers · doi:10.1155/2015/301781 · Cited by 21
“Several studies have identifiedmolecular alterations associated with AM development and progression [22], including those associated with proteins involved in the apoptotic and cellular proliferation pathways [23, 24].”
BackgroundMandal, D. P., Lahiry, L., Bhattacharyya, A., Bhattacharyya, S., Sa, G., & Das, T. (2005) · International Immunopharmacology · doi:10.1016/j.intimp.2005.09.005 · Cited by 21
Is there an association between cigarette smoking and gland size in benign prostatic hyperplasia?
Matzkin, H., Cytron, S., & Simon, D. (1996) · The Prostate · doi:10.1002/(sici)1097-0045(199607)29:1 · Cited by 16
Apoptotic Cell Death in Chronic Lymphocytic Leukemia
Robertson, L. E., & Plunkett, W. K. (1993) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199309064265 · Cited by 21
Apoptosis‐associated proteins in oral hairy leukoplakia
Chrysomali, E., Js, G., Dekker, N., et al. (1996) · Oral Diseases · doi:10.1111/j.1601-0825.1996.tb00238.x · Cited by 21
Expression of bcl-2 oncoprotein in various types of glomerulonephritis and renal allografts
Nakopoulou, L., Stefanaki, K., Papadakis, J., et al. (1996) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/11.6.997 · Cited by 21
Genetic Evidence for an Additional Factor Required for Erythropoietin-Induced Signal Transduction
Gaffen, S. L., Lai, S. Y., Longmore, G. D., Liu, K. D., & Goldsmith, M. A. (1999) · Blood · doi:10.1182/blood.v94.1.74.413k36_74_86 · Cited by 21
Ceccarelli, C., Santini, D., Chieco, P., et al. (1995) · Annals of Oncology · doi:10.1093/oxfordjournals.annonc.a059158 · Cited by 21
Effect of preoperative 5-fluorouracil on apoptosis of advanced gastric cancer
Inada, T., Ichikawa, A., Igarashi, S., et al. (1997) · Journal of Surgical Oncology · doi:10.1002/(sici)1096-9098(199706)65:2 · Cited by 20
Bcl-2 expression and apoptosis in the regulation of hematopoietic stem cells
Orelio, C. C., & Dzierzak, E. A. (2007) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190601032529 · Cited by 20
Botros, S. S., Hammam, O. A., Mahmoud, M. R., et al. (2010) · Apmis · doi:10.1111/j.1600-0463.2010.02645.x · Cited by 20
Waggoner, S. E., Baunoch, D., Anderson, S. A., Leigh, F., & Zagaja, V. G. (1998) · Annals of Surgical Oncology · doi:10.1007/bf02303648 · Cited by 20
Immunohistochemistry of ‘tertiary lymphoid follicles' in oral amalgam‐associated lichenoid lesions
Larsson, Ä., & Warfvinge, G. (1998) · Oral Diseases · doi:10.1111/j.1601-0825.1998.tb00277.x · Cited by 20
Regulation of apoptosis is impaired in atrophic gastritis associated with gastric cancer
Rosania, R., Varbanova, M., Wex, T., Langner, C., Bornschein, J., Giorgio, F., Ierardi, E., & Malfertheiner, P. (2017) · BMC Gastroenterology · doi:10.1186/s12876-017-0640-7 · Cited by 21
Evtodienko, Y. V., Teplova, V. V., Ts, A., et al. (1999) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006913526643 · Cited by 20
Ziv, I., Offen, D., Haviv, R., et al. (1997) · APOPTOSIS · doi:10.1023/a:1026408313758 · Cited by 20
“It was not identified in the cellular plasma membrane.(7) This selective subcellular distribution may suggest its role in the control of traffic of apoptosis mediators such as Ca, from stores in the ER to the nucleus.”
BackgroundSurvival in small cell lung carcinoma is independent of Bcl-2 expression
Maitra, A., Amirkhan, R. H., Saboorian, M. H., et al. (1999) · Human Pathology · doi:10.1016/s0046-8177(99)90099-0 · Cited by 20
Cell cycle analysis of p26-BCL-2 protein levels in proliferating lymphoma and leukemia cell lines.
