Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo

Koliatsos, Vassilis E.; Clatterbuck, Richard E.; Winslow, John W.; Cayouette, Michelle H.; Prices, Donald L.

doi:10.1016/0896-6273(93)90326-m

Cited by 539Nerve injury and regenerationHereditary Neurological DisordersAmyotrophic Lateral Sclerosis Research

Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo

Koliatsos, Vassilis E., Clatterbuck, Richard E., Winslow, John W., Cayouette, Michelle H., Prices, Donald L.·1993·Neuron

DOI 10.1016/0896-6273(93)90326-m

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Abstract

The neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) act upon populations of neurons that express specific receptors. The present study demonstrates that BDNF rescues motor neurons from degeneration and may also play a role in the normal physiology of these cells. BDNF is expressed in the local environment and in muscle targets of motor neurons; muscle expression is up-regulated by denervation. The alpha motor neurons express the gene encoding p145trkB, a receptor involved in BDNF signal transduction, whereas a subset of motor neurons express p75NGFR. BDNF is transported selectively to alpha motor neurons from skeletal muscles. Finally, BDNF prevents motor neuron death in the axotomized facial nucleus of the neonatal rat. The effects of BDNF on motor neurons raise the possibility that some neurotrophins may be useful in treating patients with motor neuropathies and amyotrophic lateral sclerosis.

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Authors: Koliatsos, V. E., Clatterbuck, R. E., Winslow, J. W., Cayouette, M. H., & Prices, D. L.
Affiliations: Johns Hopkins University (US)
Genentech (US)
ORCID: Winslow, John W.
Venue: Neuron
Publisher: Elsevier BV
Published: 1993-03
Volume: 10
Issue: 3
Pages: 359-367
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/0896-6273(93)90326-m
OpenAlex: W1983777466
Cited by: 539
References: 55
Citations by year: 2026: 3 · 2025: 8 · 2024: 9 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 7 · 2019: 8 · 2018: 9 · 2017: 9 · 2016: 8 · 2015: 11 · 2014: 14 · 2013: 13 · 2012: 11
FWCI: 14.13
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5t32ns007179-15)
National Institute on Aging (P50AG005146, AG 05146)
National Institute of Neurological Disorders and Stroke (NS-07179, NS-20471)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
Keywords: brain-derived neurotrophic factor, motor neurons, neurotrophins, nerve growth factor, neurotrophin-3, TrkB receptor, p75NGFR, alpha motoneurons, axotomy, facial nucleus, motor neuron degeneration, denervation, motor neuropathy, amyotrophic lateral sclerosis
MeSH terms: Animals, Biological Transport, Motor Neurons, Muscles, Nerve Degeneration, Nerve Growth Factors, Nerve Tissue Proteins, Receptors, Cell Surface, Recombinant Proteins, Spinal Cord, Rats, Sprague-Dawley, Brain-Derived Neurotrophic Factor, Neurotrophin 3, Rats

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Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo

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