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Cited by 1,141Schizophrenia research and treatmentNicotinic Acetylcholine Receptors StudyGenetic Associations and Epidemiology

The DOI matches its Crossref record; 62 of the 63 references it cites were found in a registry or an index.

Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus

Open access
Freedman, Robert, Coon, Hilary, Myles-Worsley, Marina, Orr-Urtreger, Avi, Olincy, Ann, Davis, Ashley, Polymeropoulos, Mihael, Holik, John, Hopkins, Jan, Hoff, Mark, Rosenthal, Judy, Waldo, Merilyne C., Reimherr, Fred, Wender, Paul, Yaw, Jeffrey, Young, David A., Breese, Charles R., Adams, Catherine, Patterson, David, Adler, Lawrence E., Kruglyak, Leonid, Leonard, Sherry, Byerley, William·1997·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.94.2.587PMC PMC19557
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Abstract

Inheritance of a defect in a neuronal mechanism that regulates response to auditory stimuli was studied in nine families with multiple cases of schizophrenia. The defect, a decrease in the normal inhibition of the P50 auditory-evoked response to the second of paired stimuli, is associated with attentional disturbances in schizophrenia. Decreased P50 inhibition occurs not only in most schizophrenics, but also in many of their nonschizophrenic relatives, in a distribution consistent with inherited vulnerability for the illness. Neurobiological investigations in both humans and animal models indicated that decreased function of the α7-nicotinic cholinergic receptor could underlie the physiological defect. In the present study, a genome-wide linkage analysis, assuming autosomal dominant transmission, showed that the defect is linked [maximum logarithm of the odds (lod) score = 5.3 with zero recombination] to a dinucleotide polymorphism at chromosome 15q13-14, the site of the α7-nicotinic receptor. Despite many schizophrenics’ extremely heavy nicotine use, nicotinic receptors were not previously thought to be involved in schizophrenia. The linkage data thus provide unique new evidence that the α7-nicotinic receptor gene may be responsible for the inheritance of a pathophysiological aspect of the illness.

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Crossref · 10.1073/pnas.94.2.587

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Research works printed but not linked: 8

  1. J-M Lalouel Am J Hum Genet 37, 700–718 (1985).
  2. L E Adler, E Pachtman, R Franks, M Pecevich, M C Waldo, R Freedman Biol Psychiatry 17, 639–654 (1982).
  3. W R Goff, P D Williamson, C VanGilder, R Allison, T C Fisher Prog Clin Neurophysiol 7, 126–145 (1980).
  4. L Kruglyak, M J Daly, M P Reeve-Daly, E S Lander Am J Hum Genet 58, 1347–1363 (1996).
  5. L Kruglyak, E S Lander Am J Hum Genet 57, 519–527 (1995).
  6. M Melissari, G Giordano, P Crafa, M Martella, R Ricci Pathologica 87, 78–81 (1995).
  7. L K Casaubon, M Melanson, I Lopes-Cendes, C Marineau, E Andersmann, F Andersmann, J Weissenbach, C Prevost, J P Bouchard, J Matheiu, G A Rouleau Am J Hum Genet 58, 28–34 (1996).
  8. 10.1002/(SICI)1096-8628(19960409)67:2<154::AID-AJMG5>3.0.CO;2-S · DOI

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Metadata

Authors
Freedman, R., Coon, H., Myles-Worsley, M., Orr-Urtreger, A., Olincy, A., Davis, A., Polymeropoulos, M., Holik, J., Hopkins, J., Hoff, M., Rosenthal, J., Waldo, M. C., Reimherr, F., Wender, P., Yaw, J., Young, D. A., Breese, C. R., Adams, C., Patterson, D., Adler, L. E., Kruglyak, L., Leonard, S., & Byerley, W.
Affiliations
  • Baylor College of Medicine (US)
  • Departments of Psychiatry, Pharmacology, Biochemistry, and Preventive Medicine and Biophysics, University of Colorado School of Medicine, Denver Veterans Affairs Medical Center, and Eleanor Roosevelt Institute for Cancer Research, Denver, CO 80262; Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT 84132; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030-3498; National Center for Human Genome Research/National Institutes of...
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1997-01-21
Volume
94
Issue
2
Pages
587-592
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.94.2.587
PMC
PMC19557
OpenAlex
W2144671685
Cited by
1,141
References
63
Citations by year
2026: 3 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 10 · 2021: 11 · 2020: 16 · 2019: 15 · 2018: 6 · 2017: 14 · 2016: 19 · 2015: 46 · 2014: 25 · 2013: 28 · 2012: 39
FWCI
62.17
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Veterans Affairs
  • National Institutes of Health (5k02mh001089-03, 1f32mh010168-01, DA09457)
  • National Institute on Aging (T32AG000029)
  • National Institute of Mental Health (MH-44212, P50MH044212, MH01089, MH-10168-F32)
  • National Institute on Drug Abuse (R01DA009457)
  • National Center for Research Resources (P41RR003655, M01RR000064)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
schizophrenia, alpha7 nicotinic acetylcholine receptor, genetic linkage, autosomal dominant inheritance, attention deficits, family-based genetic study, nicotine use
MeSH terms
Auditory Perception, Chromosomes, Human, Pair 15, Evoked Potentials, Female, Genes, Genetic Markers, Humans, Genetic Linkage, Male, Pedigree, Receptors, Nicotinic, Schizophrenia, Chromosomes, Artificial, Yeast

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