Reed, J., Tanaka, S., & Cuddy, M. (1992) · PubMed · Cited by 20
Kondo, S., Yin, D., Takeuchi, J., et al. (1994) · British Journal of Cancer · doi:10.1038/bjc.1994.321 · Cited by 20
Yang, H. S., Chen, S., Tang, Y., et al. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.05.017 · Cited by 19
Saito, K., Mori, S., Tanda, N., et al. (2000) · Journal of Periodontology · doi:10.1902/jop.2000.71.1.44 · Cited by 19
Hepatocyte steatosis in HCV patients promotes fibrosis by enhancing TGF‐β liver expression
Gabriel, A., Ziółkowski, A., Radlowski, P., et al. (2007) · Hepatology Research · doi:10.1111/j.1872-034x.2007.00258.x · Cited by 19
Satoh, T., Sasatomi, E., Yamasaki, F., et al. (1998) · Endothelium · doi:10.3109/10623329809072199 · Cited by 19
Hoyes, K. P. (2000) · International Journal of Radiation Biology · doi:10.1080/09553000050176199 · Cited by 19
5 Mechanisms of Programmed Cell Death in Caenorhabditis elegans and Vertebrates
Miura, M., & Yuan, J. (1996) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)60427-5 · Cited by 19
Expression of bcl-2, bcl-x, bax and bak in Renal Parenchyma, Oncocytomas and Renal Cell Carcinomas
Pammer, J., Exner, M., Regele, H. M., et al. (1998) · Pathology - Research and Practice · doi:10.1016/s0344-0338(98)80086-1 · Cited by 19
bcl‐2 Expression in Prostate Cancer and its Relationship to Cell Cycle and Prognosis
Matsushima, H., Hosaka, Y., Suzuki, M., et al. (1996) · International Journal of Urology · doi:10.1111/j.1442-2042.1996.tb00494.x · Cited by 19
Evidence for stem cells in cultures of mouse prostate epithelial cells
Sawicki, J. A., & Rothman, C. J. (2001) · The Prostate · doi:10.1002/pros.10031 · Cited by 19
“, sites where putative stem cells are believed to reside [4].”
BackgroundType II muscle fibers are stained by anti-Fas antibody
Yamada, H., Nakagawa, M., Higuchi, I., et al. (1995) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(95)00242-5 · Cited by 19
Masuda, M., Takano, Y., Iki, M., et al. (1997) · The Journal of Urology · doi:10.1016/s0022-5347(01)64306-4 · Cited by 19
Expression of bcl-2-like immunoreactivity in the normal breast and in breast cancer
Nathan, B., Anbazhagan, R., Dyer, M. J. S., et al. (1993) · The Breast · doi:10.1016/0960-9776(93)90055-k · Cited by 19
Expression of Bcl-2 protein in murine neural cells in culture
Mizuguchi, M., Ikeda, K., Asada, M., Mizutani, S., & Kamoshita, S. (1994) · Brain Research · doi:10.1016/0006-8993(94)91064-2 · Cited by 19
JAK-STAT signaling as an ARDS therapeutic target: Status and future trends
Zhang, Y., Gao, Z., Jiang, F., Yan, H., Yang, B., He, Q., Luo, P., Xu, Z., & Yang, X. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115382 · Cited by 18
Kuang, W., Huang, R.-Z., Fang, Y.-L., et al. (2018) · RSC Advances · doi:10.1039/c8ra04640a · Cited by 18
“27,28 A previous study proved that the ratio of Bcl-2/Bax expression is vital in the regulation of apoptosis.”
