CoChat
Sign Up
Cited by 438Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

The DOI matches its Crossref record; 24 of the 25 references it cites were found in a registry or an index.

Distinct short-term plasticity at two excitatory synapses in the hippocampus

Open access
Salin, Paul A., Scanziani, Massimo, Malenka, Robert C., Nicoll, Roger A.·1996·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.93.23.13304PMC PMC24088
Open this paper in CoChat — free account

Abstract

A single mossy fiber input contains several release sites and is located on the proximal portion of the apical dendrite of CA3 neurons. It is, therefore, well suited to exert a strong influence on pyramidal cell excitability. Accordingly, the mossy fiber synapse has been referred to as a detonator or teacher synapse in autoassociative network models of the hippocampus. The very low firing rates of granule cells [Jung, M. W. & McNaughton, B. L. (1993) Hippocampus 3, 165-182], which give rise to the mossy fibers, raise the question of how the mossy fiber synapse temporally integrates synaptic activity. We have therefore addressed the frequency dependence of mossy fiber transmission and compared it to associational/commissural synapses in the CA3 region of the hippocampus. Paired pulse facilitation had a similar time course, but was 2-fold greater for mossy fiber synapses. Frequency facilitation, during which repetitive stimulation causes a reversible growth in synaptic transmission, was markedly different at the two synapses. At associational/ commissural synapses facilitation occurred only at frequencies greater than once every 10 s and reached a magnitude of about 125% of control. At mossy fiber synapses, facilitation occurred at frequencies as low as once every 40 s and reached a magnitude of 6-fold. Frequency facilitation was dependent on a rise in intraterminal Ca2+ and activation of Ca2+/calmodulin-dependent kinase II, and was greatly reduced at synapses expressing mossy…

Overview

Integrity signals

Registry

Crossref · 10.1073/pnas.93.23.13304

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 25 references

Research works printed but not linked: 3

  1. C Yamamoto, S Sawada, S Takada Exp Brain Res 51, 128–134 (1983).
  2. L H Hamlyn J Anat 96, 112–126 (1962).
  3. B L McNaughton, L Nadel Neuroscience and Correctionist Theory, eds M A Gluck, D S Rumelhert (Erlbaum), pp. 1–60 (1990).

Cited by

Sorted by citations

Items 401–438 of 438

Related

See all

Metadata

Authors
Salin, P. A., Scanziani, M., Malenka, R. C., & Nicoll, R. A.
Affiliations
University of California, San Francisco (US)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1996-11-12
Volume
93
Issue
23
Pages
13304-13309
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.93.23.13304
PMC
PMC24088
OpenAlex
W2055775269
Cited by
438
References
25
Citations by year
2026: 6 · 2025: 14 · 2024: 13 · 2023: 19 · 2022: 12 · 2021: 17 · 2020: 17 · 2019: 15 · 2018: 20 · 2017: 15 · 2016: 13 · 2015: 11 · 2014: 18 · 2013: 15 · 2012: 10
FWCI
4.06
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
mossy fiber synapses, short-term plasticity, frequency facilitation, paired-pulse facilitation, CA3 pyramidal cells, granule cells, long-term potentiation, synaptic integration, hippocampus
MeSH terms
Animals, Calcium, Egtazic Acid, Evoked Potentials, Guinea Pigs, Hippocampus, Magnesium, Nerve Fibers, Neuronal Plasticity, Neurons, Quinoxalines, Synapses, Time Factors, 4-Aminopyridine, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Calcium-Calmodulin-Dependent Protein Kinases, Pyramidal Cells, Receptors, AMPA, 6-Cyano-7-nitroquinoxaline-2,3-dione, Calcium-Calmodulin-Dependent Protein Kinase Type 2, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review