Induction of programmed cell death in a dorsal root ganglia × neuroblastoma cell line
Linnik, M. D., Hatfield, M. D., Swope, M. D., & Ahmed, N. K. (1993) · Journal of Neurobiology · doi:10.1002/neu.480240403 · Cited by 18
In vitro induction and in vivo expression of bcl-2 in the hNT neurons
Daadi, M. M., Saporta, S., Willing, A. E., Zigova, T., McGrogan, M. P., & Sanberg, P. R. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00621-9 · Cited by 18
BCL-2 Expression and Prognosis in Childhood Acute Leukemia
Tsurusawa, M., Saeki, K., Katano, N., et al. (1998) · Pediatric Hematology and Oncology · doi:10.3109/08880019809167229 · Cited by 18
Nakamura, T., Sakai, T., & Nariya, S. (1995) · Pathology International · doi:10.1111/j.1440-1827.1995.tb03388.x · Cited by 18
Expression of bcl-2 antagonist bak in inflammatory and neoplastic skin diseases
Tomková, H., Fujimoto, W., & Arata, J. (1997) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1997.19392054.x · Cited by 18
Berghella, A. M., Pellegrini, P., Contasta, I., et al. (1998) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.1998.13.225 · Cited by 18
Scott, N., Martin, I. G., Jack, A., et al. (1996) · Molecular Pathology · doi:10.1136/mp.49.3.m151 · Cited by 18
Response of intracranial melanoma metastases to stereotactic radiosurgery
Gieger, M., Wu, J. K., Ling, M. N., Wazer, D. E., Tsai, J.-S., & Engler, M. J. (1997) · Radiation Oncology Investigations · doi:10.1002/(sici)1520-6823(1997)5:2 · Cited by 47
Molecular Pathways in Low Grade B-Cell Lymphoma
Gaïdano, G., Pastore, C., Capello, D., et al. (1997) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199709058607 · Cited by 18
Siziopikou, K. P., & Khan, S. (2005) · Applied immunohistochemistry & molecular morphology · doi:10.1097/00129039-200503000-00003 · Cited by 17
Effect of survivin on tumor growth of colorectal cancer in vivo.
Cai, Y., Ma, W., Huang, X., Cao, L., Li, H., Jiang, Y., Lu, N.-N., & Yin, Y. (2015) · PubMed · Cited by 17
Therapeutic Potential of Resveratrol in Lymphoid Malignancies
Khan, O. S., Bhat, A. A., Krishnankutty, R., et al. (2016) · Nutrition and Cancer · doi:10.1080/01635581.2016.1152386 · Cited by 17
“Follicular Lymphoma (FL) represents one of the common non-Hodgkin’s lymphoma of increasing worldwide incidence, which is consistently associated with the t (14;18) translocation leading to the rearrangement and overexpression of the Bcl-2 gene (73,74).”
BackgroundThe effects of miRNA-1180 on suppression of pancreatic cancer.
Gu, L., Zhang, J., Shi, M., et al. (2017) · PubMed · Cited by 17
Kang, S., Yang, Y.-J., Wu, Y.-L., Chen, Y.-T., Li, L., & Tian, Y. (2010) · Microvascular Research · doi:10.1016/j.mvr.2009.11.003 · Cited by 16
Immunoreactivity for bcl‐2 protein in cutaneous lymphomas and lymphoid hyperplasias
Cerroni, L., & Kerl, H. (1995) · Journal of Cutaneous Pathology · doi:10.1111/j.1600-0560.1995.tb00766.x · Cited by 17
Hauptmann, S., Hartung, P., Leclere, A., Denkert, C., Pest, S., Klosterhalfen, B., & Dietel, M. (1998) · APOPTOSIS · doi:10.1023/a:1009613325845 · Cited by 17
“As observed in spheroids, the proliferating basal cells of epithelia which are not under endocrine control express HSPs and loose these molecules in turn of differentiation.(39) Thus, the observation of both proliferation and inverse apoptosis gradients in MCTS resembles the situation in labile tissue (e.”
BackgroundThe herbal medicine inchin-ko-to (TJ-135) induces apoptosis in cultured rat hepatic stellate cells
Ikeda, H., Nagashima, K., Yanase, M., Tomiya, T., Arai, M., Inoue, Y., Tejima, K., Nishikawa, T., Watanabe, N., Kitamura, K., et al. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.09.024 · Cited by 17
Bcl-2 and Bcl-X expression in gangliogliomas
Prayson, R. A. (1999) · Human Pathology · doi:10.1016/s0046-8177(99)90097-7 · Cited by 17
EXPRESSION OF bcl-2 IN RHEUMATOID ARTHRITIS
Isomäki, P., Söderström, K., Punnonen, J., Roivainen, A., Luukkainen, R., Merilahti-Palo, R., Nikkari, S., Lassila, O., & Toivanen, P. (1996) · Lara D. Veeken · doi:10.1093/rheumatology/35.7.611 · Cited by 17
Colonic Cell Proliferation and Apoptosis in Rodent Species
Chapkin, R. S., & Lupton, J. R. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4149-3_12 · Cited by 17
Glucocorticoid-Induced Death of Immune Cells: Mechanisms of Action
Montague, J. W., & Cidlowski, J. A. (1995) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-79437-7_4 · Cited by 17
Immunologic Cytotoxicity in Alopecia Areata: Apoptosis of Dermal Papilla Cells in Alopecia Areata
Nortis, D. A., Duke, R. C., Whang, K. K., et al. (1995) · Journal of Investigative Dermatology · doi:10.1038/jid.1995.31 · Cited by 17
“The proto-oncogene Bcl-2 is found in the basal keratinocyte layer [4], and may act as an inhibitor of basal kerati nocyte apoptosis.”
BackgroundShen, C. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.3.622 · Cited by 17
“The Bcl-2 gene product is a 25 kDa membrane protein that functions to prevent cell apoptosis (21,22) and plays a central role in inducing resistance to radiotherapy and chemotherapy (23).”
BackgroundBcl-2 expression in thalamus, brainstem, cerebellum and visual cortex of adult primate
Vinet, J., Bernier, P. J., & Parent, A. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(02)00004-4 · Cited by 17
Co-expression of Fas and Fas ligand in human non-astrocytic glial tumors
Frankel, B., Longo, S. L., & Ryken, T. C. (1999) · Acta Neuropathologica · doi:10.1007/s004010051095 · Cited by 17
DiCroce, P. A., & Krontiris, T. G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10137 · Cited by 17
SERMADIRAS, S., DUMAS, M., JOLY-BERVILLIE, R., et al. (1997) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1997.19812085.x · Cited by 17
Matsuura, H., Hayashi, N., Kawamura, J., et al. (2000) · European Urology · doi:10.1159/000020120 · Cited by 17
“Tumor progression under endocrine treatment indicates that androgen–independent cell populations have attained a sufficient mass to determine the further clinical course. The mechanism of androgen resistance of prostate cancer cells remains unclear, but the involvement of Ki–67, bcl–2 and p53 oncoprotein had been disc…”
BackgroundRehman, S., Crow, J. C., & Revell, P. A. (2000) · Pathology & Oncology Research · doi:10.1007/bf03187328 · Cited by 17
Loss of heterozygosity analysis to diagnose adrenal cortical carcinoma
MANSUKHANI, M. M., & Greenebaum, E. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19990825)87:4 · Cited by 1
Cell suicide in the developing nervous system: a functional neural network model
Brown, G. D. A., Hulme, C., Hyland, P. D., & Mitchell, I. (1994) · Cognitive Brain Research · doi:10.1016/0926-6410(94)90022-1 · Cited by 17
Expression of cytokines and factors modulating apoptosis by human sinusoidal leucocytes
Jonsson, J. R., Edwards-Smith, C. J., Catania, S. C., Morotomi, Y., Hogan, P., Clouston, A. D., Bansal, A. S., Lynch, S. V., Strong, R. W., & Powell, E. E. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80388-8 · Cited by 17
Apoptosis and cancer chemotherapy
Hickman, J. A., Potten, C. S., Merritt, A. J., et al. (1995) · Springer eBooks · doi:10.1007/978-94-011-0553-8_14 · Cited by 17
Silverman, G. A., Yang, E., Proffitt, J. H., et al. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5469 · Cited by 17
Self-citationGibalová, L., Sedlák, J., Labudová, M., et al. (2009) · General Physiology and Biophysics · doi:10.4149/pb_2009_04_391 · Cited by 16
Tissue microarray technology and findings for diagnostic immunohistochemistry
van Zwieten, A. (2012) · Pathology · doi:10.1097/pat.0b013e32835b7b99 · Cited by 16
Evaluation of Artesunate and Praziquantel Combination Therapy in Murine Schistosomiasis mansoni.
Hegazy, L. A. M., Motiam, M. H. A., El-Aal, N. F. A., Ibrahim, S., & Mohamed, H. K. (2018) · Europe PMC (PubMed Central) · Cited by 16
Zhao, L., Cheng, G., Choksi, K. B., Samanta, A., Girgis, M., Soder, R. P., Vincent, R. J., Wulser, M. J., DeRuyter, M. T., McEnulty, P. G., et al. (2019) · Circulation Research · doi:10.1161/circresaha.119.315216 · Cited by 16
Gjertsen, B. T., Logothetis, C. J., & McDonnell, T. J. (1998) · Cancer and Metastasis Reviews · doi:10.1023/a:1006170332301 · Cited by 16
“Bcl-2 is expressed in the basal cells of prostatic glandular epithelium [2].”
BackgroundStaibano, S., Franco, R., Tranfa, F., et al. (2004) · PubMed · Cited by 16
Aschoff, A. P., Ott, U., Fünfstück, R., et al. (1999) · Cell and Tissue Research · doi:10.1007/s004410051295 · Cited by 16
MOLECULAR TARGETS FOR THE THERAPEUTIC MANIPULATION OF APOPTOSIS IN BLADDER CANCER
Duggan, B. J., Kelly, J. D., KEANE, P. F., & Johnston, S. R. (2001) · The Journal of Urology · doi:10.1016/s0022-5347(05)66582-2 · Cited by 16
Riva, C., Chevrier, C., Pasqual, N., et al. (2001) · Molecular and Cellular Biochemistry · doi:10.1023/a:1012772931313 · Cited by 16
BCL-2 Induction is Part of the Strategy of Epstein-Barr Virus
Finke, J., Lange, W., Mertelsmann, R. H., et al. (1994) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199409073782 · Cited by 16
Taylor, D., Wilkison, M., Voyich, J. M., & Meissner, N. N. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003558 · Cited by 15
“BCL-2 is only expressed in hematopoietic cells up to the promyelocyte stage but not in band neutrophils (43, 44).”
BackgroundBcl-2 Family of Proteins as Therapeutic Targets in Genitourinary Neoplasms
Hall, C. P., Troutman, S. M., Price, D. K., Figg, W. D., & Kang, M. H. (2012) · Clinical Genitourinary Cancer · doi:10.1016/j.clgc.2012.09.002 · Cited by 15
Xin, M., Wei, J.-H., Yang, C., Liang, G.-B., Su, D., Ma, X., & Zhang, Y. (2020) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2020.127051 · Cited by 15
Metadata
- Authors
- Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M., & Korsmeyer, S. J.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1991-08-15
- Volume
- 88
- Issue
- 16
- Pages
- 6961-6965
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC52213
- OpenAlex
- W1970629830
- Semantic Scholar
- d825dc162ad208c572711f59c9aa1c7974e89492
- Cited by
- 1,252
- References
- 40
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 9 · 2022: 4 · 2021: 5 · 2020: 10 · 2019: 9 · 2018: 9 · 2017: 9 · 2016: 7 · 2015: 10 · 2014: 15 · 2013: 10 · 2012: 12
- FWCI
- 26.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- Bcl-2, apoptosis, germinal center, light zone, plasma cells, memory B cells, thymic medulla, hematopoietic stem cells, tissue distribution, epithelial stem cells, follicular B-cell lymphoma, transgenic mice
- MeSH terms
- Adult, Bone Marrow, Breast, Cell Survival, Digestive System, Female, Humans, Immunoenzyme Techniques, Male, Neurons, Pancreas, Prostate, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Proto-Oncogenes, Skin, Thymus Gland, Palatine Tonsil, Proto-Oncogene Proteins c-bcl-2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-18, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-18 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
